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Person Details: Michael S. Denison

Superfund Research Program

Michael S. Denison

University of California-Davis
Department of Environmental Toxicology
4245 Meyer Hall
One Shields Avenue
Davis, California 95616
Phone: 530-752-3879
Fax: 530-752-3394


Research Briefs


Hazardous Waste Sites

Frontier Fertilizer

  • University of California-Davis: Development and Application of Integrated In Vitro and Cell-Based Bioassays



  • Black G, Ho G, Denison MS, Young TM. 2021. Using Estrogenic Activity and Nontargeted Chemical Analysis to Identify Contaminants in Sewage Sludge. Environ Sci Technol 55:6729-6739. doi:10.1021/acs.est.0c07846 PMID:33909413
  • Boonen I, De Nys S, Vervliet P, Covaci A, Van Landuyt KL, Duca RC, Godderis L, Denison MS, Elskens M. 2021. Assessing the estrogenic activity of chemicals present in resin based dental composites and in leachates of commercially available composites using the ERa-CALUX bioassay. Dent Mater 37(12):PMID:34579959
  • Haedrich J, Stumpf C, Denison MS. 2021. Bioanalytical screening of low levels of dioxins and dioxin-like PCBs in pig meat (pork) for checking compliance with EU maximum and action levels using highly sensitive 'third generation' recombinant H4L7.5c2 rat hepatoma cells. Environ Sci Eur 33:33. doi:10.1186/s12302-021-00474-2 PMID:33828936 PMCID:PMC7973644
  • Lin L, Denison MS, Rice RH. 2021. Woodsmoke extracts cross-link proteins and induce cornified envelope formation without stimulating keratinocyte terminal differentiation. Toxicol Sci 183(1):PMID:34086961
  • My TT, Dat ND, Van Langenhove K, Denison MS, Long HT, Elskens M. 2021. Evaluation of the dioxin-like toxicity in soil samples from Thua Thien Hue province using the AhR-CALUX bioassay - An update of Agent Orange contamination in Vietnam. Ecotoxicol Environ Saf 212:111971. doi:10.1016/j.ecoenv.2021.111971 PMID:33513480
  • Tomasek I, Damby DE, Andronico D, Baxter PJ, Boonen I, Claeys P, Denison MS, Horwell CJ, Kervyn M, Kueppers U, Romanias MN, Elskens M. 2021. Assessing the biological reactivity of organic compounds on volcanic ash: Implications for human health hazard. Bull Volcanol 83:11. doi:10.1007/s00445-021-01453-4
  • Young TM, Black G, Wong L, Bloszies CS, Fiehn O, He G, Denison MS, Vogel CF, Durbin-Johnson BP. 2021. Identifying toxicologically significant compounds in urban wildfire ash using in vitro bioassays and high-resolution mass spectrometry. Environ Sci Technol 55:3657-3667. doi:10.1021/acs.est.0c06712 PMID:33647203 PMCID:PMC8351470


  • Boonen I, Van Heyst A, Van Langenhove K, Van Hoeck E, Mertens B, Denison MS, Elskens M, Demaegdt H. 2020. Assessing the receptor-mediated activity of PAHs using AhR-, ERa - and PPAR - CALUX bioassays. Food Chem Toxicol 145:doi:10.1016/j.fct.2020.111602 PMID:32738369
  • Chan LK, Nguyen KQ, Karim N, Yang Y, Rice RH, He G, Denison MS, Nguyen TB. 2020. Relationship between the molecular composition, visible light absorption, and health-related properties of smoldering woodsmoke aerosols. Atmos Chem Phys 20:539-559. doi:10.5194/acp-20-539-2020
  • Faber SC, Tagliabue SG, Bonati L, Denison MS. 2020. The cellular and molecular determinants of naphthoquinone-dependent activation of the aryl hydrocarbon receptor. Int J Mol Sci 21:doi:10.3390/ijms21114111 PMID:32526934 PMCID:PMC7312509
  • Haedrich J, Stumpf C, Denison MS. 2020. Rapid extraction of total lipids and lipophilic POPs from all EU-regulated foods of animal origin: Smedes' method revisited and enhanced. Environ Sci Eur 32:doi:10.1186/s12302-020-00396-5 PMID:33614386 PMCID:PMC7891496
  • Hayashi A, Denison MS. 2020. Development of a novel recombinant cell line for detection and characterization of Ah receptor nuclear translocation in intact cells. Toxicol In Vitro 66:9. doi:10.1016/j.tiv.2020.104873 PMID:32333947 PMCID:PMC7260106
  • Kazzaz SA, Tagliabue SG, Franks DG, Denison MS, Hahn ME, Bonati L, Powell WH. 2020. An aryl hydrocarbon receptor from the caecilian Gymnopis multiplicata suggests low dioxin affinity in the ancestor of all three amphibian orders. Gen Comp Endocrinol 299(10):doi:10.1016/j.ygcen.2020.113592 PMID:32858041 PMCID:PMC7771225


  • Guo W, Langenhove KV, Vandermarken T, Denison MS, Elskens M, Baeyens W, Gao Y. 2019. In situ measurement of estrogenic activity in various aquatic systems using organic diffusive gradients in thin-film coupled with ERE-CALUX bioassay. Environ Int 127:13-20. PMID:30897513
  • Mexia N, Koutrakis S, He G, Skaltounis L, Denison MS, Magiatis P. 2019. RETURN TO ISSUEPREVARTICLENEXT Journal Logo A Biomimetic, One-Step Transformation of Simple Indolic Compounds to Malassezia-Related Alkaloids with High AhR Potency and Efficacy. Chem Res Toxicol 32:doi:10.1021/acs.chemrestox.9b00270 PMID:31647221 PMCID:PMC7757739 (accepted for publication)
  • Vandermarken T, Boonen I, Gryspeirt C, Croes K, Van Den Houwe K, Denison MS, Gaoa Y, Van Hoeck E, Elskens M. 2019. Assessment of estrogenic compounds in paperboard for dry food packaging with the ERE-CALUX bioassay. Chemosphere 221:99-106. doi:10.1016/j.chemosphere.2018.12.192 PMID:30634153


  • Faber SC, Soshilov AA, Tagliabue SG, Bonati L, Denison MS. 2018. Comparative in vitro and in silico analysis of the selectivity of indirubin as a human Ah receptor agonist. Int J Mol Sci 19(9):2692. doi:10.3390/ijms19092692 PMID:30201897 PMCID:PMC6165432
  • Haedrich J, Stumpf C, Denison MS. 2018. Ah-receptor based bioassay screening for PCDD/Fs and Dioxin-like PCBs in human milk samples from a WHO/UNEP global survey on halogenated POPs. Dtsch Lebensmitt Rundsch 114:389-397.
  • Haedrich J, Stumpf C, Denison MS. 2018. Bioanalytical screening for Dioxins and PCBs in EU-regulated foods: new analytical criteria adopted by the European Union in Commission Regulation (EU) 2017/644. Part 2: sample analysis criteria and the nature of bioanalytical results. Dtsch Lebensmitt Rundsch 114:167-175.
  • Haedrich J, Stumpf C, Denison MS. 2018. Bioanalytical screening for dioxins and PCBs in EU-regulated foods: new analytical criteria adopted by the European Union in Commission Regulation (EU) 2017/644. Part 3: Assay criteria, validation and quality control, reporting of results, implementation. Dtsch Lebensmitt Rundsch 114:215-228.
  • Vandermarken T, Croes K, Van Langenhove K, Boonen I, Servais P, Garcia-Armisen T, Brion N, Denison MS, Goeyens L, Elskens M. 2018. Endocrine activity in an urban river system and the biodegradation of estrogen-like endocrine disrupting chemicals through a bio-analytical approach using DRE- and ERE-CALUX bioassays. Chemosphere 201:540-549. doi:10.1016/j.chemosphere.2018.03.036 PMID:29533803
  • Vandermarken T, Gaoa Y, Baeyens W, Denison MS, Croes K. 2018. Dioxins, furans and dioxin-like PCBs in sediment samples and suspended particulate matter from the Scheldt estuary and the North Sea Coast: comparison of CALUX concentration levels in historical and recent samples. Sci Total Environ 626:109-116. doi:10.1016/j.scitotenv.2018.01.084 PMID:29335165


  • Anderson CG, Joshi G, Bair DA, Oriol C, He G, Parikh SJ, Denison MS, Scow KM. 2017. Use of nuclear receptor luciferase-based bioassays to detect endocrine active chemicals in a biosolids-biochar amended soil. Chemosphere 181:160-167. doi:10.1016/j.chemosphere.2017.04.035 PMID:28437741
  • Denison MS, Faber SC. 2017. And now for something completely different: Diversity in ligand-dependent activation of Ah receptor response. Curr Opin Toxicol 2:124-131. doi:10.1016/j.cotox.2017.01.006 PMID:28845473 PMCID:PMC5570615
  • Guo W, Van Langenhove K, Denison MS, Baeyens W, Elskens M, Gao Y. 2017. Estrogenic activity measurements in water using diffusive gradients in thin-film coupled with an estrogen bioassay. Anal Chem 89:13357-13364. doi:10.1021/acs.analchem.7b03537 PMID:29151339
  • Khedidji S, Croes K, Yassaa N, Ladji R, Denison MS, Baeyens W, Elskens M. 2017. Assessment of dioxin-like activity in PM10 air samples from an industrial location in Algeria, using the DRE-CALUX bioassay. Environ Sci Pollut Res Int 24(13):11868–11877. doi:10.1007/s11356-015-5841-4 PMID:26611627
  • Mehinto AC, VanDervort DR, Lao W, He G, Denison MS, Vliet SM, Volz DC, Mazor RD, Maruya KA. 2017. High throughput in vitro and in vivo screening of inland waters of Southern California. Environ Sci Process Impacts 19:1142-1149. doi:10.1039/c7em00170c PMID:28612856


  • Brennan JC, Bassal A, He G, Denison MS. 2016. Development of a recombinant human ovarian (BG1) cell line containing estrogen receptor alpha and beta for improved detection of estrogenic/antiestrogenic chemicals. Environ Toxicol Chem 35(1):91-100. doi:10.1002/etc.3146 PMID:26139245 PMCID:PMC4772679
  • Cole BJ, Brander SM, Jeffries KM, Hasenbein S, He G, Denison MS, Fangue NA, Connon RE. 2016. Changes in Menidia beryllina gene expression and in vitro hormone-receptor activation after exposure to estuarine waters near treated wastewater outfalls. Arch Environ Contam Toxicol 71(2):210-223. doi:10.1007/s00244-016-0282-8 PMID:27155869 PMCID:PMC4772679
  • Croes K, Debaillie P, Van den Bril B, Staelens J, Vandermarken T, Van Langenhove K, Denison MS, Leermakers M, Elskens M. 2016. Assessment of estrogenic activity in PM₁₀ air samples with the ERE-CALUX bioassay: Method optimization and implementation at an urban location in Flanders (Belgium). Chemosphere 144:392-398. doi:10.1016/j.chemosphere.2015.09.020 PMID:26383266
  • Denison MS, Croes K, Van den Heuvel R, Van den Bril B, Van Langenhove K, Staelens J, Vandermarken T, Elskens M. 2016. Assessment of estrogenic and androgenic activity in PM10 air samples from an urban, industrial and rural area in Flanders (Belgium) using the CALUX bioassay. Environ Res 150:66-72. doi:10.1016/j.envres.2016.05.044 PMID:27257826
  • Joshi G, Schmidt R, Denison MS, Hristova KR. 2016. Effect of benzene and ethylbenzene on the transcription of methyl-tert-butyl ether degradation genes of Methylibium petroleiphilum PM1. Microbiology 162(9):1563-1571. doi:10.1099/mic.0.000338 PMID:27450417 PMCID:PMC4459789
  • Vandermarken T, de Galan S, Croes K, Van Langenhove K, Vercammen J, Sanctorum H, Denison MS, Goeyens L, Elskens M, Baeyens W. 2016. Characterisation and implementation of the ERE-CALUX bioassay on indoor dust samples of kindergartens to assess estrogenic potencies. Psychiatr Pol 155(PtB):182-189. doi:10.1016/j.jsbmb.2015.01.005 PMID:25595043




  • Brander SM, Connon RE, He G, Hobbs JA, Smalling KL, Teh SJ, White JW, Werner I, Denison MS, Cherr GN. 2013. From 'omics to otoliths: responses of an estuarine fish to endocrine disrupting compounds across biological scales. PLoS One 8(9):e74251. doi:10.1371/journal.pone.0074251 PMID:24086325 PMCID:PMC3783432
  • Brennan JC, Denison MS, Holstege DM, Magiatis P, Dallas JL, Gutierrez EG, Soshilov AA, Millam JR. 2013. 2,3-cis-2R, 3R-(-)-epiafzelechin-3-O-p-coumarate, a novel flavan-3-ol isolated from Fallopia convolvulus seed, is an estrogen receptor agonist in human cell lines. BMC Complement Altern Med 13:133. doi:10.1186/1472-6882-13-133 PMID:23768005 PMCID:PMC3695784
  • Croes K, Colles A, Koppen G, de Galan S, Vandermarken T, Govarts E, Bruckers L, Nelen V, Schoeters G, Van Larebeke N, Denison MS, Mampaey M, Baeyens W. 2013. Determination of PCDD/Fs, PBDD/Fs and dioxin-like PCBs in human milk from mothers residing in the rural areas in Flanders, using the CALUX bioassay and GC-HRMS. Talanta 113:99-105. doi:10.1016/j.talanta.2013.03.086 PMID:23708629 PMCID:PMC3690775
  • Fraccalvieri D, Soshilov AA, Karchner SI, Franks DG, Pandini A, Bonati L, Hahn ME, Denison MS. 2013. Comparative analysis of homology models of the AH receptor ligand binding domain: verification of structure-function predictions by site-directed mutagenesis of a nonfunctional receptor. Biochemistry 52:714-725. doi:10.1021/bi301457f PMID:23286227 PMCID:PMC3568667
  • He G, Zhao J, Brennan JC, Affatato AA, Zhao B, Rice RH, Denison MS. 2013. Cell-based assays for identification of aryl hydrocarbon (Ah) receptor activators. In: Optimization of Drug Discovery: In Vitro Methods (2E). Humana Press, New York, NY. pp.221-235.
  • He G, Zhao J, Brennan JC, Affatato AA, Zhao B, Rice RH, Denison MS. 2013. Cell-based assays for identification of aryl hydrocarbon (AhR) receptor activators. Chapter 13 in: Optimization of Drug Discovery: In Vitro Methods (2E). Humana Press, New York, NY. pp.221-235.
  • Hu Q, He G, Zhao J, Soshilov AA, Denison MS, Zhang A, Yin H, Fraccalvieri D, Bonati L, Xie Q, Zhao B. 2013. Ginsenosides are novel naturally-occurring aryl hydrocarbon receptor ligands. PLoS One 8:e66258. doi:10.1371/journal.pone.0066258 PMID:23776647 PMCID:PMC3679084
  • Kamenickova A, Anzenbacherova E, Pavek P, Soshilov AA, Denison MS, Anzenbacher P, Dvorak Z. 2013. Pelargonidin activates the AhR and induces CYP1A1 in primary human hepatocytes and human cancer cell lines HepG2 and LS174T. Toxicol Lett 218(3):253-259. doi:10.1016/j.toxlet.2013.01.020 PMID:23419638 PMCID:PMC3644221
  • Kamenickova A, Anzenbacherova E, Pavek P, Soshilov AA, Denison MS, Zapletalova M, Anzenbacher P, Dvorak Z. 2013. Effects of anthocyanins on the AhR-CYP1A1 signaling pathway in human hepatocytes and human cancer cell lines. Toxicol Lett 221(1):1-8. doi:10.1016/j.toxlet.2013.05.007 PMID:23735880 PMCID:PMC3759295
  • Magiatis P, Pappas P, Gaitanis G, Mexia N, Melliou E, Galanou M, Vlachos C, Stathopoulou K, Skaltsounis AL, Marselos M, Velegraki A, Denison MS, Bassukas ID. 2013. Malassezia yeasts produce a collection of exceptionally potent activators of the Ah (dioxin) receptor detected in diseased human skin. Journal of Investigative Dermatology 133(8):2023-2030. doi:10.1038/jid.2013.92 PMID:23448877 PMCID:PMC3714356
  • Zhao B, Bohonowych JE, Timme-Laragy AR, Jung D, Affatato AA, Rice RH, Di Giulio RT, Denison MS. 2013. Common commercial and consumer products contain activators of the aryl hydrocarbon (dioxin) receptor. PLoS One 8(2):e56860. doi:10.1371/journal.pone.0056860 PMID:23441220 PMCID:PMC3575475



  • Baston DS, Denison MS. 2011. Considerations for potency equivalent calculations in the Ah receptor-based CALUX bioassay: normalization of superinduction results for improved sample potency estimation. Talanta 83(5):1415-1421. doi:10.1016/j.talanta.2010.11.035 PMID:21238730 PMCID:PMC3036574
  • Croes K, Van Langenhove K, Den Hond E, Bruckers L, Colles A, Koppen G, Loots I, Nelen V, Schoeters G, Nawrot T, Van Larebeke N, Denison MS, Vandermarken T, Elskens M, Baeyens W. 2011. Quantification of PCDD/Fs and dioxin-like PCBs in small amounts of human serum using the sensitive H1L75c1 mouse hepatoma cell line: optimization and analysis of human serum samples from adolescents of the Flemish human biomonitoring program FLEHS II. Talanta 85(5):2484-2491. doi:10.1016/j.talanta.2011.07.103 PMID:21962672 PMCID:PMC3523230
  • Denison MS, Soshilov AA, He G, DeGroot DE, Zhao B. 2011. Exactly the same but different: promiscuity and diversity in the molecular mechanisms of action of the aryl hydrocarbon (dioxin) receptor. Toxicol Sci 124:1-22. doi:10.1093/toxsci/kfr218 PMID:21908767 PMCID:PMC3196658
  • He G, Tsutsumi T, Baston DS, Zhao B, Zhao J, Heath-Pagliuso S, Denison MS. 2011. Third-generation Ah receptor-responsive luciferase reporter plasmids: amplification of dioxin-responsive elements dramatically increases CALUX bioassay sensitivity and responsiveness. Toxicol Sci 123:511-522. doi:10.1093/toxsci/kfr189 PMID:21775728 PMCID:PMC3179681
  • He G, Zhao B, Denison MS. 2011. Identification of benzothiazole derivatives and polycyclic aromatic hydrocarbons as aryl hydrocarbon receptor agonists present in tire extracts. Environ Toxicol Chem 30:1915-1925. doi:10.1002/etc.581 PMID:21590714 PMCID:PMC3263332
  • Motto I, Bordogna A, Soshilov AA, Denison MS, Bonati L. 2011. New aryl hydrocarbon receptor homology model targeted to improve docking reliability. J Chem Inf Model 51(11):2868-2881. doi:10.1021/ci2001617 PMID:21981577 PMCID:PMC3263330




  • Chen J, Ahn K, Zhao B, Denison MS, Lasley BL, Pessah IN, Kültz D, Chang DP, Gee SJ, Hammock BD, Cherednichenko G. 2008. In vitro biologic activities of the antimicrobials triclocarban, its analogs, and triclosan in bioassay screens: receptor-based bioassay screens. Environ Health Perspect 116:1203-1210. doi:10.1289/ehp.11200 PMID:18795164 PMCID:PMC2535623


  • Brown DJ, Orelien J, Gordon JD, Chu AC, Chu MD, Nakamura M, Handa H, Kayama F, Denison MS, Clark GC. 2007. Mathematical model developed for environmental samples: prediction of GC/MS dioxin TEQ from XDS-CALUX bioassay data. Environ Sci Technol 41(12):4354-4360. PMID:17626436 PMCID:PMC2877589
  • Nording M, Denison MS, Baston DS, Persson Y, Spinnel E, Haglund P. 2007. Analysis of dioxins in contaminated soils with the calux and caflux bioassays, an immunoassay, and gas chromatography/high-resolution mass spectrometry. Environ Toxicol Chem 26(6):1122-9. PMID:17571676


  • Denison MS, Han D, Nagy SR, Zhao B, Baston DS, Hayashi A, Knockaert M, Meijer L. 2006. Indirubins as activators of the aryl hydrocarbon receptor signal transduction pathways. Chapter 16 in: Indirubin, The Red Shade of Indigo. Roscoff, France. pp.157-167.
  • Denison MS, Khan EM, Sorrentino C, Zhao B. 2006. Enhanced CALUX and CAFLUX cell bioassay responses through intracellular signaling pathways and incubation temperature. Organohalogen Compounds 68:1265-1268.
  • Gordon JD, Denison MS, Chu AC, Chu MD, Matherly C, Kayama F, Clark GC. 2006. Proposed classification system for tier-1 screening of estrogenic EDC using the Lumi-Cell ER bioassay. Organohalogen Compounds 68:1273-1276.
  • Klein GP, Hodge EM, Diamond ML, Yip A, Dann T, Stern G, Denison MS, Harper PA. 2006. Gas-phase ambient air contaminants exhibit significant dioxin-like and estrogen-like activity In vitro. Environ Health Perspect 114(5):697-703. PMID:16675423
  • Peters AK, Leonards PE, Zhao B, Bergman A, Denison MS, van den Berg M. 2006. Determination of in vitro relative potency (REP) values for mono-ortho polychlorinated biphenyls after purification with active charcoal. Toxicol Lett 165(3):230-241. PMID:16750337
  • Peters AK, Nijmeijer S, Gradin K, Backlund M, Bergman A, Poellinger L, Denison MS, van den Berg M. 2006. Interactions of polybrominated diphenyl ethers with the aryl hydrocarbon receptor pathway. Toxicol Sci 92(1):133-142. PMID:16601081
  • Zhao B, Baston DS, Hammock BD, Denison MS. 2006. Interaction of diuron and related substituted phenylureas with the Ah receptor pathway. J Biochem Mol Toxicol 20(3):103-113. PMID:16788953
  • Zhao B, Bohonowych JE, Denison MS. 2006. Differential responsiveness of the Ah receptor dependent gene expression induced by HAHs and PAHs. Organohalogen Compounds 68:1745-1748.


  • Clark GC, Orelien J, Gordon JD, Chu AC, Chu MD, Denison MS. 2005. Mathematical model predictions of GC/MS data for dioxin contaminated environmental samples using CALUX® by XDS. Organohalogen Compounds 67:50-53.
  • Gordon JD, Chu AC, Chu MD, Matherly C, Denison MS, Grune G, Clark GC. 2005. Estrogenic potency of many popular suncreens and it's "non-active" components detected using the LUMI-cell" ER bioassay. Organohalogen Compounds 67:
  • Peters AK, Nijmeijer S, Zhao B, Denison MS, Bergman A, Sanderson J, van den Berg M. 2005. Polybrominated diphenyl ethers (PBDEs) antagonize or inhibit TCDD induced CYP1A1 activity in various in vitro systems. Organohalogen Compounds 67:2290-2293.
  • Windal I, Denison MS, Birnbaum LS, Van Wouwe N, Baeyens W, Goeyens L. 2005. Chemically activated luciferase gene expression (CALUX) cell bioassay analysis for the estimation of dioxin-like activity: critical parameters of the CALUX procedure that impact assay results. Environ Sci Technol 39(19):7357-7364. PMID:16245802


  • Bohonowych JE, Denison MS. 2004. Binding of 2,3,7,8-tetrachlorodibehzo-p-dioxin to the AhR from various species is essentially irreversible. Organohalogen Compounds 55:3291-3295.
  • Brown DJ, Van Overmeire I, Goeyens L, Denison MS, De Vito MJ, Clark GC. 2004. Analysis of Ah receptor pathway activation by brominated flame retardants. Organohalogen Compounds 55(11):1509-1518. PMID:15099731
  • Denison MS, Rogers WJ, Bohonowych JE, Zhao B, Dey A, Williams RS, Pollock DM, Stepp DW, Newman JW, Hammock BD, Imig JD. 2004. Promiscuous ligand-dependent activation of the Ah receptor: chemicals in crude extracts from commercial and consumer products bind to and activate the Ah receptor and Ah receptor-dependent gene expression. Organohalogen Compounds 66:2966-2971.
  • Denison MS, Zhao B, Baston DS, Clark GC, Murata H, Han D. 2004. Recombinant cell bioassay systems for the detection and relative quantitation of halogenated dioxins and related chemicals. Talanta 63(5):1123-1133. PMID:18969542
  • Gordon JD, Chu AC, Chu MD, Denison MS, Clark GC. 2004. Detection of estrogen receptor endocrine disrupter potency of commonly used organochlorine pesticides using the LUMI-CELL ER" bioassay. Organohalogen Compounds 66:169-174.
  • Han D, Nagy SR, Denison MS. 2004. Comparison of recombinant cell bioassays for the detection of Ah receptor agonists. Biofactors 20(1):11-22. PMID:15096657
  • Knockaert M, Blondel M, Bach S, Leost M, Elbi C, Hager GL, Nagy SR, Han D, Denison MS, Ffrench M, Ryan XP, Magiatis P, Polychronopoulos P, Greengard P, Skaltsounis L, Meijer L. 2004. Independent actions on cyclin-dependent kinases and aryl hydrocarbon receptor mediate the antiproliferative effects of indirubins. Oncogene 23(25):4400-4412. PMID:15077192
  • Zhao B, Denison MS. 2004. Development and characterization of a green fluorescent protein-based rat cell bioassay system for detection of Ah receptor ligands. Organohalogen Compounds 66:3285-3290.
  • Zhao B, Nagy SR, Rogers JM, Nantz MH, Kurth M, Springsteel M, Denison MS. 2004. Identification and analysis of novel flavonoid agonists and antagonists for the Ah and estrogen receptor. Organohalogen Compounds 66:2919-2924.


  • Baston DS, Nagy SR, Nantz MH, Kurth M, Springsteel M, Denison MS. 2003. Identification of novel agonists and antagonists of the Ah receptor signal transduction pathway. Organohalogen Compounds 65:142-145.
  • Denison MS, Han D, Heath-Pagliuso S, Scovill J, Meijer L, Skaltounis L, Gillam EM, Nagy SR. 2003. Activation of the Ah receptor and Ah receptor signal transduction pathway by tryptophan-derived agonists. Organohalogen Compounds 65:90-93.
  • Denison MS, Nagy SR. 2003. Activation of the aryl hydrocarbon receptor by structurally diverse exogenous and endogenous chemicals. Annu Rev Pharmacol Toxicol 43:309-334. PMID:12540743
  • Gordon JD, Chu AC, Chu MD, Taylor CL, Denison MS, Clark GC. 2003. Validation of the LUMI-CELLTM ER recombinant bioassay for rapid evaluatin of chemicals for potential estrogenic activity. Organohalogen Compounds 65:78-81.
  • Han D, Zhao B, Baston DS, Springsteel M, Kurth M, Nantz MH, Denison MS. 2003. Identification and characterization of novel flavone agonists of th Ah receptor. Organohalogen Compounds 65:126-129.
  • Jeuken A, Keser BJ, Khan EM, Brouwer A, Koeman JH, Denison MS. 2003. Activation of the Ah receptor by extracts of dietary herbal supplements, vegetables, and fruits. J Agric Food Chem 51(18):5478-5487. PMID:12926901
  • Monk SA, Denison MS, Rice RH. 2003. Reversible stepwise negative regulation of CYP1A1 in cultured rat epidermal cells. Arch Biochem Biophys 419(12):158-169. PMID:14592459
  • Wuilloud JC, Wuilloud RG, Sadi BM, Caruso JA, Denison MS, Nagy SR. 2003. Trace humic and fulvic acid determination in natural water by cloud point extraction/preconcentration using non-ionic and cationic surfactants with FI-UV detection. Analyst 128(5):453-458. PMID:12790196
  • Zhao B, Nagy SR, Baston DS, Han D, Nantz MH, Kurth M, Springsteel M, Denison MS. 2003. Screening and analysis of novel naphthoflavone ligands for the Ah receptor. Organohalogen Compounds 65:102-105.


  • Denison MS, Nagy SR, Ziccardi MH, Clark GC, Chu MD, Brown DJ, Shan G, Sugawara Y, Gee SJ, Sanborn JR, Hammock BD. 2002. Bioanalytical approaches for the detection of dioxin and related halogenated aromatic hydrocarbons. In: Biomarkers of Environmentally Associated Disease: Technologies, Concepts, and Perspectives. CRC Press Company, Boca Raton, FL. pp.483-494.
  • Han D, Nagy SR, Denison MS. 2002. Recombinant cell lines for the detection of dioxins and Ah receptor ligands - not all assays are created equal. Organohalogen Compounds 58:421-424.
  • Khan EM, Denison MS. 2002. NF-kB is involved in cross-talk between Ah receptor and signal transduction pathways. Organohalogen Compounds 59:411-414.
  • Lashley MR, Niedzinski EJ, Rogers JM, Denison MS, Nantz MH. 2002. Synthesis and estrogen receptor affinity of a 4-hydroxytamoxifen-labeled ligand for diagnostic imaging. Bioorg Med Chem 10(12):4075-4082. PMID:12413861
  • Nagy SR, Denison MS. 2002. Specificity of nuclear protein binding to a CYP1A1 negative regulatory element. Biochem Biophys Res Commun 296(4):799-805. PMID:12200118
  • Nagy SR, Liu G, Lam KS, Denison MS. 2002. Identification of novel Ah receptor agonists using a high-throughput green fluorescent protein-based recombinant cell bioassay. Biochemistry 41(3):861-868. PMID:11790108
  • Nagy SR, Sanborn JR, Hammock BD, Denison MS. 2002. Development of a green fluorescent protein based cell bioassay for the rapid and inexpensive detection and characterization of AhR agonists. Toxicol Sci 65(2):200-210. PMID:11812924
  • Natarajan K, Overstreet JW, Rogers JM, Denison MS, Chen J, Lohstroh PN, McConnell DS, Lasley BL. 2002. Detection of xenoestrogens in serum after immunoprecipitation of endogenous steroidal estrogens. Environ Health Perspect 110(8):791-795. PMID:12153760
  • Rogers JM, Denison MS. 2002. Analysis of the antiestrogenic activity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in human ovarian carcinoma BG-1 cells. Mol Pharmacol 61(6):1393-1403. PMID:12021401
  • Rushing SR, Denison MS. 2002. The silencing mediator of retinoic acid and thyroid hormone receptors can interact with the aryl hydrocarbon (Ah) receptor but fails to repress Ah receptor-dependent gene expression. Arch Biochem Biophys 403(2):189-201. PMID:12139968
  • Ziccardi MH, Gardner IA, Denison MS. 2002. Application of the luciferase recombinant cell culture bioassay system for the analysis of polycyclic aromatic hydrocarbons. Environ Toxicol Chem 21(10):2027-2033. PMID:12371477
  • Ziccardi MH, Gardner IA, Mazet JA, Denison MS. 2002. Application of the luciferase cell culture bioassay for the detection of refined petroleum products. Mar Pollut Bull 44(10):983-991. PMID:12474956


  • Monk SA, Denison MS, Rice RH. 2001. Transient expression of CYP1A1 in rat epithelial cells cultured in suspension. Arch Biochem Biophys 393(1):154-162. PMID:11516172
  • Rogers JM, Denison MS. 2001. Analysis of the anti-estrogen effect of TCDD in human ovarian carcinoma (BG-1) cells. Organohalogen Compounds 53:5-9.
  • Seidel SD, Winters GM, Rogers JM, Ziccardi MH, Li V, Keser BJ, Denison MS. 2001. Activation of the Ah receptor signaling pathway by prostaglandins. J Biochem Mol Toxicol 15(4):187-196. PMID:11673847
  • Ziccardi MH, Gardner IA, Denison MS. 2001. Application of the luciferase recombinant cell culture bioassay for detection of dioxin-like activity of PAHs in the serum of wildlife. Organohalogen Compounds 54:73-76.


  • Arrieta DE, Ontiveros C, Denison MS, Washburn BS. 2000. Ah receptor mediated effects of particulate organic extracts from the Paso Del Norte airshed along the U.S.-Mexico border. Organohalogen Compounds 45:212-215. PMID:12896850
  • Bohonowych JE, Rogers JM, Jeuken A, Denison MS. 2000. Activation of Ah and estrogen receptor based cell bioassay systems by extracts of natural dietary herbal supplements. Organohalogen Compounds 45:240-243.
  • Heath-Pagliuso S, Mui R, Milici A, Giese S, Chin R, Denison MS. 2000. Tryptophan metabolites, indole-3-pyruvic acid, DL-3-indolelactic acid, L-kynurenine, and kynurenic acid activate Ah receptor signal transduction. Organohalogen Compounds 49:289-292.
  • Nagy SR, Lui G, Lam KS, Denison MS. 2000. A green fluorescent protein based recombinant cell bioassay for the detection of activators of the aryl hydrocarbon receptor: application for screening of a 1,5-dialkylamino-2,4-dinitrobenzene combinatorial chemical library. Organohalogen Compounds 45:232-235.
  • Rogers JM, Denison MS. 2000. Application of a human ovarian cell bioassay for the detection and analysis of estrogen-toxicant interaction. Organohalogen Compounds 49:338-341.
  • Rogers JM, Denison MS. 2000. Recombinant cell bioassays for endocrine disruptors: development of a stably transfected human ovarian cell line for the detection of estrogenic and anti-estrogenic chemicals. In Vitr Mol Toxicol 13(1):67-82. PMID:10900408
  • Seidel SD, Li V, Winters GM, Rogers WJ, Martinez EI, Denison MS. 2000. Ah receptor-based chemical screening bioassays: application and limitations for the detection of Ah receptor agonists. Toxicol Sci 55(1):107-115. PMID:10788565
  • Shan G, Sanborn JR, Gilman DS, Nagy SR, Gee SJ, Stoutamire DW, Mercer RS, Jones AD, Stanker LH, Denison MS, Hammock BD. 2000. Surrogates for dioxin analyses: analytical, ELISA and toxicological aspects. Organohalogen Compounds 45:188-191.
  • Williams SN, Shih H, Guenette DK, Brackney W, Denison MS, Pickwell GV, Quattrochi LC. 2000. Comparative studies on the effects of green tea extracts and individual tea catechins on human CYP1A gene expression. Chem Biol Interact 128(3):211-229. PMID:11064004
  • Ziccardi MH, Gardner IA, Denison MS. 2000. Development and modification of a recombinant cell bioassay to directly detect halogenated and polycyclic aromatic hydrocarbons in serum. Toxicol Sci 54(1):183-193. PMID:10746945


  • Denison MS, Seidel SD, Ziccardi MH, Rogers WJ, Brown DJ, Clark GC. 1999. Ah receptor-based bioassays for dioxins and related chemicals: applications and limitations. Organohalogen Compounds 40:27-30.
  • Levine SL, Oris JT, Denison MS. 1999. Modulation of CYP1A expression in rainbow trout by a technical grade formulation of propriconazole. Environ Toxicol Chem 18(11):2565-2573.


  • Besselink HT, Denison MS, Hahn ME, Karchner SI, Vethaak AD, Koeman JH, Brouwer A. 1998. Low inducibility of CYP1A activity by polychlorinated biphenyls (PCBs) in flounder (Platichthys flesus): characterization of the Ah receptor and the role of CYP1A inhibition. Toxicol Sci 43(2):161-171. doi:10.1006/toxs.1998.2455 PMID:9710958
  • Denison MS, Heath-Pagliuso S. 1998. The Ah receptor: a regulator of the biochemical and toxicological actions of structurally diverse chemicals. Bull Environ Contam Toxicol 61:557-568. PMID:9841714
  • Denison MS, Phelan D, Elferink CJ. 1998. The Ah receptor signal transduction pathway. In: Toxicant-Receptor Interactions. Taylor and Francis, Philadelphia, PA. pp.3-33.
  • Denison MS, Phelan D, Winters GM, Ziccardi MH. 1998. Carbaryl, a carbamate insecticide, is a ligand for the hepatic Ah (dioxin) receptor. Toxicol Appl Pharmacol 152(2):406-414. PMID:9853009
  • Heath-Pagliuso S, Rogers WJ, Tullis K, Seidel SD, Cenijn PH, Brouwer A, Denison MS. 1998. Activation of the Ah receptor by tryptophan and tryptophan metabolites. Biochemistry 37(33):11508-11515. PMID:9708986
  • Phelan D, Winters GM, Rogers WJ, Lam JC, Denison MS. 1998. Activation of the Ah receptor signal transduction pathway by bilirubin and biliverdin. Arch Biochem Biophys 357(1):155-163. PMID:9721195


  • Murk AJ, Leonards PE, Bulder AS, Jonas AS, Rozemeijer MJ, Denison MS, Koeman JH, Brouwer A. 1997. The CALUX (chemical-activated luciferase expression) assay adapted and validated for measuring TCDD equivalents in blood plasma. Environ Toxicol Chem 16(8):1583-1589.
  • Richter CA, Giesy JP, Tieber VL, Denison MS. 1997. An in vitro rainbow trout cell bioassay for AhR-mediated toxins. Environ Toxicol Chem 16:543-550.
  • Washburn BS, Rein KS, Baden DG, Walsh PJ, Hinton DE, Tullis K, Denison MS. 1997. Brevetoxin-6 (PbTx-6), a nonaromatic marine neurotoxin, is a ligand of the aryl hydrocarbon receptor. Arch Biochem Biophys 343(2):149-156. PMID:9224724
  • Ziccardi MH, Rogers WJ, Schecter AJ, Papke O, Denison MS. 1997. Direct detection of dioxins and related chemicals in small quantities of human serum using a recombinant cell bioassay. Organohalogen Compounds 31:215-218.


  • Denison MS, Rogers WJ, Fair M, Ziccardi MH, Clark GC, Murk AJ, Brouwer A. 1996. Applications of the CALUX bioassay system for the detection of dioxin-like chemicals (Ah receptor ligands) in whole serum samples in extracts from commercial and consumer products. Organohalogen Compounds 27:280-284.
  • Garrison PA, Tullis K, Aarts JM, Brouwer A, Giesy JP, Denison MS. 1996. Species-specific recombinant cell lines as bioassay systems for the detection of 2,3,7,8-tetrachlorodibenzo-p-dioxin-like chemicals. Fundam Appl Toxicol 30(2):194-203. PMID:8812265
  • Gebremichael A, Tullis K, Denison MS, Cheek JM, Pinkerton KE. 1996. Ah-receptor-dependent modulation of gene expression by aged and diluted sidestream cigarette smoke. Toxicol Appl Pharmacol 141(1):76-83. PMID:8917678
  • Murk AJ, Legler J, Denison MS, Giesy JP, van der Guchte CJ, Brouwer A. 1996. Chemical-activated luciferase gene expression (CALUX): a novel in vitro bioassay for Ah receptor active compounds in sediments and pore water. Fundam Appl Toxicol 33(1):149-160. PMID:8812260
  • Sanderson J, Aarts JM, Brouwer A, Froese KL, Denison MS, Giesy JP. 1996. Comparison of Ah receptor-mediated luciferase and ethoxyresorufin-O-deethylase induction in H4IIE cells: implications for their use as bioanalytical tools for the detection of polyhalogenated aromatic hydrocarbons. Toxicol Appl Pharmacol 137(2):316-325. PMID:8661358
  • Villalobos SA, Anderson MJ, Denison MS, Hinton DE, Tullis K, Kennedy IM, Jones AD, Chang DP, Yang G, Kelly PB. 1996. Dioxin-like properties of a trichloroethylene combustion-generated aerosol. Environ Health Perspect 104(7):734-743. PMID:8841759
  • Walsh AA, Tullis K, Rice RH, Denison MS. 1996. Identification of a novel cis-acting negative regulatory element affecting expression of the CYP1A1 gene in rate epidermal cells. J Biol Chem 271(37):22746-22753.


  • Newsted JL, Giesy JP, Ankley GT, Tillitt DE, Crawford RA, Gooch JL, Jones PD, Denison MS. 1995. Development of toxic equivalency factors for PCB congeners and the assessment of TCDD and PCB mixtures in rainbow trout. Environ Toxicol Chem 14(5):861-871.
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