Superfund Research Program
Mouse Molecular Genetics Core
Project Leader: Pamela L. Mellon
Grant Number: P42ES010337
Funding Period: 2000-2017
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Final Progress Reports
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Final Progress Reports
The Mouse Core's major function is the creation of novel genetically manipulated mouse models for the Superfund investigators. In addition, Dr. Mellon’s team assists with the design, characterization, and maintenance of these important mouse models. The core is heavily used by the laboratories of Drs. Karin, Tukey, Glass, and Taylor. A substantial array of transgenic and knock-out mouse models have been created in the initial years of the Superfund granting period. Highlights include the creation of conditional knock-outs for the IKKb gene, knock-outs of alternatively spliced exons of acetylcholinesterase, a conditional knock-out of PPARg, total knock-outs of JNK1 and 2, and transgenic reporter systems for the detection of toxic agents. This year, the core has performed quite a number of embryonic stem cell targeting procedures, performed cryopreservation of a number of important mouse lineages for the project investigators, and created a number of lines of transgenic mice including those carrying Bacterial Artificial Chromosomes. Many of these projects are leading to new directions and have provided important information for the core’s competing renewal.