Superfund Research Program
Environmental, Microbial and Mammalian Biomolecular Responses to AhR Ligands
Center Director: Norbert E. Kaminski
Grant Number: P42ES004911
Funding Period: 1989-2027
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Title: RNA-Seq Analysis of Dose-Dependent TCDD-Elicited Hepatic Gene Expression in Male Mice
Accession Number: GSE87519
Link to Dataset: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE87519
Repository: Gene Expression Omnibus (GEO)
Data Type(s): Gene Expression
Experiment Type(s): Array expression profiling by high throughput sequencing, ChIP-Seq
Organism(s): Mus musculus
Summary: Dose-dependent hepatic gene expression was examined following repeated exposure (every 4 days for 28 days) to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). These data were used to examine the effect of repeated TCDD exposure on gene expression in the liver of C57BL/6 male mice.
Publication(s) associated with this dataset:- Fader KA, Nault R, Kirby MP, Markous G, Matthews J, Zacharewski TR. 2017. Convergence of hepcidin defiency, systemic iron overloading, heme accumulation, and REV-ERBalpha/beta activation in aryl hydrocarbon receptor-elicited hepatotoxicity. Toxicol Appl Pharmacol 321:1-17. doi:10.1016/j.taap.2017.02.006 PMID:28213091