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Your Environment. Your Health.

Oregon State University: Dataset Details, ID=GSE128471

Superfund Research Program

Predicting the Toxicity of Complex PAH Mixtures

Project Leader: Robyn L. Tanguay
Co-Investigator: Lisa Truong
Grant Number: P42ES016465
Funding Period: 2009-2025
View this project in the NIH Research Portfolio Online Reporting Tools (RePORT)

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Title: Benzo[a]pyrene and dibenzo[def,p]chrysene in 3D primary human bronchial epithelial cells [RNA-seq]

Accession Number: GSE128471

Link to Dataset: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE128471

Repository: Gene Expression Omnibus (GEO)

Data Type(s): Gene Expression

Experiment Type(s): Expression profiling by high throughput sequencing

Organism(s): Homo sapiens

Summary: In this study, we assess potential differences in mechanism of action for two PAHs, benzo[a]pyrene (BAP) and dibenzo-[def,p]chrysene (DBC), in a primary human 3D bronchial epithelial culture (HBEC) model based on short-term biosignatures identified from global transcriptional profiling.

Publication(s) associated with this dataset:
  • Chang Y, Siddens LK, Heine L, Sampson D, Yu Z, Fischer K, Lohr CV, Tilton SC. 2019. Comparative mechanisms of PAH toxicity by benzo a pyrene and dibenzo def,p chrysene in primary human bronchial epithelial cells cultured at air-liquid interface. Toxicol Appl Pharmacol 379:114644. doi:10.1016/j.taap.2019.114644 PMID:31255691 PMCID:PMC6708476
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