Superfund Research Program
Predicting the Toxicity of Complex PAH Mixtures
Project Leader: Robyn L. Tanguay
Co-Investigator: Lisa Truong
Grant Number: P42ES016465
Funding Period: 2009-2025
Project-Specific Links
Title: Transcriptional profiling of zebrafish embryos developmentally exposed to oxygenated PAHs 1,9-benz-10-anthrone and benzanthracene-7,12-dione
Accession Number: GSE68666
Link to Dataset: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE68666
Repository: Gene Expression Omnibus (GEO)
Data Type(s): Gene Expression
Experiment Type(s): Expression profiling by high throughput sequencing
Organism(s): Danio rerio
Summary: The purpose of this study was to identify transcripts differentially expressed in zebrafish embryos exposed to two oxygenated PAHs, 1,9-benz-10-anthrone and benzanthracene-7,12-dione, which cause abnormal development
Publication(s) associated with this dataset:- Goodale BC, La Du JK, Tilton SC, Sullivan CM, Bisson WH, Waters KM, Tanguay RL. 2015. Ligand-specific transcriptional mechanisms underlie aryl hydrocarbon receptor-mediated developmental toxicity of oxygenated PAHs. Toxicol Sci 147(2):397-411. doi:10.1093/toxsci/kfv139 PMID:26141390 PMCID:PMC4612346