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Final Progress Reports: University of Iowa: Research Support Core: Analytical Core

Superfund Research Program

Research Support Core: Analytical Core

Project Leader: Keri C. Hornbuckle
Co-Investigator: Hans-Joachim Lehmler
Grant Number: P42ES013661
Funding Period: 2006-2025
View this project in the NIH Research Portfolio Online Reporting Tools (RePORT)

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Final Progress Reports

Year:   2019  2014  2009 

The Analytical Core provides both routine and original customized analytical services to support the Iowa Superfund Research Program Center. These services include project management, personnel training, and expert personnel along with equipment, supplies, analytical standards, and instrumentation for the analysis of polychlorinated biphenyls (PCBs) and related compounds in laboratory-generated and environmental samples.

In 2019, Analytical Core researchers developed and implemented 14 priority analysis plans for use of Analytical Core facilities and personnel including a rigorous quality assurance plan for each project to assure accuracy, precision, representativeness, reproducibility, and comparability. Routine analyses included the entire suite of 209 PCBs and 72 commercially available OH-PCBs as MeO-PCBs. In collaboration with the Synthesis Core, the Analytical Core expanded the suite of OH-PCBs by adding 52 standards (as MeO-PCBs), which will allow for quantification of 124 OH-PCBs in complex environmental and biological matrixes. In 2019, the Analytical Core supported method development for measurement of PCBs in food, detection of PCB sulfate metabolites in human serum, PCBs and PCB metabolites in human brain tissue, and PCBs in modern construction materials. The Analytical Core trained and hosted undergraduate students, graduate students, post-docs, and research staff from the Colleges of Engineering, Public Health, and Pharmacy in extraction and analysis of PCBs and PCB breakdown products in air, sediment, human serum, and plant tissue, human tissue, and animal tissue. The Analytical Core contributed to 11 research papers, six data sets published or in progress, and 22 presentations in 2019 concerning the sources, exposure, remediation, metabolism, and toxicity of PCB congeners and their transformation products.

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