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Your Environment. Your Health.

Project Publications: Oregon State University: Predicting the Toxicity of Complex PAH Mixtures

Superfund Research Program

Predicting the Toxicity of Complex PAH Mixtures

Project Leader: Robyn L. Tanguay
Co-Investigator: Lisa Truong
Grant Number: P42ES016465
Funding Period: 2009-2025

Learn More About the Grantee

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Publications

2020

  • Garland MA, Geier MC, Bugel SM, Shankar P, Dunham CL, Brown JM, Tilton SC, Tanguay RL. 2020. Aryl hydrocarbon receptor mediates larval zebrafish fin duplication following exposure to benzofluoranthenes. Toxicol Sci doi:10.1093/toxsci/kfaa063 (accepted for publication)
  • Shen Q, Truong L, Simonich MT, Huang C, Tanguay RL, Dong Q. 2020. Rapid well-plate assays for motor and social behaviors in larval zebrafish. Behav Brain Res 391:10. doi:10.1016/j.bbr.2020.112625 PMID:32428631

2019

  • Brown J, Phillips AR, Lewis DA, Mans M, Chang Y, Tanguay RL, Peterson ES, Waters KM, Tilton SC. 2019. Bioinformatics Resource Manager: a systems biology web tool for microRNA and omics data integration. BMC Bioinformatics 20:255. doi:10.1186/s12859-019-2805-6 PMID:31101000
  • Chang Y, Siddens LK, Heine L, Sampson D, Yu Z, Fischer K, Lohr CV, Tilton SC. 2019. Comparative mechanisms of PAH toxicity by benzo a pyrene and dibenzo def,p chrysene in primary human bronchial epithelial cells cultured at air-liquid interface. Toxicol Appl Pharmacol 379:114644. doi:10.1016/j.taap.2019.114644 PMID:31255691 PMCID:PMC6708476
  • Hagstrom D, Truong L, Zhang S, Tanguay RL, Collins ES. 2019. Comparative analysis of zebrafish and planarian model systems for developmental neurotoxicity screens using an 87-compound library. Toxicol Sci 167(1):15-25. doi:10.1093/toxsci/kfy180 PMID:30011007 PMCID:PMC6317421
  • Hamm JT, Ceger P, Allen D, Stout MD, Maull EA, Baker GL, Zmarowski A, Padilla S, Perkins EJ, Planchart A, Stedman D, Tal TL, Tanguay RL, Volz DC, Wilbanks M, Walker NJ. 2019. Characterizing sources of variability in zebrafish embryo screening protocols. ALTEX 36(1):103-120. doi:10.14573/altex.1804162 PMID:30415271
  • Roper C, Santiago-Delgado L, Barrett D, Simonich SL, Tanguay RL. 2019. PM2.5 filter extraction methods: Implications for chemical and toxicological analyses. Environ Sci Technol 53:434-442. doi:10.1021/acs.est.8b04308 PMID:30507171
  • Shankar P, Geier MC, Truong L, McClure RS, Pande P, Waters KM, Tanguay RL. 2019. Coupling genome-wide transcriptomics and developmental toxicity profiles in zebrafish to characterize polycyclic aromatic hydrocarbon (PAH) hazard. Int J Mol Sci 20:2570. doi:10.3390/ijms20102570 PMID:31130617 PMCID:PMC6566387
  • Thomas DG, Shankaran H, Truong L, Tanguay RL, Waters KM. 2019. Time-dependent behavioral data from zebrafish reveals novel signatures of chemical toxicity using point of departure analysis. Comput Toxicol 9:50-60. doi:10.1016/j.comtox.2018.11.001 PMID:31485548 PMCID:PMC6726397
  • Trine LS, Davis EL, Roper C, Truong L, Tanguay RL, Simonich SL. 2019. Formation of PAH derivatives and increased developmental toxicity during steam enhanced extraction remediation of creosote contaminated Superfund soil. Environ Sci Technol 53(8):4460-4469. doi:10.1021/acs.est.8b07231 PMID:30957485

2018

2017

  • Bergmann AJ, Tanguay RL, Anderson KA. 2017. Using passive sampling and zebrafish to identify developmental toxicants in complex mixtures. Environ Toxicol Chem 36(9):2290-2298. doi:10.1002/etc.3802 PMID:28326615
  • Chlebowski A, Garcia GR, La Du JK, Bisson WH, Simonich SL, Tanguay RL. 2017. Mechanistic investigations into the developmental toxicity of nitrated and heterocyclic PAHs. Toxicol Sci 157(1):246-259. doi:10.1093/toxsci/kfx035 PMID:28186253 PMCID:PMC5414855
  • Chlebowski A, La Du JK, Truong L, Simonich SL, Tanguay RL. 2017. Investigating the application of a nitroreductase-expressing transgenic zebrafish line for high-throughput toxicity testing. Toxicol Rep 4:202-210. doi:10.1016/j.toxrep.2017.04.005 PMID:28758069 PMCID:PMC5527975
  • Curtis L, Bravo CF, Bayne CJ, Tilton F, Arkoosh MR, Lambertini E, Loge FJ, Collier TK, Meador J, Tilton SC. 2017. Transcriptional changes in innate immunity genes in head kidneys from Aeromonas salmonicida-challenged rainbow trout fed a mixture of polycyclic aromatic hydrocarbons. Ecotoxicol Environ Saf 142:157-163. doi:10.1016/j.ecoenv.2017.03.044 PMID:28407501
  • Garcia GR, Goodale BC, Wiley MW, La Du JK, Hendrix DA, Tanguay RL. 2017. In vivo characterization of an AHR-dependent long noncoding RNA required for proper Sox9b expression. Mol Pharmacol 91(6):609-619. doi:10.1124/mol.117.108233 PMID:28385905 PMCID:PMC5438132
  • Haggard DE, Das SR, Tanguay RL. 2017. Comparative toxicogenomic responses to the flame retardant mITP in developing zebrafish. Chem Res Toxicol 30(2):508-515. doi:10.1021/acs.chemrestox.6b00423 PMID:27957850
  • Knecht AL, Truong L, Marvel S, Reif DM, Garcia A, Lu C, Simonich MT, Teeguarden J, Tanguay RL. 2017. Transgenerational inheritance of neurobehavioral and physiological deficits from developmental exposure to benzo[a]pyrene in zebrafish. Toxicol Appl Pharmacol 329:148-157. doi:10.1016/j.taap.2017.05.033 PMID:28583304 PMCID:PMC5539966
  • Knecht AL, Truong L, Simonich MT, Tanguay RL. 2017. Developmental benzo[a]pyrene (B[a]P) exposure impacts larval behavior and impairs adult learning in zebrafish. Neurotoxicol Teratol 59:27-34. doi:10.1016/j.ntt.2016.10.006 PMID:27989697 PMCID:PMC5235990
  • Schrlau J, Kramer AL, Chlebowski A, Truong L, Tanguay RL, Simonich SL, Semprini L. 2017. Formation of developmentally toxic phenanthrene metabolite mixtures by mycobacterium sp ELW1. Environ Sci Technol 51:8569-8578. doi:10.1021/acs.est.7b01377 PMID:28727453
  • Truong L, Tanguay RL. 2017. Evaluation of embryotoxicity using the zebrafish model. Methods Mol Biol 1641:325-333. doi:10.1007/978-1-4939-7172-5_18 PMID:28748473
  • Zhang G, Roell K, Truong L, Tanguay RL, Reif DM. 2017. A data-driven weighting scheme for multivariate phenotypic endpoints recapitulates zebrafish developmental cascades. Toxicol Appl Pharmacol 314:109-117. doi:10.1016/j.taap.2016.11.010 PMID:27884602 PMCID:PMC5224523
  • Zhang G, Truong L, Tanguay RL, Reif DM. 2017. A new statistical approach to characterize chemical-elicited behavioral effects in high-throughput studies using zebrafish. PLoS One 12(1):e0169408. doi:10.1371/journal.pone.0169408 PMID:28099482 PMCID:PMC5242475
  • Zhang G, Truong L, Tanguay RL, Reif DM. 2017. Integrating morphological and behavioral phenotypes in developing zebrafish. In: The rights and wrongs of zebrafish: behavioral phenotyping of zebrafish. Springer International Publishing, pp.259-272.

2016

  • Bugel SM, Bonventre JA, Tanguay RL. 2016. Comparative developmental toxicity of flavonoids using an integrative zebrafish system. Toxicology 154(1):55-68. doi:10.1093/toxsci/kfw139 PMID:27492224 PMCID:PMC5091365
  • Bugel SM, Wehmas LC, La Du JK, Tanguay RL. 2016. Phenotype anchoring in zebrafish reveals a potential role for matrix metalloproteinases (MMPs) in tamoxifen's effects on skin epithelium. Toxicol Appl Pharmacol 296:31-41. doi:10.1016/j.taap.2016.02.013 PMID:26908177 PMCID:PMC4792761
  • Chlebowski A, Tanguay RL, Simonich SL. 2016. Quantitation and prediction of sorptive losses during toxicity testing of polycyclic aromatic hydrocarbon (PAH) and nitrated PAH (NPAH) using polystyrene 96-well plates. Neurotoxicol Teratol 57:30-38. doi:10.1016/j.ntt.2016.05.001 PMID:27170619
  • Garcia GR, Noyes PD, Tanguay RL. 2016. Advancements in zebrafish applications for 21st century toxicology. Pharmacol Ther 161:11-21. doi:10.1016/j.pharmthera.2016.03.009 PMID:27016469 PMCID:PMC4851906
  • Haggard DE, Noyes PD, Waters KM, Tanguay RL. 2016. Phenotypically anchored transcriptome profiling of developmental exposure to the antimicrobial agent, triclosan, reveals hepatotoxicity in embryonic zebrafish. Toxicol Appl Pharmacol 308:32-45. doi:10.1016/j.taap.2016.08.013 PMID:27538710 PMCID:PMC5023494
  • Noyes PD, Garcia GR, Tanguay RL. 2016. Zebrafish as an in vivo model for sustainable chemical design. Green Chem 18:6410-6430. doi:10.1039/c6gc02061e PMID:28461781 PMCID:PMC5408959
  • Olivares CI, Sierra-Alvarez R, Abrell L, Chorover J, Simonich MT, Tanguay RL, Field JA. 2016. Zebrafish embryo toxicity of anaerobic biotransformation products from the insensitive munitions compound 2,4-dinitroanisole. Environ Toxicol Chem 35(11):2774-2781. doi:10.1002/etc.3446 PMID:27058972 PMCID:PMC5052101
  • Reif DM, Truong L, Mandrell D, Marvel S, Zhang G, Tanguay RL. 2016. High-throughput characterization of chemical-associated embryonic behavioral changes predicts teratogenic outcomes. Arch Toxicol 90(6):1459-1470. doi:10.1007/s00204-015-1554-1 PMID:26126630 PMCID:PMC4701642
  • Roper C, Tanguay RL. 2016. Zebrafish as a model for developmental biology and toxicology. Chapter 12 in: Handbook of Development Neurotoxicology. Academic Press, San Diego, CA.
  • Teeguarden J, Tan Y, Edwards SW, Leonard JA, Anderson KA, Corley RA, Harding A, Kile ML, Simonich SL, Stone D, Tanguay RL, Waters KM, Harper SL, Williams DE. 2016. Expanding on successful concepts, models, and organization. Environ Sci Technol 50(17):8921-8922. doi:10.1021/acs.est.6b03027 PMID:27509267
  • Teeguarden J, Tan Y, Edwards SW, Leonard JA, Anderson KA, Corley RA, Kile ML, Simonich SL, Stone D, Tanguay RL, Waters KM, Harper SL, Williams DE. 2016. Completing the link between exposure science and toxicology for improved environmental health decision making: the aggregate exposure pathway framework. Environ Sci Technol 50(9):4579-4586. doi:10.1021/acs.est.5b05311 PMID:26759916 PMCID:PMC4854780
  • Titaley IA, Chlebowski A, Truong L, Tanguay RL, Simonich SL. 2016. Identification and toxicological evaluation of unsubstituted PAHs and novel PAH derivatives in pavement sealcoat products. Environ Sci Technol 3(6):234-242. doi:10.1021/acs.estlett.6b00116
  • Truong L, Bugel SM, Chlebowski A, Usenko CY, Simonich MT, Simonich SL, Tanguay RL. 2016. Optimizing multi-dimensional high throughput screening using zebrafish. Reprod Toxicol 65:139-147. doi:10.1016/j.reprotox.2016.05.015 PMID:27453428 PMCID:PMC5067206
  • Truong L, Simonich MT, Tanguay RL. 2016. Better, faster, cheaper: getting the most out of high-throughput screening with zebrafish. Methods Mol Biol 1473:89-98. doi:10.1007/978-1-4939-6346-1_10 PMID:27518627
  • Zhang G, Marvel S, Truong L, Tanguay RL, Reif DM. 2016. Aggregate entropy scoring for quantifying activity across endpoints with irregular correlation structure. Reprod Toxicol 62:92-99. doi:10.1016/j.reprotox.2016.04.012 PMID:27132190 PMCID:PMC4905797

2015

  • Chibwe L, Geier MC, Nakamura J, Tanguay RL, Aitken MD, Simonich SL. 2015. Aerobic bioremediation of PAH contaminated soil results in increased genotoxicity and developmental toxicity. Environ Sci Technol 49(23):13889-13898. doi:10.1021/acs.est.5b00499 PMID:26200254 PMCID:PMC4666737
  • Elie MR, Choi J, Nkrumah-Elie YM, Gonnerman GD, Stevens JF, Tanguay RL. 2015. Metabolomic analysis to define and compare the effects of PAHs and oxygenated PAHs in developing zebrafish. Environ Res 140:502-510. doi:10.1016/j.envres.2015.05.009 PMID:26001975 PMCID:PMC4492807
  • Goodale BC, La Du JK, Tilton SC, Sullivan CM, Bisson WH, Waters KM, Tanguay RL. 2015. Ligand-specific transcriptional mechanisms underlie aryl hydrocarbon receptor-mediated developmental toxicity of oxygenated PAHs. Toxicol Sci 147(2):397-411. doi:10.1093/toxsci/kfv139 PMID:26141390 PMCID:PMC4612346
  • Noyes PD, Haggard DE, Gonnerman GD, Tanguay RL. 2015. Advanced morphological - behavioral test platform reveals neurodevelopmental defects in embryonic zebrafish exposed to comprehensive suite of halogenated and organophosphate flame retardants. Toxicol Sci 145(1):177-195. doi:10.1093/toxsci/kfv044 PMID:25711236 PMCID:PMC4408965
  • Weber DN, Hoffmann RG, Hoke ES, Tanguay RL. 2015. Bisphenol a exposure during early development induces sex-specific changes in adult zebrafish social interactions. J Toxicol Environ Health A 78:50-66. doi:10.1080/15287394.2015.958419 PMID:25424546 PMCID:PMC4246420

2014

2013

2012

2011

2010

2009

  • Bisson WH, Koch DC, O'Donnell EF, Khalil SM, Kerkvliet NI, Tanguay RL, Abagyan R, Kolluri SK. 2009. Modeling of the aryl hydrocarbon receptor (AhR) ligand binding domain and its utility in virtual ligand screening to predict new AhR ligands. J Med Chem 52(18):5635-5641. doi:10.1021/jm900199u PMID:19719119 PMCID:PMC3289977
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