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Your Environment. Your Health.

Project Publications: Michigan State University: TCDD-Elicited Steatosis: The Role of Aryl Hydrocarbon Receptor Regulation in Lipid Uptake, Metabolism, and Transport

Superfund Research Program

TCDD-Elicited Steatosis: The Role of Aryl Hydrocarbon Receptor Regulation in Lipid Uptake, Metabolism, and Transport

Project Leader: Timothy R. Zacharewski
Grant Number: P42ES004911
Funding Period: 2006-2021
View this project in the NIH Research Portfolio Online Reporting Tools (RePORT)

Learn More About the Grantee

Visit the grantee's eNewsletter page Visit the grantee's eNewsletter page

Publications

2021

2020

  • Doskey CM, Fader KA, Nault R, Lydic TA, Matthews J, Potter D, Sharratt B, Williams K, Zacharewski TR. 2020. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) alters hepatic polyunsaturated fatty acid metabolism and eicosanoid biosynthesis in female Sprague-Dawley rats. Toxicol Appl Pharmacol 398:14. doi:10.1016/j.taap.2020.115034 PMID:32387183 PMCID:PMC7294678
  • Fling RR, Doskey CM, Fader KA, Nault R, Zacharewski TR. 2020. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) dysregulates hepatic one carbon metabolism during the progression of steatosis to steatohepatitis with fibrosis in mice. Sci Rep 10:14831. doi:10.1038/s41598-020-71795-0 PMID:32908189 PMCID:PMC7481292

2019

  • Dornbos P, Jurgelewicz A, Fader KA, Williams K, Zacharewski TR, LaPres JJ. 2019. Characterizing the role of HMG-CoA reductase in aryl hydrocarbon receptor-mediated liver injury in C57BL/6 mice. Sci Rep 9(1):15828. doi:10.1038/s41598-019-52001-2 PMID:31676775 PMCID:PMC6825130
  • Fader KA, Nault R, Doskey CM, Fling RR, Zacharewski TR. 2019. 2,3,7,8-Tetrachlorodibenzo-p-dioxin abolishes circadian regulation of hepatic metabolic activity in mice. Sci Rep 9:6514. doi:10.1038/s41598-019-42760-3 PMID:31015483 PMCID:PMC6478849
  • Josyula N, Andersen ME, Kaminski NE, Dere E, Zacharewski TR, Bhattacharya S. 2019. Gene co-regulation and co-expression in the aryl hydrocarbon receptor-mediated transcriptional regulatory network in the mouse liver. Arch Toxicol 94:113-126. doi:10.1007/s00204-019-02620-5 PMID:31728591

2018

  • Fader KA, Nault R, Raehtz S, McCabe LR, Zacharewski TR. 2018. 2,3,7,8-Tetrachlorodibenzo-p-dioxin dose-dependently increases bone mass and decreases marrow adiposity in juvenile mice. Toxicol Appl Pharmacol 348:85-98. doi:10.1016/j.taap.2018.04.013 PMID:29673856 PMCID:PMC5984050
  • Nault R, Doskey CM, Fader KA, Rockwell CE, Zacharewski TR. 2018. Comparison of hepatic NRF2 and aryl hydrocarbon receptor binding in 2,3,7,8-tetrachlorodibenzo-p-dioxin-treated mice demonstrates NRF2-independent PKM2 induction. Mol Pharmacol 94(2):876-884. doi:10.1124/mol.118.112144 PMID:29752288 PMCID:6022803

2017

2016

  • Nault R, Fader KA, Ammendolia DA, Dornbos P, Potter D, Sharratt B, Kumagai K, Harkema JR, Lunt SY, Matthews J, Zacharewski TR. 2016. Dose-dependent metabolic reprogramming and differential gene expression in TCDD-elicited hepatic fibrosis. Toxicol Sci 154(2):253-266. doi:10.1093/toxsci/kfw163 PMID:27562557 PMCID:PMC5139066
  • Nault R, Fader KA, Kirby MP, Ahmed S, Matthews J, Jones AD, Lunt SY, Zacharewski TR. 2016. Pyruvate kinase isoform switching and hepatic metabolic reprogramming by the environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Sci 149(2):358-371. doi:10.1093/toxsci/kfv245 PMID:26582802 PMCID:PMC4900217
  • Nault R, Fader KA, Kopec AK, Harkema JR, Zacharewski TR, Luyendyk J. 2016. From the cover: coagulation-driven hepatic fibrosis requires protease activated receptor-1 (PAR-1) in a mouse model of TCDD-elicited steatohepatitis. Toxicol Sci 154(2):381-391. doi:10.1093/toxsci/kfw175 PMID:27613713 PMCID:PMC5139072

2015

  • Fader KA, Nault R, Ammendolia DA, Harkema JR, Williams KJ, Crawford RB, Kaminski NE, Potter D, Sharratt B, Zacharewski TR. 2015. 2,3,7,8-Tetrachlorodibenzo-p-dioxin alters lipid metabolism and depletes immune cell populations in the jejunum of C57BL/6 mice. Toxicol Sci 148(2):567-580. doi:10.1093/toxsci/kfv206 PMID:26377647 PMCID:PMC5009443
  • Nault R, Colbry D, Brandenberger C, Zacharewski TR, Harkema JR. 2015. Development of a computational high-throughput tool for the quantitative examination of dose-dependent histological features. Toxicol Pathol 43(3):366-375. doi:10.1177/0192623314544379 PMID:25274660 PMCID:PMC4382446
  • Nault R, Fader KA, Zacharewski TR. 2015. RNA-Seq versus oligonucleotide array assessment of dose-dependent TCDD-elicited hepatic gene expression in mice. BMC Genomics 16:373. doi:10.1186/s12864-015-1527-z PMID:25958198 PMCID:PMC4456707

2013

2011

  • Angrish MM, Jones AD, Harkema JR, Zacharewski TR. 2011. Aryl hydrocarbon receptor-mediated induction of stearoyl-CoA desaturase 1 alters hepatic fatty acid composition in TCDD-elicited steatosis. Toxicol Sci 124(2):299-310. doi:10.1093/toxsci/kfr226 PMID:21890736 PMCID:PMC3216411
  • Dere E, Forgacs AL, Zacharewski TR, Burgoon LD. 2011. Genome-wide computational analysis of dioxin response element location and distribution in the human, mouse, and rat genomes. Chem Res Toxicol 24:494-504. doi:10.1021/tx100328r PMID:21370876 PMCID:PMC4038167
  • Dere E, Lee AW, Burgoon LD, Zacharewski TR. 2011. Differences in TCDD-elicited gene expression profiles in human HepG2, mouse Hepa1c1c7 and rat H4IIE hepatoma cells. BMC Genomics 12:doi:10.1186/1471-2164-12-193 PMID:21496263 PMCID:PMC3089798
  • Dere E, Lo R, Celius T, Matthews J, Zacharewski TR. 2011. Integration of genome-wide computation DRE search, AhR ChIP-chip and gene expression analyses of TCDD-elicited responses in the mouse liver. BMC Genomics 12:365. doi:10.1186/1471-2164-12-365 PMID:21762485 PMCID:PMC3160422
  • Kopec AK, D'Souza ML, Mets BD, Burgoon LD, Reese SE, Archer KJ, Potter D, Tashiro C, Sharratt B, Harkema JR, Zacharewski TR. 2011. Non-additive hepatic gene expression elicited by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and 2,2 ',4,4 ',5,5 '-hexachlorobiphenyl (PCB153) co-treatment in C57BL/6 mice. Toxicol Appl Pharmacol 256:154-167. doi:10.1016/j.taap.2011.08.002 PMID:21851831 PMCID:PMC4126514
  • Lo R, Celius T, Dere E, MacPherson L, Harper PA, Zacharewski TR, Matthews J. 2011. Identification of aryl hydrocarbon receptor binding targets in mouse hepatic tissue treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Appl Pharmacol 257:38-47. doi:10.1016/j.taap.2011.08.016 PMID:21889950

2010

  • Forgacs AL, Burgoon LD, Lynn SG, LaPres JJ, Zacharewski TR. 2010. Effects of TCDD on the expression of nuclear encoded mitochondrial genes. Toxicol Appl Pharmacol 246(1-2):58-65. doi:10.1016/j.taap.2010.04.006 PMID:20399798 PMCID:PMC4030424
  • Kopec AK, Burgoon LD, Ibrahim-Aibo D, Burg AR, Lee AW, Tashiro C, Sharratt B, Harkema JR, Rowlands C, Budinsky R, Zacharewski TR. 2010. Automated dose-response analysis and comparative toxicogenomic evaluation of the hepatic effects elicited by TCDD, TCDF, and PCB126 in C57BL/6 mice. Toxicol Sci 118(1):286-297. doi:10.1093/toxsci/kfq236 PMID:20702594 PMCID:PMC2955213
  • Kopec AK, Burgoon LD, Ibrahim-Aibo D, Mets BD, Tashiro C, Potter D, Sharratt B, Harkema JR, Zacharewski TR. 2010. PCB153-elicited hepatic responses in the immature, ovariectomized C57BL/6 mice: comparative toxicogenomic effects of dioxin and non-dioxin-like ligands. Toxicol Appl Pharmacol 243(3):359-371. doi:10.1016/j.taap.2009.12.003 PMID:20005886 PMCID:PMC3987113

2008

  • Boverhof DR, Burgoon LD, Williams KJ, Zacharewski TR. 2008. Inhibition of estrogen-mediated uterine gene expression responses by dioxin. Mol Pharmacol 73(1):82-93. doi:10.1124/mol.107.040451 PMID:17942748
  • Kopec AK, Boverhof DR, Burgoon LD, Ibrahim-Aibo D, Harkema JR, Tashiro C, Chittim B, Zacharewski TR. 2008. Comparative toxicogenomic examination of the hepatic effects of PCB126 and TCDD in immature, ovariectomized C57BL/6 mice. Toxicol Sci 102(1):61-75. doi:10.1093/toxsci/kfm289 PMID:18042819
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