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Columbia University: Dataset Details, ID=GSE57711

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Superfund Research Program

Health Effects and Geochemistry of Arsenic

Center Director: Ana Navas-Acien
Grant Number: P42ES010349
Funding Period: 2000-2021

Program Links

Title: Sex-related changes in gene expression patterns of adults exposed to arsenic contaminated drinking water

Accession Number: GSE57711

Link to Dataset: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE57711

Repository: Gene Expression Omnibus (GEO)

Data Type(s): Gene Expression

Experiment Type(s): Expression profiling by array

Organism(s): Homo sapiens

Summary: Arsenic contamination of drinking water occurs globally and is associated with numerous diseases including skin, lung, and bladder cancers, and cardiovascular disease. The mechanisms behind arsenic's effects remain unclear, but recent research indicates that aresnic acts along sex-specific lines and may be an endocrine disruptor. The objective of this study was to evaluate the nature of gene expression chagnes among males and females exposed to arsenic contaminated water in Bangladesh at high and low dose exposures.The median wAs concentration for the low exposure group was 103 µg/L for males and 117 µg/L for females (range 50–200 µg/L). For the high exposure group, the median wAs concentration was 355 µg /L for males (range 250-500 µg /L) and 434 µg/L for females (range 232–1000 µg /L). The PBMCs of males with high exposure compared to those with low exposure there were 534 differentially expressed genes (p <0.05); and for females with high exposure relative to low exposure there were 645 differentially expressed genes (p <0.05) in PBMCs of females.

Publication(s) associated with this dataset:
  • Munoz A, Chervona Y, Hall MN, Kluz T, Gamble MV, Costa M. 2015. Sex-specific patterns and deregulation of endocrine pathways in the gene expression profiles of Bangladeshi adults exposed to arsenic contaminated drinking water. Toxicol Appl Pharmacol 284(3):330-338. doi:10.1016/j.taap.2015.02.025 PMID:25759245 PMCID:PMC4410068
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