Superfund Research Program

Andres Cardenas

Stanford University
Department of Epidemiology and Population Health
Research Park
1701 Page Mill Road
Stanford, California 94305-5405
Phone: 650-497-2815
Email: andresca@stanford.edu

Projects

• University of California-Berkeley: Administrative Core (2022-2027)
• University of California-Berkeley: Data Management and Analysis Core (DMAC) (2022-2027)
• University of California-Berkeley: Data Science and Laboratory Core (2017-2022)
• University of California-Berkeley: Influence of Exposure to a Mixture of PFAS and Metals on the Developing Immune System (2022-2027)

Research Briefs

• 357 - Early Life Exposures May Shape Infant Immune System
• 333 - Combining Arsenic Data Across Populations Sheds Light on Exposure Sources
• 321 - First-of-its-Kind Arsenic Meta-Analysis Paves the Way for Future Data Integration

Publications

2024

• Bozack AK, Navas-Acien A, Cardenas A. 2024. DNA methylation-based biomarkers of protein levels and cardiovascular disease risk: Opportunities and challenges for precision cardiology. Circ Genom Precis Med 17(2):e004571. doi:10.1161/circgen.124.004571 PMID:38348680 PMCID:11021153
• Smith A, Lin PD, Rifas-Shiman S, Fleisch AF, Wright RO, Coull BA, Finn P, Oken E, Gold DR, Cardenas A. 2024. Prenatal blood metals, per- and polyfluoroalkyl substances and antigen- or mitogen-stimulated cord blood lymphocyte proliferation and cytokine secretion. Environ Res 259:doi:10.1016/j.envres.2024.119555 PMID:38964580

2023

• Cardenas A, Fadadu RP, Bunyavanich S. 2023. Climate change and epigenetic biomarkers in allergic and airway diseases. Journal of Allergy and Clinical Immunology 152(5):1060-1072. doi:10.1016/j.jaci.2023.09.011 PMID:37741554
• Cardenas A, Fadadu RP, Koppelman GH. 2023. Epigenome-wide association studies of allergic disease and the environment. Journal of Allergy and Clinical Immunology 152(3):582-590. doi:10.1016/j.jaci.2023.05.020 PMID:37295475
• Fang F, Zhou L, Perng W, Marsit CJ, Knight A, Cardenas A, Aung MT, Hivert M, Aris I, Goodrich JM, Smith A, Gaylord A, Fry RC, Oken E, O'Connor G, Ruden D, Trasande L, Herbstman JB, Camargo C, Bush NR, Dunlop AL, Dabelea D, Karagas MR, Breton CV, Ober C, Everson TM, Page GP, Ladd-Acosta C. 2023. Evaluation of pediatric epigenetic clocks across multiple tissues. Clin Epigenetics 15(1):142. doi:10.1186/s13148-023-01552-3 PMID:37660147 PMCID:10475199

2022

• Beene D, Collender P, Cardenas A, Harvey CF, Huhmann LB, Lin Y, Lewis JL, Lolacono NJ, Navas-Acien A, Nigra AE, Steinmaus CM, van Geen AF. 2022. A mass-balance approach to evaluate arsenic intake and excretion in different populations. Environ Int 166:107371. doi:10.1016/j.envint.2022.107371 PMID:35809487
• Bozack AK, Boileau P, Hubbard AE, Sille FC, Ferreccio Readi C, Steinmaus CM, Smith MT, Cardenas A. 2022. The impact of prenatal and early-life arsenic exposure on epigenetic age acceleration among adults in Northern Chile. Environ Epigenet 8(1):doi:10.1093/eep/dvac014 PMID:35769198 PMCID:PMC9235373
• Germolec DR, Lebrec H, Anderson SE, Burleson GR, Cardenas A, Corsini E, Elmore S, Kaplan BL, Lawrence BP, Lehmann GM, Maier CC, McHale CM, Myers LP, Pallardy M, Rooney AA, Zeise L, Zhang L, Smith MT. 2022. Consensus on the key characteristics of immunotoxic agents as a basis for hazard identification. Environ Health Perspect 130(10):105001. doi:10.1289/EHP10800 PMID:36201310 PMCID:PMC9536493
• Phillips RV, Wei L, Cardenas A, Hubbard AE, McHale CM, Vermeulen R, Wei H, Smith MT, Zhang L, Lan Q, Rothman N. 2022. Epigenome-wide association studies of occupational exposure to benzene and formaldehyde. Epigenetics 1-19. doi:10.1080/15592294.2022.2115604 PMID:36017556

2021

• Bozack AK, Boileau P, Wei L, Hubbard AE, Sille FC, Ferreccio Readi C, Acevedo J, Hou L, Ilievski V, Steinmaus CM, Smith MT, Navas-Acien A, Gamble MV, Cardenas A. 2021. Exposure to arsenic at different life-stages and DNA methylation meta-analysis in buccal cells and leukocytes. Environ Health 20:79. doi:10.1186/s12940-021-00754-7 PMID:34243768 PMCID:PMC8272372
• Bozack AK, Rifas-Shiman SL, Coull BA, Baccarelli A, Wright RO, Amarasiriwardena CJ, Gold DR, Oken E, Hivert M, Cardenas A. 2021. Prenatal metal exposure, cord blood DNA methylation and persistence in childhood: An epigenome-wide association study of 12 metals. Clin Epigenetics 13(1):208. doi:10.1186/s13148-021-01198-z PMID:34798907 PMCID:PMC8605513
• Joyce BT, Gao T, Koss K, Zheng Y, Cardenas A, Heiss J, Just AC, Zhang K, van Horn L, Bai Allen N, Greenland P, Cohen S, Gordon-Larsen P, Mitchell C, McLanahan S, Schneper L, Notterman D, Rifas-Shiman SL, Oken E, Hivert M, Wright RO, Baccarelli A, Lloyd-Jones D, Hou L. 2021. Impact of paternal education on epigenetic ageing in adolescence and mid-adulthood: a multi-cohort study in the USA and Mexico. Int J Epidemiol PMID:34534313
• Nwanaji-Enwerem JC, Chung FF, van der Laan L, Novoloaca A, Cuenin C, Johansson H, Bonanni B, Hubbard AE, Smith MT, Hartman SJ, Cardenas A, Sears DD, Herceg Z. 2021. An epigenetic aging analysis of randomized metformin and weight loss interventions in overweight postmenopausal breast cancer survivors. Clin Epigenetics 13(1):224. doi:10.1186/s13148-021-01218-y PMID:34920739 PMCID:PMC8684118
• Nwanaji-Enwerem JC, Jackson CL, Ottinger M, Cardenas A, James KA, Malecki K, Chen J, Geller AM, Mitchell UA. 2021. Adopting a 'compound' exposome approach in environmental aging biomarker research: A call to action for advancing racial health equity. Environ Health Perspect 129(4):4500. doi:10.1289/EHP8392 PMID:33822649 PMCID:PMC8043128
• Smith A, Lin PD, Rifas-Shiman SL, Rahman ML, Gold DR, Baccarelli A, Claus Henn B, Amarasiriwardena CJ, Wright RO, Coull BA, Hivert M, Oken E, Cardenas A. 2021. Prospective associations of early pregnancy metal mixtures with mitochondria DNA copy number and telomere length in maternal and cord blood. Environ Health Perspect 129(11):117007. doi:10.1289/EHP9294 PMID:34797165 PMCID:PMC8604047
• van der Laan L, Cardenas A, Vermeulen R, Fadadu RP, Hubbard AE, Phillips RV, Zhang L, Breeze C, Hu W, Wen C, Huang Y, Tang X, Smith MT, Rothman N, Lan Q. 2021. Epigenetic aging biomarkers and occupational exposure to benzene, trichloroethylene and formaldehyde. Environ Int 158:106871. doi:10.1016/j.envint.2021.106871 PMID:34560324

2020

• Bozack AK, Cardenas A, Geldhof J, Quamruzzaman Q, Rahman M, Mostofa G, Christiani DC, Kile ML. 2020. Cord blood DNA methylation of DNMT3A mediates the association between in utero arsenic exposure and birth outcomes: results from a prospective birth cohort in Bangladesh. Environ Res doi:10.1016/j.envres.2020.109134 PMID:32018205 PMCID:PMC7167334
• Bozack AK, Domingo-Relloso A, Haack K, Gamble MV, Tellez-Plaza M, Umans JG, Best LG, Yracheta J, Gribble MO, Cardenas A, Francesconi KA, Goessler W, Tang W, Fallin MD, Cole SA, Navas-Acien A. 2020. Locus-specific differential DNA methylation and urinary arsenic: An epigenome-wide association study in blood among adults with low -to -moderate arsenic exposure. Environ Health Perspect 128:12. doi:10.1289/EHP6263 PMID:32603190 PMCID:PMC7534587
• Smith MT, Guyton KZ, Kleinstreuer N, Borrell A, Cardenas A, Chiu WA, Felsher DW, Gibbons CF, Goodson III WH, Houck K, Kane AB, La Merrill MA, Lebrec H, Lowe L, McHale CM, Minocherhomji S, Rieswijk L, Sandy MS, Sone H, Wang A, Zhang L, Zeise L, Fielden MR. 2020. The Key Characteristics of Carcinogens: Relationship to the Hallmarks of Cancer, Relevant Biomarkers, and Assays to Measure Them. Cancer Epidemiol Biomarkers Prev 29(10):doi:10.1158/1055-9965.EPI-19-1346 PMID:32152214 PMCID:PMC7483401

2018

• Bozack AK, Cardenas A, Quamruzzaman Q, Rahman M, Mostofa G, Christiani DC, Kile ML. 2018. DNA methylation in cord blood as mediator of the association between prenatal arsenic exposure and gestational age. Epigenetics 13(9):923-940. doi:10.1080/15592294.2018.1516453 PMID:30175652 PMCID:PMC6284783

2016

• Kile ML, Cardenas A, Rodrigues EG, Mazumdar M, Dobson CB, Golam M, Quamruzzaman Q, Rahman M, Christiani DC. 2016. Estimating effects of arsenic exposure during pregnancy on perinatal outcomes in a Bangladeshi cohort. Epidemiology 27(2):173-181. doi:10.1097/EDE.0000000000000416 PMID:26583609 PMCID:PMC4733817

2015

• Cardenas A, Koestler DC, Houseman EA, Jackson BP, Kile ML, Karagas MR, Marsit CJ. 2015. Differential DNA methylation in umbilical cord blood of infants exposed to mercury and arsenic in utero. Epigenetics 10(6):508-515. doi:10.1080/15592294.2015.1046026 PMID:25923418 PMCID:PMC4622995

2014

• Kile ML, Houseman EA, Baccarelli A, Quamruzzaman Q, Rahman M, Mostofa G, Cardenas A, Wright RO, Christiani DC. 2014. Effect of prenatal arsenic exposure on DNA methylation and leukocyte subpopulations in cord blood. Epigenetics 9(5):774-782. doi:10.4161/epi.28153 PMID:24525453 PMCID:PMC4063836

2013

• Sudakin D, Smit E, Cardenas A, Harding A. 2013. Naphthalene biomarkers and relationship with hemoglobin and hematocrit in White, Black, and Hispanic adults: results from the 2003–2004 National Health and Nutrition Examination Survey. J Med Toxicol 9(2):133-138. doi:10.1007/s13181-012-0262-y PMID:23007805 PMCID:PMC3556176

2012

• Forsberg ND, Stone D, Harding A, Harper B, Harris S, Matzke MM, Cardenas A, Waters KM, Anderson KA. 2012. Effect of Native American fish smoking methods on dietary exposure to polycyclic aromatic hydrocarbons and possible risks to human health. J Agric Food Chem 60(27):6899-6906. doi:10.1021/jf300978m PMID:22690788 PMCID:PMC3567306