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Your Environment. Your Health.

Program Publications: Massachusetts Institute of Technology: MIT Superfund Hazardous Substance Basic Research Program

Superfund Research Program

MIT Superfund Hazardous Substance Basic Research Program

Center Director: William G. Thilly
Grant Number: P42ES004675
Funding Period: 1987-2000

Program Links



  • Knauer K, Behra R, Hemond HF. 1999. Toxicity of inorganic and methylated arsenic to algal communities from lakes along an arsenic contamination gradient. Aquat Toxicol 46(3-4):221-230.
  • Risoul V, Pichon C, Trouve G, Peters WA, Gilot P, Prado G. 1999. Thermogravimetric study of thermal decontamination of soils polluted by hexachlorobenzene, 4-chlorobiphenyl, naphthalene, or n-decane. J Hazard Mater 64(3):295-311. PMID:10337399
  • Risoul V, Trouve G, Peters WA, Gilot P. 1999. Effect of oxidizing gas pressure on laboratory-scale decontamination of soils polluted by hydrocarbons. Thermochimica Acta 325(1):77-87.
  • Tay ST, Hemond HF, Polz MF, Cavanaugh CM, Krumholz LR. 1999. Importance of Xanthobacter autotrophicus in toluene biodegradation within a contaminated stream. Syst Appl Microbiol 22(1):113-118. doi:10.1016/S0723-2020(99)80034-4 PMID:10188284


  • Bjorheim J, Lystad S, Lindblom A, Kressner U, Westring S, Wahlberg S, Lindmark G, Gaudernack G, Ekstrom P, Roe J, Thilly WG, Borresen-Dale AL. 1998. Mutation analyses of KRAS exon 1 comparing three different techniques: temporal temperature gradient electrophoresis, constant denaturant capillary electrophoresis and allele specific polymerase chain reaction. Mutat Res 403:103-112. PMID:9726011
  • Coller HA, Khrapko K, Torres A, Frampton MW, Utell MJ, Thilly WG. 1998. Mutational spectra of a 100-base pair mitochondrial DNA target sequence in bronchial epithelial cells: a comparison of smoking and nonsmoking twins. Cancer Res 58(6):1268-1277. PMID:9515815
  • Coller HA, Thilly WG. 1998. Mutational Spectra Technology. In: Encyclopedia of environmental analysis and remediation. Wiley-Interscience, pp.2967-3005.
  • Durant JL, Lafleur AL, Plummer EF, Taghizadeh K, Busby WF, Thilly WG. 1998. Human lymphoblast mutagens in urban airborne particles. Environ Sci Technol 32:1894-1906.
  • Hannigan MP, Cass GR, Penman BW, Crespi CL, Lafleur AL, Busby WF, Thilly WG. 1998. Bioassay-directed chemical analysis of Los Angeles airborne particulate matter using a human cell mutagenicity assay. Environ Sci Technol 32:3502-3514.
  • Harriman SP, Hill JA, Tannenbaum SR, Wishnok JS. 1998. Detection and identification of carcinogen-peptide adducts by nanoelectrospray tandem mass spectrometry. J Am Soc Mass Spectrom 9(3):202-207. PMID:9879357
  • Herrero-Jimenez P, Thilly G, Southam PJ, Tomita AV, Morgenthaler S, Furth EE, Thilly WG. 1998. Mutation, cell kinetics, and subpopulations at risk for colon cancer in the United States. Mutat Res 400:553-578. PMID:9685710
  • Hughey BJ, Klinkowstein RE, Shefer RE, Fried NA, Skipper PL, Wishnok JS, Jiao K, Tannenbaum SR. 1998. Development of a GC-AMS system for biomedical research. In: Synthesis and Applications of Isotopically Labelled Compounds. John Wiley & Sons, Ltd, Chichester, United Kingdom. pp.107-109.
  • Khrapko K, Coller HA, Hanekamp JS, Thilly WG. 1998. Identification of point mutations in mixtures by capillary electrophoresis hybridization. Nucleic Acids Res 26(24):5738-5740. PMID:9838007
  • Kim H, Hemond HF. 1998. Natural discharge of volatile organic compounds from contaminated aquifer to surface waters. J Environ Eng (New York) 124(8):744-751. doi:10.1061/(ASCE)0733-9372(1998)124:8(744)
  • Lafleur AL, Howard JB, Plummer EF, Taghizadeh K, Necula A, Scott LT, Swallow KC. 1998. Identification of some novel cyclopenta-fused polycyclic aromatic hydrocarbons in ethylene flames. Polycyclic Aromatic Compounds 12:223-237.
  • Li X, Thilly WG. 1998. Scanning technology for point mutants within 100-bp sequences in human blood and tissues. Journal of Disease Gene Identification: Methods and Protocols, a series of Methods in Molecular Medicine
  • Marcelino LA, Andre PC, Khrapko K, Coller HA, Griffith J, Thilly WG. 1998. Chemically induced mutations in mitochondrial DNA of human cells: Mutational spectrum of N-Methyl-N'-nitro-N-nitrosoguanidine. Cancer Res 58:2857-2862. PMID:9661902
  • Marrone PA, Arias TA, Peters WA, Tester JW. 1998. Solvation effects on kinetics of methylene chloride reactions in sub- and supercritical water: theory, experiment, and ab initio calculations. J Phys Chem A 102(A):7013-7028.
  • Marrone PA, Gschwend PM, Swallow KC, Peters WA, Tester JW. 1998. Product distribution and reaction pathways for methylene chloride hydrolysis and oxidation under hydrothermal conditions. Journal of Supercritical Fluids 12:239-254.
  • Marulanda C, Culligan PJ, Germaine J. 1998. A study of air flow in air sparging applications. In: Centrifuge '98. (Kimura, Kusakabe and Takemura, eds.) Balkema. pp.577-582.
  • Miller PL, Vasudevan D, Gschwend PM, Roberts AL. 1998. Transformation of hexachloroethane in a sulfidic natural water. Environ Sci Technol 32:1269-1275. doi:10.1021/es970687w
  • Saito HH, Bucala V, Howard JB, Peters WA. 1998. Thermal removal of pyrene contamination from soil: basic studies and environmental health implications. Environ Health Perspect 106(supp.4):1097-1107. PMID:9703498
  • Saito HH, Howard JB, Peters WA, Bucala V. 1998. Soil Thermal Decontamination: Fundamentals. In: Encyclopedia of environmental analysis and remediation. Wiley-Interscience, pp.4554-4589.
  • Tay ST, Hemond HF, Polz MF, Cavanaugh CM, DeJesus I, Krumholz LR. 1998. Two new Mycobacterium strains and their role in toluene degradation in a contaminated stream. Appl Environ Microbiol 64(5):1715-1720. PMID:9572941 PMCID:PMC106220
  • Tester JW, Marrone PA, DiPippo MM, Sako K, Reagan MT, Arias TA, Peters WA. 1998. Chemical reactions and phase equilibria of model halocarbons in sub- and supercritical water (200 to 300 bar, 100 to 600C). Journal of Supercritical Fluids 13(1-3):225-240.
  • Tomita AV, Muniappan BP, Herrero-Jimenez P, Zarbl HF, Thilly WG. 1998. Single nucleotide polymorphism spectra in newborns and centenarians: identification of genes coding for risk of mortal disease. Gene 26:381-391. PMID:9858772
  • Wick LY, Gschwend PM. 1998. By-products of a former phenol manufacturing site in a small lake adjacent to a Superfund site in the Aberjona watershed. Environ Health Perspect 106(supp.4):1069-1074. PMID:9703495
  • Wick LY, Gschwend PM. 1998. Source and chemodynamic behavior of diphenylsulfone, ortho- and para-hydroxybiphenyl in a small lake receiving discharges from an adjacent Superfund site. Environ Sci Technol 32:1319-1328.
  • Zeeb PJ, Hemond HF. 1998. Hydrologic response of a wetland to changing moisture conditions: modeling effects of soil heterogeneity. Climatic Change 40:211-227.


  • Ahmann D, Krumholz LR, Hemond HF, Lovley DR, Morel FM. 1997. Microbial mobilization of arsenic from sediments of the Aberjona Watershed. Environ Sci Technol 31:2923-2930.
  • Brunmark P, Harriman SP, Skipper PL, Wishnok JS, Amin S, Tannenbaum SR. 1997. Identification of subdomain IB in human serum albumin as a major binding site for polycyclic aromatic hydrocarbon epoxides. Chem Res Toxicol 10(8):880-886. PMID:9282837
  • Busby WF, Smith H, Plummer EF, Lafleur AL, Mulder PP, Boere BB, Cornelisse J, Lugtenburg J. 1997. Mutagenicity of cyclopenta-fused polynuclear aromatic hydrocarbons and a non-polar fraction from a fuel combustion sample in a Salmonella forward mutation assay without exogenous metabolic activation. Mutat Res 391:117-125. PMID:9268036
  • Gilot P, Howard JB, Peters WA. 1997. Evaporation phenomena during thermal decontamination of soils. Environ Sci Technol 31(2):461-466.
  • Gustafsson O, Gschwend PM. 1997. Soot as a strong partition medium for polycyclic aromatic hydrocarbons in aquatic stems. In: Molecular Markers in Environmental Geochemistry. ACS Symposium Series, pp.365-381.
  • Gustafsson O, Haghseta F, Chan C, MacFarlane JK, Gschwend PM. 1997. Quantification of dilute sedimentary soot phase: implications for PAH speciation and bioavailabilty. Environ Sci Technol 31(1):203-209.
  • Hannigan MP, Cass GR, Penman BW, Crespi CL, Lafleur AL, Busby WF, Thilly WG. 1997. Human cell mutagens in Los Angeles air. Environ Sci Technol 31:438-447.
  • Holmen BA, Gschwend PM. 1997. Estimating sorption rates of hydrophobic organic compounds in iron oxide- and aluminosilicate clay-coated aquifer sands. Environ Sci Technol 31(1):105-113.
  • Jiao K, Lafleur AL. 1997. Improved detection of polycyclic aromatic compounds in complex mixtures by liquid chromatographic fractionation on poly(divinylbenzene) prior to gas chromatography/mass spectrometry: application to the analysis of diesel particulates. Journal of Chromatographic Science 791(1-2):203-211. PMID:9463900
  • Khrapko K, Coller HA, Andre PC, Li X, Hanekamp JS, Thilly WG. 1997. Mitochondrial mutational spectra in human cells and tissues. Proc Natl Acad Sci U S A 94(25):13798-13803. PMID:9391107
  • Kinnicutt P, Noack C, Einstein H. 1997. Three Dimensional Stratigraphic Characterization for Geotechnical Exploration.
  • Moore MV, Pace ML, Mather JR, Murdoch PS, Howarth RW, Folt CL, Chen CY, Hemond HF, Flebbe PA, Driscoll CT. 1997. Potential effects of climate change on freshwater ecosystems of the New England/Mid-Atlantic region. Hydrological Processes 11:925-947.
  • Nepf H, Oldham C. 1997. Exchange dynamics of a shallow contaminated wetland. Aquatic Sciences 59(3):193-213. doi:10.1007/BF02523273
  • Pichon C, Risoul V, Trouve G, Peters WA, Gilot P, Prado G. 1997. Study of evaporation of organic pollutants by thermogravimetric analysis: experiments and modelling. Thermochimica Acta 306:143-151.
  • Rogers CE, Tomita AV, Trowbridge PR, Gone J, Chen J, Zeeb PJ, Hemond HF, Thilly WG, Olmez I, Durant JL. 1997. Hair analysis does not support hypothesized arsenic and chromium exposure from drinking water in Woburn, Massachusetts. Environ Health Perspect 105(10):1090-1097. PMID:9349834


  • Bucala V, Saito HH, Howard JB, Peters WA. 1996. Products compositions and release rates from thermal treatment of soil. Ind Eng Chem Res 35:2725-2734.
  • Cha RS, Guerra L, Thilly WG, Zarbl HF. 1996. Ha-ras-1 oncogene mutations in mammary epithelial cells do not contribute to initiation of spontaneous mammary tumorigenesis in rats. Carcinogenesis 17(11):2519-2524. PMID:8968072
  • Chen J, Thilly WG. 1996. Mutational spectra vary with exposure conditions: benzo(a)pyrene in human cells. Mutat Res 357(1-2):209-217. PMID:8876696
  • Durant JL, Busby WF, Lafleur AL, Penman BW, Crespi CL. 1996. Human cell mutagenicity of oxygenated, nitrated and unsubstituted polycyclic aromatic hydrocarbons associated with urban aerosols. Mutat Res 371:123-157. PMID:9008716
  • Hanekamp JS, Thilly WG, Chaudry A. 1996. Screening for human mitochondrial DNA polymorphisms with denaturing gradient gel electrophoresis. Hum Genet 98:243-245. PMID:8698353
  • Khrapko K, Coller HA, Thilly WG. 1996. Efficiency of separation of DNA mutations by constant denaturant capillary electrophoresis (CDCE) is controlled by the kinetics of DNA melting equilibrium. Electrophoresis 17(12):1867-1874. PMID:9034768
  • Marrone PA. 1996. Hydrolysis and Oxidation Kinetics of Methylene Chloride in Sub- and Supercritical Water: The Effects of Preheating, Heat Transfer, and Solvent Effects. In: Proceedings of the Third International Conference on Advanced Oxidation Technologies for Water and Air Remediation, October 26-29. Cincinnati, OH.
  • Mitton DB, Marrone PA, Latanision RM. 1996. Interpretation of the rationale for feed modification in SCWO systems. J Electrochem Soc 143(3):L59-L61.
  • Ozbal CC, Kartha VB, Velic I, Skipper PL, Dasari R, Tannenbaum SR. 1996. Quantification of pyrene-based polycyclic aromatic hydrocarbon adducts in human bronchial epithelium. Proc Am Assoc Cancer Res 37:706.
  • Shi W, Rodi WL, Mackie RL, Zhang J. 1996. 3-D d.c. electrical resistivity inversion with application to a contamination site in the Aberjona Watershed. In: Proceedings of SAGEEP (Symposium on the Application of Geophysics to Environmental and Engineering Problems). Environmental and Engineering Geophysical Society. Keystone, CO. pp.1257-1267.
  • Skipper PL. 1996. Influence of tertiary structure on nucleophilic substitution reactions of proteins. Chem Res Toxicol 9(6):918-923. PMID:8870977
  • Thilly WG. 1996. On the trail of mutations at MIT. Environ Health Perspect 104(2):142-145.


  • Bucala V, Saito HH, Howard JB, Peters WA. 1995. Thermal Treatment of Contaminated and Neat Soil. In: Proceedings of the Workshop on Geo-Environmental Issues Facing the Americas, Univeristy of Puerto Rico Mayaguez Campus, Sept. 21-23, 1994. American Socieity of Civil Engineers. Washington, DC.
  • Cha RS, Thilly WG. 1995. Specificity, Efficiency, and Fidelity of PCR. In: PCR Primer A Laboratory Manual. Cold Spring Harbor, NY. pp.37-51.
  • Cist DB, Mackie RL, Zeeb PJ, Toksoz N. 1995. Correlating GPR and resistivity surveys with cone penetrometer and shallow coring studies along the Aberjona River. In: Proceedings of SAGEEP (Symposium on the Application of Geophysics to Environmental and Engineering Problems). Environmental and Engineering Geophysical Society. Orlando, FL. pp.87-96.
  • Cohen BA, Krumholz LR, Kim H, Hemond HF. 1995. In Situ biodegradation of toluene in a contaminated stream. 2. Laboratory studies. Environ Sci Technol 29(1):117-125. PMID:22200209
  • Durant JL, Chen J, Hemond HF, Thilly WG. 1995. Elevated incidence of childhood leukemia in Woburn, Massachusetts: NIEHS Superfund Basic Research Program Search for Causes. Environ Health Perspect 103(Suppl.6):93-98. PMID:8549500
  • Hanekamp JS, Andre PC, Coller HA, Li X, Thilly WG, Khrapko K. 1995. A protocol for constant denaturant capillary electrophoresis (CDCE): Mutant DNA sequence detection. In: Mutation Detection Visby Sweden, Laboratory Protocols. Oxford University Press, pp.38-41.
  • Hanekamp JS, Thilly WG. 1995. Chromatographic separations of genetically altered DNA sequences in humans: Mutational Spectrometry. In: Chromatographic Analysis of Environment, 3rd Edition. Marcel Dekker, Inc, NY.
  • Holgate HR, Meyer JC, Tester JW. 1995. Glucose hydrolysis and oxidation in supercritical water. AIChE Journal 41:637-648. doi:10.1002/aic.690410320
  • Hu G. 1995. Multi-copy nuclear pseudogenes of mitochondrial DNA reveal recent acute genetic changes in the human genome. Curr Genet 28:410-414. PMID:8575012
  • Ivanova V. 1995. Three-Dimensional Stochastic Modeling of Rock Fracture Systems. M.Sc. thesis submitted to the M.I.T., Department of Civil and Environmental Engineering.
  • Ivanova V, Yu X, Veneziano D, Einstein H. 1995. Development of Stochastic Models for Fracture Systems. In: Proceedings of the 35th U.S. Rock Mechanics Symposium, Lake Tahoe. June, 1995.
  • Jonsson BA, Wishnok JS, Skipper PL, Stillwell WG, Tannenbaum SR. 1995. Lysine adducts between methyltetrahydropthalic anhydride and collagen in guinea-pig lung. Toxicol Appl Pharmacol 135(1):156-162. PMID:7482535
  • Kim H. 1995. Discharge of Volatile Organic Compounds from a Contaminated Aquifer and Their Fate in a Stream. Ph.D. Thesis, M.I.T., Department of Civil and Environmental Engineering.
  • Kim H, Hemond HF, Krumholz LR, Cohen BA. 1995. In situ biodegradation of toluene in a contaminated stream. 1. Field studies. Environ Sci Technol 29(1):108-116. PMID:22200208
  • Kinnicutt P. 1995. "Three-dimensional Stratigraphic Characterization for Geotechnical Exploration". In: TRB (Transportation Research Board) 75th Annual Meeting. Washington, DC.
  • Kinnicutt P. 1995. A Decision Support Framework for Planning Geotechnical Exploration Programs. Ph.D. Thesis, M.I.T., Department of Civil and Environmental Engineering.
  • Kumar R, Hanekamp JS, Louhelainen J, Burvall J, Onfelt A, Hemminki K, Thilly WG. 1995. Separation of transforming amino acid-substituting mutations in codons 12, 13 and 61 the N-ras gene by constant denaturant capillary electrophoresis (CDCE). Carcinogenesis 16(11):2667-2673. PMID:7586184
  • Lachance RP. 1995. Oxidation and Hydrolysis Reactions in Supercritical Water: Chlorinated Hydrocarbons and Organosulfur Compounds. MS Thesis, Massachusetts Institute of Technology, Cambridge, MA.
  • Marrone PA, Lachance RP, Di Naro JL, Phenix BD, Meyer JC, Tester JW, Peters WA, Swallow KC. 1995. Methylene Chloride Oxidation and Hydrolysis in Supercritical Water. Chapter 13 in: Innovations in Supercritical Fluids: Science and Technology (ACS Symposium Series, 608). American Chemical Society, Washington, DC.
  • Mason RP, Morel FM, Hemond HF. 1995. The role of microorganisms in elemental mercury formation in natural waters. Water Air Soil Pollut 80(1-4):775-787. doi:10.1007/BF01189729
  • McBrearty D. 1995. Fracture Flow as Influenced by Geologic Features in the Aberjona Valley, Massachusetts. M.Sc. thesis submitted to the M.I.T., Department of Civil and Environmental Engineering.
  • Meyer JC, Marrone PA, Tester JW. 1995. Acetic acid oxidation and hydrolysis in supercritical water. AIChE Journal 41:2108-2121. doi:10.1002/aic.690410910
  • Saito HH. 1995. Effects of Temperature and Heating Rate on Off-Gas Composition and Pyrene Removal from an Artificially-Contaminated Soil. Ph.D. Thesis, Department of Chemical Engineering, MIT.
  • Spliethoff HM. 1995. Biotic and Abiotic Transformations of Arsenic in the Upper Mystic Lake. MS thesis submitted to the MIT, Department of Civil and Environmental Engineering.
  • Spliethoff HM, Mason RP, Hemond HF. 1995. Interannual variability in the speciation and mobility of arsenic in a dimictic lake. Environ Sci Technol 29(8):2157-2161. doi:10.1021/es00008a041 PMID:22191370
  • Trowbridge PR. 1995. Rapid Redox Transformations of Arsenic and Characterization of the Internal Seiches in the Upper Mystic Lake, Medford, Massachusetts. MS thesis submitted to the MIT, Department of Civil and Environmental Engineering.
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