Skip Navigation

Project Publications: University of Iowa: Research Support Core: Analytical Core

Superfund Research Program

Research Support Core: Analytical Core

Project Leader: Keri C. Hornbuckle
Co-Investigator: Hans-Joachim Lehmler
Grant Number: P42ES013661
Funding Period: 2006-2025
View this project in the NIH Research Portfolio Online Reporting Tools (RePORT)

Project-Specific Links

Connect with the Grant Recipients

Visit the grantee's eNewsletter page Visit the grantee's eNewsletter page Visit the grantee's Twitter page



  • Bako CM, Martinez A, Marek RF, Hornbuckle KC, Schnoor JL, Mattes TE. 2023. Lab-scale biodegradation assay using passive samplers to determine microorganisms' ability to reduce polychlorinated biphenyl (PCB) volatilization from contaminated sediment. MethodsX 10:102039. doi:10.1016/j.mex.2023.102039 PMID:36798837 PMCID:PMC9926300
  • Bannavti MK, Marek RF, Just CL, Hornbuckle KC. 2023. Congener-specific emissions from floors and walls characterize indoor airborne polychlorinated biphenyls. Environ Sci Technol 10(9):762-767. doi:10.1021/acs.estlett.3c00360 PMID:37719204 PMCID:PMC10501191
  • Bullert AJ, Li X, Chunyun Z, Lee K, Pulliam CF, Cagle B, Doorn JA, Klingelhutz AJ, Robertson LW, Lehmler H. 2023. Disposition and metabolomic effects of 2,2',5,5'-tetrachlorobiphenyl in female rats following intraperitoneal exposure. Environ Toxicol Pharmacol 102:104245. doi:10.1016/j.etap.2023.104245 PMID:37572994
  • Hua J, Marek RF, Hornbuckle KC. 2023. Polyurethane foam emission samplers to identify sources of airborne polychlorinated biphenyls from glass-block windows and other room surfaces in a Vermont school. Environ Sci Technol 57(38):14310-14318. doi:10.1021/acs.est.3c05195 PMID:37713326 PMCID:PMC10537452
  • Mouat JS, Li X, Neier K, Zhu Y, Mordaunt CE, La Merrill MA, Lehmler H, Jones MP, Lein PJ, Schmidt RJ, LaSalle J. 2023. Networks of placental DNA methylation correlate with maternal serum PCB concentrations and child neurodevelopment. Environ Res 220:115227. doi:10.1016/j.envres.2023.115227 PMID:36608759
  • Zhang C, Li X, Stietz KP, Sethi S, Yang W, Marek RF, Ding X, Lein PJ, Hornbuckle KC, Lehmler H. 2023. Rebuttal to correspondence on "machine learning-assisted identification and quantification of hydroxylated metabolites of polychlorinated biphenyls in animal samples". Environ Sci Technol 57(15):6251-6252. doi:10.1021/acs.est.3c01659 PMID:37017328


  • Bako CM, Martinez A, Ewald JM, Hua J, Ramotowski DJ, Dong Q, Schnoor JL, Mattes TE. 2022. Aerobic bioaugmentation to decrease polychlorinated biphenyl (PCB) emissions from contaminated sediments to air. Environ Sci Technol 56(20):14338-14349. doi:10.1021/acs.est.2c01043 PMID:36178372 PMCID:PMC9583607
  • Li X, Hefti MM, Marek RF, Hornbuckle KC, Wang K, Lehmler H. 2022. Assessment of polychlorinated biphenyls and their hydroxylated metabolites in postmortem human brain samples: Age and brain region differences. Environ Sci Technol 56(13):9515-9526. doi:10.1021/acs.est.2c00581 PMID:35658127 PMCID:PMC9260965
  • Li X, Lim JJ, Wang K, Prasad B, Bhatt D, Cui JY, Lehmler H. 2022. The disposition of polychlorinated biphenyls (PCBs) differs between germ-free and conventional mice. Environ Toxicol Pharmacol 92:103854. doi:10.1016/j.etap.2022.103854 PMID:35331926 PMCID:PMC9090986
  • Martinez A, Awad AM, Jones MP, Hornbuckle KC. 2022. Intracity occurrence and distribution of airborne PCB congeners in Chicago. Sci Total Environ 812:doi:10.1016/j.scitotenv.2021.151505 PMID:34762940 PMCID:PMC8810667
  • Martinez A, Hua J, Haque E, Hornbuckle KC, Thorne PS. 2022. Occurrence and spatial distribution of individual polychlorinated biphenyl congeners in residential soils from East Chicago, southwest Lake Michigan. Sci Total Environ 850:157705. doi:10.1016/j.scitotenv.2022.157705 PMID:35931157
  • Saktrakulkla P, Li X, Martinez A, Lehmler H, Hornbuckle KC. 2022. Hydroxylated polychlorinated biphenyls are emerging legacy pollutants in contaminated sediments. Environ Sci Technol 56:2269-2278. doi:10.1021/acs.est.1c04780 PMID:35107261 PMCID:PMC8851693
  • Wang H, Adamcakova-Dodd A, Lehmler H, Hornbuckle KC, Thorne PS. 2022. Toxicity assessment of 91-day repeated inhalation exposure to an indoor school air mixture of PCBs. Environ Sci Technol doi:10.1021/acs.est.1c05084 PMID:34994547
  • Zhang C, Li X, Flor S, Ruiz P, Kruve A, Ludewig G, Lehmler H. 2022. Metabolism of 3-chlorobiphenyl (PCB 2) in a human-relevant cell line: evidence of dechlorinated metabolites. Environ Sci Technol 56(17):12460-12472. doi:10.1021/acs.est.2c03687 PMID:35994059 PMCID:PMC9573771
  • Zhang C, Li X, Stietz KP, Sethi S, Yang W, Marek RF, Ding X, Lein PJ, Hornbuckle KC, Joachim-Lehmler H. 2022. Machine learning-assisted identification and quantification of hydroxylated metabolites of polychlorinated biphenyls in animal samples. Environ Sci Technol 56(18):13169-13178. doi:10.1021/acs.est.2c02027 PMID:36047920
  • Zhang D, Saktrakulkla P, Marek RF, Lehmler H, Wang K, Thorne PS, Hornbuckle KC, Duffel MW. 2022. PCB sulfates in serum from mothers and children in urban and rural US communities. Environ Sci Technol doi:10.1021/acs.est.2c00223 PMID:35500099 PMCID:PMC9118556



  • Heiger-Bernays WJ, Tomsho KS, Basra K, Petropoulos ZE, Crawford KA, Martinez A, Hornbuckle KC, Scammell MK. 2020. Human health risks due to airborne polychlorinated biphenyls are highest in New Bedford Harbor communities living closest to the harbor. Sci Total Environ 710:doi:10.1016/j.scitotenv.2019.135576 PMID:31785914 PMCID:PMC7015809
  • Li X, Zhang C, Wang K, Lehmler H. 2020. Fatty liver and impaired hepatic metabolism alter the congener-specific distribution of polychlorinated biphenyls (PCBs) in mice with a liver-specific deletion of cytochrome P450 reductase. Environ Pollut 266:115233. doi:10.1016/j.envpol.2020.115233 PMID:32712482 PMCID:PMC7492420
  • Lim JJ, Li X, Lehmler H, Wang D, Gu H, Cui JY. 2020. Gut microbiome critically impacts PCB-induced changes in metabolic fingerprints and the hepatic transcriptome in mice. Toxicol Sci 177:168-187. doi:10.1093/toxsci/kfaa090 PMID:32544245 PMCID:PMC7553702
  • Qian J, Martinez A, Marek RF, Nagorzanski MR, Zhi H, Furlong ET, Kolpin DW, LeFevre G, Cwiertny DM. 2020. Polymeric nanofiber-carbon nanotube composite mats as fast-equilibrium passive samplers for polar organic contaminants. Environ Sci Technol 54:6703-6712. doi:10.1021/acs.est.0c00609 PMID:32343558 PMCID:PMC7665838
  • Saktrakulkla P, Lan T, Hua J, Marek RF, Thorne PS, Hornbuckle KC. 2020. Polychlorinated biphenyls in food. Environ Sci Technol 54:11443-11452. doi:10.1021/acs.est.0c03632 PMID:32816464 PMCID:PMC7759298
  • Wang H, Adamcakova-Dodd A, Flor S, Gosse L, Klenov V, Stolwijk J, Lehmler H, Hornbuckle KC, Ludewig G, Thorne PS. 2020. Comprehensive subchronic inhalation toxicity assessment of an indoor school air mixture of PCBs. Environ Sci Technol 54:15976-15985. doi:10.1021/acs.est.0c04470 PMID:33256405 PMCID:PMC7879961
  • Zhang C, Flor S, Ludewig G, Lehmler H. 2020. Atropselective partitioning of polychlorinated biphenyls in a HepG2 cell culture system: Experimental and modeling results. Environ Sci Technol 54:13817-13827. doi:10.1021/acs.est.0c02508 PMID:33059451 PMCID:PMC7642102
  • Zhang C, Flor S, Ruiz P, Dhakal RC, Hu X, Teesch LM, Ludewig G, Lehmler H. 2020. 3,3'-dichlorobiphenyl is metabolized to a complex mixture of oxidative metabolites, including novel methoxylated metabolites, by HepG2 cells. Environ Sci Technol 54:12345-12357. doi:10.1021/acs.est.0c03476 PMID:32910851 PMCID:PMC7544623




  • Grimm FA, Lehmler H, Koh W, DeWall J, Teesch LM, Hornbuckle KC, Thorne PS, Robertson LW, Duffel MW. 2017. Identification of a sulfate metabolite of PCB 11 in human serum. Environ Int 98:120-128. doi:10.1016/j.envint.2016.10.023 PMID:27816204 PMCID:PMC5127762
  • Kania-Korwel I, Lukasiewicz T, Barnhart CD, Stamou M, Chung H, Kelly KM, Bandiera SM, Lein PJ, Lehmler H. 2017. Congener-specific disposition of chiral polychlorinated biphenyls in lactating mice and their offspring: Implications for PCB developmental neurotoxicity. Toxicol Sci 158(1):101-115. doi:10.1093/toxsci/kfx071 PMID:28431184 PMCID:PMC6070089
  • Marek RF, Thorne PS, Herkert N, Awad AM, Hornbuckle KC. 2017. Airborne PCBs and OH-PCBs inside and outside urban and rural U.S. schools. Environ Sci Technol 51(14):7853-7860. doi:10.1021/acs.est.7b01910 PMID:28656752 PMCID:PMC5777175
  • Martinez A, Hadnott BN, Awad AM, Herkert N, Tomsho KS, Basra K, Scammell MK, Heiger-Bernays WJ, Hornbuckle KC. 2017. Release of airborne polychlorinated biphenyls from New Bedford Harbor results in elevated concentrations in the surrounding air. Environ Sci Technol Lett 4(4):127-131. doi:10.1021/acs.estlett.7b00047 PMID:28413805 PMCID:PMC5390305
  • Uwimana E, Maiers A, Li X, Lehmler H. 2017. Microsomal metabolism of prochiral polychlorinated biphenyls results in the enantioselective formation of chiral metabolites. Environ Sci Technol 51(3):1820-1829. doi:10.1021/acs.est.6b05387 PMID:28038482 PMCID:PMC5300040



  • Ampleman MD, Martinez A, DeWall J, Rawn DF, Hornbuckle KC, Thorne PS. 2015. Inhalation and dietary exposure to PCBs in urban and rural cohorts via congener-specific measurements. Environ Sci Technol 49(2):1156-1164. doi:10.1021/es5048039 PMID:25510359 PMCID:PMC4303332
  • Grimm FA, He X, Teesch LM, Lehmler H, Robertson LW, Duffel MW. 2015. Tissue distribution, metabolism, and excretion of 3,3'-dichloro-4'-sulfooxy-biphenyl in the rat. Environ Sci Technol 49(13):8087-8095. doi:10.1021/acs.est.5b01499 PMID:26046945 PMCID:PMC4496304
  • Grimm FA, Hu D, Kania-Korwel I, Lehmler H, Ludewig G, Hornbuckle KC, Duffel MW, Bergman A, Robertson LW. 2015. Metabolism and metabolites of polychlorinated biphenyls. Crit Rev Toxicol 45(3):245-272. doi:10.3109/10408444.2014.999365 PMID:25629923 PMCID:PMC4383295
  • Hu X, Adamcakova-Dodd A, Lehmler H, Gibson-Corley KN, Thorne PS. 2015. Toxicity evaluation of exposure to an atmospheric mixture of polychlorinated biphenyls by nose-only and whole-body inhalation regimens. Environ Sci Technol 49(19):11875-11883. doi:10.1021/acs.est.5b02865 PMID:26348937 PMCID:PMC4711378
  • Kania-Korwel I, Barnhart CD, Lein PJ, Lehmler H. 2015. Effect of pregnancy on the disposition of 2,2',3,5',6-pentachlorobiphenyl (PCB 95) atropisomers and their hydroxylated metabolites in female mice. Chem Res Toxicol 28(9):1774-1783. doi:10.1021/acs.chemrestox.5b00241 PMID:26271003 PMCID:PMC4579038
  • Koh WX, Hornbuckle KC, Thorne PS. 2015. Human serum from urban and rural adolescents and their mothers shows exposure to polychlorinated biphenyls not found in commercial mixtures. Environ Sci Technol 49(13):8105-8112. doi:10.1021/acs.est.5b01854 PMID:26053216 PMCID:PMC4774248
  • Martinez A, Spak SN, Petrich NT, Hu D, Carmichael G, Hornbuckle KC. 2015. Atmospheric dispersion of PCB from a contaminated Lake Michigan harbor. Atmos Environ (1994) 122:791-798. doi:10.1016/j.atmosenv.2015.10.040 PMID:26594127 PMCID:PMC4649934
  • Peverly A, Ma Y, Vinier M, Rodenburg ZL, Spak SN, Hornbuckle KC, Hites RA. 2015. Variations of flame retardant, polycyclic aromatic hydrocarbon, and pesticide concentrations in Chicago's atmosphere measured using passive sampling. Environ Sci Technol 49(9):5371-5379. doi:10.1021/acs.est.5b00216 PMID:25874663
  • Peverly A, O'Sullivan C, Liu L, Venier M, Martinez A, Hornbuckle KC, Hites RA. 2015. Chicago's sanitary and ship canal sediment: polycyclic aromatic hydrocarbons, polychlorinated biphenyls, brominated flame retardants, and organophosphate esters. Chemosphere 134:380-386. doi:10.1016/j.chemosphere.2015.04.065 PMID:25981316
  • Shanahan CE, Spak SN, Martinez A, Hornbuckle KC. 2015. Inventory of PCBs in Chicago and opportunities for reduction in airborne emissions and human exposure. Environ Sci Technol 49(23):13878-13888. doi:10.1021/acs.est.5b00906 PMID:26440379
  • Stamou M, Uwimana E, Flannery BM, Kania-Korwel I, Lehmler H, Lein PJ. 2015. Subacute nicotine co-exposure has no effect on 2,2',3,5',6- pentachlorobiphenyl disposition but alters hepatic cytochrome P450 expression in the male rat. Toxicology 338:59-68. doi:10.1016/j.tox.2015.10.002 PMID:26463278 PMCID:PMC4658283
  • Wu X, Barnhart CD, Lein PJ, Lehmler H. 2015. Hepatic metabolism affects the atropselective disposition of 2,2',3,3',6,6'-hexachlorobiphenyl (PCB 136) in mice. Environ Sci Technol 49(1):616-625. doi:10.1021/es504766p PMID:25420130 PMCID:PMC4291784


  • Aqil F, Shen H, Jeyabalan J, Xin X, Lehmler H, Ludewig G, Robertson LW, Gupta RC. 2014. Sustained expression of CYPs and DNA adduct accumulation with continuous exposure to PCB126 and PCB153 through a new delivery method: Polymeric implants. Toxicol Rep 1:820-833. doi:10.1016/j.toxrep.2014.09.010 PMID:25530946 PMCID:PMC4266188
  • Dhakal K, Uwimana E, Adamcakova-Dodd A, Thorne PS, Lehmler H, Robertson LW. 2014. Disposition of phenolic and sulfated metabolites after inhalation exposure to 4-chlorobiphenyl (PCB3) in female rats. Chem Res Toxicol 27(8):1411-1420. doi:10.1021/tx500150h PMID:24988477 PMCID:PMC4137987
  • Ekuase EJ, Lehmler H, Robertson LW, Duffel MW. 2014. Binding interactions of hydroxylated polychlorinated biphenyls (OHPCBs) with human hydroxysteroid sulfotransferase hSULT2A1. Chem Biol Interact 212:56-64. doi:10.1016/j.cbi.2014.01.018 PMID:24508592 PMCID:PMC3994546
  • Hu X, Adamcakova-Dodd A, Thorne PS. 2014. The fate of inhaled (14)C-labeled PCB11 and its metabolites in vivo. Environ Int 63:92-100. doi:10.1016/j.envint.2013.10.017 PMID:24275706 PMCID:PMC3950335
  • Liang Y, Martinez A, Hornbuckle KC, Mattes TE. 2014. Potential for polychlorinated biphenyl biodegradation in sediments from Indiana Harbor and Ship Canal. Int Biodeterior Biodegradation 89:50-57. doi:10.1016/j.ibiod.2014.01.005 PMID:24764649 PMCID:PMC3993986
  • Marek RF, Thorne PS, DeWall J, Hornbuckle KC. 2014. Variability in PCB and OH-PCB serum levels in children and their mothers in urban and rural US communities. Environ Sci Technol 48(22):13459-13467. doi:10.1021/es502490w PMID:25300024 PMCID:PMC4238695
  • Salman KN, Stuart MA, Schmidt J, Borges T, McClain CJ, Robinson FR, Li M, Robertson LW. 2014. The effects of 3,3',4,4'-tetrabromobiphenyl on rats fed diets containing a constant level of copper and varying levels of molybdenum. Environ Sci Pollut Res Int 21(10):6400-6409. doi:10.1007/s11356-013-1638-5 PMID:23532536 PMCID:PMC3732555
  • Stamou M, Wu X, Kania-Korwel I, Lehmler H, Lein PJ. 2014. Cytochrome p450 mRNA expression in the rodent brain: species-, sex-, and region-dependent differences. Drug Metab Dispos 42(2):239-244. doi:10.1124/dmd.113.054239 PMID:24255117 PMCID:PMC3912540
  • Wu X, Kammerer A, Lehmler H. 2014. Microsomal oxidation of 2,2',3,3',6,6'-hexachlorobiphenyl (PCB 136) results in species-dependent chiral signatures of the hydroxylated metabolites. Environ Sci Technol 48(4):2436-2444. doi:10.1021/es405433t PMID:24467194 PMCID:PMC3983324
  • Yang DR, Kania-Korwel I, Ghogha A, Chen H, Stamou M, Bose DD, Pessah IN, Lehmler H, Lein PJ. 2014. PCB 136 atropselectively alters morphometric and functional parameters of neuronal connectivity in cultured rat hippocampal neurons via ryanodine receptor-dependent mechanisms. Toxicol Sci 138(2):379-392. doi:10.1093/toxsci/kft334 PMID:24385416 PMCID:PMC4007107
  • Zhai G, Lehmler H, Schnoor JL, Gutowski SM. 2014. Enantioselective transport and biotransformation of chiral hydroxylated metabolites of polychlorinated biphenyls in whole poplar plants. Environ Sci Technol 48(20):12213-12220. doi:10.1021/es503443e PMID:25238141 PMCID:PMC4207536


  • Hu X, Lehmler H, Adamcakova-Dodd A, Thorne PS. 2013. Elimination of inhaled 3,3'-dichlorobiphenyl and the formation of the 4-hydroxylated metabolite. Environ Sci Technol 47(9):4743-4751. doi:10.1021/es3049114 PMID:23582014 PMCID:PMC3962796
  • Marek RF, Martinez A, Hornbuckle KC. 2013. Discovery of hydroxylated polychlorinated biphenyls (OH-PCBs) in sediment from a Lake Michigan waterway and original commercial aroclors. Environ Sci Technol 47(15):8204–8210. doi:10.1021/es402323c PMID:23862721 PMCID:PMC3781593
  • Marek RF, Thorne PS, Wang K, DeWall J, Hornbuckle KC. 2013. PCBs and OH-PCBs in serum from children and mothers in urban and rural U.S. communities. Environ Sci Technol 47(7):3353-3361. doi:10.1021/es304455k PMID:23452180 PMCID:PMC3645264
  • Martinez A, O'Sullivan C, Reible DD, Hornbuckle KC. 2013. Sediment pore water distribution coefficients of PCB congeners in enriched black carbon sediment. Environ Pollut 182:357-363. doi:10.1016/j.envpol.2013.07.015 PMID:23974165 PMCID:PMC3833079
  • Petrich NT, Spak SN, Carmichael G, Hu D, Martinez A, Hornbuckle KC. 2013. Simulating and explaining passive air sampling rates for semivolatile compounds on polyurethane foam passive samplers. Environ Sci Technol 47(15):8591–8598. doi:10.1021/es401532q PMID:23837599 PMCID:PMC3764502
  • Rignall B, Grote K, Gavrilov A, Weimer M, Kopp-Schneider A, Krause E, Appel KE, Buchmann A, Robertson LW, Lehmler H, Kania-Korwel I, Chahoud I, Schwarz M. 2013. Biological and tumor-promoting effects of dioxin-like and non-dioxin-like polychlorinated biphenyls in mouse liver after single or combined treatment. Toxicol Sci 133(1):29-41. doi:10.1093/toxsci/kft034 PMID:23457121 PMCID:PMC3627557
  • Yucuis RA, Stanier CO, Hornbuckle KC. 2013. Cyclic siloxanes in air, including identification of high levels in Chicago and distinct diurnal variation. Chemosphere 92(8):905-910. doi:10.1016/j.chemosphere.2013.02.051 PMID:23541357 PMCID:PMC3975597
  • Zhai G, Wu X, Lehmler H, Schnoor JL. 2013. Atropisomeric determination of chiral hydroxylated metabolites of polychlorinated biphenyls using HPLC-MS. Chem Cent J 7(1):183. doi:10.1186/1752-153X-7-183 PMID:24360245 PMCID:PMC3879188
  • Zhu Y, Mapuskar KA, Marek RF, Xu W, Lehmler H, Robertson LW, Hornbuckle KC, Spitz DR, Aykin-Burns N. 2013. A new player in environmentally induced oxidative stress: polychlorinated biphenyl congener, 3,3'-dichlorobiphenyl (PCB11). Toxicol Sci 136(1):39-50. doi:10.1093/toxsci/kft186 PMID:23997111 PMCID:PMC3829572




to Top