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Project Publications: University of California-San Diego: Mouse Molecular Genetics Core

Superfund Research Program

Mouse Molecular Genetics Core

Project Leader: Pamela L. Mellon
Grant Number: P42ES010337
Funding Period: 2000-2017
View this project in the NIH Research Portfolio Online Reporting Tools (RePORT)

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Publications

2018

  • Hoffman HM, Gong P, Tamrazian A, Mellon PL. 2018. Transcriptional interaction between cFOS and the homeodomain-binding transcription factor VAX1 on the GnRH promoter controls Gnrh1 expression levels in a GnRH neuron maturation specific manner. Mol Cell Endocrinol 461:143-154. doi:10.1016/j.mce.2017.09.004 PMID:28890143 PMCID:PMC5756504

2017

2016

2015

  • Kauffman AS, Thackray VG, Ryan GE, Tolson KP, Glidewell-Kenney CA, Semaan SJ, Poling MC, Iwata N, Breen KM, Duleba AJ, Stener-Victorin E, Shimasaki S, Webster NJ, Mellon PL. 2015. A novel letrozole model recapitulates both the reproductive and metabolic phenotypes of polycystic ovary syndrome in female mice. Biol Reprod 93(3):69. doi:10.1095/biolreprod.115.131631 PMID:26203175 PMCID:PMC4710190
  • Skowronska-Krawczyk D, Zhao L, Zhu J, Weinreb RN, Cao G, Luo J, Flagg K, Patel S, Wen C, Krupa M, Luo H, Ouyang H, Lin D, Wang W, Li G, Xu Y, Li O, Chung C, Yeh E, Jafari M, Ai M, Zhong Z, Shi W, Zin C, Mellon PL, Gao W, Abagyan R, Zhang L, Sun X, Zhong Z, Zhuo Y, Rosenfeld MG, Liu Y, Zhang K. 2015. P16INK4a upregulation mediated by SIX6 defines retinal ganglion cell pathogenesis in glaucoma. Mol Cell 59(6):931-940. doi:10.1016/j.molcel.2015.07.027 PMID:26365380 PMCID:PMC4648709
  • Stephens SB, Tolson KP, Rouse ML, Poling MC, Hashimoto-Partyka MK, Mellon PL, Kauffman AS. 2015. Absent progesterone signaling in kisspeptin neurons disrupts the LH surge and impairs fertility in female mice. Endocrinology 156(9):3091-3097. doi:10.1210/en.2015-1300 PMID:26076042 PMCID:PMC4541622
  • Xie H, Hoffman HM, Meadows JD, Mayo S, Trang C, Leming SS, Maruggi C, Davis SW, Larder R, Mellon PL. 2015. Homeodomain proteins SIX3 and SIX6 regulate gonadotrope-specific genes during pituitary development. Mol Endocrinol 29(6):842-855. doi:10.1210/me.2014-1279 PMID:25915183 PMCID:PMC4447639

2014

  • Ahow M, Min L, Pampillo M, Nash C, Wen J, Soltis K, Carroll RS, Glidewell-Kenney CA, Mellon PL, Bhattacharya M, Tobet SA, Kaiser UB, Babwah AV. 2014. KISS1R signals independently of Gαq/11 and triggers LH secretion via the β-arrestin pathway in the male mouse. Endocrinology 155(11):4433-4446. doi:10.1210/en.2014-1304 PMID:25147978 PMCID:PMC4197989
  • Breen KM, Mellon PL. 2014. Influence of stress-induced intermediates on gonadotropin gene expression in gonadotrope cells. Mol Cell Endocrinol 385(1-2):71-77. doi:10.1016/j.mce.2013.08.014 PMID:24012628 PMCID:PMC3942370
  • Glidewell-Kenney CA, Trang C, Shao PP, Gutierrez-Reed N, Uzo-Okereke AM, Coss D, Mellon PL. 2014. Neurokinin B induces c-fos transcription via protein kinase C and activation of serum response factor and Elk-1 in immortalized GnRH neurons. Endocrinology 155(10):3909-3919. doi:10.1210/en.2014-1263 PMID:25057795 PMCID:PMC4164922
  • Hoffmann HM, Tamrazian A, Xie H, Perez-Millan MI, Kauffman AS, Mellon PL. 2014. Heterozygous deletion of ventral anterior homeobox (vax1) causes subfertility in mice. Endocrinology 155(10):4043-4053. doi:10.1210/en.2014-1277 PMID:25060364 PMCID:PMC4164932
  • Roybal LL, Hambarchyan A, Meadows JD, Barakat AI, Pepa PA, Breen KM, Mellon PL, Coss D. 2014. Roles of binding elements, FOXL2 domains, and interactions with cJUN and SMADs in regulation of FSHβ. Mol Endocrinol 28(10):1640-1655. doi:10.1210/me.2014-1008 PMID:25105693 PMCID:PMC4179627

2013

2012

2007

  • Naugler WE, Sakurai T, Kim S, Maeda S, Kim K, Elsharkawy AM, Karin M. 2007. Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production. Science 317(5834):121-124. doi:10.1126/science.1140485 PMID:17615358

2006

  • Long JM, LaPorte P, Merscher S, Funke B, Saint-Jore B, Puech A, Kucherlapati R, Morrow BE, Skoultchi AI, Wynshaw-Boris A. 2006. Behavior of mice with mutations in the conserved region deleted in velocardiofacial/DiGeorge syndrome. Neurogenetics 7(4):247-57. PMID:16900388

2004

  • Comoletti D, De Jaco A, Jennings LL, Flynn RE, Gaietta G, Tsigelny I, Ellisman MH, Taylor PW. 2004. The Arg451Cys-neuroligin-3 mutation associated with autism reveals a defect in protein processing. J Neurosci 24(20):4889-4893. PMID:15152050
  • Dooley CT, Dore TM, Hanson GT, Jackson WC, Remington SJ, Tsien RY. 2004. Imaging dynamic redox changes in mammalian cells with green fluorescent protein indicators. J Biol Chem 279(21):22284-22293. PMID:14985369
  • Hanson GT, Aggeler R, Oglesbee D, Cannon M, Capaldi RA, Tsien RY, Remington SJ. 2004. Investigating mitochondrial redox potential with redox-sensitive green fluorescent protein indicators. J Biol Chem 279(13):13044-13053. PMID:14722062
  • Long JM, LaPorte P, Paylor R, Wynshaw-Boris A. 2004. Expanded characterization of the social interaction abnormalities in mice lacking Dvl1. Genes Brain Behav 3(1):51-62. PMID:14960015
  • Sil AK, Maeda S, Sano Y, Roop DR, Karin M. 2004. Abstract IkappaB kinase-alpha acts in the epidermis to control skeletal and craniofacial morphogenesis. Nature 428(6983):660-664. PMID:15071597

2003

  • Chen L, Egan LJ, Li Z, Kagnoff MF, Karin M. 2003. The two faces of IKK and NF-kappa B inhibition: prevention of systemic inflammation but increased local injury following intestinal ischemia-reperfusion. Nat Med 9(5):575-581. PMID:12692538
  • He L, Perkins GA, Poblenz AT, Harris JB, Hung M, Ellisman MH, Fox DA. 2003. Bcl-xL overexpression blocks bax-mediated mitochondrial contact site formation and apoptosis in rod photoreceptors of lead-exposed mice. Proc Natl Acad Sci U S A 100(3):1022-1027. doi:10.1073/pnas.0333594100 PMID:12540825 PMCID:PMC298719
  • Middleton SS, Bencheikh-Latmani R, Mackey MR, Ellisman MH, Tebo BM, Criddle CS. 2003. Cometabolism of Cr(VI) by Shewanella oneidensis MR-1 produces cell-associated reduced chromium and inhibits growth. Biotechnol Bioeng 83(6):627-637. PMID:12889027

2002

  • Adams SR, Campbell RE, Gross LA, Martin BR, Walkup GK, Yao Y, Llopis J, Tsien RY. 2002. New biarsenical ligands and tetracysteine motifs for protein labeling in vitro and in vivo: synthesis and biologiacal applications. J Am Chem Soc 124(21):6063-76. PMID:12022841
  • Corbo JC, Deuel TA, Long JM, LaPorte P, Tsai E, Wynshaw-Boris A, Walsh CA. 2002. Double cortin is required in mice for lamination of the hippocampus but not the neocortex. J Neurosci 22(17):7548-7557. PMID:12196578
  • Huang Y, Galijatovic A, Nguyen N, Geske D, Beaton D, Green J, Green M, Peters WH, Tukey RH. 2002. Identification and functional characterization of UDP-glucuronosyltransferases UGT1A8*1, UGT1A8*2 and UGT1A8*3. Pharmacogenet Genomics 12(4):287-297. PMID:12042666
  • Kuchitsu K, Ward JM, Allen GJ, Schelle I, Schroeder JI. 2002. Loading acetoxymethyl ester fluorescent dyes into the cytoplasam of Arabidopsis and Commelina guard cells. New Phytologist 153:527-533.
  • Wang Y, Schachter H, Marth JD. 2002. Mice with a homozygous deletion of the Mgat2 gene encoding UDP-N-acetylglucosamine:alpha-6-D-mannoside beta1,2-N-acetylglucosaminyltransferase II: a model for congenital disorder of glycosylation type IIa. Biochim Biophys Acta 1573(3):301-311. PMID:12417412

2001

  • Senftleben U, Cao Y, Xiao G, Greten FR, Krahn G, Bonizzi G, Chen Y, Hu Y, Fong A, Sun S, Karin M. 2001. Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway. Science 293(5534):1495-1499. doi:10.1126/science.1062677 PMID:11520989
  • Wang Y, Tan J, Sutton-Smith M, Ditto D, Panico M, Campbell RM, Varki NM, Long JM, Jaeken J, Levinson SR, Wynshaw-Boris A, Morris HR, Le D, Dell A, Schachter H, Marth JD. 2001. Modeling human congenital disorder of glycosylation type Iia in the mouse: conservation of asparagines-linked slycan-dependent functions in mammalian physiology and insights into disease pathogenesis. Glycobiology 11(12):1051-1070. PMID:11805078

2000

  • Gross LA, Baird GS, Hoffman RC, Baldridge KK, Tsien RY. 2000. The structure of the chromophore within DsRed, a red fluorescent protein from coral. Proc Natl Acad Sci U S A 97(22):11990-11995. PMID:11050230
  • Kapahi P, Takahashi T, Natoli G, Adams SR, Chen Y, Tsien RY, Karin M. 2000. Inhibition of NF-kappa B activation by arsenite through reaction with a critical cysteine in the activation loop of Ikappa B kinase. J Biol Chem 275(46):36062-36066. doi:10.1074/jbc.M007204200 PMID:10967126
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Last Reviewed: October 17, 2024