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Columbia University

Superfund Research Program

Health Effects and Geochemistry of Arsenic and Manganese

Center Director: Joseph H. Graziano
Grant Number: P42ES010349
Funding Period: 2000-2021
View this project in the NIH Research Portfolio Online Reporting Tools (RePORT)

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Summary (2012-2017)

The Columbia University Superfund Research Program (SRP) Center conducts substantial work at the single most seriously arsenic-affected Superfund site in Vineland, NJ. It also involves unique epidemiologic studies of arsenic (As) and manganese (Mn)-exposed adults and adolescents residing in Bangladesh as well as an important mechanistic investigation of As-induced epigenetic dysregulation. As in the past, the Columbia University SRP includes a balance between biomedical and non-biomedical research.

The Center includes three biomedical research projects: Health Effects of As Longitudinal Study (HEALS); Consequences of As and Mn Exposure on Children's Health; and Impact of Nutrition on Arsenic-Induced Epigenetic Dysregulation. The biomedical research is intimately intertwined with three nonbiomedical projects: Arsenic, Iron, Sulfur and Organic Carbon Speciation, and Their Impact on Groundwater Arsenic; Application of Enhanced Mitigation Methods for Groundwater As at US Superfund Sites; and Defining the Sustainable Uses of Low-As Aquifers in Bangladesh. The projects are supported by four Research Support Core Laboratories: Data Management; Trace Metals; Biogeochemistry; and Hydrogeology.

A Research Translation Core (RTC) entitled, "Collaborating with government & the NIEHS SRP: As & Mn Exposure in Groundwater" works with several government agencies to help understand and solve their local groundwater problems. Finally, the RTC will work closely with the Community Engagement Core (CEC) entitled "Promoting As Testing and Treatment to Reduce Health Risks for Residents in Maine." The CEC has developed naturally from the Center's past biomedical and geochemical As research in Maine.

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