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Your Environment. Your Health.

Person Details: Frank E. Loeffler

Superfund Research Program

Frank E. Loeffler

University of Tennessee, Knoxville
676 Dabney Hall
1416 Circle Drive
Knoxville, Tennessee 37996-1605
Phone: 865-974-4933


Research Briefs

Hazardous Waste Sites

Third Creek site

  • University of Tennessee, Knoxville: Biogeochemical Controls over Corrinoid Bioavailability to Organohalide-Respiring Chloroflexi



  • Yin Y, Yan J, Chen G, Murdoch FK, Pfisterer N, Loeffler FE. 2019. Nitrous oxide is a potent inhibitor of bacterial reductive dechlorination. Environ Sci Technol 53(2):692-701. doi:10.1021/acs.est.8b05871 PMID:30558413


  • Clark K, Taggart DM, Baldwin BR, Ritalahti KM, Murdoch RW, Hatt JK, Loeffler FE. 2018. Normalized quantitative PCR measurements as predictors for ethene formation at sites impacted with chlorinated ethenes. Environ Sci Technol 52:13410-13420. doi:10.1021/acs.est.8b04373 PMID:30365883
  • Yan J, Bi M, Bourdon AK, Farmer AT, Wang P, Molenda O, Quaile AT, Jiang N, Yang Y, Yin Y, Şimşir B, Campagna SR, Edwards EA, Loeffler FE. 2018. Purinyl-cobamide is a native prosthetic group of reductive dehalogenases. Nat Chem Biol 14:8-14. doi:10.1038/nchembio.2512 PMID:29106396


  • Wang P, Tang S, Nemr K, Flick R, Yan J, Mahadevan R, Yakunin AF, Loeffler FE, Edwards EA. 2017. Refined experimental annotation reveals conserved corrinoid autotrophy in chloroform-respiring Dehalobacter isolates. ISME J 11:626-640. doi:10.1038/ismej.2016.158 PMID:27898054 PMCID:PMC5322310
  • Yang Y, Higgins SA, Yan J, Simsir B, Chourey K, Iyer R, Hettich RL, Baldwin BR, Ogles D, Loeffler FE. 2017. Grape pomace compost harbors organohalide-respiring Dehalogenimonas species with novel reductive dehalogenase genes. ISME J 11:2767-2780. doi:10.1038/ismej.2017.127 PMID:28809851 PMCID:PMC5702733


  • Yan J, Şimşir B, Farmer AT, Bi M, Yang Y, Campagna SR, Loeffler FE. 2016. The corrinoid cofactor of reductive dehalogenases affects dechlorination rates and extents in organohalide-respiring Dehalococcoides mccartyi. ISME J 10(5):1092-1101. doi:10.1038/ismej.2015.197 PMID:26555247 PMCID:PMC5029212


  • Himmelheber DW, Thomas SH, Loeffler FE, Taillefert M, Hughes JB. 2009. Microbial colonization of an in situ sediment cap and correlation to stratified redox zones. Environ Sci Technol 43(1):66-74. doi:10.1021/es801834e PMID:19209586


  • Himmelheber DW, Taillefert M, Thomas SH, Loeffler FE, Pennell KD, Hughes JB. 2008. Spatial Distribution of Biogeochemical Processes Following In Situ Capping of Contaminated Sediments. In: Proceedings of The Sixth International Conference on Remediation of Chlorinated and Recalcitrant Compounds. Battelle Press, Columbus, OH.
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