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Your Environment. Your Health.

Program Publications: University of Tennessee, Knoxville: Biogeochemical Controls over Corrinoid Bioavailability to Organohalide-Respiring Chloroflexi

Superfund Research Program

Biogeochemical Controls over Corrinoid Bioavailability to Organohalide-Respiring Chloroflexi

Project Leader: Frank E. Loeffler
Co-Investigators: Jun Yan, Shawn R. Campagna
Grant Number: R01ES024294
Funding Period: 2014-2019
View this project in the NIH Research Portfolio Online Reporting Tools (RePORT)

Program Links



  • Yan J, Wang J, Villalobos Solis MI, Jin H, Chourey K, Li X, Yang Y, Yin Y, Hettich RL, Loffler F. 2021. Respiratory vinyl chloride reductive dechlorination to ethene in TceA-expressing Dehalococcoides mccartyi. Environ Sci Technol 55:4831-4841. doi:10.1021/acs.est.0c07354 PMID:33683880


  • Yin Y, Yan J, Chen G, Murdoch FK, Pfisterer N, Loeffler FE. 2019. Nitrous oxide is a potent inhibitor of bacterial reductive dechlorination. Environ Sci Technol 53(2):692-701. doi:10.1021/acs.est.8b05871 PMID:30558413


  • Clark K, Taggart DM, Baldwin BR, Ritalahti KM, Murdoch RW, Hatt JK, Loeffler FE. 2018. Normalized quantitative PCR measurements as predictors for ethene formation at sites impacted with chlorinated ethenes. Environ Sci Technol 52:13410-13420. doi:10.1021/acs.est.8b04373 PMID:30365883
  • Yan J, Bi M, Bourdon AK, Farmer AT, Wang P, Molenda O, Quaile AT, Jiang N, Yang Y, Yin Y, Şimşir B, Campagna SR, Edwards EA, Loeffler FE. 2018. Purinyl-cobamide is a native prosthetic group of reductive dehalogenases. Nat Chem Biol 14:8-14. doi:10.1038/nchembio.2512 PMID:29106396


  • Wang P, Tang S, Nemr K, Flick R, Yan J, Mahadevan R, Yakunin AF, Loeffler FE, Edwards EA. 2017. Refined experimental annotation reveals conserved corrinoid autotrophy in chloroform-respiring Dehalobacter isolates. ISME J 11:626-640. doi:10.1038/ismej.2016.158 PMID:27898054 PMCID:PMC5322310
  • Yang Y, Higgins SA, Yan J, Simsir B, Chourey K, Iyer R, Hettich RL, Baldwin BR, Ogles D, Loeffler FE. 2017. Grape pomace compost harbors organohalide-respiring Dehalogenimonas species with novel reductive dehalogenase genes. ISME J 11:2767-2780. doi:10.1038/ismej.2017.127 PMID:28809851 PMCID:PMC5702733


  • Yan J, Şimşir B, Farmer AT, Bi M, Yang Y, Campagna SR, Loeffler FE. 2016. The corrinoid cofactor of reductive dehalogenases affects dechlorination rates and extents in organohalide-respiring Dehalococcoides mccartyi. ISME J 10(5):1092-1101. doi:10.1038/ismej.2015.197 PMID:26555247 PMCID:PMC5029212
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