Superfund Research Program

Frank E. Loeffler

University of Tennessee, Knoxville
676 Dabney Hall
1416 Circle Drive
Knoxville, Tennessee 37996-1605
Phone: 865-974-4933
Email: frank.loeffler@utk.edu

Projects

• Microbial Insights, Inc.: Expanding the Tool Box: Environmental Metabolomics Improves Decision Making and Management of Contaminated (Superfund) Sites (Phase I: April 2019 - March 2021)
• University of Tennessee, Knoxville: Biogeochemical Controls over Corrinoid Bioavailability to Organohalide-Respiring Chloroflexi (2014-2019)

Research Briefs

• 292 - Nitrous Oxide Halts Breakdown of Chlorinated Compounds
• 276 - Novel Cobamide Structure May Hold Clues for More Effective Biological Degradation of Chlorinated Compounds
• 255 - The Effect of Corrinoid Co-factors on Bioremediation of Chlorinated Compounds

Hazardous Waste Sites

Third Creek site

• University of Tennessee, Knoxville: Biogeochemical Controls over Corrinoid Bioavailability to Organohalide-Respiring Chloroflexi

Publications

2019

• Yin Y, Yan J, Chen G, Murdoch FK, Pfisterer N, Loeffler FE. 2019. Nitrous oxide is a potent inhibitor of bacterial reductive dechlorination. Environ Sci Technol 53(2):692-701. doi:10.1021/acs.est.8b05871 PMID:30558413

2018

• Clark K, Taggart DM, Baldwin BR, Ritalahti KM, Murdoch RW, Hatt JK, Loeffler FE. 2018. Normalized quantitative PCR measurements as predictors for ethene formation at sites impacted with chlorinated ethenes. Environ Sci Technol 52:13410-13420. doi:10.1021/acs.est.8b04373 PMID:30365883
• Yan J, Bi M, Bourdon AK, Farmer AT, Wang P, Molenda O, Quaile AT, Jiang N, Yang Y, Yin Y, Şimşir B, Campagna SR, Edwards EA, Loeffler FE. 2018. Purinyl-cobamide is a native prosthetic group of reductive dehalogenases. Nat Chem Biol 14:8-14. doi:10.1038/nchembio.2512 PMID:29106396

2017

• Wang P, Tang S, Nemr K, Flick R, Yan J, Mahadevan R, Yakunin AF, Loeffler FE, Edwards EA. 2017. Refined experimental annotation reveals conserved corrinoid autotrophy in chloroform-respiring Dehalobacter isolates. ISME J 11:626-640. doi:10.1038/ismej.2016.158 PMID:27898054 PMCID:PMC5322310
• Yang Y, Higgins SA, Yan J, Simsir B, Chourey K, Iyer R, Hettich RL, Baldwin BR, Ogles D, Loeffler FE. 2017. Grape pomace compost harbors organohalide-respiring Dehalogenimonas species with novel reductive dehalogenase genes. ISME J 11:2767-2780. doi:10.1038/ismej.2017.127 PMID:28809851 PMCID:PMC5702733

2016

• Yan J, Şimşir B, Farmer AT, Bi M, Yang Y, Campagna SR, Loeffler FE. 2016. The corrinoid cofactor of reductive dehalogenases affects dechlorination rates and extents in organohalide-respiring Dehalococcoides mccartyi. ISME J 10(5):1092-1101. doi:10.1038/ismej.2015.197 PMID:26555247 PMCID:PMC5029212

2009

• Himmelheber DW, Thomas SH, Loeffler FE, Taillefert M, Hughes JB. 2009. Microbial colonization of an in situ sediment cap and correlation to stratified redox zones. Environ Sci Technol 43(1):66-74. doi:10.1021/es801834e PMID:19209586

2008

• Himmelheber DW, Taillefert M, Thomas SH, Loeffler FE, Pennell KD, Hughes JB. 2008. Spatial Distribution of Biogeochemical Processes Following In Situ Capping of Contaminated Sediments. In: Proceedings of The Sixth International Conference on Remediation of Chlorinated and Recalcitrant Compounds. Battelle Press, Columbus, OH.