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Your Environment. Your Health.

Person Details: Dr. Michael Karin

Superfund Research Program

Dr. Michael Karin

University of California-San Diego
Department of Pharmacology
Leichtag Biomedical Research Building, Room 214
9500 Gilman Dr., MC 0723
La Jolla, California 92093-0723
Phone: 858-534-1361
Fax: 858-534-8158
Email: karinoffice@ucsd.edu

Projects

Research Briefs

Patents

Publications

2019

2018

  • Dhar D, Antonucci L, Nakagawa H, Kim J, Glitzner E, Caruso S, Shalapour S, Yang L, Valasek MA, Lee S, Minnich K, Seki E, Tuckermann J, Sibilia M, Zucman-Rossi J, Karin M. 2018. Liver cancer initiation requires p53 inhibition by CD44-enhanced growth factor signaling. Cancer Cell 33:1061. doi:10.1016/j.ccell.2018.05.003 PMID:29894692 PMCID:PMC6005359
  • Dow M, Pyke RM, Tsui BY, Alexandrov LB, Nakagawa H, Taniguchi K, Seki E, Harismendy O, Shalapour S, Karin M, Carter H, Font-Burgada J. 2018. Integrative genomic analysis of mouse and human hepatocellular carcinoma. Proc Natl Acad Sci U S A 115:E9879-E9888. doi:10.1073/pnas.1811029115 PMID:30287485 PMCID:PMC6196518
  • Kim J, Garcia-Carbonell R, Yamachika S, Zhao P, Dhar D, Loomba R, Kaufman RJ, Saltiel AR, Karin M. 2018. ER stress drives lipogenesis and steatohepatitis via caspase-2 activation of S1P. Cell 175(1):133-145. doi:10.1016/j.cell.2018.08.020 PMID:30220454 PMCID:PMC6159928
  • Song N, Zhu F, Wang Z, Willette-Brown J, Xi S, Sun Z, Su L, Xu X, Ma B, Nussinov R, Xia X, Schrump DS, Johnson PF, Karin M, Hu Y. 2018. IKK alpha inactivation promotes Kras-initiated lung adenocarcinoma development through disrupting major redox regulatory pathways. Proc Natl Acad Sci U S A 115:E812-E821. doi:10.1073/pnas.1717520115 PMID:29311298 PMCID:PMC5789942
  • Tripathi A, Debelius J, Brenner DA, Karin M, Loomba R, Schnabl B, Knight R. 2018. The gut-liver axis and the intersection with the microbiome. Nat Rev Gastroenterol Hepatol 15:397-411. doi:10.1038/s41575-018-0011-z PMID:29748586 PMCID:PMC6319369
  • Zhong Z, Liang S, Sanchez-Lopez E, He F, Shalapour S, Lin X, Wong J, Ding S, Seki E, Schnabl B, Hevener AL, Greenberg HB, Kisseleva T, Karin M. 2018. New mitochondrial DNA synthesis enables NLRP3 inflammasome activation. Nature 560:198-203. doi:10.1038/s41586-018-0372-z PMID:30046112 PMCID:PMC6329306

2017

  • Chen S, Lu W, Yueh MF, Rettenmeier E, Liu M, Auwerx J, Yu RT, Evans RM, Wang K, Karin M, Tukey RH. 2017. Intestinal NCoR1, a regulator of epithelial cell maturation, controls neonatal hyperbilirubinemia. Proc Natl Acad Sci U S A 114(8):E1432-E1440. doi:10.1073/pnas.1700232114 PMID:28167773 PMCID:PMC5338369
  • Shalapour S, Lin X, Bastian IN, Brain J, Burt AD, Aksenov AA, Vrbanac AF, Li W, Perkins A, Matsutani T, Zhong Z, Dhar D, Navas-Molina JA, Xu J, Loomba R, Downes M, Yu RT, Evans RM, Dorrestein PC, Knight R, Benner CW, Anstee QM, Karin M. 2017. Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity. Nature 551(7680):340-345. doi:10.1038/nature24302 PMID:29144460 PMCID:PMC5884449

2016

2015

  • Antonucci L, Fagman JB, Kim J, Todoric J, Gukovsky I, Mackey MR, Ellisman MH, Karin M. 2015. Basal autophagy maintains pancreatic acinar cell homeostasis and protein synthesis and prevents ER stress. Proc Natl Acad Sci U S A 112(45):E6166-E6174. doi:10.1073/pnas.1519384112 PMID:26512112 PMCID:PMC4653219
  • Finkin S, Yuan D, Stein I, Taniguchi K, Weber A, Unger K, Browning JL, Goossens N, Nakagawa S, Gunasekaran G, Schwartz ME, Kobayashi M, Kumada H, Berger M, Pappo O, Rajewsky K, Hoshida Y, Karin M, Heikenwalder M, Ben-Neriah Y, Pikarsky E. 2015. Ectopic lymphoid structures function as microniches for tumor progenitor cells in hepatocellular carcinoma. Nat Immunol 16(12):1235-1244. doi:10.1038/ni.3290 PMID:26502405 PMCID:PMC4653079
  • Font-Burgada J, Shalapour S, Ramasamy S, Hsueh B, Rossell D, Umemura A, Taniguchi K, Nakagawa H, Valasek MA, Ye L, Kopp JL, Sander M, Carter H, Deisseroth K, Verma IM, Karin M. 2015. Hybrid periportal hepatocytes regenerate the injured liver without giving rise to cancer. Cell 162(4):766-779. doi:10.1016/j.cell.2015.07.026 PMID:26276631 PMCID:PMC4545590

2014

  • Dhar D, Seki E, Karin M. 2014. NCOA5, IL-6, type 2 diabetes, and HCC: the deadly quartet. Cell Metab 19(1):6-7. doi:10.1016/j.cmet.2013.12.010 PMID:24411937 PMCID:PMC3947913
  • Inokuchi-Shimizu S, Park E, Roh Y, Yang L, Zhang B, Song J, Liang S, Pimienta M, Taniguchi K, Wu X, Asahina K, Lagakos W, Mackey MR, Akira S, Ellisman MH, Sears DD, Olefsky J, Karin M, Brenner DA, Seki E. 2014. TAK1-mediated autophagy and fatty acid oxidation prevent hepatosteatosis and tumorigenesis. J Clin Invest 124(8):3566-3578. doi:10.1172/JCI74068 PMID:24983318 PMCID:PMC4109552
  • Moles A, Murphy L, Wilson C, Chakraborty JB, Fox C, Park E, Mann J, Oakley F, Howarth R, Brain JD, Masson S, Karin M, Seki E, Mann DA. 2014. A TLR2/S100A9/CXCL-2 signaling network is necessary for neutrophil recruitment in acute and chronic liver injury in the mouse. J Hepatol 60(4):782-791. doi:10.1016/j.jhep.2013.12.005 PMID:24333183 PMCID:PMC3960359
  • Nakagawa H, Umemura A, Taniguchi K, Font-Burgada J, Dhar D, Ogata H, Zhong Z, Valasek MA, Seki E, Hidalgo J, Koike K, Kaufman RJ, Karin M. 2014. ER stress cooperates with hypernutrition to trigger TNF-dependent spontaneous HCC development. Cancer Cell 26(3):331-343. doi:10.1016/j.ccr.2014.07.001 PMID:25132496 PMCID:PMC4165611
  • Parmigiani A, Nourbakhsh A, Ding B, Wang W, Kim YC, Akopiants K, Guan K, Karin M, Budanov AV. 2014. Sestrins inhibit mTORC1 kinase activation through the GATOR complex. Cell Rep 9(4):1281-1291. doi:10.1016/j.celrep.2014.10.019 PMID:25457612 PMCID:PMC4303546
  • Umemura A, Park E, Taniguchi K, Lee J, Shalapour S, Valasek MA, Aghajan M, Nakagawa H, Seki E, Hall MN, Karin M. 2014. Liver damage, inflammation, and enhanced tumorigenesis after persistent mTORC1 inhibition. Cell Metab 20(1):133-144. doi:10.1016/j.cmet.2014.05.001 PMID:24910242 PMCID:PMC4079758
  • Yueh MF, Taniguchi K, Chen S, Evans RM, Hammock BD, Karin M, Tukey RH. 2014. The commonly used antimicrobial additive triclosan is a liver tumor promoter. Proc Natl Acad Sci U S A 111(48):17200-17205. doi:10.1073/pnas.1419119111 PMID:25404284 PMCID:PMC4260592

2013

  • Chen S, Yueh MF, Bigo C, Barbier O, Wang K, Karin M, Nguyen N, Tukey RH. 2013. Intestinal glucuronidation protects against chemotherapy-induced toxicity by irinotecan (CPT-11). Proc Natl Acad Sci U S A 110(47):19143-19148. doi:10.1073/pnas.1319123110 PMID:24191041 PMCID:PMC3839688
  • Du H, Sun X, Guma M, Luo J, Ouyang H, Zhang X, Zeng J, Quach J, Nguyen DH, Shaw PX, Karin M, Zhang K. 2013. JNK inhibition reduces apoptosis and neovascularization in a murine model of age-related macular degeneration. Proc Natl Acad Sci U S A 110(6):2377-2382. doi:10.1073/pnas.1221729110 PMID:23341606 PMCID:PMC3568328
  • He G, Dhar D, Nakagawa H, Font-Burgada J, Ogata H, Jiang Y, Shalapour S, Seki E, Yost SE, Jepsen K, Frazer KA, Harismendy O, Hatziapostolou M, Iliopoulos D, Suetsugu A, Hoffman RM, Tateishi R, Koike K, Karin M. 2013. Identification of liver cancer progenitors whose malignant progression depends on autocrine IL-6 signaling. Cell 155(2):384-396. doi:10.1016/j.cell.2013.09.031 PMID:24120137 PMCID:PMC4015514
  • Lee J, Budanov AV, Karin M. 2013. Sestrins orchestrate cellular metabolism to attenuate aging. Cell Metab 18(6):792-801. doi:10.1016/j.cmet.2013.08.018 PMID:24055102 PMCID:PMC3858445
  • Sakurai T, Kudo M, Umemura A, He G, Elsharkawy AM, Seki E, Karin M. 2013. p38αlpha inhibits liver fibrogenesis and consequent hepatocarcinogenesis by curtailing accumulation of reactive oxygen species. Cancer Res 73(1):215-224. doi:10.1158/0008-5472.CAN-12-1602 PMID:23271722 PMCID:PMC3605785

2012

2011

  • Hatziapostolou M, Polytarchou C, Aggelidou E, Drakaki A, Poultsides GA, Jaeger SA, Ogata H, Karin M, Struhl K, Hadzopoulou-Cladaras M, Iliopoulos D. 2011. An HNF4alpha-miRNA inflammatory feedback circuit regulates hepatocellular oncogenesis. Cell 147(6):1233-1247. doi:10.1016/j.cell.2011.10.043 PMID:22153071 PMCID:PMC3251960
  • Holzer RG, Park E, Li N, Tran H, Chen M, Choi C, Solinas G, Karin M. 2011. Saturated fatty acids induce c-Src clustering within membrane subdomains, leading to JNK activation. Cell 147(1):173-184. doi:10.1016/j.cell.2011.08.034 PMID:21962514 PMCID:PMC3295636
  • Osterreicher C, Penz-Osterreicher M, Grivennikov S, Guma M, Koltsova E, Datz C, Sasik R, Hardiman G, Karin M, Brenner DA. 2011. Fibroblast-specific protein 1 identifies an inflammatory subpopulation of macrophages in the liver. Proc Natl Acad Sci U S A 108(1):308-313. doi:10.1073/pnas.1017547108 PMID:21173249 PMCID:PMC3017162

2010

2009

  • Haybaeck J, Zeller N, Wolf MJ, Weber A, Kurrer M, Bremer J, lezzi G, Graf R, Clavien P, Ndeospasov SA, Zatloukal K, Ramzan M, Ciesek S, Pietschmann T, Marche PN, Karin M, Kopf M, Browning JL, Aguzzi A, Heikenwalder M, Wagner U, Thimme R, Blum H. 2009. A lymphotoxin-driven pathway to hepatocellular carcinoma. Cancer Cell 16(4):295-308. doi:10.1016/j.ccr.2009.08.021 PMID:19800575 PMCID:PMC4422166
  • Koch KS, Maeda S, Karin M, Leffert HL, He G. 2009. Targeted deletion of hepatocyte Ikkbeta confers growth advantages. Biochem Biophys Res Commun 380(2):349-354. doi:10.1016/j.bbrc.2009.01.085 PMID:19171122 PMCID:PMC2663043

2008

2007

  • Naugler WE, Sakurai T, Kim S, Maeda S, Kim K, Elsharkawy AM, Karin M. 2007. Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production. Science 317(5834):121-124. doi:10.1126/science.1140485 PMID:17615358

2006

  • Chang L, Kamata H, Solinas G, Luo J, Maeda S, Venuprasad K, Liu Y, Karin M. 2006. The E3 ubiquitin ligase itch couples JNK activation to TNF±-induced cell death by inducing c-FLIPL turnover. Cell 124:601-603. PMID:16469705
  • Sakurai T, Maeda S, Chang L, Karin M. 2006. Loss of hepatic NF-kappa B activity enhances chemical hepatocarcinogenesis through sustained c-Jun N-terminal kinase 1 activation. Proc Natl Acad Sci U S A 103(28):10544-10551. doi:10.1073/pnas.0603499103 PMID:16807293 PMCID:PMC1502270

2005

  • Kamata H, Honda S, Maeda S, Hirata H, Karin M. 2005. Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases. Cell 120(5):649-661. doi:10.1016/j.cell.2004.12.041 PMID:15766528
  • Karin M, Greten FR. 2005. NF-ºB: Linking inflammmation and immunity to cancer development and progression. Nat Rev Immunol 5(10):749-759. PMID:16175180
  • Maeda S, Kamata H, Luo J, Leffert HL, Karin M. 2005. IKKB couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis. Cell 121(7):977-990. PMID:15989949

2004

  • Bonizzi G, Karin M. 2004. The two NF-kappaB activation pathways and their role in innate and adaptive immunity. Trends Immunol 25(6):280-288. PMID:15145317
  • Galijatovic A, Beaton D, Nguyen N, Chen S, Bonzo JA, Johnson RS, Maeda S, Karin M, Guengerich FP, Tukey RH. 2004. The human CYP1A1 gene is regulated in a developmental and tissue-specific fashion in transgenic mice. J Biol Chem 279(23):23969-23976. PMID:15037607
  • Greten FR, Eckmann L, Greten TF, Park JM, Li Z, Egan LJ, Kagnoff MF, Karin M. 2004. IKKB links inflammation and tumorigenesis in a mouse model of colitis-associated cancer. Cell 118(3):285-296. PMID:15294155
  • Hsu L, Park JM, Zhang K, Luo J, Maeda S, Kaufman RJ, Eckmann L, Guiney DG, Karin M. 2004. The protein kinase PKR is required for macrophage apoptosis after activation of Toll-like receptor 4. Nature 428(6980):341-345. PMID:15029200
  • Shen H, Lin Y, Choksi S, Tran JH, Jin T, Chang L, Karin M, Zhang J, Liu Z. 2004. Essential roles of receptor-interacting protein and TRAF2 in oxidative stress-induced cell death. Mol Cell Biol 24(13):5914-22. PMID:15199146
  • Sil AK, Maeda S, Sano Y, Roop DR, Karin M. 2004. Abstract IkappaB kinase-alpha acts in the epidermis to control skeletal and craniofacial morphogenesis. Nature 428(6983):660-664. PMID:15071597
  • Valledor AF, Hsu L, Ogawa S, Sawka-Verhelle D, Karin M, Glass CK. 2004. Activation of liver X receptors and retinoid X receptors prevents bacterial-induced macrophage apoptosis. Proc Natl Acad Sci U S A 101(51):17813-17818. PMID:15601766

2003

  • Chen F, Castranova V, Li Z, Karin M, Shi X. 2003. Inhibitor of nuclear factor kappa B kinase deficiency enhances oxidative stress and prolongs c-jun NH2-terminal kinase activation induced by arsenic. Cancer Res 63(22):7689-7693. PMID:14633691
  • Chen L, Egan LJ, Li Z, Kagnoff MF, Karin M. 2003. The two faces of IKK and NF-kappa B inhibition: prevention of systemic inflammation but increased local injury following intestinal ischemia-reperfusion. Nat Med 9(5):575-581. PMID:12692538
  • Chen S, Nguyen N, Tamura K, Karin M, Tukey RH. 2003. The role of the Ah receptor and p38 in benzo[a]pyrene-7,8-dihydrodiol and benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide-induced apoptosis. J Biol Chem 278(21):19526-19533. PMID:12637498
  • Hayakawa M, Miyashita H, Sakamoto I, Kitagawa M, Tanaka H, Yasuda H, Karin M, Kikugawa K. 2003. Evidence that reactive oxygen species do not mediate NF-kappa B activation. EMBO J 22(13July):3356-3366. PMID:12839997
  • Li Z, Omori SA, Labuda T, Karin M, Rickert RC. 2003. IKK beta is required for peripheral B cell survival and proliferation. J Immunol 170(9):4630-4637. PMID:12707341
  • Maeda S, Chang L, Li Z, Luo J, Leffert HL, Karin M. 2003. IKK beta is required for prevention of apoptosis mediated by cell-bound but not by circulating TNF alpha. Immunity 19(5):725-737. PMID:14614859
  • Zhang L, Wang W, Hayashi Y, Jester JV, Birk DE, Gao M, Liu Y, Kao WW, Karin M, Xia Y. 2003. A role for MEK kinase 1 in TGF-beta/activin-induced epithelium movement and embryonic eyelid closure. EMBO J 22(17):4443-4454. doi:10.1093/emboj/cdg440 PMID:12941696 PMCID:PMC202382

2002

  • Hirosumi J, Tuncman G, Chang L, Gorgun CZ, Uysal KT, Maeda K, Karin M, Hotamisligil GS. 2002. A central role for JNK in obesity and insulin resistance. Nature 420(6913):333-336. PMID:12447443
  • Park JM, Greten FR, Li Z, Karin M. 2002. Macrophage apoptosis by anthrax lethal factor through p38 MAP kinase inhibition. Science 297(5589):2048-2051. PMID:12202685

2001

  • Cao Y, Bonizzi G, Seagroves TN, Greten FR, Johnson RS, Schmidt EV, Karin M. 2001. IKK± provides an essential link between RANK signaling and cyclin D1 expression during mammary gland development. Cell 107:763-775. PMID:11747812
  • Senftleben U, Cao Y, Xiao G, Greten FR, Krahn G, Bonizzi G, Chen Y, Hu Y, Fong A, Sun S, Karin M. 2001. Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway. Science 293(5534):1495-1499. doi:10.1126/science.1062677 PMID:11520989
  • Tang G, Minemoto Y, Dibling B, Purcell NH, Li Z, Karin M, Lin A. 2001. Inhibition of JNK activation by NF-kB target genes. Nature 414(6861):313-317. PMID:11713531

2000

  • Kapahi P, Takahashi T, Natoli G, Adams SR, Chen Y, Tsien RY, Karin M. 2000. Inhibition of NF-kappa B activation by arsenite through reaction with a critical cysteine in the activation loop of Ikappa B kinase. J Biol Chem 275(46):36062-36066. doi:10.1074/jbc.M007204200 PMID:10967126

1989

  • Hee Lee J, Cho U, Karin M. 1989. Discovery of 12-(S)-hydroxy-5,8,10,14-icosatetraenoic acid [12-(S)-HETE] in the tropical red alga Platysiphonia miniata. Sci Signal 37(2):303-308. PMID:2727309
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