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Your Environment. Your Health.

Person Details: Timothy D. Phillips

Superfund Research Program

Timothy D. Phillips

Texas A&M University
Veterinary Integrative Biosciences
404 Vet. Medical Research Bldg.
4458 TAMU
College Station, Texas 77843-4458
Phone: 979-845-6414
Fax: 979-862-4929
Email: tphillips@cvm.tamu.edu

Projects

Research Briefs

Patents

Hazardous Waste Sites

Houston Ship Channel/Galveston Bay

  • Texas A&M University: Mitigation of Chemical and Mixture Effects Through Broad-Acting Sorbents

Publications

2021

  • Hearon S, Wang M, McDonald TJ, Phillips TD. 2021. Decreased bioavailability of aminomethylphosphonic acid (AMPA) in genetically modified corn with activated carbon or calcium montmorillonite clay inclusion in soil. J Environ Sci (China) 100:131-143. doi:10.1016/j.jes.2020.06.029 (ahead of print)

2020

  • Orr AA, He S, Wang M, Goodall A, Hearon S, Phillips TD, Tamamis P. 2020. Insights into the interactions of bisphenol and phthalate compounds with unamended and carnitine-amended montmorillonite clays. Computers & Chemical Engineering 143:107063. doi:10.1016/j.compchemeng.2020.107063
  • Wang M, Bera G, Mitra K, Wade TL, Knap A, Phillips TD. 2020. Tight sorption of arsenic, cadmium, mercury, and lead by edible activated carbon and acid-processed montmorillonite clay. Environ Sci Pollut Res Int doi:10.1007/s11356-020-10973-z PMID:33009611

2019

2018

  • Onel M, Beykal B, Wang M, Grimm FA, Zhou L, Wright FA, Phillips TD, Rusyn I, Pistikopoulos EN. 2018. Optimal chemical grouping and sorbent material design by data analysis, modeling and dimensionality reduction techniques. Computer Aided Chemical Engineering 43:421-426. doi:10.1016/B978-0-444-64235-6.50076-0 PMID:30534632
  • Phillips TD, Wang M, Elmore SE, Hearon S, Wang J. 2018. NovaSil clay for the protection of humans and animals from aflatoxins and other contaminants. Clays and Clay Minerals 67(1):99-110. doi:10.1007/s42860-019-0008-x

2017

2013

  • Taylor JF, Robinson A, Mitchell NJ, Marroquin-Cardona A, Johnson N, Elmore SE, Romoser AA, Phillips TD. 2013. In vivo efficacy of ferrihydrite as an enterosorbent for arsenic: Short-term evaluation in rodents. J Toxicol Environ Health A 76:167-175. doi:10.1080/15287394.2013.752322 PMID:23356646

2009

  • Taylor JF, Robinson A, Johnson N, Marroquin-Cardona A, Brattin B, Taylor RJ, Phillips TD. 2009. In vitro evaluation of ferrihydrite as an enterosorbent for arsenic from contaminated drinking water. Environ Sci Technol 43(14):5501-6. doi:10.1021/es803624b PMID:19708388 PMCID:PMC2735052

2008

  • Phillips TD, Afriyie-Gyawu E, Williams J, Huebner HJ, Ankrah N, Ofori-Adjei D, Jolly PE, Johnson N, Taylor JF, Marroquin-Cardona A, Xu L, Tang LS, Wang J. 2008. Reducing human exposure to aflatoxin through the use of clay: a review. Food Addit Contam Part A Chem Anal Control Expo Risk Assess 25(2):134-145. doi:10.1080/02652030701567467 PMID:18286403

2007

  • Dash B, Afriyie-Gyawu E, Huebner HJ, Porter WW, Wang J, Jolly PE, Phillips TD. 2007. Determinants of the variability of aflatoxin-albumin adduct levels in Ghanaians. J Toxicol Environ Health A 70(1):58-66. doi:10.1080/15287390600748880 PMID:17162498
  • Dash B, Metz RP, Huebner HJ, Porter WW, Phillips TD. 2007. Molecular characterization of two superoxide dismutases from Hydra vulgaris. Gene 387(1-2):93-108. PMID:17150313

2006

  • Dash B, Afriyie-Gyawu E, Huebner HJ, Porter WW, Wang J, Jolly PE, Phillips TD. 2006. Noninvasive identification of interindividual variation in xenobiotic-metabolizing enzymes: implications for cancer epidemiology and biomarker studies. J Toxicol Environ Health A 69(13):1203-1216. PMID:16754536
  • Jolly PE, Jiang Y, Ellis W, Awuah R, Nnedu O, Phillips TD, Wang J, Afriyie-Gyawu E, Tang L, Person S, Williams J, Jolly CM. 2006. Determinants of aflatoxin levels in Ghanaians: Sociodemographic factors, knowledge of aflatoxin and food handling and consumption practices. Int J Hyg Environ Health 209(4):345-358. PMID:16644281

2005

  • Afriyie-Gyawu E, Mackie J, Dash B, Wiles MC, Taylor JF, Huebner HJ, Tang L, Guan H, Wang J, Phillips TD. 2005. Chronic toxicological evaluation of dietary NovaSil clay in Sprague-Dawley rats. Food Addit Contam Part A Chem Anal Control Expo Risk Assess 22(3):259-169. PMID:16019794
  • Afriyie-Gyawu E, Wiles MC, Richardson MB, Fickey C, Phillips TD. 2005. Prevention of zearalenone-induced hyperestrogenism in prepubertal mice. J Toxicol Environ Health A 68(5):353-368. PMID:15799627
  • Ottinger SE, Barhoumi R, McKenzie KS, McDonald TJ, Burghardt RC, Huebner HJ, Phillips TD. 2005. FIA/MS analysis of temporally ozonated benzo[a]pyrene and pyrene and their reaction products: inhibition of gap junction-mediated intercellular communication. Chemosphere 60(8):1025-1033. doi:10.1016/j.chemosphere.2005.01.025 PMID:15993149
  • Wang J, Luo H, Billam M, Wang Z, Guan H, Tang L, Goldston T, Afriyie-Gyawu E, Lovett C, Griswold J, Brattin B, Taylor RJ, Huebner HJ, Phillips TD. 2005. Short-term safety evaluation of processed calcium montmorillonite clay (NovaSil) in humans. Food Addit Contam Part A Chem Anal Control Expo Risk Assess 22(3):270-279. PMID:16019795
  • Wiles MC, Huebner HJ, McDonald TJ, Donnelly KC, Phillips TD. 2005. Matrix-immobilized organoclay for the sorption of polycyclic aromatic hydrocarbons and pentachlorophenol from groundwater. Chemosphere 59(10):1455-1464. PMID:15876388

2004

  • Herrera P, Burghardt RC, Huebner HJ, Phillips TD. 2004. The efficacy of sand-immobilized organoclays as filtration bed materials for bacteria. Food Microbiol 21(1):1-10.
  • Pimpukdee K, Kubena LF, Bailey CA, Huebner HJ, Afriyie-Gyawu E, Phillips TD. 2004. Aflatoxin-induced toxicity and depletion of hepatic vitamin A in young broiler chicks: protection of chicks in the presence of low levels of NovaSil PLUS in the diet. Poultry Science 83(5):737-744. PMID:15141830
  • Wiles MC, Huebner HJ, Afriyie-Gyawu E, Taylor RJ, Bratton GR, Phillips TD. 2004. Toxicological evaluation and metal bioavailability in pregnant rats following exposure to clay minerals in the diet. J Toxicol Environ Health A 67(11):863-874. doi:10.1080/15287390490425777 PMID:15205041

2003

  • Ake CL, Wiles MC, Huebner HJ, McDonald TJ, Cosgriff D, Richardson MB, Donnelly KC, Phillips TD. 2003. Porous organoclay composite for the sorption of polycyclic aromatic hydrocarbons and pentachlorophenol from groundwater. Chemosphere 51(9):835-844. doi:10.1016/S0045-6535(03)00040-7 PMID:12697173
  • Bingham AK, Phillips TD, Bauer JE. 2003. Potential for dietary protection against the effects of aflatoxins in animals. J Am Vet Med Assoc 222(5):591-596. doi:10.2460/javma.2003.222.591 PMID:12619837
  • Huebner HJ, Phillips TD. 2003. Clay-based affinity probes for selective cleanup and determination of aflatoxin B1 using nanostructured montmorillonite on quartz. J AOAC Int 86(3):534-539. PMID:12852572
  • Lum KT, Huebner HJ, Li Y, Phillips TD, Raushel FM. 2003. Organophosphate nerve agent toxicity in Hydra attenuata. Chem Res Toxicol 16(8):953-957. PMID:12924922
  • Meek IB, Peplow AW, Ake CL, Phillips TD, Beremand MN. 2003. Tri1 encodes the cytochrome P450 monooxygenase for C-8 hydroxylation during trichothecene biosynthesis in Fusarium sporotrichioides and resides upstream of another new Tri gene. Appl Environ Microbiol 69(3):1607-1613. PMID:12620849
  • Peplow AW, Meek IB, Wiles MC, Phillips TD, Beremand MN. 2003. Tri16 is required for esterification of position C-8 during trichothecene mycotoxin production by Fusarium sporotrichioides. Appl Environ Microbiol 69(10):5935-5940. PMID:14532047
  • Phillips TD, Lemke SL, Grant PG. 2003. Characterization of clay-based enterosorbents for the prevention of aflatoxicosis. In: Advances in Experimental Medicine and Biology. Kluwer Academic/Plenum Publishers, NY. pp.157-173.

2001

  • Ake CL, Mayura K, Huebner HJ, Bratton GR, Phillips TD. 2001. Development of porous clay-based composites for the sorption of lead from water. J Toxicol Environ Health A 63(6):459-475. PMID:11482800
  • Lemke SL, Mayura K, Reeves WR, Wang N, Fickey C, Phillips TD. 2001. Investigation of organophilic montmorillonite clay inclusion in zearalenone-contaminated diets using the mouse uterine weight bioassay. J Toxicol Environ Health A 62(4):243-258. doi:10.1080/009841001459405 PMID:11245394
  • Lemke SL, Ottinger SE, Ake CL, Mayura K, Phillips TD. 2001. Deamination of fumonisin B1 and biological assessment of reaction product toxicity. Chem Res Toxicol 14(1):11-15. PMID:11170503
  • Lemke SL, Ottinger SE, Mayura K, Ake CL, Pimpukdee K, Wang N, Phillips TD. 2001. Development of a multi-tiered approach to the in vitro prescreening of clay-based enterosorbents. Animal Feed Science and Technology 93(1-2):17-29. doi:10.1016/S0377-8401(01)00272-3
  • Reeves WR, Barhoumi R, Burghardt RC, Lemke SL, Mayura K, McDonald TJ, Phillips TD, Donnelly KC. 2001. Evaluation of methods for predicting the toxicity of polycyclic aromatic hydrocarbon mixtures. Environ Sci Technol 35(8):1630-1636. doi:10.1021/es001689a PMID:11329713

2000

  • Barhoumi R, Mouneimne Y, Ramos KS, Safe SH, Phillips TD, Centonze VE, Ainley C, Gupta MS, Burghardt RC. 2000. Analysis of Benzo[a]pyrene partitioning and cellular homeostasis in a rat liver cell line. Toxicol Sci 53:264-270. PMID:10696774
  • Herrera P, Burghardt RC, Phillips TD. 2000. Adsorption of Salmonella enteritidis by cetyl pyridinium exchanged montmorillonite clays. Vet Microbiol 74:259-272. PMID:10808094
  • Huebner HJ, Mayura K, Pallaroni L, Ake CL, Lemke SL, Phillips TD. 2000. Development and characterization of a carbon-based composite for reducing patulin levels in apple juice. J Food Prot 63(1):106-110. PMID:10643778
  • Tag A, Hicks J, Garifullina G, Ake CL, Phillips TD, Beremand MN, Keller NP. 2000. G-protein signaling mediates differential production of toxic secondary metabolites. EMBO J 38(3):658-665. PMID:11069688

1999

  • Huebner HJ, Lemke SL, Mayura K, Phillips TD, Ottinger SE. 1999. Molecular characterization of high affinity, high capacity clays for the equilibrium sorption of ergotamine. Food Addit Contam Part A Chem Anal Control Expo Risk Assess 16(4):159-171. doi:10.1080/026520399284118 PMID:10560569
  • Lemke SL, Mayura K, Ottinger SE, McKenzie KS, Wang N, Fickey C, Kubena LF, Phillips TD. 1999. Assessment of the estrogenic effects of zearalenone after treatment with ozone utilizing the mouse uterine weight bioassay. J Toxicol Environ Health A 56(4):283-295. doi:10.1080/009841099158114 PMID:10706245
  • Mayura K, Huebner HJ, Dwyer MR, McKenzie KS, Donnelly KC, Kubena LF, Phillips TD. 1999. Multi-bioassay approach for assessing the potency of complex mixtures of polycyclic aromatic hydrocarbons. Chemosphere 38(8):1721-1732. PMID:10101844
  • Ottinger SE, Mayura K, Lemke SL, McKenzie KS, Wang N, Kubena LF, Phillips TD. 1999. Utilization of electrochemically generated ozone in the degradation and detoxification of benzo[a]pyrene. J Toxicol Environ Health A 56(8):565-583. doi:10.1080/009841099157511 PMID:10515574
  • Phillips TD. 1999. Dietary clay in the chemoprevention of aflatoxin-induced disease. Toxicol Sci 52:118-126. PMID:10630600
  • Springman KR, Mayura K, McDonald TJ, Donnelly KC, Kubena LF, Phillips TD. 1999. Organoclay adsorption of wood-preserving waste from groundwater. Environ Toxicol Chem 71(1-2):247-259.

1998

  • Clark KJ, Grant PG, Sarr AB, Belakere JR, Swaggerty CL, Phillips TD, Woode GN. 1998. An in vitro study of theaflavins extracted from black tea to neutralize bovine rotavirus and bovine coronavirus infections. Vet Microbiol 63(2-4):147-157. doi:10.1016/S0378-1135(98)00242-9 PMID:9850995
  • Clark KJ, Sarr AB, Grant PG, Phillips TD, Woode GN. 1998. In vitro studies on the use of clay, clay minerals and charcoal to adsorb bovine rotavirus and bovine coronavirus. Vet Microbiol 63:137-146. PMID:9850994
  • Grant PG, Lemke SL, Dwyer MR, Phillips TD. 1998. Modified Langmuir equation for S-shaped and multi-site isotherm plots. Langmuir 14:4292-4299.
  • Grant PG, Phillips TD. 1998. Isothermal adsorption of aflatoxin B1 on HSCAS clay. J Agric Food Chem 46:599-605. PMID:10554284
  • Lemke SL, Grant PG, Phillips TD. 1998. Adsorption of zearalenone by organophilic montmorillonite clay. J Agric Food Chem 46:3789-3796.
  • Lopez Y, Keller NP, Sarr AB, Phillips TD, Cuero RG, Smith OD. 1998. Visual estimation of aflatoxin production in peanut with Aspergillus norsolorinic acid mutants. Peanut Science 25:92-99.
  • Mayura K, Abdel-Wahhab MA, McKenzie KS, Sarr AB, Edwards JF, Naguib K, Phillips TD. 1998. Prevention of maternal and developmental toxicity in rats via dietary inclusion of common aflatoxin sorbents: Potential for hidden risks. Toxicol Sci 41:175-182. PMID:9520353
  • McKenzie KS, Kubena LF, Denvir AJ, Rogers TD, Hitchens GD, Bailey RH, Harvey RB, Buckley SG, Phillips TD. 1998. Aflatoxicosis in turkey poults is prevented by treatment of naturally-contaminated corn with ozone generated by electrolysis. Poultry Science 77:1094-1102. PMID:9706072

1997

  • Donnelly KC, Phillips TD, Onufrock AM, Collie SL, Huebner HJ. 1997. Genotoxicity model and complex mixtures of polycyclic aromatic hydrocarbons. In: Environmental Toxicology and Risk Assessment: Biomarkers and Risk Assessment. ASTM Special Tech. Publ. 1071-720X, Vol. 1306, Am. Soc. for Testing and Materials, Philadelphia, PA. pp.138-148.
  • Dwyer MR, Kubena LF, Harvey RB, Mayura K, Sarr AB, Buckley SG, Bailey RH, Phillips TD. 1997. Effects of inorganic adsorbents and cyclopiazonic acid in broiler chickens. Poultry Science 76:1141-1149. PMID:9251144
  • McKenzie KS, Sarr AB, Mayura K, Bailey RH, Miller DR, Rogers TD, Norred WP, Voss KA, Plattner RD, Kubena LF, Phillips TD. 1997. Oxidative degradation and detoxification of mycotoxins using a novel source of ozone. Food Chem Toxicol 35(8):807-820. doi:10.1016/S0278-6915(97)00052-5 PMID:9350226
  • Zhao F, Mayura K, Kocurek N, Edwards JF, Kubena LF, Safe SH, Phillips TD. 1997. Inhibition of 3,3',4,4',5-pentachlorobiphenyl-induced chicken embryotoxicity by 2,2',4,4',5,5'-hexachlorobiphenyl. Fundam Appl Toxicol 35:1-8. PMID:9024668
  • Zhao F, Mayura K, Safe SH, Phillips TD, Harper N. 1997. Inhibition of 3,3',4,4',5-Pentachlorobiphenyl induced fetal cleft palate and immunotoxicity in C57BL/6 mice by 2,2',4,4',5,5'-Hexacholorobiphenyl. Chemosphere 34(5-7):1605-1613. doi:10.1016/S0045-6535(97)00456-6 PMID:9134691

1996

  • Barhoumi R, Mouneimne Y, Phillips TD, Safe SH, Burghardt RC. 1996. Alteration of oxytocin-induced calcium oscillations in Clone 9 cells by toxin-exposure. Fundam Appl Toxicol 33:220-228. PMID:8921340
  • Washburn KS, Huebner HJ, Safe SH, Phillips TD, Donnelly KC. 1996. Development of an Instrumental Fractionation and Quantitation Scheme for Selected Polynuclear Aromatic Hydrocarbons Present in extracts from Wood-Preserving Waste. In: Proceedings of the Hazardous Substance Research Center (HSRC) / Waste-Management Education & Research Consortium Joint Conference on the Environment. pp.400-407.

1995

  • Safe SH, Washburn KS, Zacharewski TR, Phillips TD. 1995. Synthesis and characterization of hydroxylated polychlorinated biphenyls (PCBs) identified in human serum. Chemosphere 31(4):3017-3023. doi:10.1016/0045-6535(95)00162-2 PMID:7552046
  • Washburn KS, Phillips TD. 1995. Development of a field-practical assay for water-solvated chlorophenols. J Hazard Mater 41:371-381.
  • Zhao F, Mayura K, Hutchinson RW, Lewis RP, Burghardt RC, Phillips TD. 1995. Developmental toxicity and structure-activity relationships of chlorophenols using human embryonic palatal mesenchymal cells. Toxicol Lett 78(1):35-42. doi:10.1016/0378-4274(95)99684-A PMID:7604397
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