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Your Environment. Your Health.

Person Details: Martyn T. Smith

Superfund Research Program

Martyn T. Smith

University of California-Berkeley
School of Public Health
Environmental Health Sciences Division
50 University Hall #7360
Berkeley, California 94720-7360
Phone: 510-642-8770
Fax: 510-642-0427
Email: martynts@berkeley.edu

Projects

Research Briefs

Publications

2019

  • Arzuaga X, Smith MT, Gibbons CF, Skakkelmek NE, Yost EE, Beverly BE, Hotchkiss AK, Hauser R, Pagani RL, Schrader SM, Zeise L, Prins GS. 2019. Proposed key characteristics of male reproductive toxicants as an approach for organizing and evaluating mechanistic evidence in human health hazard assessments. Environ Health Perspect 127(6):65001. doi:10.1289/ehp5045 PMID:31199676
  • Eick SM, Ferreccio Readi C, Acevedo J, Castriota F, Cordero JF, Roh T, Smith AH, Smith MT, Steinmaus CM. 2019. Socioeconomic status and the association between arsenic exposure and type 2 diabetes. Environ Res 172:578-585. doi:10.1016/j.envres.2019.03.013 PMID:30875511
  • Lee KM, Bassig BA, Zhang L, Vermeulen R, Hu W, Wong JJ, Wen C, Huang Y, Purdue MP, Ji B, Li L, Tang X, Rothman N, Smith MT, Lan Q. 2019. Association between occupational exposure to trichloroethylene and serum levels of microRNAs: a cross-sectional molecular epidemiology study in China. Int Arch Occup Environ Health doi:10.1007/s00420-019-01448-x PMID:31161417
  • Lee KM, Zhang L, Vermeulen R, Hu W, Bassig BA, Wong JJ, Qiu C, Purdue MP, Wen C, Walker DI, Jones DP, Li L, Huang Y, Rothman N, Smith MT, Lan Q. 2019. Alterations in immune and renal biomarkers among workers occupationally exposed to low levels of trichloroethylene below current regulatory standards. Occup Environ Med 76(6):376-381. doi:10.1136/oemed-2018-105583 PMID:30971425
  • Luderer U, Eskenazi B, Hauser R, Korach KS, McHale CM, Moran-Messen FM, Rieswijk L, Solomon G, Udagawa O, Zhang L, Zlatnik M, Zeise L, Smith MT. 2019. Proposed key characteristics of female reproductive toxicants as an approach for organizing and evaluating mechanistic data in hazard assessment. Environ Health Perspect 127(7):75001. doi:10.1289/ehp4971 PMID:31322437
  • Phillips RV, Rieswijk L, Hubbard AE, Vermeulen R, Zhang J, Hu W, Li L, Bassig BA, Wong JJ, Reiss B, Huang Y, Wen C, Purdue MP, Tang X, Smith MT, Rothman N, Lan Q. 2019. Human exposure to trichloroethylene is associated with increased variability of blood DNA methylation that is enriched in genes and pathways related to autoimmune disease and cancer. Epigenetics doi:10.1080/15592294.2019.1633866 PMID:31241004

2018

  • Castriota F, Acevedo J, Ferreccio Readi C, Smith AH, Liaw J, Smith MT, Steinmaus CM. 2018. Obesity and increased susceptibility to arsenic-related type 2 diabetes in Northern Chile. Environ Res 167:248-254. doi:10.1016/j.envres.2018.07.022 PMID:30059859 PMCID:PMC6277209
  • Daniels SI, Chambers JC, Sanchez SS, La Merrill MA, Hubbard AE, Macherone A, McMullin M, Zhang L, Elliott P, Smith MT, Kooner JS. 2018. Elevated levels of organochlorine pesticides in South Asian immigrants are associated with an increased risk of diabetes. J Endocr Soc 2(8):832-841. doi:10.1210/js.2017-00480 PMID:30019022 PMCID:PMC6041775
  • Grigoryan H, Edmands WM, Lan Q, Carlsson H, Vermeulen R, Zhang L, Yin S, Li G, Smith MT, Rothman N, Rappaport SM. 2018. Adductomic signatures of benzene exposure provide insights into cancer induction. Carcinogenesis 39:661-668. doi:10.1093/carcin/bgy042 PMID:29538615 PMCID:PMC5932554
  • Guyton KZ, Rieswijk L, Wang A, Chiu WA, Smith MT. 2018. Key characteristics approach to carcinogenic hazard identification. Chem Res Toxicol 31(12):1290-1292. doi:10.1021/acs.chemrestox.8b00321 PMID:30521319
  • Guyton KZ, Rusyn I, Chiu WA, Corpet DE, van den Berg M, Ross MK, Christiani DC, Beland FA, Smith MT. 2018. Application of the key characteristics of carcinogens in cancer hazard identification. Carcinogenesis 39(4):614-622. doi:10.1093/carcin/bgy031 PMID:29562322 PMCID:PMC5888955
  • Guyton KZ, Rusyn I, Chiu WA, Corpet DE, van den Berg M, Ross MK, Christiani DC, Beland FA, Smith MT. 2018. Re: Application of the key characteristics of carcinogens in cancer hazard evaluation : response to Goodman, Lynch and Rhomberg. Carcinogenesis 39(8):1091-1093. doi:10.1093/carcin/bgy082 PMID:29982359 PMCID:PMC6067125
  • McHale CM, Osborne G, Morello-Frosch R, Salmon AG, Sandy MS, Solomon G, Zhang L, Smith MT, Zeise L. 2018. Assessing health risks from multiple environmental stressors: moving from G x E to I x E. Mutat Res Rev Mutat Res 775:11-20. doi:10.1016/j.mrrev.2017.11.003 PMID:29555026 PMCID:PMC5863617
  • Rothman N, Zhang L, Smith MT, Vermeulen R, Lan Q. 2018. Formaldehyde, hematotoxicity, and chromosomal changes-response. Cancer Epidemiol Biomarkers Prev 27:120-121. doi:10.1158/1055-9965.epi-17-0804 PMID:29311167
  • Schiffman C, McHale CM, Hubbard AE, Zhang L, Thomas R, Vermeulen R, Li G, Shen M, Rappaport SM, Yin S, Lan Q, Smith MT, Rothman N. 2018. Identification of gene expression predictors of occupational benzene exposure. PLoS One 13(10):e0205427. doi:10.1371/journal.pone.0205427 PMID:30300410
  • Tachachartvanich P, Sangsuwan R, Ruiz HS, Sanchez SS, Durkin KA, Zhang L, Smith MT. 2018. Assessment of the endocrine-disrupting effects of trichloroethylene and its metabolites using in vitro and in silico approaches. Environ Sci Technol 52(3):1542-1550. doi:10.1021/acs.est.7b04832 PMID:29294279 PMCID:PMC6290898

2017

  • de la Rosa R, Steinmaus CM, Akers NK, Conde L, Ferreccio Readi C, Kalman DA, Zhang KR, Skibola CF, Smith AH, Zhang L, Smith MT. 2017. Associations between arsenic (+3 oxidation state) methyltransferase (AS3MT) and N-6 adenine-specific DNA methyltransferase 1 (N6AMT1) polymorphisms, arsenic metabolism, and cancer risk in a Chilean population. Environ Mol Mutagen 58(6):411-422. doi:10.1002/em.22104 PMID:28640505 PMCID:PMC5515250
  • De La Rosa VY, Asfaha J, Fasullo M, Loguinov AV, Li P, Moore LE, Rothman N, Nakamura J, Swenberg JA, Scelo G, Zhang L, Smith MT, Vulpe CD. 2017. Editor's highlight: High-throughput functional genomics identifies modulators of TCE metabolite genotoxicity and candidate susceptibility genes. Toxicol Sci 160:111-120. doi:10.1093/toxsci/kfx159 PMID:28973557 PMCID:PMC5837773
  • Rothman N, Lan Q, Smith MT, Vermeulen R, Zhang L. 2017. Response to letter to the editor of Carcinogenesis by Pira et al., 2017. Carcinogenesis 38:1253-1255. doi:10.1093/carcin/bgx111 PMID:29040449
  • Steinmaus CM, Smith MT. 2017. Steinmaus and Smith respond to Proximity to gasoline stations and childhood leukemia. Am J Epidemiol 185(1):5-7. doi:10.1093/aje/kww133 PMID:27923799 PMCID:PMC6267941

2016

  • Bassig BA, Zhang L, Vermeulen R, Tang X, Li G, Hu W, Guo W, Purdue MP, Yin S, Rappaport SM, Shen M, Ji Z, Qiu C, Ge Y, Hosgood H, Reiss B, Wu B, Xie Y, Li L, Yue F, Freeman LB, Blair AE, Hayes RB, Huang H, Smith MT, Rothman N, Lan Q. 2016. Comparison of hematological alterations and markers of B-cell activation in workers exposed to benzene, formaldehyde and trichloroethylene. Carcinogenesis 37(7):692-700. doi:10.1093/carcin/bgw053 PMID:27207665 PMCID:PMC4936387
  • Carlos-Wallace FM, Zhang L, Smith MT, Rader G, Steinmaus CM. 2016. Parental, in utero, and early-life exposure to benzene and the risk of childhood leukemia: a meta-analysis. Am J Epidemiol 183(1):1-14. doi:10.1093/aje/kwv120 PMID:26589707 PMCID:PMC4751231
  • Cote I, Andersen ME, Ankley GT, Barone S, Birnbaum LS, Boekelheide K, Bois FY, Burgoon LD, Chiu WA, Crawford-Brown D, Crofton K, DeVito MJ, Devlin RB, Edwards SW, Guyton KZ, Hattis D, Judson RS, Knight D, Krewski D, Lambert J, Maull EA, Mendrick D, Paoli GM, Patel CJ, Perkins EJ, Poje G, Portier CJ, Rusyn I, Schulte PA, Simeonov A, Smith MT, Thayer KA, Thomas RS, Thomas R, Tice RR, Vandenberg JJ, Villeneuve DL, Wesselkamper SC, Whelan M, Whittaker C, White R, Xia M, Yauk C, Zeise L, Zhao J, DeWoskin RS. 2016. The next generation of risk assessment multi-year study-highlights of findings, applications to risk assessment, and future directions. Environ Health Perspect 124(11):1671-1682. doi:10.1289/ehp233 PMID:27091369 PMCID:PMC5089888
  • Portier CJ, Armstrong BK, Baguley B, Baur X, Belyaev I, Belle R, Belpoggi F, Biggeri A, Bosland MC, Bruzzi P, Budnik L, Bugge M, Burns K, Calaf GM, Carpenter DO, Carpenter H, Lopez-Carillo L, Clapp R, Cocco P, Consonni D, Comba P, Craft ES, Dalvie M, Davis D, Demers PA, De Roos AJ, DeWitt JT, Forastiere F, Freedman JH, Fritschi L, Gaus C, Gohlke J, Goldberg M, Greiser E, Hansen J, Hardell L, Hauptmann M, Huang W, Huff J, James MO, Jameson C, Kortenkamp A, Kopp-Schneider A, Kromhout H, Larramendy M, Landrigan PJ, Lash LH, Leszczynski D, Lynch CF, Magnani C, Mandrioli D, Martin FL, Merler E, Michelozzi P, Miligi L, Miller A, Mirabelli D, Mirer F, Naidoo S, Perry MJ, Petronio M, Pirastu R, Portier R, Ramos KS, Robertson LW, Rodriguez T, Roosli M, Ross M, Roy D, Rusyn I, Saldiva P, Sass J, Savolainen K, Scheepers P, Sergi C, Silbergeld EK, Smith MT, Stewart BW, Sutton P, Tateo F, Terracini B, Thielmann H, Thomas DB, Vainio H, Vena J, Vineis P, Weiderpass E, Weisenburger DD, Woodruff TJ, Yorifuji T, Yu I, Zambon P, Zeeb H, Zhou SF. 2016. Differences in the carcinogenic evaluation of glyphosate between the International Agency for Research on Cancer (IARC) and the European Food Safety Authority (EFSA). J Epidemiol Community Health 70(8):741-745. doi:10.1136/jech-2015-207005 PMID:26941213 PMCID:PMC4975799
  • Shen H, McHale CM, Haider SI, Jung C, Zhang S, Smith MT, Zhang L. 2016. Identification of genes that modulate susceptibility to formaldehyde and imatinib by functional genomic screening in human haploid KBM7 cells. Toxicol Sci 151(1):10-22. doi:10.1093/toxsci/kfw032 PMID:27008852 PMCID:PMC4914802
  • Smith MT, Guyton KZ, Gibbons CF, Fritz JM, Portier CJ, Rusyn I, DeMarini DM, Caldwell JC, Kavlock RJ, Lambert PF, Hecht SS, Bucher JR, Stewart BW, Baan R, Cogliano VJ, Straif K. 2016. Key characteristics of carcinogens as a basis for organizing data on mechanisms of carcinogenesis. Environ Health Perspect 124(6):713-721. doi:10.1289/ehp.1509912 PMID:26600562 PMCID:PMC4892922
  • Walker D, Uppal K, Zhang L, Vermeulen R, Smith MT, Hu W, Purdue MP, Tang X, Reiss B, Kim S, Li L, Huang H, Pennell KD, Jones DP, Rothman N, Lan Q. 2016. High-resolution metabolomics of occupational exposure to trichloroethylene. Int J Epidemiol 45(5):1517-1527. doi:10.1093/ije/dyw218 PMID:27707868 PMCID:PMC5100622

2015

  • Ji Z, McHale CM, Bersonda J, Tung J, Smith MT, Zhang L. 2015. Induction of centrosome amplification by formaldehyde, but not hydroquinone, in human lymphoblastoid TK6 cells. Environ Mol Mutagen 56(6):535-544. doi:10.1002/em.21947 PMID:25821186
  • Lan Q, Smith MT, Tang X, Guo W, Vermeulen R, Ji Z, Hu W, Hubbard AE, Shen M, McHale CM, Qiu C, Liu S, Reiss B, Beane-Freeman L, Blair AE, Ge Y, Xiong J, Li L, Rappaport SM, Huang H, Rothman N, Zhang L. 2015. Chromosome-wide aneuploidy study of cultured circulating myeloid progenitor cells from workers occupationally exposed to formaldehyde. Carcinogenesis 36(1):160-167. doi:10.1093/carcin/bgu229 PMID:25391402 PMCID:PMC4291049
  • Landrigan PJ, Wright RO, Cordero JF, Eaton DL, Goldstein BD, Hennig B, Maier RM, Ozonoff DM, Smith MT, Tukey RH. 2015. The NIEHS Superfund Research Program: 25 Years of Translational Research for Public Health. Environ Health Perspect 123(10):909-918. doi:10.1289/ehp.1409247 PMID:25978799 PMCID:PMC4590764
  • Pearce N, Blair AE, Vineis P, Ahrens W, Andersen A, Anto JM, Armstrong BK, Baccarelli A, Beland FA, Berrington A, Bertazzi PA, Birnbaum LS, Brownson RC, Bucher JR, Cantor KP, Cardis E, Cherrie JW, Christiani DC, Cocco P, Coggon D, Comba P, Demers PA, Dement JM, Douwes J, Eisen EA, Engel LS, Fenske RA, Fleming LE, Fletcher T, Fontham E, Forastiere F, Frentzel-Beyme R, Fritschi L, Gerin M, Goldberg M, Grandjean P, Grimsrud TK, Gustavsson P, Haines A, Hartge P, Hansen J, Hauptmann M, Heederik D, Hemminki K, Hemon D, Hertz-Picciotto I, Hoppin JA, Huff J, Jarvholm B, Kang D, Karagas MR, Kjaerheim K, Kjuus H, Kogevinas M, Kriebel D, Kristensen P, Kromhout H, Laden F, Lebailly P, LeMasters G, Lubin JH, Lynch CF, Lynge E, Mannetje A, McMichael AJ, McLaughlin J, Marrett L, Martuzzi M, Merchant JA, Merler E, Merletti F, Miller A, Mirer F, Monson RR, Nordby K, Olshan A, Parent M, Perera F, Perry MJ, Pesatori AC, Pirastu R, Porta M, Pukkala E, Rice C, Richardson DB, Ritter L, Ritz B, Ronckers CM, Rushton L, Rusiecki JA, Rusyn I, Samet JM, Sandler DP, de Sanjose S, Schernhammer E, Costantini A, Seixas N, Shy C, Siemiatycki J, Silverman DT, Simonato L, Smith AH, Smith MT, Spinelli JJ, Spitz MR, Stallones L, Stayner LT, Steenland K, Stenzel M, Stewart BW, Stewart P, Symanski E, Terracini B, Tolbert PE, Vainio H, Vena J, Vermeulen R, Victora CG, Ward EM, Weinberg CR, Weisenburger DD, Wesseling C, Weiderpass E, Zahm SH. 2015. IARC monographs: 40 years of evaluating carcinogenic hazards to humans. Environ Health Perspect 123(6):507-514. doi:10.1289/ehp.1409149 PMID:25712798 PMCID:PMC4455595
  • Shen H, McHale CM, Smith MT, Zhang L. 2015. Functional genomic screening approaches in mechanistic toxicology and potential future applications of CRISPR-Cas9. Mutat Res Rev Mutat Res 764:31-42. doi:10.1016/j.mrrev.2015.01.002 PMID:26041264 PMCID:PMC4456615
  • Steinmaus CM, Castriota F, Ferreccio Readi C, Smith AH, Yuan Y, Liaw J, Acevedo J, Perez L, Meza R, Calcagno S, Uauy R, Smith MT. 2015. Obesity and excess weight in early adulthood and high risks of arsenic-related cancer in later life. Environ Res 142:594-601. doi:10.1016/j.envres.2015.07.021 PMID:26301739 PMCID:PMC4664040
  • Vijai J, Wang Z, Berndt SI, Skibola CF, Slager SL, de Sanjose S, Melbye M, Glimelius B, Bracci PM, Birmann BM, Wang SS, Brooks-Wilson AR, Lan Q, de Bakker PI, Vermeulen R, Portlock CJ, Ansell SA, Link BK, Riby J, North KE, Gu J, Hjalgrim H, Cozen W, Becker N, Teras LR, Spinelli JJ, Turner J, Zhang Y, Purdue MP, Giles GG, Kelly RS, Zeleniuch-Jacquotte A, Ennas M, Monnereau A, Bertrand KA, Albanes D, Lightfoot TJ, Chung CC, Burdett L, Hutchinson A, Lawrence C, Montalvan R, Liang L, Huang J, Ma B, Villano DJ, Maria A, Corines M, Thomas T, Novak AJ, Dogan A, Liebow M, Thompson CA, Witzig TE, Habermann TM, Weiner GJ, Smith MT, Holly EA, Jackson RD, Tinker LF, Ye Y, Adami H, Smedby KE, De Roos AJ, Hartge P, Morton LM, Severson RK, Benavente Y, Boffetta P, Brennan P, Foretova L, Maynadie M, McKay J, Staines A, Diver WR, Vajdic CM, Armstrong BK, Kricker A, Zheng T, Holford TR, Severi G, Vineis P, Ferri GM, Ricco R, Clavel J, Giovannucci E, Kraft P, Virtamo J, Smith A, Kane E, Roman E, Chiu BC, Fraumeni JF, Wu X. 2015. A genome-wide association study of marginal zone lymphoma shows association to the HLA region. Nat Commun 6:5751. doi:10.1038/ncomms6751 PMID:25569183 PMCID:PMC4287989
  • Wild CP, Bucher JR, de Jong BW, Dillner J, von Gertten C, Groopman JD, Herceg Z, Holmes E, Holmila R, Olsen JH, Ringborg U, Scalbert A, Shibata T, Smith MT, Ulrich CM, Vineis P, McLaughlin J. 2015. Translational cancer research: balancing prevention and treatment to combat cancer globally. J Natl Cancer Inst 107(1):353. doi:10.1093/jnci/dju353 PMID:25515230 PMCID:PMC4334834
  • Zhang L, Samad A, Pombo-de-Oliveira MS, Scelo G, Smith MT, Feusner J, Wiemels JL, Metayer C. 2015. Global characteristics of childhood acute promyelocytic leukemia. Blood Rev 29(2):101-125. doi:10.1016/j.blre.2014.09.013 PMID:25445717 PMCID:PMC4379131

2014

  • Bassig BA, Zhang L, Cawthon RM, Smith MT, Yin S, Li G, Hu W, Shen M, Rappaport SM, Barone-Adesi F, Rothman N, Vermeulen R, Lan Q. 2014. Alterations in leukocyte telomere length in workers occupationally exposed to benzene. Environ Mol Mutagen 55(8):673-678. doi:10.1002/em.21880 PMID:24945723 PMCID:PMC4360990
  • Cerhan JR, Berndt SI, Vijai J, Ghesquieres H, McKay J, Wang SS, Wang Z, Yeager M, Conde L, de Bakker PI, Nieters A, Cox DP, Burdett L, Monnereau A, Flowers CR, De Roos AJ, Brooks-Wilson AR, Lan Q, Severi G, Melbye M, Gu J, Jackson RD, Kane E, Teras LR, Purdue MP, Vajdic CM, Spinelli JJ, Giles GG, Albanes D, Kelly RS, Zucca M, Bertrand KA, Zeleniuch-Jacquotte A, Lawrence C, Hutchinson A, Zhi D, Habermann TM, Link BK, Novak AJ, Dogan A, Asmann YW, Liebow M, Thompson CA, Ansell SA, Witzig TE, Weiner GJ, Veron AS, Zelenika D, Tilly H, Haioun C, Molina TJ, Hjalgrim H, Glimelius B, Adami H, Bracci PM, Riby J, Smith MT, Holly EA, Cozen W, Hartge P, Morton LM, Severson RK, Tinker LF, North KE, Becker N, Benavente Y, Boffetta P, Brennan P, Foretova L, Maynadie M, Staines A, Lightfoot TJ, Crouch S, Smith A, Roman E, Diver WR, Offit K, Zelenetz A, Klein RJ, Villano DJ, Zheng T, Zhang Y, Holford TR, Turner J, Southey M, Clavel J, Virtamo J, Weinstein SJ, Riboli E, Vineis P, Trichopoulos D, Vermeulen R, Boeing H, Tjonneland A, Angelucci E, Di Lollo S, Rais M, Birmann BM, Laden F, Giovannucci E, Kraft P, Huang J, Ma B, Ye Y, Chiu BC, Sampson J, Liang L, Park J, Chung CC, Weisenburger DD, Chatterjee N, Fraumeni JF, Slager SL, Wu X, de Sanjose S, Smedby KE, Salles G, Skibola CF, Rothman N, Chanock SJ. 2014. Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma. Nat Genet 46(11):1233-1238. doi:10.1038/ng.3105 PMID:25261932 PMCID:PMC4213349
  • Daniels SI, Sille FC, Goldbaum A, Yee B, Key EF, Zhang L, Smith MT, Thomas R. 2014. Improving power to detect changes in blood miRNA expression by accounting for sources of variability in experimental designs. Cancer Epidemiol Biomarkers Prev 23(12):2658-2666. doi:10.1158/1055-9965.EPI-14-0623 PMID:25472674 PMCID:PMC4256675
  • McHale CM, Smith MT, Zhang L. 2014. Application of toxicogenomic profiling to evaluate effects of benzene and formaldehyde: From yeast to human. Ann N Y Acad Sci 1310:74-83. doi:10.1111/nyas.12382 PMID:24571325 PMCID:PMC3978411
  • North M, Shuga J, Fromowitz M, Loguinov AV, Shannon K, Zhang L, Smith MT, Vulpe CD. 2014. Modulation of Ras signaling alters the toxicity of hydroquinone, a benzene metabolite and component of cigarette smoke. BMC Cancer 14:6. doi:10.1186/1471-2407-14-6 PMID:24386979 PMCID:PMC3898384
  • Skibola CF, Berndt SI, Vijai J, Conde L, Wang Z, Yeager M, de Bakker PI, Birmann BM, Vajdic CM, Lightfoot TJ, Foo J, Bracci PM, Vermeulen R, Slager SL, de Sanjose S, Wang SS, Linet MS, Salles G, Lan Q, Severi G, Hjalgrim H, Melbye M, Gu J, Ghesquieres H, Link BK, Morton LM, Holly EA, Smith A, Tinker LF, Teras LR, Kricker A, Becker N, Purdue MP, Spinelli JJ, Zhang Y, Giles GG, Vineis P, Monnereau A, Bertrand KA, Albanes D, Zeleniuch-Jacquotte A, Gabbas A, Chung CC, Burdett L, Hutchinson A, Lawrence C, Montalvan R, Liang L, Huang J, Ma B, Liu J, Adami H, Glimelius B, Ye Y, Nowakowski GS, Dogan A, Thompson CA, Habermann TM, Novak AJ, Liebow M, Witzig TE, Weiner GJ, Schenker MB, Hartge P, De Roos AJ, Cozen W, Zhi D, Akers NK, Riby J, Smith MT, Lacher M, Villano DJ, Maria A, Roman E, Kane E, Jackson RD, North KE, Diver WR, Turner J, Armstrong BK, Benavente Y, Boffetta P, Brennan P, Foretova L, Maynadie M, Staines A, McKay J, Brooks-Wilson AR, Zheng T, Holford TR, Kaaks R, Kelly RS, Ohlsson B, Travis RC, Weiderpass E, Clavel J, Giovannucci E, Kraft P, Virtamo J, Mazza P, Cocco P, Ennas M, Chiu BC, Fraumeni JF, Nieters A, Offit K, Wu X, Cerhan JR, Smedby KE, Chanock SJ, Rothman N. 2014. Genome-wide association study identifies five susceptibility loci for follicular lymphoma outside the HLA region. Am J Hum Genet 95(4):462-471. doi:10.1016/j.ajhg.2014.09.004 PMID:25279986 PMCID:PMC4185120
  • Smith AH, Marshall G, Yuan Y, Steinmaus CM, Liaw J, Smith MT, Wood L, Heirich M, Fritzemeier R, Pegram M, Ferreccio Readi C. 2014. Rapid reduction in breast cancer mortality with inorganic arsenic in drinking water. EBioMedicine 1(1):58-63. doi:10.1016/j.ebiom.2014.10.005 PMID:25580451 PMCID:PMC4286879
  • Thomas R, Hubbard AE, McHale CM, Zhang L, Rappaport SM, Lan Q, Rothman N, Vermeulen R, Guyton KZ, Jinot J, Sonawane B, Smith MT. 2014. Characterization of changes in gene expression and biochemical pathways at low levels of benzene exposure. PLoS One 9(5):e91828. doi:10.1371/journal.pone.0091828 PMID:24786086 PMCID:PMC4006721

2013

  • Dangleben NL, Skibola CF, Smith MT. 2013. Arsenic immunotoxicity: a review. Environ Health 12(1):73. doi:10.1186/1476-069x-12-73 PMID:24004508 PMCID:PMC3848751
  • Hebels DG, Georgiadis P, Keun HC, Athersuch TJ, Vineis P, Vermeulen R, Portengen L, Bergdahl IA, Hallmans G, Palli D, Bendinelli B, Krogh V, Tumino R, Sacerdote C, Panico S, Kleinjans JC, de Kok TM, Smith MT, Kyrtopoulos SA. 2013. Performance in omics analyses of blood samples in long-term storage: opportunities for the exploitation of existing biobanks in environmental health research. Environ Health Perspect 121(4):480-487. doi:10.1289/ehp.1205657 PMID:23384616 PMCID:PMC3620742
  • Herceg Z, Lambert MP, van Veldhoven K, Demetriou C, Vineis P, Smith MT, Straif K, Wild CP. 2013. Towards incorporating epigenetic mechanisms into carcinogen identification and evaluation. Carcinogenesis 34(9):1955-1967. doi:10.1093/carcin/bgt212 PMID:23749751 PMCID:PMC3765050
  • Hosgood H, Zhang L, Tang X, Vermeulen R, Hao Z, Shen M, Qiu C, Ge Y, Hua M, Ji Z, Li S, Xiong J, Reiss B, Liu S, Xin KX, Azuma M, Xie Y, Freeman LB, Ruan X, Guo W, Galvan N, Blair AE, Li L, Huang H, Smith MT, Rothman N, Lan Q. 2013. Occupational exposure to formaldehyde and alterations in lymphocyte subsets. Am J Ind Med 56:252-257. doi:10.1002/ajim.22088 PMID:22767408 PMCID:PMC3493854
  • Howcroft TK, Campisi J, Louis GB, Smith MT, Wise B, Wyss-Coray T, Augustine AD, McElhaney JE, Kohanski R, Sierra F. 2013. The role of inflammation in age-related disease. Aging-US 5(1):84-93. doi:10.18632/aging.100531 PMID:23474627 PMCID:PMC3616233
  • McHale CM, Zhang L, Lan Q, Thomas R, Hubbard AE, Vermeulen R, Li G, Rappaport SM, Yin S, Smith MT, Rothman N. 2013. Toxicogenomic and systems biology approaches in the understanding of toxicity and leukemogenesis induced by benzene. The Toxicologist, Society of Toxicology Meeting, March 2013.
  • McHale CM, Zhang L, Thomas R, Smith MT. 2013. Analysis of the transcriptome in molecular epidemiology studies. Environ Mol Mutagen 54(7):500-517. doi:10.1002/em.21798 PMID:23907930 PMCID:PMC5142298
  • Metayer C, Zhang L, Wiemels JL, Bartley K, Schiffman J, Ma X, Aldrich MC, Chang JS, Selvin S, Fu CH, Ducore J, Smith MT, Buffler PA. 2013. Tobacco smoke exposure and the risk of childhood acute lymphoblastic and Myeloid Leukemias by cytogenetic subtype. Cancer Epidemiol Biomarkers Prev 22(9):1600. doi:10.1158/1055-9965.epi-13-0350 PMID:23853208 PMCID:PMC3769478
  • Ren X, Ji Z, McHale CM, Yuh J, Bersonda J, Tang M, Smith MT, Zhang L. 2013. The impact of FANCD2 deficiency on formaldehyde-induced toxicity in human lymphoblastoid cell lines. Arch Toxicol 87(1):189-196. doi:10.1007/s00204-012-0911-6 PMID:22872141 PMCID:PMC4312773
  • Shuga J, Zeng Y, Novak R, Lan Q, Tang X, Rothman N, Vermeulen R, Li L, Hubbard AE, Zhang L, Mathies RA, Smith MT. 2013. Single molecule quantitation and sequencing of rare translocations using microfluidic nested digital PCR. Nucleic Acids Res 41(16):e159. doi:10.1093/nar/gkt613 PMID:23873959 PMCID:PMC3763562
  • Thomas R, McHale CM, Lan Q, Hubbard AE, Zhang L, Vermeulen R, Li G, Rappaport SM, Yin S, Rothman N, Smith MT. 2013. Global gene expression response of a population exposed to benzene: A pilot study exploring the use of RNA-sequencing technology. Environ Mol Mutagen 54(7):566-573. doi:10.1002/em.21801 PMID:23907980 PMCID:PMC4353497
  • Zhang L, Bassig BA, Mora JL, Vermeulen R, Ge Y, Curry JD, Hu W, Shen M, Qiu C, Ji Z, Reiss B, McHale CM, Liu S, Guo W, Purdue MP, Yue F, Li L, Smith MT, Huang H, Tang X, Rothman N, Lan Q. 2013. Alterations in serum immunoglobulin levels in workers occupationally exposure to trichloroethylene. Carcinogenesis 34(4):799-802. doi:10.1093/carcin/bgs403 PMID:23276795 PMCID:PMC3616671

2012

  • Fromowitz M, Shuga J, Wlassowsky AY, Ji Z, North M, Vulpe CD, Smith MT, Zhang L. 2012. Bone marrow genotoxicity of 2,5-dimethylfuran, a green biofuel candidate. Environ Mol Mutagen 53:488-491. doi:10.1002/em.21707 PMID:22730236
  • Godderis L, Thomas R, Hubbard AE, Tabish AM, Hoet P, Zhang L, Smith MT, Veulemans H, McHale CM. 2012. Effect of chemical mutagens and carcinogens on gene expression profiles in human TK6 cells. PLoS One 7(6):e39205. doi:10.1371/journal.pone.0039205 PMID:22723965 PMCID:PMC3377624
  • Hosgood H, Zhang L, Tang X, Vermeulen R, Qiu C, Shen M, Smith MT, Ge Y, Ji Z, Xiong J, He J, Reiss B, Liu S, Xie Y, Guo W, Galvan N, Li L, Hao Z, Rothman N, Huang H, Lan Q. 2012. Decreased numbers of CD4+ naive and effector memory T cells, and CD8+, are associated with trichloroethylene exposure. Front Oncol 1:53. doi:10.3389/fonc.2011.00053 PMID:22649769 PMCID:PMC3355872
  • McHale CM, Zhang L, Smith MT. 2012. Current understanding of the mechanism of benzene-induced leukemia in humans: implications for risk assessment. Carcinogenesis doi:10.1093/carcin/bgr297 PMID:22166497 PMCID:PMC3271273
  • O'Connor SF, Lan J, North M, Loguinov AV, Zhang L, Smith MT, Gu AZ, Vulpe CD. 2012. Genome-wide functional and stress response profiling reveals toxic mechanism and genes required for tolerence to benzo[a]pyrene in S. cerevisiae. Front Genet 3:316. doi:10.3389/fgene.2012.00316 PMID:23403841 PMCID:PMC3567348
  • Sille FC, Thomas R, Smith MT, Conde L, Skibola CF. 2012. Post-GWAS functional characterization of susceptibility variants for chronic lymphocytic leukemia. PLoS One 7(1):e29632. doi:10.1371/journal.pone.0029632 PMID:22235315 PMCID:PMC3250464
  • Vermeulen R, Zhang L, Spierenburg A, Bonventre JV, Reiss B, Shen M, Smith MT, Qiu C, Ge Y, Ji Z, Xiong J, He J, Hao Z, Liu S, Xie Y, Yue F, Guo W, Purdue MP, Freeman LB, Sabbisetti V, Li L, Huang H, Rothman N, Lan Q, Tang X. 2012. Elevated urinary levels of kidney injury molecule-1 among Chinese factory workers exposed to trichloroethylene. Carcinogenesis 33(8):1538-1541. doi:10.1093/carcin/bgs191 PMID:22665366 PMCID:PMC3499056
  • Zhang L, Lan Q, Ji Z, Li G, Shen M, Guo W, Hubbard AE, McHale CM, Rappaport SM, Hayes RB, Linet MS, Yin S, Smith MT, Rothman N, Vermeulen R. 2012. Leukemia-specific chromosomal loss detected in hematopoietic progenitor cells of benzene-exposed workers. Leukemia 26(12):2494-2498. doi:10.1038/leu.2012.143 PMID:22643707 PMCID:PMC3472034

2011

  • Chu F, Ren X, Chasse A, Hickman T, Zhang L, Yuh J, Smith MT, Burlingame AL. 2011. Quantitative mass spectrometry reveals the epigenome as a target of arsenic. Chem Biol Interact 192(1-2):113-117. doi:10.1016/j.cbi.2010.11.003 PMID:21075096 PMCID:PMC4360996
  • McHale CM, Zhang L, Hubbard AE, Smith MT. 2011. Transcriptomic studies in human populations. Chapter 9 in: Applications of toxicogenomics in safety evaluation and risk assessment. John Wiley & Sons, Hoboken, NJ. pp.177-206.
  • McHale CM, Zhang L, Lan Q, Vermeulen R, Li G, Hubbard AE, Porter KE, Thomas R, Portier CJ, Shen M, Rappaport SM, Yin S, Rothman N, Smith MT. 2011. Global gene expression profiling of a population exposed to a range of benzene levels. Environ Health Perspect 119:628-634. doi:10.1289/ehp.1002546 PMID:21147609 PMCID:PMC3094412
  • North M, Tandon VJ, Thomas R, Loguinov AV, Gerlovina I, Hubbard AE, Zhang L, Smith MT, Vulpe CD. 2011. Genome-wide functional profiling reveals genes required for tolerance to benzene metabolites in yeast. PLoS One 6(8):e24205. doi:10.1371/journal.pone.0024205 PMID:21912624 PMCID:PMC3166172
  • Novak R, Shuga J, Venugopalan G, Fletcher D, Smith MT, Mathies RA. 2011. Single-cell multiplex gene detection and sequencing with microfluidically generated agarose emulsions. Angew Chem Int Ed Engl 50:390-5. doi:10.1002/anie.201006089 PMID:21132688 PMCID:PMC3027204
  • Ren X, Aleshin M, Jo WJ, Kalman DA, Vulpe CD, Smith MT, Zhang L. 2011. Involvement of N-6 adenine-specific DNA methyltransferase 1 (N6AMT1) in arsenic biomethylation and its role in arsenic-induced toxicity. Environ Health Perspect 119:771-777. doi:10.1289/ehp.1002733 PMID:21193388 PMCID:PMC3114810
  • Ren X, Lim S, Ji Z, Yuh J, Peng V, Smith MT, Zhang L. 2011. Comparison of proliferation and genomic instability responses to WRN silencing in hematopoietic HL60 and TK6 cells. PLoS One 6:e14546. doi:10.1371/journal.pone.0014546 PMID:21267443 PMCID:PMC3022623
  • Ren X, McHale CM, Skibola CF, Smith AH, Smith MT, Zhang L. 2011. An emerging role for epigenetic dysregulation in arsenic toxicity 
and carcinogenesis. Environ Health Perspect 119(1):11-19. doi:10.1289/ehp.1002114 PMID:20682481 PMCID:PMC3018488
  • Shen M, Zhang L, Lee KM, Vermeulen R, Hosgood H, Yin S, Rothman N, Chanock SJ, Smith MT, Lan Q, Li G. 2011. Polymorphisms in genes involved in innate immunity and susceptibility to benzene-induced hematotoxicity. Exp Mol Med 43:374-378. doi:10.3858/emm.2011.43.6.041 PMID:21540635 PMCID:PMC3128916
  • Smith MT, Zhang L, McHale CM, Skibola CF, Rappaport SM. 2011. Benzene, the exposome and future investigations of leukemia etiology. Chem Biol Interact 192(1-2):155-159. doi:10.1016/j.cbi.2011.02.010 PMID:21333640 PMCID:PMC3461963
  • Zhang L, Lan Q, Guo W, Hubbard AE, Li G, Rappaport SM, McHale CM, Shen M, Vermeulen R, Yin S, Rothman N, Smith MT, Ji Z. 2011. Chromosome-wide aneuploidy study (CWAS) in workers exposed to an established leukemogen, benzene. Carcinogenesis 32:605-612. doi:10.1093/carcin/bgq286 PMID:21216845 PMCID:PMC3066415

2010

  • Ji Z, Zhang L, Peng V, Ren X, McHale CM, Smith MT. 2010. A comparison of the cytogenetic alterations and global DNA hypomethylation induced by the benzene metabolite, hydroquinone, with those induced by melphalan and etoposide. Leukemia 24(5):986-991. doi:10.1038/leu.2010.43 PMID:20339439 PMCID:PMC4353491
  • Lan Q, Zhang L, Tang X, Shen M, Smith MT, Qiu C, Ge Y, Ji Z, Xiong J, He J, Reiss B, Hao Z, Liu S, Xie Y, Guo W, Purdue MP, Galvan N, Xin KX, Hu W, Freeman LB, Blair AE, Li L, Rothman N, Vermeulen R, Huang H. 2010. Occupational exposure to trichloroethylene is associated with a decline in lymphocyte subsets and soluble CD27 and CD30 markers. Carcinogenesis 31(9):1592-1596. doi:10.1093/carcin/bgq121 PMID:20530238 PMCID:PMC2930801
  • Lightfoot TJ, Johnston WT, Painter D, Simpson J, Roman E, Skibola CF, Smith MT, Allan JM, Taylor GM. 2010. Genetic variation in the folate metabolic pathway and risk of childhood leukemia. Blood 115(19):3923-3929. doi:10.1182/blood-2009-10-249722 PMID:20101025 PMCID:PMC2869556
  • Porter KE, Basu A, Hubbard AE, Bates MN, Kalman DA, Rey OA, Smith AH, Smith MT, Steinmaus CM, Skibola CF. 2010. Association of genetic variation in cystathionine-beta-synthase and arsenic metabolism. Environ Res 110(6):580-587. doi:10.1016/j.envres.2010.05.001 PMID:20670920 PMCID:PMC2913479
  • Rappaport SM, Smith MT. 2010. Epidemiology. Environment and disease risks. Science 330:460-1. doi:10.1126/science.1192603 PMID:20966241 PMCID:PMC4841276
  • Shuga J, Zeng Y, Novak R, Mathies RA, Hainaut P, Smith MT. 2010. Selected technologies for measuring acquired genetic damage in humans. Environ Mol Mutagen 51:851-70. doi:10.1002/em.20630 PMID:20872848
  • Smith MT. 2010. Advances in understanding benzene health effects and susceptibility. Annu Rev Public Health 31:133-48. doi:10.1146/annurev.publhealth.012809.103646 PMID:20070208 PMCID:PMC4360999
  • Steinmaus CM, Yuan Y, Kalman DA, Rey OA, Skibola CF, Dauphine DC, Basu A, Porter KE, Hubbard AE, Bates MN, Smith MT, Smith AH. 2010. Individual differences in arsenic metabolism and lung cancer in a case-control study in Cordoba, Argentina. Toxicol Appl Pharmacol 247(2):138-145. doi:10.1016/j.taap.2010.06.006 PMID:20600216 PMCID:PMC3849353
  • Vlaanderan J, Moore LE, Smith MT, Lan Q, Zhang L, Skibola CF, Rothman N, Vermeulen R. 2010. Application of OMICS technologies in occupational and environmental health research; current status and projections. Occup Environ Med 67(2):136-143. doi:10.1136/oem.2008.042788 PMID:19933307 PMCID:PMC2910417
  • Ward EM, Schulte PA, Straif K, Hopf NB, Caldwell JC, Carreon T, DeMarini DM, Fowler BA, Goldstein BD, Hemminki K, Hines CJ, Pursiainen K, Kuempel E, Lewtas J, Lunn RM, Lynge E, McElvenny DM, Muhle H, Nakajima T, Robertson LW, Rothman N, Ruder AM, Schubauer-Berigan MK, Siemiatycki J, Silverman DT, Smith MT, Sorahan T, Steenland K, Stevens RG, Vineis P, Zahm SH, Zeise L, Cogliano VJ. 2010. Research recommendations for selected IARC-classified agents. Environ Health Perspect 118:1355-62. doi:10.1289/ehp.0901828 PMID:20562050 PMCID:PMC2957912
  • Zhang L, McHale CM, Rothman N, Li G, Ji Z, Vermeulen R, Hubbard AE, Ren X, Shen M, Rappaport SM, North M, Skibola CF, Yin S, Vulpe CD, Chanock SJ, Smith MT, Lan Q. 2010. Systems biology of human benzene exposure. Chem Biol Interact 184(1-2):86-93. doi:10.1016/j.cbi.2009.12.011 PMID:20026094 PMCID:PMC2846187
  • Zhang L, Tang X, Rothman N, Vermeulen R, Ji Z, Shen M, Qiu C, Guo W, Liu S, Reiss B, Freeman LB, Ge Y, Hubbard AE, Hua M, Blair AE, Galvan N, Ruan X, Alter BP, Xin KX, Li S, Moore LE, Kim S, Xie Y, Hayes RB, Azuma M, Hauptmann M, Xiong J, Stewart P, Li L, Rappaport SM, Huang H, Fraumeni JF, Smith MT, Lan Q. 2010. Occupational exposure to formaldehyde, hematotoxicity, and leukemia-specific chromosome changes in cultured myeloid progenitor cells. Cancer Epidemiol Biomarkers Prev 19(1):80-88. doi:10.1158/1055-9965.EPI-09-0762 PMID:20056626 PMCID:PMC2974570

2009

  • Guyton KZ, Kyle AD, Aubrecht J, Cogliano VJ, Eastmond DA, Jackson M, Keshava N, Sandy MS, Sonawane B, Zhang L, Waters M, Smith MT. 2009. Improving prediction of chemical carcinogenicity by considering multiple mechanisms and applying toxicogenomic approaches. Mutat Res Rev Mutat Res 681(2-3):230-240. doi:10.1016/j.mrrev.2008.10.001 PMID:19010444
  • Ji Z, Zhang L, Guo W, McHale CM, Smith MT. 2009. The benzene metabolite, hydroquinone and etoposide both induce endoreduplication in human lymphoblastoid TK6 cells. Mutagenesis 24(4):367-372. doi:10.1093/mutage/gep018 PMID:19491217 PMCID:PMC2701990
  • Jo WJ, Loguinov AV, Wintz H, Chang M, Smith AH, Vulpe CD, Kalman DA, Zhang L, Smith MT. 2009. Comparative functional genomic analysis identifies distinct and overlapping sets of genes required for resistance to monomethylarsonous acid (MMAIII) and arsenite (AsIII) in yeast. Toxicol Sci 111(2):424-436. doi:10.1093/toxsci/kfp162 PMID:19635755 PMCID:PMC2742584
  • Jo WJ, Ren X, Chu F, Aleshin M, Wintz H, Burlingame AL, Smith MT, Vulpe CD, Zhang L. 2009. Acetylated H4K16 by MYST1 protects UROtsa cells from arsenic toxicity and is decreased following chronic arsenic exposure. Toxicol Appl Pharmacol 241(3):294-302. doi:10.1016/j.taap.2009.08.027 PMID:19732783 PMCID:PMC2784148
  • Lan Q, Zhang L, Shen M, Jo WJ, Vermeulen R, Li G, Vulpe CD, Lim S, Ren X, Rappaport SM, Berndt SI, Yeager M, Yuenger J, Hayes RB, Linet MS, Yin S, Chanock SJ, Smith MT, Rothman N. 2009. Large-scale evaluation of candidate genes identifies associations between DNA repair and genomic maintenance and development of benzene hematotoxicity. Carcinogenesis 30(1):50-58. doi:10.1093/carcin/bgn249 PMID:18978339 PMCID:PMC2639030
  • McHale CM, Zhang L, Lan Q, Li G, Hubbard AE, Forrest MS, Vermeulen R, Chen J, Shen M, Rappaport SM, Yin S, Smith MT, Rothman N. 2009. Changes in the peripheral blood transcriptome associated with occupational benzene exposure identified by cross-comparison on two microarray platforms. Genomics 93(4):343-349. doi:10.1016/j.ygeno.2008.12.006 PMID:19162166 PMCID:PMC2693268
  • Rappaport SM, Kim S, Lan Q, Vermeulen R, Waidyanatha S, Zhang L, Li G, Yin S, Hayes RB, Rothman N, Smith MT. 2009. Evidence that humans metabolize benzene via two pathways. Environ Health Perspect 117:946-952. doi:10.1289/ehp.0800510 PMID:19590688 PMCID:PMC2702411
  • Ren X, Lim S, Smith MT, Zhang L. 2009. Werner syndrome protein, WRN, protects cells from DNA damage induced by the benzene metabolite hydroquinone. Toxicol Sci 107(2):367-375. doi:10.1093/toxsci/kfn254 PMID:19064679 PMCID:PMC2639759
  • Scelo G, Metayer C, Zhang L, Wiemels JL, Aldrich MC, Selvin S, Month S, Smith MT, Buffler PA. 2009. Household exposure to paint and petroleum solvents, chromosomal translocations, and the risk of childhood leukemia. Environ Health Perspect 117(1):133-139. PMID:19165400
  • Smith MT, Rappaport SM. 2009. Building exposure biology centers to put the E into "G x E" interaction studies. Environ Health Perspect 117(8):A334-5. doi:10.1289/ehp.12812 PMID:19672377 PMCID:PMC2721881
  • Zhang L, Steinmaus CM, Eastmond DA, Xin XK, Smith MT. 2009. Formaldehyde exposure and leukemia: a new meta-analysis and potential mechanisms. Mutat Res Rev Mutat Res 681(2-3):150-168. doi:10.1016/j.mrrev.2008.07.002 PMID:18674636

2008

  • Galvan N, Lim S, Zmugg S, Smith MT, Zhang L. 2008. Depletion of WRN enhances DNA damage in HeLa cells exposed to the benzene metabolite, hydroquinone. Mutat Res 649(1-2):54-61. doi:10.1016/j.mrgentox.2007.07.011 PMID:17875398 PMCID:PMC3461953
  • Guha N, Chang JS, Chokkalingam AP, Wiemels JL, Smith MT, Buffler PA. 2008. NQO1 polymorphisms and de novo childhood leukemia: a HuGE review and meta-analysis. Am J Epidemiol 168(11):1221-1232. doi:10.1093/aje/kwn246 PMID:18945694 PMCID:PMC2727266
  • Hegedus CM, Skibola CF, Warner M, Skibola DR, Zhang L, Steinmaus CM, Smith AH, Smith MT, Moore LE, Alexander D, Lim S, Dangleben NL, Clark M, Pfeiffer RM. 2008. Decreased urinary beta-defensin-1 expression as a biomarker of response to arsenic. Toxicol Sci 106(1):74-82. doi:10.1093/toxsci/kfn104 PMID:18511430 PMCID:PMC2563143
  • Skibola CF, Nieters A, Bracci PM, Curry JD, Agana L, Skibola DR, Hubbard AE, Becker N, Smith MT, Holly EA. 2008. A functional TNFRSF5 gene variant is associated with risk of lymphoma. Blood 111(8):4348-4354. doi:10.1182/blood-2007-09-112144 PMID:18287517 PMCID:PMC2288730
  • Smith MT. 2008. Misuse of genomics in assigning causation in relation to benzene exposure. Int J Occup Environ Health 14(2):144-146. PMID:18507292
  • Smith MT, Kyle AD. 2008. Strategies to Advance Science and Policy for the Environment and Health. Convening of academic, government, and community partners to discuss future directions for environmental health. In: Superfund Basic Research Program and the National Institute for Environmental Health. Berkley, CA.
  • Steinmaus CM, Smith AH, Jones RM, Smith MT. 2008. Meta-analysis of benzene exposure and non-Hodgkin lymphoma: biases could mask an important association. Occup Environ Med 65(6):371-378. doi:10.1136/oem.2007.036913 PMID:18417556 PMCID:PMC4353490
  • Wiemels JL, Hofmann J, Kang M, Selzer R, Green R, Zhou M, Zhong S, Zhang L, Smith MT, Marsit CJ, Loh ML, Buffler PA, Yeh R. 2008. Chromosome 12p deletions in TEL-AML1 childhood acute lymphoblastic leukemia are associated with retrotransposon elements and occur postnatally. Cancer Res 68(23):9935-9944. doi:10.1158/0008-5472.CAN-08-2139 PMID:19047175 PMCID:PMC2597307

2007

  • Chen J, van der Laan MJ, Smith MT, Hubbard AE. 2007. A comparison of methods to control type I errors in microarray studies. Stat Appl Genet Mol Biol 6:Article28. doi:10.2202/1544-6115.1310 PMID:18052911
  • Escobar PA, Smith MT, Vasishta A, Hubbard AE, Zhang L. 2007. Leukaemia-specific chromosome damage detected by comet with fluorescence in situ hybridization (comet-FISH). Mutagenesis 22(5):321-327. doi:10.1093/mutage/gem020 PMID:17575318
  • Hegedus CM, Skibola CF, Bracci PM, Holly EA, Smith MT. 2007. Screening the human serum proteome for genotype-phenotype associations: an analysis of the IL6 -174G>C polymorphism. Proteomics 7(4):548-557. doi:10.1002/pmic.200600366 PMID:17309100
  • Kim S, Lan Q, Waidyanatha S, Chanock SJ, Johnson BA, Vermeulen R, Smith MT, Zhang L, Li G, Shen M, Yin S, Rothman N, Rappaport SM. 2007. Genetic polymorphisms and benzene metabolism in humans exposed to a wide range of air concentrations. Pharmacogenet Genomics 17(10):789-801. PMID:17885617
  • Lin Y, Vermeulen R, Tsai CH, Waidyanatha S, Lan Q, Rothman N, Smith MT, Zhang L, Shen M, Li G, Yin S, Kim S, Rappaport SM. 2007. Albumin adducts of electrophilic benzene metabolites in benzene-exposed and control workers. Environ Health Perspect 115(1):28-34. PMID:17366815
  • McHale CM, Zhang L, Hubbard AE, Zhao X, Baccarelli A, Pesatori AC, Smith MT, Landi MT. 2007. Microarray analysis of gene expression in peripheral blood mononuclear cells from dioxin-exposed human subjects. Toxicology 229:101-113. PMID:17101203
  • Smith MT, Hartge P. 2007. Environmental and behavioral factors and the risk of non-Hodgkin lymphoma. Cancer Epidemiol Biomarkers Prev 16(3):367-8. PMID:17344463
  • Smith MT, Jones RM, Smith AH. 2007. Benzene exposure and risk of non-Hodgkin lymphoma. Cancer Epidemiol Biomarkers Prev 16(3):385-391. doi:10.1158/1055-9965.EPI-06-1057 PMID:17337645
  • Zhang L, Rothman N, Li G, Guo W, Yang W, Hubbard AE, Hayes RB, Yin S, Lu W, Smith MT. 2007. Aberrations in chromosomes associated with lymphoma and therapy-related leukemia in benzene-exposed workers. Environ Mol Mutagen 48(6):467-74. PMID:17584886

2006

  • Aldrich MC, Zhang L, Wiemels JL, Ma X, Loh ML, Metayer C, Selvin S, Feusner J, Smith MT, Buffler PA. 2006. Cytogenetics of hispanic and white children with acute lymphoblastic leukemia in california. Cancer Epidemiol Biomarkers Prev 15(3):578-581. PMID:16537719
  • Birkner MD, Hubbard AE, van der Laan MJ, Skibola CF, Hegedus CM, Smith MT. 2006. Issues of processing and multiple testing of SELDI-TOF MS proteomic data. Stat Appl Genet Mol Biol 5:Article11. doi:10.2202/1544-6115.1198 PMID:16646865
  • Kim S, Vermeulen R, Waidyanatha S, Johnson BA, Lan Q, Rothman N, Smith MT, Zhang L, Li G, Shen M, Yin S, Rappaport SM. 2006. Using urinary biomarkers to elucidate dose-related patterns of human benzene metabolism. Carcinogenesis 27(4):772-81. PMID:16339183
  • Kim S, Vermeulen R, Waidyanatha S, Johnson BA, Lan Q, Smith MT, Zhang L, Li G, Shen M, Yin S, Rothman N, Rappaport SM. 2006. Modeling human metabolism of benzene following occupational and environmental exposures. Cancer Epidemiol Biomarkers Prev 15(11):2246-52. PMID:17119053
  • Paynter RA, Skibola DR, Skibola CF, Buffler PA, Wiemels JL, Smith MT. 2006. Accuracy of multiplexed Illumina platform-based single-nucleotide polymorphism genotyping compared between genomic and whole genome amplified DNA collected from multiple sources. Cancer Epidemiol Biomarkers Prev 15(12):2533-2536. doi:10.1158/1055-9965.EPI-06-0219 PMID:17164381
  • Shen M, Lan Q, Zhang L, Chanock SJ, Li G, Vermeulen R, Rappaport SM, Guo W, Hayes RB, Linet MS, Yin S, Yeager M, Welch R, Forrest MS, Rothman N, Smith MT. 2006. Polymorphisms in genes involved in DNA double-strand break repair pathway and susceptibility to benzene-induced hematotoxicity. Carcinogenesis 27(10):2083-2089. doi:10.1093/carcin/bgl061 PMID:16728435
  • Vermeulen R, Lan Q, Li G, Rappaport SM, Kim S, van Wendel de Joode B, Shen M, Bohong X, Smith MT, Zhang L, Yin S, Rothman G. 2006. Assessment of dermal exposure to benzene and toluene in shoe manufacturing by activated carbon cloth patches. J Environ Monit 8(11):1143-8. PMID:17075621

2005

  • Lan Q, Zhang L, Hakim F, Shen M, Memon S, Li G, Vermeulen R, Smith MT, Rappaport SM, Hayes RB, Linet MS, Yin S, Rothman N, Rabkin CS. 2005. Lymphocyte toxicity and T cell receptor excision circles in workers exposed to benzene. Chem Biol Interact 153-154:111-115. PMID:15935806
  • Lan Q, Zhang L, Shen M, Smith MT, Li G, Vermeulen R, Rappaport SM, Forrest MS, Hayes RB, Linet MS, Dosemeci M, Alter BP, Weinberg RS, Yin S, Yeager M, Welch R, Waidyanatha S, Kim S, Chanock SJ, Rothman N. 2005. Polymorphisms in cytokine and cellular adhesion molecule genes and susceptibility to hematotoxicity among workers exposed to benzene. Cancer Res 65(20):9574-9581. doi:10.1158/0008-5472.CAN-05-1419 PMID:16230423
  • Rappaport SM, Waidyanatha S, Yeowell-O'Connell K, Rothman N, Smith MT, Zhang L, Qu Q, Shore R, Li G, Yin S. 2005. Protein adducts as biomarkers of human benzene metabolism. Chem Biol Interact 153-154:103-109. PMID:15935805
  • Smith MT, McHale CM, Wiemels JL, Zhang L, Wiencke JK, Zheng S, Gunn L, Skibola CF, Ma X, Buffler PA. 2005. Molecular biomarkers for the study of childhood leukemia. Toxicol Appl Pharmacol 206(2):237-245. PMID:15967214
  • Weis BK, Balshaw DM, Barr JR, Brown D, Ellisman MH, Lioy PJ, Omenn G, Potter JD, Smith MT, Sohn L, Suk WA, Sumner S, Swenberg JA, Walt DR, Watkins S, Thompson CL, Wilson SH. 2005. Personalized exposure assessment: promising approaches for human environmental health research. Environ Health Perspect 113(7):840-848. PMID:16002370 PMCID:PMC1257643
  • Wiemels JL, Zhang Y, Chang J, Zheng S, Metayer C, Zhang L, Smith MT, Ma X, Selvin S, Buffler PA, Wiencke JK. 2005. RAS mutation is associated with hyperdiploidy and parental characteristics in pediatric acute lymphoblastic leukemia. Leukemia 19(3):415-419. PMID:15674422

2004

  • Lan Q, Zhang L, Li G, Vermeulen R, Weinberg RS, Dosemeci M, Rappaport SM, Shen M, Alter BP, Wu Y, Kopp W, Waidyanatha S, Rabkin CS, Guo W, Chanock SJ, Hayes RB, Linet MS, Kim S, Yin S, Rothman N, Smith MT. 2004. Hematotoxicity in workers exposed to low levels of benzene. Science 306(5702):1774-1776. doi:10.1126/science.1102443 PMID:15576619 PMCID:PMC1256034
  • McHale CM, Smith MT. 2004. Prenatal origin of chromosomal translocations in acute childhood leukemia: Implications and future directions. Am J Hematol 75(4):254-257. PMID:15054823
  • Toraason M, Albertini R, Baynard S, Bigbee W, Blair AE, Boffetta P, Bonassi S, Chanock SJ, Christiani DC, Eastmond DA, Hanash S, Henry C, Kadlubar FF, Mirer F, Nebert DW, Rappaport SM, Rest K, Rothman N, Ruder AM, Savage R, Schulte PA, Siemiatycki J, Shields P, Smith MT, Tolbert PE, Vermeulen R, Vineis P, Wacholder S, Ward EM, Waters M. 2004. Applying new biotechnologies to the study of occupational cancer - A workshop summary. Environ Health Perspect 112(4):413-416. PMID:15033588
  • Vermeulen R, Li G, Lan Q, Dosemeci M, Rappaport SM, Bohong X, Smith MT, Zhang L, Hayes RB, Linet MS, Mu R, Wang L, Xu J, Yin S, Rothman N. 2004. Detailed exposure assessment for a molecular epidemiology study of benzene in two shoe factories in China. Ann Occup Hyg 48(2):105-116. PMID:14990432
  • Waidyanatha S, Rothman N, Li G, Smith MT, Yin S, Rappaport SM. 2004. Rapid determination of six urinary benzene metabolites in occupationally exposed and unexposed subjects. Anal Biochem 327(2):184-199. PMID:15051535
  • Zhang L, Hayes RB, Guo W, McHale CM, Yin S, Wiencke JK, O'Neill JP, Rothman N, Li G, Smith MT. 2004. Lack of increased genetic damage in 1,3-butadiene-exposed Chinese workers studied in relation to EPHX1 and GST genotypes. Mutat Res 558(1-2):63-74. PMID:15036120
  • Zheng S, Ma X, Zhang L, Gunn L, Smith MT, Wiemels JL, Leung K, Buffler PA, Wiencke JK. 2004. Hypermethylation of the 5 ' CpG island of the FHIT gene is associated with hyperdiploid and translocation-negative subtypes of pediatric leukemia. Cancer Res 64(6):2000-2006. PMID:15026336

2003

  • Albertini R, Clewell H, Himmelstein MW, Morinello EJ, Olin S, Preston J, Scarano L, Smith MT, Swenberg JA, Tice RR, Travis C. 2003. The use of non-tumor data in cancer risk assessment: reflections on butadiene, vinyl chloride, and benzene. Regul Toxicol Pharmacol 37(1):105-132. PMID:12662914
  • Curry JD, Smith MT. 2003. Measurement of SIL-TAL1 fusion gene transcripts associated with human T-cell lymphocytic leukemia by real-time reverse transcriptase-PCR. Leuk Res 27(7):575-582. PMID:12681356
  • Escobar PA, Zhang L, Smith MT. 2003. Chemically induced damage to specific regions of DNA detected by cometfish. Environ Mol Mutagen 41(3):174.
  • Holland NT, Smith MT, Eskenazi B, Bastaki B. 2003. Challenges of biological sample collection and processing for large epidemiological projects. Mutat Res Rev Mutat Res 7702:1-18.
  • Holland NT, Smith MT, Eskenazi B, Bastaki M. 2003. Biological sample collection and processing for molecular epidemiological studies. Mutat Res Rev Mutat Res 543(3):217-234. PMID:12787814
  • McHale CM, Wiemels JL, Zhang L, Ma X, Buffler PA, Feusner J, Matthay KK, Dahl GV, Smith MT. 2003. Prenatal origin of childhood acute myeloid leukemias harboring chromosomal rearrangements t(15;17) and inv(16). Blood 101(11):4640-4641. PMID:12756163
  • McHale CM, Wiemels JL, Zhang L, Ma X, Buffler PA, Guo W, Loh ML, Smith MT. 2003. Prenatal origin of TEL-AML1-positive acute lymphoblastic leukemia in children born in California. Genes, Chromosomes and Cancer 37(1):36-43. PMID:12661004
  • Smith MT, Wiencke JK, Wiemels JL, Zhang L, Ma X, McHale CM, Buffler PA. 2003. Molecular epidemiology of childhood leukemia. Environ Mol Mutagen 41(3):206.
  • Wiencke JK, Zheng S, Smith MT, Zhang L, Ma X, Wiemels JL, Marsit CJ, Kelsey KT, Buffler PA. 2003. Methylation of transcribed PTEN pseudogene in pediatric leukemia is associated with subtypes of common ALL containing t(12;21) translocation. In: Proceedings of the Ninety Fourth Annual Meeting of the (AACR) American Association for Cancer Research, July 11-14, 2003, San Francisco. San Franciso, CA.
  • Zhang L, Zheng S, Ma X, Wiemels JL, Buffler PA, Smith MT, Wiencke JK. 2003. Molecular cytogenetic characterization of childhood acute lymphoblastic leukemia and its relation to FHIT gene methylation. Environ Mol Mutagen 41(3):215.
  • Zheng S, Ma X, Wiemels JL, Zhang L, Gunn L, Smith MT, Buffler PA, Wiencke JK. 2003. Hypermethylation of the 5'CpG island of the FHIT gene is associated with hyperdiploid and translocation negative subtypes of pediatric leukemia. In: Proceedings of the Ninety Fourth Annual Meeting of the (AACR) American Association for Cancer Research, July 11-14, 2003, San Francisco. San Franciso, CA.

2002

  • Allan JM, Wild CP, Rollinson S, Roddam PL, Dring AM, Dasgupta R, Sibley K, Worrilow L, Willet EV, Law GR, Roman E, Dovey GJ, Cartwright RA, Holowaty E, Kohler B, Wiklund, Pukkala E, Smith MT, Travis LB, Morgan GJ. 2002. Genetic polymophisms in DNA repair and cell cycle regulatory genes are associated with susceptibility to therapy-related acute myeloid leukemia. In: Proceedings of the Ninety Third (AACR) American Association for Cancer Research, April 6-10, 2002, San Francisco. San Franciso, CA. pp.4213.
  • Curry JD, McHale CM, Smith MT. 2002. Low efficiency of the Moloney murine leukemia virus reverse transcriptase during reverse transcription of rare t(8;21) fusion gene transcripts. Biotechniques 32(4):768-775. PMID:11962598
  • Gunn L, Forrest MS, Zhang L, Holland NT, Smith MT. 2002. Biomarkers of early effect in the study of cancer risk. Chapter 22 in: Biomarkers of Environmentally Associated Disease: Technologies, Concepts, and Perspectives. CRC Press Company, Boca Raton, FL. pp.319.
  • Guo W, Zhang L, Yang W, Smith MT. 2002. Chromosomal aneuploidy detected at different stages of cervical cancer using interphase cytongenetics. In: Proceedings of the Ninety Third (AACR) American Association for Cancer Research, April 6-10, 2002, San Francisco. San Franciso, CA. pp.3698.
  • Holland NT, Duramad P, Rothman N, Figgs LW, Blair AE, Hubbard AE, Smith MT. 2002. Micronucleus frequency and proliferation in human lymphocytes after exposure to herbicide 2,4-dichlorophenoxyacetic acid in vitro and in vivo. Mutat Res 521(1-2):165-78. PMID:12438013
  • Ma X, Buffler PA, Gunier RB, Dahl GV, Smith MT, Reinier K, Reynolds P. 2002. Critical windows of exposure to household pesticides and risk of childhood leukemia. Environ Health Perspect 110(9):955-960. PMID:12204832
  • McHale CM, Wiemels JL, Zhang L, Ma X, Buffler PA, Smith MT. 2002. Prenatal origin of TEL-AML positive acute lymphoblastic leukemia in children born in California. In: Proceedings of the Ninety Third (AACR) American Association for Cancer Research, April 6-10, 2002, San Francisco. San Franciso, CA. pp.4566.
  • Morgan GJ, Smith MT. 2002. Metabolic enzyme polymorphisms and susceptibility to acute leukemia in adults. Am J Pharmacogenomics 2(2):79-92. PMID:12083944
  • Rappaport SM, Yeowell-O'Connell K, Smith MT, Dosemeci M, Hayes RB, Zhang L, Li G, Yin S, Rothman N. 2002. Non-linear production of benzene oxide-albumin adducts with human exposure to benzene. J Chromatogr A 778:367-374. PMID:12376141
  • Rollinson S, Allan JM, Law GR, Roddam PL, Smith AG, Higuchi R, Germer S, Roman E, Smith MT, Morgan GJ. 2002. Polymorphic variants of DNA repair and cell cycle genes associated with acute myeloid leukemia identified by genotyping DNA pools. In: COMPSTAT 2002, Proceedings in Computational Staistics. Heidelberg: Physica-Verlag, Berlin, Germany. pp.5048.
  • Skibola CF, Smith MT, Hubbard AE, Shane B, Roberts AC, Law GR, Rollinson S, Roman E, Cartwright RA, Morgan GJ. 2002. Polymorphisms in the thymidylate synthase and serine hydroxymethyltransferase genes and risk of adult acute lymphocytic leukemia. Blood 99(10):3786-3791. PMID:11986237
  • Skibola CF, Smith MT, Hubbard AE, Shane B, Roberts AC, Law GR, Rollinson S, Roman E, Cartwright RA, Morgan GJ. 2002. Polymorphisms in the thymidylate synthase and serine hydroxymethyltransferase genes increase the risk of adult acute leukemia. In: Proceedings of the Ninety Third (AACR) American Association for Cancer Research, April 6-10, 2002, San Francisco. San Franciso, CA. pp.3807.
  • Smith MT, Linet MS, Morgan GJ. 2002. Causative agents in the etiology of myelodysplastic syndromes and the acute myeloid leukemias. Chapter 3 in: The Myelodysplastic Syndromes: Pathobiology and Clinical Management. Dekker Press, New York, NY. pp.29.
  • Smith MT, Wang Y, Skibola CF, Slater DJ, Nigro LL, Nowell PC, Lange BJ, Felix CA. 2002. Low NAD(P)H: quinone oxidoreductase (NQO1) activity is associated with increased risk of leukemia with MLL translocations in infants and children. In: Proceedings of the Ninety Third (AACR) American Association for Cancer Research, April 6-10, 2002, San Francisco. San Franciso, CA. pp.3805.
  • Wiemels JL, Leonard BC, Wang Y, Segal MR, Hunger SP, Smith MT, Crouse V, Ma X, Buffler PA, Pine SR. 2002. Site-specific translocation and evidence of postnatal origin of the t(1;19) E2A-PBX1 fusion in childhood acute lymphoblastic leukemia. Proc Natl Acad Sci U S A 99(23):15101-15106. PMID:12415113
  • Wiemels JL, Xiao Z, Buffler PA, Maia AT, Ma X, Dicks BM, Smith MT, Zhang L, Feusner J, Wiencke JK, Pritchard-Jones K, Kempski H, Greaves MF. 2002. In utero origin of t(8;21) AML1-ETO translocations in childhood acute myeloid leukemia. In: Proceedings of the Ninety Third (AACR) American Association for Cancer Research, April 6-10, 2002, San Francisco. San Franciso, CA. pp.4567.
  • Wiemels JL, Xiao Z, Buffler PA, Maia AT, Ma X, Dicks BM, Smith MT, Zhang L, Feusner J, Wiencke JK, Pritchard-Jones K, Kempski H, Greaves MF. 2002. In utero origin of t(8;21) AML1-ETO translocations in childhood acute myeloid leukemia. Blood 99(10):3801-3805. PMID:11986239
  • Yang W, Zhang L, Hubbard AE, Wang Y, Smith MT. 2002. Non-random chromosome damage may be important in chemical carinogenesis. In: Proceedings of the Ninety Third (AACR) American Association for Cancer Research, April 6-10, 2002, San Francisco. San Franciso, CA. pp.3451.
  • Zhang L, Eastmond DA, Smith MT. 2002. The nature of chromosomal aberrations detected in humans exposed to benzene. Crit Rev Toxicol 32(1):1-42. PMID:11846214
  • Zhang L, Guo W, Rothman N, Lan Q, Yang W, Lo C, Li G, Turakulov RI, Yin S, Smith MT. 2002. Application of OctoChrome FISH device to detect leukemia and lymphoma specific chromosome aberrations in molecular epidemiology and toxicology. In: Proceedings of the Ninety Third (AACR) American Association for Cancer Research, April 6-10, 2002, San Francisco. San Franciso, CA. pp.3810.
  • Zhang L, Yang W, Hubbard AE, Wang Y, Smith MT. 2002. Is chromosomal aneuploidy induced by benzene metabolites random or selective?. Environ Mol Mutagen 39(Suppl33):230.

2001

  • Curry JD, Glaser MC, Smith MT. 2001. Real-time RT-PCR detection and quantification of t(1;19)(E2A-PBX1) fusion genes associated with leukaemia. British Journal of Haematology 115(4):826-830. PMID:11843816
  • Smith MT. 2001. Chromosome damage from biological reactive intermediates of benzene and 1,3-butadiene in leukemia. Advances in Experimental Medicine and Biology 500:279-287. PMID:11764955
  • Waidyanatha S, Rothman N, Fustinoni S, Smith MT, Hayes RB, Bechtold WE, Dosemeci M, Li G, Yin S, Rappaport SM. 2001. Urinary benzene as a biomarker of exposure among occupationally exposed and unexposed subjects. Carcinogenesis 22:279-286. PMID:11181449
  • Xiao Z, Greaves MF, Buffler PA, Smith MT, Segal MR, Dicks BM, Wiencke JK, Wiemels JL. 2001. Molecular characterization of genomic AML1-ETO fusions in childhood leukemia. Leukemia 15:1906-1913. PMID:11753612
  • Yeowell-O'Connell K, Rothman N, Waidyanatha S, Smith MT, Hayes RB, Li G, Bechtold WE, Dosemeci M, Zhang L, Yin S, Rappaport SM. 2001. Protein adducts of 1,4-benzoquinone and benzene oxide among smokers and nonsmokers exposed to benzene in China. Cancer Epidemiol Biomarkers Prev 10:831-838. PMID:11489749
  • Zheng S, Ma X, Buffler PA, Smith MT, Wiencke JK. 2001. Whole genome amplification increases the efficiency and validity of buccal cell genotyping in pediatric populations. Cancer Epidemiol Biomarkers Prev 10:697-700. PMID:11401921

2000

  • Hayes RB, Yin S, Rothman N, Dosemeci M, Li G, Travis LB, Smith MT, Linet MS. 2000. Benzene and lymphohematopoietic malignancies in China. J Toxicol Environ Health A 61(5-6):419-432. PMID:11086948
  • Hayes RB, Zhang L, Yin S, Swenberg JA, Xi L, Wiencke JK, Bechtold WE, Yao M, Rothman N, Haas R, O'Neill JP, Zhang D, Wiemels JL, Dosemeci M, Li G, Smith MT. 2000. Genotoxic markers among butadiene-polymer workers in China. Carcinogenesis 21(1):55-62. PMID:10607734
  • Smith MT, Rothman N. 2000. Biomarkers in the molecular epidemiology of benzene-exposed workers. J Toxicol Environ Health A 61(5-6):439-445. PMID:11086950
  • Smith MT, Zhang L, Jeng M, Wang Y, Guo W, Duramad P, Hubbard AE, Hofstadler G, Holland NT. 2000. Hydroquinone, a benzene metabolite, increases the level of aneusomy of chromosomes 7 and 8 in human CD34-positive blood progenitor cells. Carcinogenesis 21(8):1485-1490. PMID:10910948
  • Zhang L, Rothman N, Wang Y, Guo W, Hayes RB, Li G, Yin S, Smith MT. 2000. Spectrum of chromosomal changes detected by fluorescence in situ hybridization in workers exposed to benzene. Proc Am Assoc Cancer Res 41:Abstract2777.

1999

  • Holland NT, Ahlborn T, Turteltaub KW, Markee C, Moore DH, Wyrobek AJ, Smith MT. 1999. Acrylamide causes preimplantation abnormalities in embryos and induces chromatin-adducts in male germ cells of mice. Reprod Toxicol 13(3):167-178. PMID:10378466
  • Holland NT, Zhang L, Smith MT. 1999. Cytogenetic biomarkers and air pollution. In: Proceedings of the 7th International Inhalation Symposium, 1999. Hanover, Germany.
  • Liu Y, Jeng M, Lubin B, Smith MT. 1999. Large quantitative variation in V(D)J recombination error among children. In: Proceedings of the Ninetieth Annual Meeting of the (AACR) American Association of Cancer Research, 1999. pp.477.
  • Rothman N, Campleman S, Hayes RB, Hoener B, Yin S, Dosemeci M, Meyer KB, Li G, Zhang L, Smith MT. 1999. High CYP2E1 activity is a risk factor for benzene poisoning. In: Proceedings of the Ninetieth Annual Meeting of the (AACR) American Association of Cancer Research, 1999. pp.282.
  • Rothman N, Traver RD, Smith MT, Hayes RB, Li G, Campleman S, Dosemeci M, Zhang L, Linet MS, Wacholder S, Yin S, Ross D. 1999. Lack of NAD(P)H:quinone oxidoreductase activity (NQ01) is associated with increased risk of benzene hematotoxicity. In: Proceedings of the Ninetieth Annual Meeting of the (AACR) American Association of Cancer Research, 1999. pp.258.
  • Smith MT. 1999. Benzene, NQO1, and genetic susceptibility to cancer. Proc Natl Acad Sci U S A 96(14):7624-7626. PMID:10393869
  • Smith MT, Zhang L, Wang Y, Li G, Hayes RB, Kolachana P, Dosemeci M, Holland NT, Xi L, Yin S, Rothman N. 1999. Translocations between chromosome 8 and 21 in workers exposed to benzene. In: Proceedings of the Ninetieth Annual Meeting of the (AACR) American Association of Cancer Research, 1999.
  • Traver RD, Rothman N, Smith MT, Yin S, Hayes RB, Li G, Franklin WF, Ross D. 1999. Incidence of a polymorphism in NAD(P)H: Quinone Oxidoreductase (NQO1). In: Proceedings of the Ninetieth Annual Meeting of the (AACR) American Association of Cancer Research, 1999. pp.278.
  • Wiemels JL, Wiencke JK, Varkonyi A, Smith MT. 1999. Modulation of the toxicity and macromolecular binding of benzene metabolites by NAD(P)H:Quinone oxidoreductase in transfected HL-60 cells. Chem Res Toxicol 12(6):467-475. doi:10.1021/tx9800811 PMID:10368308
  • Xi L, Zhang L, Wang Y, Smith MT. 1999. Induction of chromosome-specific aneusomy and micronuclei in human lymphocytes by metabolites of 1, 3-butadiene. In: Proceedings of the Ninetieth Annual Meeting of the (AACR) American Association of Cancer Research, 1999.
  • Yeowell-O'Connell K, Rothman N, Smith MT, Hayes RB, Li G, Bechtold WE, Dosemeci M, Zhang L, Yin S, Rappaport SM. 1999. Hemoglobin adducts of benzene oxide in workers exposed to high levels of benzene in China. In: Proceedings of the Ninetieth Annual Meeting of the (AACR) American Association of Cancer Research, 1999. pp.251.
  • Yeowell-O'Connell K, Rothman N, Waidyanatha S, Smith MT, Hayes RB, Li G, Bechtold WE, Dosemeci M, Zhang L, Yin S, Rappaport SM. 1999. Albumin adducts of benzene oxide, 1, 2- and 1, 4 benzoquinones in benzene exposed workers. In: Proceedings of the Ninetieth Annual Meeting of the (AACR) American Association of Cancer Research, 1999. pp.477.
  • Zhang L, Rothman N, Li G, Wang Y, Hayes RB, Guo W, Lu W, Zhang D, Yin S, Smith MT. 1999. Molecular cytogenetics of humans exposed to benzene and 1,3-butadiene. In: Proceedings of the 1999 HEI (The Health Effects Institute ) Annual Conference. San Diego, CA.
  • Zhang L, Rothman N, Wang Y, Hayes RB, Li G, Dosemeci M, Yin S, Kolachana P, Titenko-Holland N, Smith MT. 1999. Benzene exposure is associated with increased aneusomy and long arm deletion of chromosomes 5 and 7 in Chinese workers. In: Proceedings of the Ninetieth Annual Meeting of the (AACR) American Association of Cancer Research, 1999. pp.628.
  • Zhang L, Rothman N, Wang Y, Hayes RB, Yin S, Li G, Smith MT. 1999. Aneuploidy of chromosomes 7, 8 and 9 detected by fluorescence in situ hybridization in workers exposed to benzene. In: Proceedings of the Ninetieth Annual Meeting of the (AACR) American Association of Cancer Research, 1999. pp.112.
  • Zhang L, Rothman N, Wang Y, Hayes RB, Yin S, Titenko-Holland N, Dosemeci M, Wang Y, Kolachana P, Lu W, Xi L, Li G, Smith MT. 1999. Benzene increases aneuploidy in the lymphocytes of exposed workers: A comparison of data obtained by fluorescence in situ hybridization in interphase and metaphase cells. Environ Mol Mutagen 34:260-268. PMID:10618174
  • Zhang L, Wang Y, Shang N, Smith MT. 1999. Differential chromosome sensitivity to aneuploidy induced by benzene and its metabolites. Proc Am Assoc Cancer Res Abstract3365.

1998

  • Holland NT, Jacob RA, Shang N, Balaraman A, Smith MT. 1998. Micronuclei in lymphocytes and exfoliated buccal cells of postmenopausal women with dietary changes in folate. Mutat Res 417(2-3):101-114. PMID:9733936
  • Jeng M, Holland NT, Smith MT. 1998. A comparison of cytogenetic damage in human hematopoietic CD34+ progenitor cells and peripheral blood lymphocytes. Blood 92(10,supp.1):
  • Liu Y, Jeng M, Lubin B, Smith MT. 1998. Large quantitative variation in V(D)J recombination error among children. Chapter 39in: Proceedings of the Eighty Nineth Annual Meeting of the (AACR) American Association for Cancer Research, March 28th-April 1st, 1998. New Oreleans, LA. pp.477Abstract.
  • Rothman N, Bechtold WE, Yin S, Dosemeci M, Li G, Wang Y, Griffith WC, Smith MT, Hayes RB. 1998. Urinary excretion of phenol, catechol, hydroquinone, and muconic acid by workers occupationally exposed to benzene. Occup Environ Med 55(10):705-711. PMID:9930093
  • Smith MT. 1998. Genetic susceptibility and risk factors for leukemia. J Biomol Struct Dyn 16:149-187.
  • Smith MT, Rothman N. 1998. Biomarkers of leukemia risk from benzene. In: Biomarkers: Medical and Workplace Applications. Joseph Henry Press, Washington, DC. pp.355-374.
  • Smith MT, Rothman N, Yin S. 1998. Biomarkers in the molecular epidemiology of benzene exposed workers. Environ Mol Mutagen 31(29):24.
  • Smith MT, Zhang L. 1998. Biomarkers of leukemia risk: benzene as a model. Environ Health Perspect 106(4):937-946. PMID:9703476
  • Smith MT, Zhang L, Wang Y, Hayes RB, Li G, Wiemels JL, Dosemeci M, Holland NT, Xi L, Kolachana P, Yin S, Rothman N. 1998. Increased translocations and aneusomy in chromosomes 8 and 21 among workers exposed to benzene. Cancer Res 58(10):2176-2181. PMID:9605763
  • Titenko-Holland N, Ahlborn T, Lowe X, Shang N, Smith MT, Wyrobek AJ. 1998. Micronucleal and developmental abnormalities in 4-day mouse embryos after paternal treatment with acrylamide. Environ Mol Mutagen 31(3):206-217. PMID:9585259
  • Titenko-Holland N, Shao J, Zhang L, Xi L, Ngo H, Shang N, Smith MT. 1998. Studies on the genotoxicity of molybdenum salts in human cells in vitro and in mice in vivo. Environ Mol Mutagen 32(3):251-259. PMID:9814440
  • Titenko-Holland N, Zhang L, Smith MT. 1998. Biomarkers of genetic damage in humans. In: Proceedings of the Pacific Basin Conference on Hazardous Waste, Honolulu, Hawaii, 22-24 April, 1998. Honolulu, HI. pp.141-143.
  • Yeowell-O'Connell K, Rothman N, Smith MT, Hayes RB, Li G, Waidyanatha S, Dosemeci M, Zhang L, Yin S, Titenko-Holland N, Rappaport SM. 1998. Hemoglobin and albumin adducts of benzene oxide among workers exposed to high levels of benzene. Carcinogenesis 19(9):1565-1571. PMID:9771926
  • Yeowell-O'Connell K, Rothman N, Waidyanatha S, Smith MT, Hayes RB, Li G, Bechtold WE, Dosemeci M, Zhang L, Yin S, Rappaport SM. 1998. Albumin adducts of benzene oxide, 1, 2-and 1, 4 benzoquinones in benzene exposed workers. Chapter 39in: Proceedings of the Eighty Nineth Annual Meeting of the (AACR) American Association for Cancer Research, March 28th-April 1st, 1998. New Oreleans, LA. pp.477.
  • Zhang L, Rothman N, Wang Y, Hayes RB, Li G, Dosemeci M, Yin S, Kolachana P, Titenko-Holland N, Smith MT. 1998. Increased aneusomy and long arm deletion of chromosomes 5 and 7 in the lymphocytes of Chinese workers exposed to benzene. Carcinogenesis 19(11):1955-1961. PMID:9855009
  • Zhang L, Rothman N, Wang Y, Hayes RB, Li G, Titenko-Holland N, Yin S, Shang N, Smith MT. 1998. The loss and long arm deletions of chromosomes 5 and 7 in human lymphocytes treated with benzene metabolites and in workers exposed to benzene. Environ Mol Mutagen 31(29):72.
  • Zhang L, Rothman N, Wang Y, Hayes RB, Yin S, Titenko-Holland N, Dosemeci M, Kolachana P, Xi L, Li G, Smith MT. 1998. A comparison of interphase and metaphase FISH analysis of aneusomy in benzene-exposed workers. Environ Mol Mutagen 31(29):72.
  • Zhang L, Wang L, Shang N, Smith MT. 1998. Benzene metabolites induce the loss and long arm deletion of chromosomes 5 and 7 in human lymphocytes. Leuk Res 22(2):105-113. PMID:9593466

1997

  • Biggs ML, Kalman DA, Moore LE, Hopenhayn-Rich C, Smith MT, Smith AH. 1997. Relationship of urinary arsenic to intake estimates and a biomarker of effect, bladder cell micronuclei. Mutat Res Rev Mutat Res 386:185-195. PMID:9219557
  • Fanning EW, Bois FY, Rothman N, Bechtold WE, Li G, Hayes RB, Smith MT. 1997. Population toxicokinetics of benzene and its metabolites. In: Proceedings of the 36th Society of Toxicology (SOT) Annual Meeting, March 9-13, 1997. Cincinnati, OH.
  • Holland NT, Shao J, Zhang L, Ngo H, Shang N, Smith MT. 1997. Molybdenum salts are genotoxic. In: Proceedings of Environmental Mutagen Society Meeting, 1997. Minneapolis, MN.
  • Moore LE, Smith AH, Hopenhayn-Rich C, Biggs ML, Kalman DA, Smith MT. 1997. Decrease in bladder cell micronucleus prevalance after intervention to lower the concentration of arsenic in drinking water. Cancer Epidemiol Biomarkers Prev 6(12):1051-1056. PMID:9419402
  • Moore LE, Smith AH, Hopenhayn-Rich C, Biggs ML, Kalman DA, Smith MT. 1997. Micronuclei in exfoliated bladder cells among individuals chronically exposed to arsenic in drinking water. Cancer Epidemiol Biomarkers Prev 6(1):31-36. PMID:8993795
  • Rothman N, Smith MT, Hayes RB, Traver RD, Hoener B, Campleman S, Li G, Dosemeci M, Linet MS, Zhang L, Xi L, Wacholder S, Lu W, Meyer KB, Titenko-Holland N, Stewart JT, Yin S, Ross D. 1997. Benzene poisoning, a risk factor for hematologic malignancy, is associated with the NQ01 609C->T mutation and rapid fractional excretion of chlorzoxazone. Cancer Res 57(14):2839-2842. PMID:9230185
  • Smith MT, Fanning EW. 1997. Mechanism Based Risk Assessment for Benzene-induced Leukemia. In: Proceedings of the 36th Society of Toxicology (SOT) Annual Meeting, March 9-13, 1997. Cincinnati, OH.
  • Smith MT, Fanning EW. 1997. Report on the workshop entitled: modeling chemically-induced leukemia - implications for benzene risk assessment. Leuk Res 21(5):361-374. PMID:9225061
  • Smith MT, Rothman N, Yin S, Zhang L, Dosemeci M, Wang Y, Li G, Hayes RB. 1997. Benzene exposure and risk of MDS/AML. Leuk Res Supp.1:S3.
  • Subrahmanyam VV, Smith MT. 1997. Free radical mediated hematopoietic toxicity by drugs, environmental pollutants and ionizing radiation. In: Free Radical Toxicology. Taylor and Francis, pp.249-278.
  • Xi L, Zhang L, Wang Y, Smith MT. 1997. Induction of chromosome-specific aneuploidy and micronuclei in human lymphocytes by metabolites of 1,3-butadiene. Carcinogenesis 18(9):1687-1693. PMID:9328162
  • Xi L, Zhang L, Wang Y, Smith MT. 1997. Induction of chromosome-specific aneusomy and micronuclei in human lymphocytes by metabolites of 1, 3-butadiene. Chapter 38in: Proceedings of the Eighty Eightieth Annual Meeting of the (AACR) American Association for Cancer Research, 1997.
  • Zhang L, Rothman N, Wang Y, Hayes RB, Li G, Dosemeci M, Yin S, Kolachana P, Titenko-Holland N, Smith MT. 1997. Benzene exposure is associated with increased aneusomy and long arm deletion of chromosomes 5 and 7 in Chinese workers. Chapter 38in: Proceedings of the Eighty Eightieth Annual Meeting of the (AACR) American Association for Cancer Research, 1997. pp.628.

1996

  • Bois FY, Jackson ET, Pekari K, Smith MT. 1996. Population toxicokinetics of benzene. Environ Health Perspect 104(Suppl.6):1405-1411. PMID:9118927
  • Buffler PA, Reynolds P, Smith MT, Lea C, Wood S. 1996. The molecular epidemiology of childhood leukemia with emphasis on chemical exposures. In: Proceedings of the Pacific Basin Conference on Hazardous Waste, November 4-8, 1996, Kuala Lumpur, Malaysia. East-West Center, Kuala Lumpur, Malaysia.
  • Moore LE, Smith AH, Hopenhayn-Rich C, Biggs ML, Warner M, Kalman DA, Smith MT. 1996. Increased micronuclei found in two populations environmentally exposed to arsenic. Clin Chem 41(12):1915-1917.
  • Moore LE, Warner M, Smith AH, Kalman DA, Smith MT. 1996. Use of the fluorescent micronucleus assay to detect the clastogenic effects of radiation and arsenic in human exfoliated epithelial cells. Environ Mol Mutagen 27:176-184. PMID:8625953
  • Rothman N, Li G, Dosemeci M, Bechtold WE, Marti GE, Wang Y, Linet MS, Xi L, Lu W, Smith MT, Titenko-Holland N, Zhang L, Blot W, Yin S, Hayes RB. 1996. Hematotoxicity among Chinese workers heavily exposed to benzene. Am J Ind Med 29:236-246. PMID:8833776
  • Rothman N, Smith MT, Hayes RB, Li G, Irons RD, Dosemeci M, Haas R, Stillman WS, Linet MS, Xi L, Bechtold WE, Wiemels JL, Campleman S, Zhang L, Quintana PJ, Titenko-Holland N, Wang Y, Lu W, Kolachana P, Meyer KB, Yin S. 1996. An epidemiologic study of early biologic effects of benzene in Chinese workers. Environ Health Perspect 104(6):1365-1370. PMID:9118921
  • Rothman N, Traver RD, Smith MT, Hayes RB, Li G, Campleman S, Dosemeci M, Zhang L, Linet MS, Wacholder S, Yin S, Ross D. 1996. Lack of NAD(P)H:quinone oxidoreductase activity (NQ01) is associated with increased risk of benzene hematotoxicity. Chapter 37in: Proceedings of the Eighty Seventh Annual Meeting of the (AACR) American Association of Cancer Research, 1996. pp.258.
  • Shao J, Zhang L, Semenza JC, Beach B, Smith MT. 1996. Tetrasomy 8 detected by interphase cytogenetics in a child with acute lymphocytic leukemia. Cancer Genet Cytogenet 92:135-140. PMID:8976370
  • Smith MT. 1996. Mechanistic studies of benzene toxicity: implications for risk assessment. In: Biological Reactive Intermediates V: Basic Mechanistic Research in Toxicology and Human Risk Assessment. Plenum Publishing, New York, NY. pp.259-266.
  • Smith MT. 1996. Overview of benzene-induced aplastic anaemia. Eur J Haematol 60:107-110. PMID:8987251
  • Smith MT. 1996. The mechanism of benzene-induced leukemia: a hypothesis and speculations on the causes of leukemia. Environ Health Perspect 104(6):1219-1225. PMID:9118896
  • Smith MT, Rothman N. 1996. Diet and risk of human leukemia. In: Proceedings of the Meeting on Modulation of Chemical Toxicity and Risk Assessment. Tucson, AZ.
  • Smith MT, Rothman N, Zhang L, Wang Y, Hayes RB, Yin S. 1996. Molecular cytogenetics of humans exposed to benzene. Environ Health Perspect 30(1,part2):911.
  • Smith MT, Zhang L, Wang Y, Li G, Hayes RB, Kolachana P, Dosemeci M, Titenko-Holland N, Xi L, Yin S, Rothman N. 1996. Translocations between chromosome 8 and 21 in workers exposed to benzene. In: Proceedings of the Eighty Seventh Annual Meeting of the (AACR) American Association of Cancer Research, 1996.
  • Traver RD, Rothman N, Smith MT, Yin S, Hayes RB, Li G, Franklin WF, Ross D. 1996. Incidence of a polymorphism in HAD(P)H: Quinone Oxidoreductase (NQO1). Chapter 37in: Proceedings of the Eighty Seventh Annual Meeting of the (AACR) American Association of Cancer Research, 1996. pp.278.
  • Zhang L, Rothman N, Wang Y, Hayes RB, Bechtold WE, Venkatesh P, Yin S, Wang Y, Dosemeci M, Li G, Lu W, Smith MT. 1996. Interphase cytogenetics of workers exposed to benzene. Environ Health Perspect 104Suppl6:1325-1329. PMID:9118914 PMCID:PMC1469718

1995

  • Rothman N, Campleman S, Hayes RB, Hoener B, Yin S, Dosemeci M, Meyer KB, Li G, Zhang L, Smith MT. 1995. High CYP2E1 activity is a risk factor for benzene poisoning. Chapter 36in: Proceedings of the Eighty Sixth Annual Meeting of the (AACR) American Association of Cancer Research, March, 1995. Ontario, Canada. pp.282.
  • Rothman N, Haas R, Hayes RB, Li G, Wiemels JL, Campleman S, Quintana PJ, Xi L, Dosemeci M, Titenko-Holland N, Meyer KB, Lu W, Zhang L, Bechtold WE, Wang Y, Kolachana P, Yin S, Blot W, Smith MT. 1995. Benzene induces gene-duplicating but not gene-inactivating mutations at the glycophorin A locus in exposed humans. Proc Natl Acad Sci U S A 92(9):4069-4073. PMID:7732033
  • Salmon AG, Kizer KW, Zeise L, Jackson RJ, Smith MT. 1995. Potential carcinogenicity of chloral hydrate - a review. Journal of Toxicology and Clinical Toxicology 33(2):115-121. PMID:7897749
  • Smith MT, Lea C, Buffler PA. 1995. Human population changes caused by hazardous waste. Eur J Public Health 2(3):77-79. PMID:7655408
  • Titenko-Holland N, Turteltaub KW, Wyrobek AJ, Smith MT. 1995. Acrylamide induces DNA adducts in male germ cells and causes preimplantation abnormalities and dominant lethal mutations in mice. Environ Health Perspect 15(1):167.
  • Xi L, Zhang L, Smith MT. 1995. Butadiene metabolites induce micronuclei and aneuploidy in human lymphocytes. In: Proceedings of the International symposium on evaluation of butadiene & isoprene health risks. Blaine, WA.
  • Zhang L, Rothman N, Wang Y, Hayes RB, Yin S, Li G, Smith MT. 1995. Aneuploidy of chromosomes 7, 8 and 9 detected by fluorescence in situ hybridization in workers exposed to benzene. Chapter 36in: Proceedings of the Eighty Sixth Annual Meeting of the (AACR) American Association of Cancer Research, March, 1995. Ontario, Canada. pp.112.
  • Zhang L, Smith MT, Bandy B, Tamaki SJ, Davison AJ. 1995. Role of quinones, active oxygen species and metals in the genotoxicity of 1,2,4-benzenetriol, a metabolite of benzene. In: Free radicals in the Environment, and Toxicology. Richelieu Press, London, United Kingdom. pp.521-562.
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