Superfund Research Program

Research Support Core: Analytical Core

Project Leader: Keri C. Hornbuckle
Co-Investigator: Hans-Joachim Lehmler
Grant Number: P42ES013661
Funding Period: 2006-2025

Project-Specific Links

Publications

2023

• Bako CM, Martinez A, Marek RF, Hornbuckle KC, Schnoor JL, Mattes TE. 2023. Lab-scale biodegradation assay using passive samplers to determine microorganisms' ability to reduce polychlorinated biphenyl (PCB) volatilization from contaminated sediment. MethodsX 10:102039. doi:10.1016/j.mex.2023.102039 PMID:36798837 PMCID:PMC9926300
• Bannavti MK, Marek RF, Just CL, Hornbuckle KC. 2023. Congener-specific emissions from floors and walls characterize indoor airborne polychlorinated biphenyls. Environ Sci Technol 10(9):762-767. doi:10.1021/acs.estlett.3c00360 PMID:37719204 PMCID:PMC10501191
• Bullert AJ, Li X, Chunyun Z, Lee K, Pulliam CF, Cagle B, Doorn JA, Klingelhutz AJ, Robertson LW, Lehmler H. 2023. Disposition and metabolomic effects of 2,2',5,5'-tetrachlorobiphenyl in female rats following intraperitoneal exposure. Environ Toxicol Pharmacol 102:104245. doi:10.1016/j.etap.2023.104245 PMID:37572994
• Hua J, Marek RF, Hornbuckle KC. 2023. Polyurethane foam emission samplers to identify sources of airborne polychlorinated biphenyls from glass-block windows and other room surfaces in a Vermont school. Environ Sci Technol 57(38):14310-14318. doi:10.1021/acs.est.3c05195 PMID:37713326 PMCID:PMC10537452
• Mouat JS, Li X, Neier K, Zhu Y, Mordaunt CE, La Merrill MA, Lehmler H, Jones MP, Lein PJ, Schmidt RJ, LaSalle J. 2023. Networks of placental DNA methylation correlate with maternal serum PCB concentrations and child neurodevelopment. Environ Res 220:115227. doi:10.1016/j.envres.2023.115227 PMID:36608759
• Zhang C, Li X, Stietz KP, Sethi S, Yang W, Marek RF, Ding X, Lein PJ, Hornbuckle KC, Lehmler H. 2023. Rebuttal to correspondence on "machine learning-assisted identification and quantification of hydroxylated metabolites of polychlorinated biphenyls in animal samples". Environ Sci Technol 57(15):6251-6252. doi:10.1021/acs.est.3c01659 PMID:37017328

2022

• Bako CM, Martinez A, Ewald JM, Hua J, Ramotowski DJ, Dong Q, Schnoor JL, Mattes TE. 2022. Aerobic bioaugmentation to decrease polychlorinated biphenyl (PCB) emissions from contaminated sediments to air. Environ Sci Technol 56(20):14338-14349. doi:10.1021/acs.est.2c01043 PMID:36178372 PMCID:PMC9583607
• Li X, Hefti MM, Marek RF, Hornbuckle KC, Wang K, Lehmler H. 2022. Assessment of polychlorinated biphenyls and their hydroxylated metabolites in postmortem human brain samples: Age and brain region differences. Environ Sci Technol 56(13):9515-9526. doi:10.1021/acs.est.2c00581 PMID:35658127 PMCID:PMC9260965
• Li X, Lim JJ, Wang K, Prasad B, Bhatt D, Cui JY, Lehmler H. 2022. The disposition of polychlorinated biphenyls (PCBs) differs between germ-free and conventional mice. Environ Toxicol Pharmacol 92:103854. doi:10.1016/j.etap.2022.103854 PMID:35331926 PMCID:PMC9090986
• Martinez A, Awad AM, Jones MP, Hornbuckle KC. 2022. Intracity occurrence and distribution of airborne PCB congeners in Chicago. Sci Total Environ 812:doi:10.1016/j.scitotenv.2021.151505 PMID:34762940 PMCID:PMC8810667
• Martinez A, Hua J, Haque E, Hornbuckle KC, Thorne PS. 2022. Occurrence and spatial distribution of individual polychlorinated biphenyl congeners in residential soils from East Chicago, southwest Lake Michigan. Sci Total Environ 850:157705. doi:10.1016/j.scitotenv.2022.157705 PMID:35931157
• Saktrakulkla P, Li X, Martinez A, Lehmler H, Hornbuckle KC. 2022. Hydroxylated polychlorinated biphenyls are emerging legacy pollutants in contaminated sediments. Environ Sci Technol 56:2269-2278. doi:10.1021/acs.est.1c04780 PMID:35107261 PMCID:PMC8851693
• Wang H, Adamcakova-Dodd A, Lehmler H, Hornbuckle KC, Thorne PS. 2022. Toxicity assessment of 91-day repeated inhalation exposure to an indoor school air mixture of PCBs. Environ Sci Technol doi:10.1021/acs.est.1c05084 PMID:34994547
• Zhang C, Li X, Flor S, Ruiz P, Kruve A, Ludewig G, Lehmler H. 2022. Metabolism of 3-chlorobiphenyl (PCB 2) in a human-relevant cell line: evidence of dechlorinated metabolites. Environ Sci Technol 56(17):12460-12472. doi:10.1021/acs.est.2c03687 PMID:35994059 PMCID:PMC9573771
• Zhang C, Li X, Stietz KP, Sethi S, Yang W, Marek RF, Ding X, Lein PJ, Hornbuckle KC, Joachim-Lehmler H. 2022. Machine learning-assisted identification and quantification of hydroxylated metabolites of polychlorinated biphenyls in animal samples. Environ Sci Technol 56(18):13169-13178. doi:10.1021/acs.est.2c02027 PMID:36047920
• Zhang D, Saktrakulkla P, Marek RF, Lehmler H, Wang K, Thorne PS, Hornbuckle KC, Duffel MW. 2022. PCB sulfates in serum from mothers and children in urban and rural US communities. Environ Sci Technol doi:10.1021/acs.est.2c00223 PMID:35500099 PMCID:PMC9118556

2021

• Bako CM, Mattes TE, Marek RF, Hornbuckle KC, Schnoor JL. 2021. Biodegradation of PCB congeners by Paraburkholderia xenovorans LB400 in presence and absence of sediment during lab bioreactor experiments. Environ Pollut 271:116364. doi:10.1016/j.envpol.2020.116364 PMID:33412450 PMCID:PMC818316
• Bako CM, Mattes TE, Marek RF, Hornbuckle KC, Schnoor JL. 2021. Dataset describing biodegradation of individual polychlorinated biphenyl congeners (PCBs) by Paraburkholderia xenovorans LB400 in presence and absence of sediment slurry. Data Brief 35:106821. doi:10.1016/j.dib.2021.106821 PMID:33604434 PMCID:PMC7873373
• Bannavti MK, Jahnke JC, Marek RF, Just CL, Hornbuckle KC. 2021. Room-to-room variability of airborne polychlorinated biphenyls in schools and the application of air sampling for targeted source evaluation. Environ Sci Technol 55(14):9460-9468. doi:10.1021/acs.est.0c08149 PMID:34033460 PMCID:PMC8427462
• Li Y, Bako CM, Saktrakulkla P, Lehmler H, Hornbuckle KC, Schnoor JL. 2021. Interconversion between methoxylated, hydroxylated and sulfated metabolites of PCB 3 in whole poplar plants. Sci Total Environ 785:147341. doi:10.1016/j.scitotenv.2021.147341 PMID:33933776 PMCID:PMC8610232
• McCarthy RA, Gupta AS. 2021. Employing and interpreting a machine learning target-cognizant technique for analysis of unknown signals in multiple reaction monitoring. IEEE Access 9:24727-24737. doi:10.1109/access.2021.3056955 PMID:33796430 PMCID:PMC8011560
• Zhang C, Klocke CR, Lein PJ, Lehmler H. 2021. Disposition of PCB 11 in mice following acute oral exposure. Chem Res Toxicol 34:988-991. doi:10.1021/acs.chemrestox.1c00067 PMID:33734669 PMCID:PMC8058299
• Zhang D, Saktrakulkla P, Tuttle K, Marek RF, Lehmler H, Wang K, Hornbuckle KC, Duffel MW. 2021. Detection and quantification of polychlorinated biphenyl sulfates in human serum. Environ Sci Technol 55:2473-2481. doi:10.1021/acs.est.0c06983 PMID:33502843 PMCID:PMC7924310

2020

• Heiger-Bernays WJ, Tomsho KS, Basra K, Petropoulos ZE, Crawford KA, Martinez A, Hornbuckle KC, Scammell MK. 2020. Human health risks due to airborne polychlorinated biphenyls are highest in New Bedford Harbor communities living closest to the harbor. Sci Total Environ 710:doi:10.1016/j.scitotenv.2019.135576 PMID:31785914 PMCID:PMC7015809
• Li X, Zhang C, Wang K, Lehmler H. 2020. Fatty liver and impaired hepatic metabolism alter the congener-specific distribution of polychlorinated biphenyls (PCBs) in mice with a liver-specific deletion of cytochrome P450 reductase. Environ Pollut 266:115233. doi:10.1016/j.envpol.2020.115233 PMID:32712482 PMCID:PMC7492420
• Lim JJ, Li X, Lehmler H, Wang D, Gu H, Cui JY. 2020. Gut microbiome critically impacts PCB-induced changes in metabolic fingerprints and the hepatic transcriptome in mice. Toxicol Sci 177:168-187. doi:10.1093/toxsci/kfaa090 PMID:32544245 PMCID:PMC7553702
• Qian J, Martinez A, Marek RF, Nagorzanski MR, Zhi H, Furlong ET, Kolpin DW, LeFevre G, Cwiertny DM. 2020. Polymeric nanofiber-carbon nanotube composite mats as fast-equilibrium passive samplers for polar organic contaminants. Environ Sci Technol 54:6703-6712. doi:10.1021/acs.est.0c00609 PMID:32343558 PMCID:PMC7665838
• Saktrakulkla P, Lan T, Hua J, Marek RF, Thorne PS, Hornbuckle KC. 2020. Polychlorinated biphenyls in food. Environ Sci Technol 54:11443-11452. doi:10.1021/acs.est.0c03632 PMID:32816464 PMCID:PMC7759298
• Wang H, Adamcakova-Dodd A, Flor S, Gosse L, Klenov V, Stolwijk J, Lehmler H, Hornbuckle KC, Ludewig G, Thorne PS. 2020. Comprehensive subchronic inhalation toxicity assessment of an indoor school air mixture of PCBs. Environ Sci Technol 54:15976-15985. doi:10.1021/acs.est.0c04470 PMID:33256405 PMCID:PMC7879961
• Zhang C, Flor S, Ludewig G, Lehmler H. 2020. Atropselective partitioning of polychlorinated biphenyls in a HepG2 cell culture system: Experimental and modeling results. Environ Sci Technol 54:13817-13827. doi:10.1021/acs.est.0c02508 PMID:33059451 PMCID:PMC7642102
• Zhang C, Flor S, Ruiz P, Dhakal RC, Hu X, Teesch LM, Ludewig G, Lehmler H. 2020. 3,3'-dichlorobiphenyl is metabolized to a complex mixture of oxidative metabolites, including novel methoxylated metabolites, by HepG2 cells. Environ Sci Technol 54:12345-12357. doi:10.1021/acs.est.0c03476 PMID:32910851 PMCID:PMC7544623

2019

• Boesen A, Martinez A, Hornbuckle KC. 2019. Air-water PCB fluxes from southwestern Lake Michigan revisited. Environ Sci Pollut Res Int doi:10.1007/s11356-019-05159-1 PMID:31062242 PMCID:PMC6834886
• Ewald JM, Humes SV, Martinez A, Schnoor JL, Mattes TE. 2019. Growth of dehalococcoides spp. and increased abundance of reductive dehalogenase genes in anaerobic PCB-contaminated sediment microcosms. Environ Sci Pollut Res Int doi:10.1007/s11356-019-05571-7 PMID:31209752 PMCID:PMC6918016
• Jahnke JC, Hornbuckle KC. 2019. PCB Emissions from Paint Colorants. Environ Sci Technol 53-9:5187-5194. doi:10.1021/acs.est.9b01087 PMID:30997998 PMCID:PMC6519452
• Li X, Wu X, Kelly KM, Veng-Pedersen P, Lehmler H. 2019. Toxicokinetics of chiral PCB 136 and its hydroxylated metabolites in mice with a liver-specific deletion of cytochrome P450 reductase. Chem Res Toxicol 32:727-736. doi:10.1021/acs.chemrestox.8b00389 PMID:30729780 PMCID:PMC6465157
• Martinez A, Awad AM, Herkert N, Hornbuckle KC. 2019. Determination of PCB fluxes from Indiana Harbor and Ship Canal using dual-deployed air and water passive samplers. Environ Pollut 244:469-476. doi:10.1016/j.envpol.2018.10.048 PMID:30366294 PMCID:PMC6277018
• Roy MA, Sant KE, Venezia OL, Shipman AB, McCormick SD, Saktrakulkla P, Hornbuckle KC, Timme-Laragy AR. 2019. The emerging contaminant 3,3'-dichlorobiphenyl (PCB-11) impedes Ahr activation and Cyp1a activity to modify embryotoxicity of Ahr ligands in the zebrafish embryo model (Danio rerio). Environ Pollut 254:113027. doi:10.1016/j.envpol.2019.113027 PMID:31421573 PMCID:PMC7027435
• Saktrakulkla P, Dhakal RC, Lehmler H, Hornbuckle KC. 2019. A semi-target analytical method for quantification of OH-PCBs in environmental samples. Environ Sci Pollut Res Int 1-13. doi:10.1007/s11356-019-05775-x PMID:31359319 PMCID:PMC6986979
• Uwimana E, Ruiz P, Li X, Lehmler H. 2019. Human CYP2A6, CYP2B6, and CYP2E1 atropselectively metabolize polychlorinated biphenyls to hydroxylated metabolites. Environ Sci Technol 53(4):2114-2123. doi:10.1021/acs.est.8b05250 PMID:30576102 PMCID:PMC6380921

2018

• Dhakal K, Gadupudi GS, Lehmler H, Ludewig G, Duffel MW, Robertson LW. 2018. Sources and toxicities of phenolic polychlorinated biphenyls (OH-PCBs). Environ Sci Pollut Res Int 25:16277-16290. doi:10.1007/s11356-017-9694-x PMID:28744683 PMCID:PMC5785587
• Herkert N, Hornbuckle KC. 2018. Effects of room airflow on accurate determination of PUF-PAS sampling rates in the indoor environment. Environ Sci Process Impacts 20:757-766. doi:10.1039/c8em00082d PMID:29611590 PMCID:PMC5966328
• Herkert N, Jahnke JC, Hornbuckle KC. 2018. Emissions of tetrachlorobiphenyls (PCBs 47, 51, and 68) from polymer resin on kitchen cabinets as a non-aroclor source to residential air. Environ Sci Technol 52(9):5154-5160. doi:10.1021/acs.est.8b00966 PMID:29667399
• Herkert N, Spak SN, Smith A, Schuster JK, Harner T, Martinez A, Hornbuckle KC. 2018. Calibration and evaluation of PUF-PAS sampling rates across the Global Atmospheric Passive Sampling (GAPS) network. Environ Sci Process Impacts 20(1):210-219. doi:10.1039/c7em00360a PMID:29094747 PMCID:PMC5783774
• Li X, Parkin S, Lehmler H. 2018. Absolute configuration of 2,2',3,3',6-pentachlorinatedbiphenyl (PCB 84) atropisomers. Environ Sci Pollut Res Int 25:16402-16410. doi:10.1007/s11356-017-9259-z PMID:28537024 PMCID:PMC5823790
• Mattes TE, Ewald JM, Liang Y, Martinez A, Awad AM, Richards P, Hornbuckle KC, Schnoor JL. 2018. PCB dechlorination hotspots and reductive dehalogenase genes in sediments from a contaminated wastewater lagoon. Environ Sci Pollut Res Int 25(17):16376-16388. doi:10.1007/s11356-017-9872-x PMID:28803405 PMCID:PMC6206866
• Sethi S, Keil KP, Lein PJ. 2018. 3,3-Dichlorobiphenyl (PCB 11) promotes dendritic arborization in primary rat cortical neurons via a CREB-dependent mechanism. Arch Toxicol 1-9. doi:10.1007/s00204-018-2307-8 PMID:30225637 PMCID:PMC6196112
• Tomsho KS, Basra K, Rubin SM, Miller CB, Juang R, Broude S, Martinez A, Hornbuckle KC, Heiger-Bernays WJ, Scammell MK. 2018. Community reporting of ambient air polychlorinated biphenyl concentrations near a Superfund site. Environ Sci Pollut Res Int 25(17):16389-16400. doi:10.1007/s11356-017-0286-6 PMID:29079973 PMCID:PMC6015112
• Uwimana E, Li X, Lehmler H. 2018. Human liver microsomes atropselectively metabolize 2,2 ',3,4 ',6-pentachlorobiphenyl (PCB 91) to a 1,2-shift product as the major metabolite. Environ Sci Technol 52:6000-6008. doi:10.1021/acs.est.8b00612 PMID:29659268 PMCID:PMC5966832

2017

• Grimm FA, Lehmler H, Koh W, DeWall J, Teesch LM, Hornbuckle KC, Thorne PS, Robertson LW, Duffel MW. 2017. Identification of a sulfate metabolite of PCB 11 in human serum. Environ Int 98:120-128. doi:10.1016/j.envint.2016.10.023 PMID:27816204 PMCID:PMC5127762
• Kania-Korwel I, Lukasiewicz T, Barnhart CD, Stamou M, Chung H, Kelly KM, Bandiera SM, Lein PJ, Lehmler H. 2017. Congener-specific disposition of chiral polychlorinated biphenyls in lactating mice and their offspring: Implications for PCB developmental neurotoxicity. Toxicol Sci 158(1):101-115. doi:10.1093/toxsci/kfx071 PMID:28431184 PMCID:PMC6070089
• Marek RF, Thorne PS, Herkert N, Awad AM, Hornbuckle KC. 2017. Airborne PCBs and OH-PCBs inside and outside urban and rural U.S. schools. Environ Sci Technol 51(14):7853-7860. doi:10.1021/acs.est.7b01910 PMID:28656752 PMCID:PMC5777175
• Martinez A, Hadnott BN, Awad AM, Herkert N, Tomsho KS, Basra K, Scammell MK, Heiger-Bernays WJ, Hornbuckle KC. 2017. Release of airborne polychlorinated biphenyls from New Bedford Harbor results in elevated concentrations in the surrounding air. Environ Sci Technol Lett 4(4):127-131. doi:10.1021/acs.estlett.7b00047 PMID:28413805 PMCID:PMC5390305
• Uwimana E, Maiers A, Li X, Lehmler H. 2017. Microsomal metabolism of prochiral polychlorinated biphenyls results in the enantioselective formation of chiral metabolites. Environ Sci Technol 51(3):1820-1829. doi:10.1021/acs.est.6b05387 PMID:28038482 PMCID:PMC5300040

2016

• Awad AM, Martinez A, Marek RF, Hornbuckle KC. 2016. Occurrence and distribution of two hydroxylated polychlorinated biphenyl congeners in Chicago air. Environ Sci Technol Lett 3:47-51. doi:10.1021/acs.estlett.5b00337
• Herkert N, Martinez A, Hornbuckle KC. 2016. A model using local weather data to determine the effective sampling volume for PCB congeners collected on passive air samplers. Environ Sci Technol 50(13):6690-6697. doi:10.1021/acs.est.6b00319 PMID:26963482 PMCID:PMC4935961
• Kania-Korwel I, Lehmler H. 2016. Chiral polychlorinated biphenyls: absorption, metabolism and excretion--a review. Environ Sci Pollut Res Int 23(3):2042-2057. doi:10.1007/s11356-015-4150-2 PMID:25651810 PMCID:PMC4527964
• Kania-Korwel I, Lehmler H. 2016. Toxicokinetics of chiral polychlorinated biphenyls across different species--a review. Environ Sci Pollut Res Int 23(3):2058-2080. doi:10.1007/s11356-015-4383-0 PMID:25824003 PMCID:PMC4591098
• Koh W, Hornbuckle KC, Wang K, Thorne PS. 2016. Serum polychlorinated biphenyls and their hydroxylated metabolites are associated with demographic and behavioral factors in children and mothers. Environ Int 94:538-545. doi:10.1016/j.envint.2016.06.014 PMID:27352881 PMCID:PMC4980156
• Koh WX, Hornbuckle KC, Marek RF, Wang K, Thorne PS. 2016. Hydroxylated polychlorinated biphenyls in human sera from adolescents and their mothers living in two US Midwestern communities. Chemosphere 147:389-395. doi:10.1016/j.chemosphere.2015.12.113 PMID:26774304 PMCID:PMC4747419
• Ma C, Zhai G, Wu H, Kania-Korwel I, Lehmler H, Schnoor JL. 2016. Identification of a novel hydroxylated metabolite of 2,2',3,5',6-pentachlorobiphenyl formed in whole poplar plants. Environ Sci Pollut Res Int 23(3):2089-2098. doi:10.1007/s11356-015-5939-8 PMID:26676542 PMCID:PMC4718877
• Martinez A, Schnoebelen DJ, Hornbuckle KC. 2016. Polychlorinated biphenyl congeners in sediment cores from the Upper Mississippi River. Chemosphere 144:1943-1949. doi:10.1016/j.chemosphere.2015.10.090 PMID:26547030 PMCID:PMC4695299
• Uwimana E, Li X, Lehmler H. 2016. 2,2',3,5',6-Pentachlorobiphenyl (PCB 95) is atropselectively metabolized to para-hydroxylated metabolites by human liver microsomes. Chem Res Toxicol 29(12):2108-2110. doi:10.1021/acs.chemrestox.6b00371 PMID:27989147 PMCID:PMC5175585
• Wu X, Lehmler H. 2016. Effects of thiol antioxidants on the atropselective oxidation of 2,2',3,3',6,6'-hexachlorobiphenyl (PCB 136) by rat liver microsomes. Environ Sci Pollut Res Int 23(3):2081-2088. doi:10.1007/s11356-015-4987-4 PMID:26155892 PMCID:PMC4706823
• Wu X, Yang J, Morisseau C, Robertson LW, Hammock BD, Lehmler H. 2016. 3,3',4,4',5-Pentachlorobiphenyl (PCB 126) decreases hepatic and systemic ratios of epoxide to diol metabolites of unsaturated fatty acids in male rats. Toxicol Sci 152(2):309-322. doi:10.1093/toxsci/kfw084 PMID:27208083 PMCID:PMC4960907

2015

• Ampleman MD, Martinez A, DeWall J, Rawn DF, Hornbuckle KC, Thorne PS. 2015. Inhalation and dietary exposure to PCBs in urban and rural cohorts via congener-specific measurements. Environ Sci Technol 49(2):1156-1164. doi:10.1021/es5048039 PMID:25510359 PMCID:PMC4303332
• Grimm FA, He X, Teesch LM, Lehmler H, Robertson LW, Duffel MW. 2015. Tissue distribution, metabolism, and excretion of 3,3'-dichloro-4'-sulfooxy-biphenyl in the rat. Environ Sci Technol 49(13):8087-8095. doi:10.1021/acs.est.5b01499 PMID:26046945 PMCID:PMC4496304
• Grimm FA, Hu D, Kania-Korwel I, Lehmler H, Ludewig G, Hornbuckle KC, Duffel MW, Bergman A, Robertson LW. 2015. Metabolism and metabolites of polychlorinated biphenyls. Crit Rev Toxicol 45(3):245-272. doi:10.3109/10408444.2014.999365 PMID:25629923 PMCID:PMC4383295
• Hu X, Adamcakova-Dodd A, Lehmler H, Gibson-Corley KN, Thorne PS. 2015. Toxicity evaluation of exposure to an atmospheric mixture of polychlorinated biphenyls by nose-only and whole-body inhalation regimens. Environ Sci Technol 49(19):11875-11883. doi:10.1021/acs.est.5b02865 PMID:26348937 PMCID:PMC4711378
• Kania-Korwel I, Barnhart CD, Lein PJ, Lehmler H. 2015. Effect of pregnancy on the disposition of 2,2',3,5',6-pentachlorobiphenyl (PCB 95) atropisomers and their hydroxylated metabolites in female mice. Chem Res Toxicol 28(9):1774-1783. doi:10.1021/acs.chemrestox.5b00241 PMID:26271003 PMCID:PMC4579038
• Koh WX, Hornbuckle KC, Thorne PS. 2015. Human serum from urban and rural adolescents and their mothers shows exposure to polychlorinated biphenyls not found in commercial mixtures. Environ Sci Technol 49(13):8105-8112. doi:10.1021/acs.est.5b01854 PMID:26053216 PMCID:PMC4774248
• Martinez A, Spak SN, Petrich NT, Hu D, Carmichael G, Hornbuckle KC. 2015. Atmospheric dispersion of PCB from a contaminated Lake Michigan harbor. Atmos Environ (1994) 122:791-798. doi:10.1016/j.atmosenv.2015.10.040 PMID:26594127 PMCID:PMC4649934
• Peverly A, Ma Y, Vinier M, Rodenburg ZL, Spak SN, Hornbuckle KC, Hites RA. 2015. Variations of flame retardant, polycyclic aromatic hydrocarbon, and pesticide concentrations in Chicago's atmosphere measured using passive sampling. Environ Sci Technol 49(9):5371-5379. doi:10.1021/acs.est.5b00216 PMID:25874663
• Peverly A, O'Sullivan C, Liu L, Venier M, Martinez A, Hornbuckle KC, Hites RA. 2015. Chicago's sanitary and ship canal sediment: polycyclic aromatic hydrocarbons, polychlorinated biphenyls, brominated flame retardants, and organophosphate esters. Chemosphere 134:380-386. doi:10.1016/j.chemosphere.2015.04.065 PMID:25981316
• Shanahan CE, Spak SN, Martinez A, Hornbuckle KC. 2015. Inventory of PCBs in Chicago and opportunities for reduction in airborne emissions and human exposure. Environ Sci Technol 49(23):13878-13888. doi:10.1021/acs.est.5b00906 PMID:26440379
• Stamou M, Uwimana E, Flannery BM, Kania-Korwel I, Lehmler H, Lein PJ. 2015. Subacute nicotine co-exposure has no effect on 2,2',3,5',6- pentachlorobiphenyl disposition but alters hepatic cytochrome P450 expression in the male rat. Toxicology 338:59-68. doi:10.1016/j.tox.2015.10.002 PMID:26463278 PMCID:PMC4658283
• Wu X, Barnhart CD, Lein PJ, Lehmler H. 2015. Hepatic metabolism affects the atropselective disposition of 2,2',3,3',6,6'-hexachlorobiphenyl (PCB 136) in mice. Environ Sci Technol 49(1):616-625. doi:10.1021/es504766p PMID:25420130 PMCID:PMC4291784

2014

• Aqil F, Shen H, Jeyabalan J, Xin X, Lehmler H, Ludewig G, Robertson LW, Gupta RC. 2014. Sustained expression of CYPs and DNA adduct accumulation with continuous exposure to PCB126 and PCB153 through a new delivery method: Polymeric implants. Toxicol Rep 1:820-833. doi:10.1016/j.toxrep.2014.09.010 PMID:25530946 PMCID:PMC4266188
• Dhakal K, Uwimana E, Adamcakova-Dodd A, Thorne PS, Lehmler H, Robertson LW. 2014. Disposition of phenolic and sulfated metabolites after inhalation exposure to 4-chlorobiphenyl (PCB3) in female rats. Chem Res Toxicol 27(8):1411-1420. doi:10.1021/tx500150h PMID:24988477 PMCID:PMC4137987
• Ekuase EJ, Lehmler H, Robertson LW, Duffel MW. 2014. Binding interactions of hydroxylated polychlorinated biphenyls (OHPCBs) with human hydroxysteroid sulfotransferase hSULT2A1. Chem Biol Interact 212:56-64. doi:10.1016/j.cbi.2014.01.018 PMID:24508592 PMCID:PMC3994546
• Hu X, Adamcakova-Dodd A, Thorne PS. 2014. The fate of inhaled (14)C-labeled PCB11 and its metabolites in vivo. Environ Int 63:92-100. doi:10.1016/j.envint.2013.10.017 PMID:24275706 PMCID:PMC3950335
• Liang Y, Martinez A, Hornbuckle KC, Mattes TE. 2014. Potential for polychlorinated biphenyl biodegradation in sediments from Indiana Harbor and Ship Canal. Int Biodeterior Biodegradation 89:50-57. doi:10.1016/j.ibiod.2014.01.005 PMID:24764649 PMCID:PMC3993986
• Marek RF, Thorne PS, DeWall J, Hornbuckle KC. 2014. Variability in PCB and OH-PCB serum levels in children and their mothers in urban and rural US communities. Environ Sci Technol 48(22):13459-13467. doi:10.1021/es502490w PMID:25300024 PMCID:PMC4238695
• Salman KN, Stuart MA, Schmidt J, Borges T, McClain CJ, Robinson FR, Li M, Robertson LW. 2014. The effects of 3,3',4,4'-tetrabromobiphenyl on rats fed diets containing a constant level of copper and varying levels of molybdenum. Environ Sci Pollut Res Int 21(10):6400-6409. doi:10.1007/s11356-013-1638-5 PMID:23532536 PMCID:PMC3732555
• Stamou M, Wu X, Kania-Korwel I, Lehmler H, Lein PJ. 2014. Cytochrome p450 mRNA expression in the rodent brain: species-, sex-, and region-dependent differences. Drug Metab Dispos 42(2):239-244. doi:10.1124/dmd.113.054239 PMID:24255117 PMCID:PMC3912540
• Wu X, Kammerer A, Lehmler H. 2014. Microsomal oxidation of 2,2',3,3',6,6'-hexachlorobiphenyl (PCB 136) results in species-dependent chiral signatures of the hydroxylated metabolites. Environ Sci Technol 48(4):2436-2444. doi:10.1021/es405433t PMID:24467194 PMCID:PMC3983324
• Yang DR, Kania-Korwel I, Ghogha A, Chen H, Stamou M, Bose DD, Pessah IN, Lehmler H, Lein PJ. 2014. PCB 136 atropselectively alters morphometric and functional parameters of neuronal connectivity in cultured rat hippocampal neurons via ryanodine receptor-dependent mechanisms. Toxicol Sci 138(2):379-392. doi:10.1093/toxsci/kft334 PMID:24385416 PMCID:PMC4007107
• Zhai G, Lehmler H, Schnoor JL, Gutowski SM. 2014. Enantioselective transport and biotransformation of chiral hydroxylated metabolites of polychlorinated biphenyls in whole poplar plants. Environ Sci Technol 48(20):12213-12220. doi:10.1021/es503443e PMID:25238141 PMCID:PMC4207536

2013

• Hu X, Lehmler H, Adamcakova-Dodd A, Thorne PS. 2013. Elimination of inhaled 3,3'-dichlorobiphenyl and the formation of the 4-hydroxylated metabolite. Environ Sci Technol 47(9):4743-4751. doi:10.1021/es3049114 PMID:23582014 PMCID:PMC3962796
• Marek RF, Martinez A, Hornbuckle KC. 2013. Discovery of hydroxylated polychlorinated biphenyls (OH-PCBs) in sediment from a Lake Michigan waterway and original commercial aroclors. Environ Sci Technol 47(15):8204–8210. doi:10.1021/es402323c PMID:23862721 PMCID:PMC3781593
• Marek RF, Thorne PS, Wang K, DeWall J, Hornbuckle KC. 2013. PCBs and OH-PCBs in serum from children and mothers in urban and rural U.S. communities. Environ Sci Technol 47(7):3353-3361. doi:10.1021/es304455k PMID:23452180 PMCID:PMC3645264
• Martinez A, O'Sullivan C, Reible DD, Hornbuckle KC. 2013. Sediment pore water distribution coefficients of PCB congeners in enriched black carbon sediment. Environ Pollut 182:357-363. doi:10.1016/j.envpol.2013.07.015 PMID:23974165 PMCID:PMC3833079
• Petrich NT, Spak SN, Carmichael G, Hu D, Martinez A, Hornbuckle KC. 2013. Simulating and explaining passive air sampling rates for semivolatile compounds on polyurethane foam passive samplers. Environ Sci Technol 47(15):8591–8598. doi:10.1021/es401532q PMID:23837599 PMCID:PMC3764502
• Rignall B, Grote K, Gavrilov A, Weimer M, Kopp-Schneider A, Krause E, Appel KE, Buchmann A, Robertson LW, Lehmler H, Kania-Korwel I, Chahoud I, Schwarz M. 2013. Biological and tumor-promoting effects of dioxin-like and non-dioxin-like polychlorinated biphenyls in mouse liver after single or combined treatment. Toxicol Sci 133(1):29-41. doi:10.1093/toxsci/kft034 PMID:23457121 PMCID:PMC3627557
• Yucuis RA, Stanier CO, Hornbuckle KC. 2013. Cyclic siloxanes in air, including identification of high levels in Chicago and distinct diurnal variation. Chemosphere 92(8):905-910. doi:10.1016/j.chemosphere.2013.02.051 PMID:23541357 PMCID:PMC3975597
• Zhai G, Wu X, Lehmler H, Schnoor JL. 2013. Atropisomeric determination of chiral hydroxylated metabolites of polychlorinated biphenyls using HPLC-MS. Chem Cent J 7(1):183. doi:10.1186/1752-153X-7-183 PMID:24360245 PMCID:PMC3879188
• Zhu Y, Mapuskar KA, Marek RF, Xu W, Lehmler H, Robertson LW, Hornbuckle KC, Spitz DR, Aykin-Burns N. 2013. A new player in environmentally induced oxidative stress: polychlorinated biphenyl congener, 3,3'-dichlorobiphenyl (PCB11). Toxicol Sci 136(1):39-50. doi:10.1093/toxsci/kft186 PMID:23997111 PMCID:PMC3829572

2012

• Martinez A, Erdman NR, Rodenburg ZL, Eastling PM, Hornbuckle KC. 2012. Spatial distribution of chlordanes and PCB congeners in soil in Cedar Rapids, Iowa, USA. Environ Pollut 161:222-228. doi:10.1016/j.envpol.2011.10.028 PMID:22230089 PMCID:PMC3255082

2011

• Ela WP, Sedlak DL, Barlaz MA, Henry HF, Muir DG, Swackhamer DL, Weber EJ, Arnold RG, Ferguson PL, Field JA, Furlong ET, Giesy JP, Halden RU, Henry T, Hites RA, Hornbuckle KC, Howard PH, Luthy RG, Meyer AK, Saez AE, vom Saal FS, Vulpe CD, Wiesner MR. 2011. Toward identifying the next generation of superfund and hazardous waste site contaminants. Environ Health Perspect 119(1):6-10. doi:10.1289/ehp.1002497 PMID:21205582 PMCID:PMC3018501
• Hu D, Martinez A, Hornbuckle KC. 2011. Sedimentary records of non-Aroclor and Aroclor PCB mixtures in the Great Lakes. Journal of Great Lakes Research 37:359-364. doi:10.1016/j.jglr.2011.03.001 PMID:23538476 PMCID:PMC3607302
• Joshi SN, Vyas SM, Duffel MW, Parkin S, Lehmler H. 2011. Synthesis of sterically hindered polychlorinated biphenyl derivatives. Synthesis 7:1045-1054. doi:10.1055/s-0030-1258454 PMID:21516177 PMCID:PMC3080045
• Joshi SN, Vyas SM, Wu H, Duffel MW, Parkin S, Lehmler H. 2011. Regioselective iodination of chlorinated aromatic compounds using silver salts. Tetrahedron 67(39):7461-7469. doi:10.1016/j.tet.2011.07.064 PMID:21918585 PMCID:PMC3170769
• Kania-Korwel I, Duffel MW, Lehmler H. 2011. Gas chromatographic analysis with chiral cyclodextrin phases reveals the enantioselective formation of hydroxylated polychlorinated biphenyls by rat liver microsomes. Environ Sci Technol 45:9590-9596. doi:10.1021/es2014727 PMID:21966948 PMCID:PMC3216237
• Martinez A, Hornbuckle KC. 2011. Record of PCB congeners, sorbents and potential toxicity in core samples in Indiana Harbor and Ship Canal. Chemosphere 85:542-547. doi:10.1016/j.chemosphere.2011.08.018 PMID:21899876 PMCID:PMC3222236
• Wu X, Pramanik A, Duffel MW, Hrycay EG, Bandiera SM, Lehmler H, Kania-Korwel I. 2011. 2,2',3,3',6,6'-Hexachlorobiphenyl (PCB 136) is enantioselectively oxidized to hydroxylated metabolites by rat liver microsomes. Chem Res Toxicol 24(12):2249-2257. doi:10.1021/tx200360m PMID:22026639 PMCID:PMC3243785

2010

• Correa PA, Lin L, Just CL, Hu D, Hornbuckle KC, Schnoor JL, Van Aken B. 2010. The effects of individual PCB congeners on the soil bacterial community structure and the abundance of biphenyl dioxygenase genes. Environ Int 36(8):901-906. doi:10.1016/j.envint.2009.07.015 PMID:19716603 PMCID:PMC2928393
• Hu D, Hornbuckle KC. 2010. Inadvertent PCB congeners in commercial pigments. Environ Sci Technol 44:2822-2827. doi:10.1021/es902413k PMID:19957996 PMCID:PMC2853905
• Hu X, Adamcakova-Dodd A, Lehmler H, Hu D, Kania-Korwel I, Hornbuckle KC, Thorne PS. 2010. Time course of congener uptake and elimination in rats after short-term inhalation exposure to an airborne polychlorinated biphenyl (PCB) mixture. Environ Sci Technol 44(17):6893-6900. doi:10.1021/es101274b PMID:20698547 PMCID:PMC3408216
• Kania-Korwel I, El-Komy MH, Veng-Pedersen P, Lehmler H. 2010. Clearance of polychlorinated biphenyl atropisomers is enantioselective in female C57BI/6 mice. Environ Sci Technol 44(8):2828-2835. doi:10.1021/es901781p PMID:20384376 PMCID:PMC2855138
• Lehmler H, Martinez A, Wang K, Hornbuckle KC, Hu D. 2010. Atmospheric PCB congeners across Chicago. Atmos Environ (1994) 44(12):1550-1557. doi:10.1016/j.atmosenv.2010.01.006 PMID:21918637 PMCID:PMC3171135
• Li X, Parkin S, Duffel MW, Robertson LW, Lehmler H. 2010. An efficient approach to sulfate metabolites of polychlorinated biphenyls. Environ Int 36:843-848. doi:10.1016/j.envint.2009.02.005 PMID:19345419 PMCID:PMC2939219
• Martinez A, Norstrom K, Wang K, Hornbuckle KC. 2010. Polychlorinated biphenyls in the surficial sediment of Indiana Harbor and Ship Canal, Lake Michigan. Environ Int 36(8):849-854. doi:10.1016/j.envint.2009.01.015 PMID:19268364 PMCID:PMC2888873
• Martinez A, Wang K, Hornbuckle KC. 2010. Fate of PCB congeners in an industrial harbor of Lake Michigan. Environ Sci Technol 44:2803-2808. doi:10.1021/es902911a PMID:20131898 PMCID:PMC3257175
• Milanowski B, Luiek J, Lehmler H, Kania-Korwel I. 2010. Assessment of the disposition of chiral polychlorinated biphenyls in female mdr 1a/b knockout versus wild-type mice using multivariate analyses. Environ Int 36:884-892. doi:10.1016/j.envint.2009.10.007 PMID:19923000 PMCID:PMC2891895
• Norstrom K, Czub G, McLachlan MS, Hu D, Thorne PS, Hornbuckle KC. 2010. External exposure and bioaccumulation of PCBs in humans living in a contaminated urban environment. Environ Int 36(8):855-861. doi:10.1016/j.envint.2009.03.005 PMID:19394084 PMCID:PMC2891214
• Persoon C, Peters TM, Kumar N, Hornbuckle KC. 2010. Spatial distribution of airborne polychlorinated biphenyls in Cleveland, Ohio and Chicago, Illinois. Environ Sci Technol 44(8):2797-2802. doi:10.1021/es901691s PMID:20384374 PMCID:PMC2855146
• Telu S, Parkin S, Robertson LW, Lehmler H. 2010. Improved syntheses of non-dioxin-like polychlorinated biphenyls (PCBs) and some of their sulfur-containing metabolites. Environ Int 36:828-834. doi:10.1016/j.envint.2009.01.013 PMID:19261331 PMCID:PMC2948577
• Zhao H, Adamcakova-Dodd A, Hu D, Hornbuckle KC, Just CL, Robertson LW, Thorne PS, Lehmler H. 2010. Development of a synthetic PCB mixture resembling the average polychlorinated biphenyl profile in Chicago air. Environ Int 36(8):819-827. doi:10.1016/j.envint.2009.03.003 PMID:19375801 PMCID:PMC2888912