Superfund Research Program

Predicting the Toxicity of Complex PAH Mixtures

Project Leader: Robyn L. Tanguay
Co-Investigator: Lisa Truong
Grant Number: P42ES016465
Funding Period: 2009-2025

Project-Specific Links

Publications

2024

• Dasgupta S, Simonich MT, Tanguay RL. 2024. Developmental toxicity assessment using zebrafish-based high-throughput screening. Methods Mol Biol 2707:71-82. doi:10.1007/978-1-0716-3401-1_4 PMID:37668905
• Huizenga JM, Schindler J, Simonich MT, Truong L, Garcia-Jaramillo M, Tanguay RL, Semprini L. 2024. PAH bioremediation with Rhodococcus rhodochrous ATCC 21198: Impact of cell immobilization and surfactant use on PAH treatment and post-remediation toxicity. J Hazard Mater 470:134109. doi:10.1016/j.jhazmat.2024.134109 PMID:38547751 PMCID:11042972

2023

• Dasgupta S, Du JL, Garcia GR, Li S, Tomono-Duval K, Rericha Y, Huang L, Tanguay RL. 2023. A CRISPR-Cas9 mutation in sox9b long intergenic noncoding RNA (slincR) affects zebrafish development, behavior, and regeneration. Toxicol Sci doi:10.1093/toxsci/kfad050 PMID:37220911 PMCID:PMC10375313
• Gosline S, Kim DN, Pande P, Thomas DG, Truong L, Hoffman PD, Barton ML, Loftus J, Moran A, Hampton S, Dowson S, Franklin L, Degnan D, Anderson LN, Thessen AE, Tanguay RL, Anderson KA, Waters KM. 2023. The Superfund Research Program Analytics Portal: linking environmental chemical exposure to biological phenotypes. Sci Data 10(1):151. doi:10.1038/s41597-023-02021-5 PMID:36944655 PMCID:PMC1003089
• McClure RS, Rericha Y, Waters KM, Tanguay RL. 2023. 3' RNA-seq is superior to standard RNA-seq in cases of sparse data but inferior at identifying toxicity pathways in a model organism. Front Bioinform 3:1234218. doi:10.3389/fbinf.2023.1234218 PMID:37576716 PMCID:PMC10414111
• Nguyen BD, Stevens BL, Elson D, Finlay D, Gamble JT, Kopparapu P, Tanguay RL, Buermeyer AB, Kerkvliet NI, Kolluri SK. 2023. 11-Cl-BBQ, a select modulator of AhR-regulated transcription, suppresses lung cancer cell growth via activation of p53 and p27(Kip1). FEBS J 290(8):2064-2084. doi:10.1111/febs.16683 PMID:36401795 PMCID:10807707
• Rericha Y, Simonich MT, Truong L, Tanguay RL. 2023. Review of the zebrafish as a model to investigate per- and polyfluoroalkyl substances toxicity. Toxicol Sci doi:10.1093/toxsci/kfad051 PMID:37220906 PMCID:PMC10375317
• Rude CI, Tidwell LG, Tilton SC, Waters KM, Anderson KA, Tanguay RL. 2023. Coupling environmental whole mixture toxicity screening with unbiased RNA-Seq reveals site-specific biological responses in zebrafish. Toxics 11(3):201. doi:10.3390/toxics11030201 PMID:36976966 PMCID:PMC1005377
• St Mary L, Truong L, Bieberich AA, Fatig RO, Rajwa B, Tanguay RL. 2023. Comparative analysis between zebrafish and an automated live-cell assay to classify developmental neurotoxicant chemicals. Toxicol Appl Pharmacol 476:116659. doi:10.1016/j.taap.2023.116659 PMID:37604412 PMCID:10529185
• Wilson LB, Moran IL, Anderson KA, Tanguay RL. 2023. Advances in PAH mixture toxicology enabled by zebrafish. Curr Opin Toxicol 34:100392. doi:10.1016/j.cotox.2023.100392 PMCID:PMC10292781

2022

• Anderson AL, Dubanksy BD, Wilson LB, Tanguay RL, Rice CD. 2022. Development and applications of a zebrafish (danio rerio) CYP1A-targeted monoclonal antibody (CRC4) with reactivity across vertebrate taxa: Evidence for a conserved CYP1A epitope. Toxics 10(7):404. doi:10.3390/toxics10070404 PMID:35878309 PMCID:PMC9320060
• Rericha Y, Truong L, Leong C, Cao D, Field JA, Tanguay RL. 2022. Dietary perfluorohexanoic acid (PFHxA) exposures in juvenile zebrafish produce subtle behavioral effects across generations. Toxics 10(7):372. doi:10.3390/toxics10070372 PMID:35878277 PMCID:PMC9319656
• Rivera BN, Ghetu CC, Chang Y, Truong L, Tanguay RL, Anderson KA, Tilton SC. 2022. Leveraging multiple data streams for prioritization of mixtures for hazard characterization. Toxics 10(11):651. doi:10.3390/toxics10110651 PMID:36355943
• Rivera BN, Wilson LB, Kim DN, Pande P, Anderson KA, Tilton SC, Tanguay RL. 2022. A comparative multi-system approach to characterizing bioactivity of commonly occurring chemicals. Int J Environ Res Public Health 19(7):3829. doi:10.3390/ijerph19073829 PMID:35409514 PMCID:PMC8998123
• Shankar P, Garcia GR, La Du JK, Sullivan CM, Dunham CL, Goodale BC, Waters KM, Stanisheuski S, Maier C, Thunga P, Reif DM, Tanguay RL. 2022. The Ahr2-Dependent wfikkn1 gene influences zebrafish transcriptome, proteome, and behavior. Toxicol Sci doi:10.1093/toxsci/kfac037 PMID:35377459
• Stagaman K, Kasschau KD, Tanguay RL, Sharpton TJ. 2022. Experimental methods modestly impact interpretation of the effect of environmental exposures on the larval zebrafish gut microbiome. Sci Rep 12(1):14538. doi:10.1038/s41598-022-18532-x PMID:36008504 PMCID:PMC9411601
• Thunga P, Truong L, Rericha Y, La Du JK, Morshead M, Tanguay RL, Reif DM. 2022. Utilizing a population-genetic framework to test for gene-environment interactions between zebrafish behavior and chemical exposure. Toxics 10(12):769. doi:10.3390/toxics10120769 PMID:36548602 PMCID:PMC9781692
• Wallis DJ, Du JL, Thunga P, Elson D, Truong L, Kolluri SK, Tanguay RL, Reif DM. 2022. Leveraging a high-throughput screening method to identify mechanisms of individual susceptibility differences in a genetically diverse zebrafish model. Front Toxicol 4:846221. doi:10.3389/ftox.2022.846221 PMID:35573279 PMCID:PMC9098949
• Wilson LB, McClure RS, Waters KM, Simonich MT, Tanguay RL. 2022. Concentration-response gene expression analysis in zebrafish reveals phenotypically-anchored transcriptional responses to retene. Front Toxicol 4:950503. doi:10.3389/ftox.2022.950503 PMID:36093370 PMCID:PMC9453431

2021

• Dasgupta S, Dunham CL, Truong L, Simonich MT, Sullivan CM, Tanguay RL. 2021. Phenotypically anchored mRNA and miRNA expression profiling in zebrafish reveals flame retardant chemical toxicity networks. Front Cell Dev Biol 9:663032. doi:10.3389/fcell.2021.663032 PMID:33898466 PMCID:PMC8063052
• Green AJ, Mohlenkamp MJ, Das J, Chaudhari M, Truong L, Tanguay RL, Reif DM. 2021. Leveraging high-throughput screening data, deep neural networks, and conditional generative adversarial networks to advance predictive toxicology. PLoS Comput Biol 17(7):e1009135. doi:10.1371/journal.pcbi.1009135 PMID:34214078 PMCID:PMC8301607
• Guan X, Truong L, Lomnicki S, Tanguay RL, Cormier SA. 2021. Developmental hazard of environmentally persistent free radicals and protective effect of TEMPOL in zebrafish model. Toxics 9:doi:10.3390/toxics9010012 PMID:33467068 PMCID:PMC7829864
• Shankar P, Dashner-Titus EJ, Truong L, Hayward K, Hudson LG, Tanguay RL. 2021. Developmental toxicity in zebrafish (Danio rerio) exposed to uranium: A comparison with lead, cadmium, and iron. Environ Pollut 269:116097. doi:10.1016/j.envpol.2020.116097 PMID:33246768 PMCID:PMC7785642
• Shankar P, McClure RS, Waters KM, Tanguay RL. 2021. Gene co-expression network analysis in zebrafish reveals chemical class specific modules. BMC Genomics 22:doi:10.1186/s12864-021-07940-4 PMID:34517816 PMCID:PMC8438978
• Thunga P, Truong L, Tanguay RL, Reif DM. 2021. Concurrent evaluation of mortality and behavioral responses: a fast and efficient testing approach for high-throughput chemical hazard identification. Front Toxicol 3:670496. doi:10.3389/ftox.2021.670496 PMID:35295121 PMCID:PMC8915815
• Wallis DJ, Truong L, La Du JK, Tanguay RL, Reif DM. 2021. Uncovering evidence for endocrine-disrupting chemicals that elicit differential susceptibility through gene-environment interactions. Toxics doi:10.3390/toxics9040077 PMID:33917455 PMCID:PMC8067468

2020

• Dasgupta S, Wang G, Simonich MT, Zhang T, Truong L, Liu H, Tanguay RL. 2020. Impacts of high dose 3.5 GHz cellphone radiofrequency on zebrafish embryonic development. PLoS One 15(7):e0235869. doi:10.1371/journal.pone.0235869 PMID:32645106 PMCID:PMC7347199
• Garland MA, Geier MC, Bugel SM, Shankar P, Dunham CL, Brown JM, Tilton SC, Tanguay RL. 2020. Aryl hydrocarbon receptor mediates larval zebrafish fin duplication following exposure to benzofluoranthenes. Toxicol Sci 176:46-64. doi:10.1093/toxsci/kfaa063 PMID:32384158 PMCID:PMC7357178
• Roper C, Perez A, Barrett D, Hystad P, Simonich SL, Tanguay RL. 2020. Workflow for comparison of chemical and biological metrics of filter collected PM2.5. Atmos Environ (1994) 226:doi:10.1016/j.atmosenv.2020.117379 PMID:32313426 PMCID:PMC7170255
• Shen Q, Truong L, Simonich MT, Huang C, Tanguay RL, Dong Q. 2020. Rapid well-plate assays for motor and social behaviors in larval zebrafish. Behav Brain Res 391:10. doi:10.1016/j.bbr.2020.112625 PMID:32428631 PMCID:PMC7341899
• Truong L, Marvel S, Reif DM, Thomas DG, Pande P, Dasgupta S, Simonich MT, Waters KM, Tanguay RL. 2020. The multi-dimensional embryonic zebrafish platform predicts flame retardant bioactivity. Reprod Toxicol 96:359-369. doi:10.1016/j.reprotox.2020.08.007 PMID:32827657 PMCID:PMC7892636
• Wilson LB, Truong L, Simonich MT, Tanguay RL. 2020. Systematic Assessment of Exposure Variations on Observed Bioactivity in Zebrafish Chemical Screening. Toxics 8:doi:10.3390/toxics8040087 PMID:33066419 PMCID:PMC7712973

2019

• Brown J, Phillips AR, Lewis DA, Mans M, Chang Y, Tanguay RL, Peterson ES, Waters KM, Tilton SC. 2019. Bioinformatics Resource Manager: a systems biology web tool for microRNA and omics data integration. BMC Bioinformatics 20:255. doi:10.1186/s12859-019-2805-6 PMID:31101000
• Chang Y, Siddens LK, Heine L, Sampson D, Yu Z, Fischer K, Lohr CV, Tilton SC. 2019. Comparative mechanisms of PAH toxicity by benzo a pyrene and dibenzo def,p chrysene in primary human bronchial epithelial cells cultured at air-liquid interface. Toxicol Appl Pharmacol 379:114644. doi:10.1016/j.taap.2019.114644 PMID:31255691 PMCID:PMC6708476
• Hagstrom D, Truong L, Zhang S, Tanguay RL, Collins ES. 2019. Comparative analysis of zebrafish and planarian model systems for developmental neurotoxicity screens using an 87-compound library. Toxicol Sci 167(1):15-25. doi:10.1093/toxsci/kfy180 PMID:30011007 PMCID:PMC6317421
• Hamm JT, Ceger P, Allen D, Stout MD, Maull EA, Baker GL, Zmarowski A, Padilla S, Perkins EJ, Planchart A, Stedman D, Tal TL, Tanguay RL, Volz DC, Wilbanks M, Walker NJ. 2019. Characterizing sources of variability in zebrafish embryo screening protocols. ALTEX 36(1):103-120. doi:10.14573/altex.1804162 PMID:30415271
• Roper C, Santiago-Delgado L, Barrett D, Simonich SL, Tanguay RL. 2019. PM2.5 filter extraction methods: Implications for chemical and toxicological analyses. Environ Sci Technol 53:434-442. doi:10.1021/acs.est.8b04308 PMID:30507171
• Shankar P, Geier MC, Truong L, McClure RS, Pande P, Waters KM, Tanguay RL. 2019. Coupling genome-wide transcriptomics and developmental toxicity profiles in zebrafish to characterize polycyclic aromatic hydrocarbon (PAH) hazard. Int J Mol Sci 20:2570. doi:10.3390/ijms20102570 PMID:31130617 PMCID:PMC6566387
• Thomas DG, Shankaran H, Truong L, Tanguay RL, Waters KM. 2019. Time-dependent behavioral data from zebrafish reveals novel signatures of chemical toxicity using point of departure analysis. Comput Toxicol 9:50-60. doi:10.1016/j.comtox.2018.11.001 PMID:31485548 PMCID:PMC6726397
• Trine LS, Davis EL, Roper C, Truong L, Tanguay RL, Simonich SL. 2019. Formation of PAH derivatives and increased developmental toxicity during steam enhanced extraction remediation of creosote contaminated Superfund soil. Environ Sci Technol 53(8):4460-4469. doi:10.1021/acs.est.8b07231 PMID:30957485

2018

• Balik-Meisner M, Truong L, Scholl EH, La Du JK, Tanguay RL, Reif DM. 2018. Elucidating gene-by-environment interactions associated with differential susceptibility to chemical exposure. Environ Health Perspect 126:8. doi:10.1289/ehp2662 PMID:29968567
• Balik-Meisner M, Truong L, Scholl EH, Tanguay RL, Reif DM. 2018. Population genetic diversity in zebrafish lines. Mamm Genome 1-11. doi:10.1007/s00335-018-9735-x PMID:29368091
• Bugel SM, Tanguay RL. 2018. Multidimensional chemobehavior analysis of flavonoids and neuroactive compounds in zebrafish. Toxicol Appl Pharmacol 344:23-34. doi:10.1016/j.taap.2018.02.019 PMID:29499247 PMCID:PMC5912343
• Garcia GR, Bugel SM, Truong L, Spagnoli S, Tanguay RL. 2018. AHR2 required for normal behavioral responses and proper development of the skeletal and reproductive systems in zebrafish. PLoS One 13(3):e0193484. doi:10.1371/journal.pone.0193484 PMID:29494622 PMCID:PMC5832240
• Garcia GR, Shankar P, Dunham CL, Garcia A, La Du JK, Truong L, Tilton SC, Tanguay RL. 2018. Signaling events downstream of AHR activation that contribute to toxic responses: The functional role of an AHR-dependent long noncoding RNA (slincR) using the zebrafish model. Environ Health Perspect 126(11):117002. doi:10.1289/EHP3281 PMID:30398377 PMCID:PMC6371766
• Geier MC, Chlebowski A, Truong L, Simonich SL, Anderson KA, Tanguay RL. 2018. Comparative developmental toxicity of a comprehensive suite of polycyclic aromatic hydrocarbons. Arch Toxicol 92(2):571-586. doi:10.1007/s00204-017-2068-9 PMID:29094189 PMCID:PMC5820187
• Geier MC, Minick DJ, Truong L, Tilton SC, Pande P, Anderson KA, Teeguardan J, Tanguay RL. 2018. Systematic developmental neurotoxicity assessment of a representative PAH Superfund mixture using zebrafish. Toxicol Appl Pharmacol 354:115-125. doi:10.1016/j.taap.2018.03.029 PMID:29630969 PMCID:PMC6087484
• Haggard DE, Noyes PD, Waters KM, Tanguay RL. 2018. Transcriptomic and phenotypic profiling in developing zebrafish exposed to thyroid hormone receptor agonists. Reprod Toxicol 77:80-93. doi:10.1016/j.reprotox.2018.02.006 PMID:29458080 PMCID:PMC5878140
• Roper C, Simonich SL, Tanguay RL. 2018. Development of a high-throughput in vivo screening platform for particulate matter exposures. Environ Pollut 235:993-1005. doi:10.1016/j.envpol.2018.01.025 PMID:29751403 PMCID:PMC5951187

2017

• Bergmann AJ, Tanguay RL, Anderson KA. 2017. Using passive sampling and zebrafish to identify developmental toxicants in complex mixtures. Environ Toxicol Chem 36(9):2290-2298. doi:10.1002/etc.3802 PMID:28326615
• Chlebowski A, Garcia GR, La Du JK, Bisson WH, Simonich SL, Tanguay RL. 2017. Mechanistic investigations into the developmental toxicity of nitrated and heterocyclic PAHs. Toxicol Sci 157(1):246-259. doi:10.1093/toxsci/kfx035 PMID:28186253 PMCID:PMC5414855
• Chlebowski A, La Du JK, Truong L, Simonich SL, Tanguay RL. 2017. Investigating the application of a nitroreductase-expressing transgenic zebrafish line for high-throughput toxicity testing. Toxicol Rep 4:202-210. doi:10.1016/j.toxrep.2017.04.005 PMID:28758069 PMCID:PMC5527975
• Curtis L, Bravo CF, Bayne CJ, Tilton F, Arkoosh MR, Lambertini E, Loge FJ, Collier TK, Meador J, Tilton SC. 2017. Transcriptional changes in innate immunity genes in head kidneys from Aeromonas salmonicida-challenged rainbow trout fed a mixture of polycyclic aromatic hydrocarbons. Ecotoxicol Environ Saf 142:157-163. doi:10.1016/j.ecoenv.2017.03.044 PMID:28407501
• Garcia GR, Goodale BC, Wiley MW, La Du JK, Hendrix DA, Tanguay RL. 2017. In vivo characterization of an AHR-dependent long noncoding RNA required for proper Sox9b expression. Mol Pharmacol 91(6):609-619. doi:10.1124/mol.117.108233 PMID:28385905 PMCID:PMC5438132
• Haggard DE, Das SR, Tanguay RL. 2017. Comparative toxicogenomic responses to the flame retardant mITP in developing zebrafish. Chem Res Toxicol 30(2):508-515. doi:10.1021/acs.chemrestox.6b00423 PMID:27957850
• Knecht AL, Truong L, Marvel S, Reif DM, Garcia A, Lu C, Simonich MT, Teeguarden J, Tanguay RL. 2017. Transgenerational inheritance of neurobehavioral and physiological deficits from developmental exposure to benzo[a]pyrene in zebrafish. Toxicol Appl Pharmacol 329:148-157. doi:10.1016/j.taap.2017.05.033 PMID:28583304 PMCID:PMC5539966
• Knecht AL, Truong L, Simonich MT, Tanguay RL. 2017. Developmental benzo[a]pyrene (B[a]P) exposure impacts larval behavior and impairs adult learning in zebrafish. Neurotoxicol Teratol 59:27-34. doi:10.1016/j.ntt.2016.10.006 PMID:27989697 PMCID:PMC5235990
• Schrlau J, Kramer AL, Chlebowski A, Truong L, Tanguay RL, Simonich SL, Semprini L. 2017. Formation of developmentally toxic phenanthrene metabolite mixtures by mycobacterium sp ELW1. Environ Sci Technol 51:8569-8578. doi:10.1021/acs.est.7b01377 PMID:28727453
• Truong L, Tanguay RL. 2017. Evaluation of embryotoxicity using the zebrafish model. Methods Mol Biol 1641:325-333. doi:10.1007/978-1-4939-7172-5_18 PMID:28748473
• Zhang G, Roell K, Truong L, Tanguay RL, Reif DM. 2017. A data-driven weighting scheme for multivariate phenotypic endpoints recapitulates zebrafish developmental cascades. Toxicol Appl Pharmacol 314:109-117. doi:10.1016/j.taap.2016.11.010 PMID:27884602 PMCID:PMC5224523
• Zhang G, Truong L, Tanguay RL, Reif DM. 2017. A new statistical approach to characterize chemical-elicited behavioral effects in high-throughput studies using zebrafish. PLoS One 12(1):e0169408. doi:10.1371/journal.pone.0169408 PMID:28099482 PMCID:PMC5242475
• Zhang G, Truong L, Tanguay RL, Reif DM. 2017. Integrating morphological and behavioral phenotypes in developing zebrafish. In: The rights and wrongs of zebrafish: behavioral phenotyping of zebrafish. Springer International Publishing, pp.259-272.

2016

• Bugel SM, Bonventre JA, Tanguay RL. 2016. Comparative developmental toxicity of flavonoids using an integrative zebrafish system. Toxicology 154(1):55-68. doi:10.1093/toxsci/kfw139 PMID:27492224 PMCID:PMC5091365
• Bugel SM, Wehmas LC, La Du JK, Tanguay RL. 2016. Phenotype anchoring in zebrafish reveals a potential role for matrix metalloproteinases (MMPs) in tamoxifen's effects on skin epithelium. Toxicol Appl Pharmacol 296:31-41. doi:10.1016/j.taap.2016.02.013 PMID:26908177 PMCID:PMC4792761
• Chlebowski A, Tanguay RL, Simonich SL. 2016. Quantitation and prediction of sorptive losses during toxicity testing of polycyclic aromatic hydrocarbon (PAH) and nitrated PAH (NPAH) using polystyrene 96-well plates. Neurotoxicol Teratol 57:30-38. doi:10.1016/j.ntt.2016.05.001 PMID:27170619
• Garcia GR, Noyes PD, Tanguay RL. 2016. Advancements in zebrafish applications for 21st century toxicology. Pharmacol Ther 161:11-21. doi:10.1016/j.pharmthera.2016.03.009 PMID:27016469 PMCID:PMC4851906
• Haggard DE, Noyes PD, Waters KM, Tanguay RL. 2016. Phenotypically anchored transcriptome profiling of developmental exposure to the antimicrobial agent, triclosan, reveals hepatotoxicity in embryonic zebrafish. Toxicol Appl Pharmacol 308:32-45. doi:10.1016/j.taap.2016.08.013 PMID:27538710 PMCID:PMC5023494
• Noyes PD, Garcia GR, Tanguay RL. 2016. Zebrafish as an in vivo model for sustainable chemical design. Green Chem 18:6410-6430. doi:10.1039/c6gc02061e PMID:28461781 PMCID:PMC5408959
• Olivares CI, Sierra-Alvarez R, Abrell L, Chorover J, Simonich MT, Tanguay RL, Field JA. 2016. Zebrafish embryo toxicity of anaerobic biotransformation products from the insensitive munitions compound 2,4-dinitroanisole. Environ Toxicol Chem 35(11):2774-2781. doi:10.1002/etc.3446 PMID:27058972 PMCID:PMC5052101
• Reif DM, Truong L, Mandrell D, Marvel S, Zhang G, Tanguay RL. 2016. High-throughput characterization of chemical-associated embryonic behavioral changes predicts teratogenic outcomes. Arch Toxicol 90(6):1459-1470. doi:10.1007/s00204-015-1554-1 PMID:26126630 PMCID:PMC4701642
• Roper C, Tanguay RL. 2016. Zebrafish as a model for developmental biology and toxicology. Chapter 12 in: Handbook of Development Neurotoxicology. Academic Press, San Diego, CA.
• Teeguarden J, Tan Y, Edwards SW, Leonard JA, Anderson KA, Corley RA, Harding A, Kile ML, Simonich SL, Stone D, Tanguay RL, Waters KM, Harper SL, Williams DE. 2016. Expanding on successful concepts, models, and organization. Environ Sci Technol 50(17):8921-8922. doi:10.1021/acs.est.6b03027 PMID:27509267
• Teeguarden J, Tan Y, Edwards SW, Leonard JA, Anderson KA, Corley RA, Kile ML, Simonich SL, Stone D, Tanguay RL, Waters KM, Harper SL, Williams DE. 2016. Completing the link between exposure science and toxicology for improved environmental health decision making: the aggregate exposure pathway framework. Environ Sci Technol 50(9):4579-4586. doi:10.1021/acs.est.5b05311 PMID:26759916 PMCID:PMC4854780
• Titaley IA, Chlebowski A, Truong L, Tanguay RL, Simonich SL. 2016. Identification and toxicological evaluation of unsubstituted PAHs and novel PAH derivatives in pavement sealcoat products. Environ Sci Technol 3(6):234-242. doi:10.1021/acs.estlett.6b00116
• Truong L, Bugel SM, Chlebowski A, Usenko CY, Simonich MT, Simonich SL, Tanguay RL. 2016. Optimizing multi-dimensional high throughput screening using zebrafish. Reprod Toxicol 65:139-147. doi:10.1016/j.reprotox.2016.05.015 PMID:27453428 PMCID:PMC5067206
• Truong L, Simonich MT, Tanguay RL. 2016. Better, faster, cheaper: getting the most out of high-throughput screening with zebrafish. Methods Mol Biol 1473:89-98. doi:10.1007/978-1-4939-6346-1_10 PMID:27518627
• Zhang G, Marvel S, Truong L, Tanguay RL, Reif DM. 2016. Aggregate entropy scoring for quantifying activity across endpoints with irregular correlation structure. Reprod Toxicol 62:92-99. doi:10.1016/j.reprotox.2016.04.012 PMID:27132190 PMCID:PMC4905797

2015

• Chibwe L, Geier MC, Nakamura J, Tanguay RL, Aitken MD, Simonich SL. 2015. Aerobic bioremediation of PAH contaminated soil results in increased genotoxicity and developmental toxicity. Environ Sci Technol 49(23):13889-13898. doi:10.1021/acs.est.5b00499 PMID:26200254 PMCID:PMC4666737
• Elie MR, Choi J, Nkrumah-Elie YM, Gonnerman GD, Stevens JF, Tanguay RL. 2015. Metabolomic analysis to define and compare the effects of PAHs and oxygenated PAHs in developing zebrafish. Environ Res 140:502-510. doi:10.1016/j.envres.2015.05.009 PMID:26001975 PMCID:PMC4492807
• Goodale BC, La Du JK, Tilton SC, Sullivan CM, Bisson WH, Waters KM, Tanguay RL. 2015. Ligand-specific transcriptional mechanisms underlie aryl hydrocarbon receptor-mediated developmental toxicity of oxygenated PAHs. Toxicol Sci 147(2):397-411. doi:10.1093/toxsci/kfv139 PMID:26141390 PMCID:PMC4612346
• Noyes PD, Haggard DE, Gonnerman GD, Tanguay RL. 2015. Advanced morphological - behavioral test platform reveals neurodevelopmental defects in embryonic zebrafish exposed to comprehensive suite of halogenated and organophosphate flame retardants. Toxicol Sci 145(1):177-195. doi:10.1093/toxsci/kfv044 PMID:25711236 PMCID:PMC4408965
• Weber DN, Hoffmann RG, Hoke ES, Tanguay RL. 2015. Bisphenol a exposure during early development induces sex-specific changes in adult zebrafish social interactions. J Toxicol Environ Health A 78:50-66. doi:10.1080/15287394.2015.958419 PMID:25424546 PMCID:PMC4246420

2014

• Bugel SM, Bonventre JA, White LA, Tanguay RL, Cooper KR. 2014. Chronic exposure of killifish to a highly polluted environment desensitizes estrogen-responsive reproductive and biomarker genes. Aquat Toxicol 152:222-231. doi:10.1016/j.aquatox.2014.04.014 PMID:24794048 PMCID:PMC4084733
• Chen J, Tanguay RL, Tal TL, Gai Z, Ma X, Bai C, Tilton SC, Jin D, Yang DR, Huang C, Dong Q. 2014. Early life perfluorooctanesulphonic acid (PFOS) exposure impairs zebrafish organogenesis. Aquat Toxicol 150:124-132. doi:10.1016/j.aquatox.2014.03.005 PMID:24667235 PMCID:PMC4159678
• Gerlach C, Das SR, Volz DC, Bisson WH, Kolluri SK, Tanguay RL. 2014. Mono-substituted isopropylated triaryl phosphate, a major component of Firemaster 550, is an AHR agonist that exhibits AHR-independent cardiotoxicity in zebrafish. Aquat Toxicol 154:71-79. doi:10.1016/j.aquatox.2014.05.007 PMID:24865613 PMCID:PMC4090055
• Truong L, Mandrell D, Mandrell R, Simonich MT, Tanguay RL. 2014. A rapid throughput approach identifies cognitive deficits in adult zebrafish from developmental exposure to polybrominated flame retardants. Neurotoxicology 43:134-142. doi:10.1016/j.neuro.2014.03.005 PMID:24674958 PMCID:PMC4134748
• Truong L, Reif DM, St Mary L, Geier MC, Truong HD, Tanguay RL. 2014. Multidimensional in vivo hazard assessment using zebrafish. Toxicol Sci 137(1):212-233. doi:10.1093/toxsci/kft235 PMID:24136191 PMCID:PMC3871932

2013

• Adenuga A, Truong L, Tanguay RL, Remcho V. 2013. Preparation of water-soluble carbon nanotubes and assessment of their biological activity in embryonic zebrafish. Int J Biomed Nanosci Nanotechnol 3(1/2):38-51. doi:10.1504/IJBNN.2013.054514 PMID:25750663 PMCID:PMC4349379
• Franzosa JA, Bugel SM, Tal TL, La Du JK, Tilton SC, Waters KM, Tanguay RL. 2013. Retinoic acid-dependent regulation of miR-19 expression elicits vertebrate axis defects. FASEB J 27(12):4866-4876. doi:10.1096/fj.12-225524 PMID:23975936 PMCID:PMC3834785
• Goodale BC, Tilton SC, Corvi MM, Wilson GR, Janszen DB, Anderson KA, Waters KM, Tanguay RL. 2013. Structurally distinct polycyclic aromatic hydrocarbons induce differential transcriptional responses in developing zebrafish. Toxicol Appl Pharmacol 272(3):656-670. doi:10.1016/j.taap.2013.04.024 PMID:23656968 PMCID:PMC4098828
• Knecht AL, Goodale BC, Truong L, Simonich MT, Swanson AJ, Matzke MM, Anderson KA, Waters KM, Tanguay RL. 2013. Comparative developmental toxicity of environmentally relevant oxygenated PAHs. Toxicol Appl Pharmacol 271(2):266-275. doi:10.1016/j.taap.2013.05.006 PMID:23684558 PMCID:PMC3976560
• Truong L, Tilton SC, Zaikova T, Richman E, Waters KM, Hutchison JE, Tanguay RL. 2013. Surface functionalities of gold nanoparticles impact embryonic gene expression responses. Nanotechnology 7:192-201. doi:10.3109/17435390.2011.648225 PMID:22263968 PMCID:PMC3399027

2012

• Allan SE, Smith BW, Tanguay RL, Anderson KA. 2012. Bridging environmental mixtures and toxic effects. Environ Toxicol Chem 31(12):2877-2887. doi:10.1002/etc.2018 PMID:23001962 PMCID:PMC3502726
• Chen J, Huang C, Truong L, La Du JK, Tilton SC, Waters KM, Lin K, Tanguay RL, Dong Q. 2012. Early life stage trimethyltin exposure induces ADP-ribosylation factor expression and perturbs the vascular system in zebrafish. Toxicology 302:129-139. doi:10.1016/j.tox.2012.09.004 PMID:23000284 PMCID:PMC3511642
• Goodale BC, La Du JK, Bisson WH, Janszen DB, Waters KM, Tanguay RL. 2012. AHR2 mutant reveals functional diversity of aryl hydrocarbon receptors in Zebrafish. PLoS One 7(1):e29346. doi:10.1371/journal.pone.0029346 PMID:22242167 PMCID:PMC3252317
• Mandrell D, Truong L, Jephson C, Sarker MR, Moore A, Lang C, Simonich MT, Tanguay RL. 2012. Automated zebrafish chorion removal and single embryo placement: optimizing throughput of zebrafish developmental toxicity screens. J Lab Autom 17(1):66-74. doi:10.1177/2211068211432197 PMID:22357610 PMCID:PMC3327291
• Tal TL, Franzosa JA, Tilton SC, Philbrick KA, Iwaniec UT, Turner RT, Waters KM, Tanguay RL. 2012. MicroRNAs control neurobehavioral development and function in zebrafish. FASEB J 26(4):1452-1461. doi:10.1096/fj.11-194464 PMID:22253472 PMCID:PMC3316906
• Tal TL, Tanguay RL. 2012. Non-coding RNAs-novel targets in neurotoxicity. Neurotoxicology 33(3):530-534. doi:10.1016/j.neuro.2012.02.013 PMID:22394481 PMCID:PMC3462486
• Tilton SC, Tal TL, Scroggins SM, Franzosa JA, Peterson ES, Tanguay RL, Waters KM. 2012. Bioinformatics resource manager v2.3: an integrated software environment for systems biology with microRNA and cross-species analysis tools. BMC Bioinformatics 13(1):311. doi:10.1186/1471-2105-13-311 PMID:23174015 PMCID:PMC3534564

2011

• Li J, Shang X, Zhao Z, Tanguay RL, Dong Q, Huang C. 2011. Polycyclic aromatic hydrocarbons in water, sediment, soil, and plants of the Aojiang River waterway in Wenzhou, China. J Hazard Mater 173(1-3):75-81. doi:10.1016/j.jhazmat.2009.08.050 PMID:19726127 PMCID:PMC3270495
• Saili KS, Corvi MM, Weber DN, Patel AU, Das SR, Przybyla J, Anderson KA, Tanguay RL. 2011. Neurodevelopmental low-dose bisphenol A exposure leads to early life-stage hyperactivity and learning deficits in adult zebrafish. Toxicology 291(1):83-92. doi:10.1016/j.tox.2011.11.001 PMID:22108044 PMCID:PMC3245816

2010

• Hillwalker WE, Allan SE, Tanguay RL, Anderson KA. 2010. Exploiting lipid-free tubing passive samplers and embryonic zebrafish to link site specific contaminant mixtures to biological responses. Chemosphere 79(1):1-7. doi:10.1016/j.chemosphere.2010.02.001 PMID:20172587 PMCID:PMC2833334 (Completed with ARRA Funds)
• O'Donnell EF, Saili KS, Koch DC, Kopparapu P, Farrer D, Bisson WH, Mathew LK, Sengupta S, Kerkvliet NI, Tanguay RL, Kolluri SK. 2010. The anti-inflammatory drug leflunomide is an agonist of the aryl hydrocarbon receptor. PLoS One 5(10):e13128. doi:10.1371/journal.pone.0013128 PMID:20957046 PMCID:PMC2948512

2009

• Bisson WH, Koch DC, O'Donnell EF, Khalil SM, Kerkvliet NI, Tanguay RL, Abagyan R, Kolluri SK. 2009. Modeling of the aryl hydrocarbon receptor (AhR) ligand binding domain and its utility in virtual ligand screening to predict new AhR ligands. J Med Chem 52(18):5635-5641. doi:10.1021/jm900199u PMID:19719119 PMCID:PMC3289977