Superfund Research Program

TCDD-Elicited Steatosis: The Role of Aryl Hydrocarbon Receptor Regulation in Lipid Uptake, Metabolism, and Transport

Project Leader: Timothy R. Zacharewski
Grant Number: P42ES004911
Funding Period: 2006-2021

Project-Specific Links

Datasets

Total number of records: 23

Dataset Title	Data Types	Data Repository
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) Alters Hepatic Polyunsaturated Fatty Acid Metabolism and Eicosanoid Biosynthesis in Female Sprague-Dawley Rats [RNA-Seq]	Gene Expression	Gene Expression Omnibus (GEO)
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) Alters Hepatic Polyunsaturated Fatty Acid Metabolism and Eicosanoid Biosynthesis in Female Sprague-Dawley Rats [RNA-Seq]	Gene Expression	Gene Expression Omnibus (GEO)
2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) Alters Lipid Metabolism and Depletes Immune Cell Populations in the Jejunum of C57BL/6 Mice	Gene Expression	Gene Expression Omnibus (GEO)
AHR ChIP-Seq of male mouse liver following 2 hour TCDD exposure	Gene Expression	Gene Expression Omnibus (GEO)
AHR ChIP-Seq of male mouse liver following 2 hour TCDD exposure	Gene Expression	Gene Expression Omnibus (GEO)
Application of singe nuclei RNA sequencing to assess the hepatic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin	Gene Expression	Gene Expression Omnibus (GEO)
Comparison of hepatic NRF2 and AHR binding in 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) treated mice demonstrates NRF2-independent PKM2 induction	Gene Expression	Gene Expression Omnibus (GEO)
Dose-dependent metabolic reprogramming and differential gene expression in TCDD-elicited hepatic fibrosis	Gene Expression	Gene Expression Omnibus (GEO)
Dose-response hepatic single nuclei RNA sequencing of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) treated mice	Gene Expression	Gene Expression Omnibus (GEO)
Hepatic pyruvate kinase muscle isoform 2 (Pkm2) induction in response to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-elicited oxidative stress is independent of NRF2 (ChIP-Seq)	Gene Expression	Gene Expression Omnibus (GEO)
Hepatic pyruvate kinase muscle isoform 2 (Pkm2) induction in response to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-elicited oxidative stress is independent of NRF2 (RNA-Seq)	Gene Expression	Gene Expression Omnibus (GEO)
RNA-Seq Analysis of Dose-Dependent TCDD-Elicited Duodenal Gene Expression in Male Mice	Gene Expression	Gene Expression Omnibus (GEO)
RNA-Seq Analysis of Dose-Dependent TCDD-Elicited Femoral Gene Expression in Male Mice	Gene Expression	Gene Expression Omnibus (GEO)
RNA-Seq Analysis of Dose-Dependent TCDD-Elicited Gene Expression in Male Mice	Gene Expression	Gene Expression Omnibus (GEO)
RNA-Seq Analysis of Dose-Dependent TCDD-Elicited Hepatic Gene Expression in Male Mice	Gene Expression	Gene Expression Omnibus (GEO)
RNA-Seq Analysis of Dose-Dependent TCDD-Elicited Ileal Gene Expression in Male Mice	Gene Expression	Gene Expression Omnibus (GEO)
RNA-Seq Analysis of Dose-Dependent TCDD-Elicited Jejunal Gene Expression in Male Mice	Gene Expression	Gene Expression Omnibus (GEO)
RNA-Seq Analysis of TCDD-Elicited Changes in Circadian Hepatic Gene Expression in Male Mice	Gene Expression	Gene Expression Omnibus (GEO)
RNA-Seq Versus Oligonucleotide Array Assessment of Dose-Dependent TCDD-elicited Hepatic Gene Expression in Mice	Gene Expression	Gene Expression Omnibus (GEO)
RNA-Seq Versus Oligonucleotide Array Assessment of Dose-Dependent TCDD-elicited Hepatic Gene Expression in Mice	Gene Expression	Gene Expression Omnibus (GEO)
RNA-Seq Versus Oligonucleotide Array Assessment of Dose-Dependent TCDD-elicited Hepatic Gene Expression in Mice [Array]	Gene Expression	Gene Expression Omnibus (GEO)
RNA-Seq Versus Oligonucleotide Array Assessment of Dose-Dependent TCDD-elicited Hepatic Gene Expression in Mice [RNA-Seq]	Gene Expression	Gene Expression Omnibus (GEO)
Temporal comparison of transcriptomic alterations in human, mouse and rat primary B lymphocytes exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)	Gene Expression	Gene Expression Omnibus (GEO)