Superfund Research Program
Role of Paraoxonases (PONs) in Modulating Cadmium and Manganese Neurotoxicity
Project Leader: Clement E. Furlong
Co-Investigators: Lucio G. Costa, Judit Marsillach Lopez
Grant Number: P42ES004696
Funding Period: 2009-2023
Project-Specific Links
Publications
- Costa LG. Central nervous system toxicity biomarkers. In: Biomarkers in Toxicology, Second Edition. Elsevier, New York, NY. pp.173-186.
2023
- Burdon J, Budnik LT, Baur X, Hageman G, Howard CV, Roig J, Coxon L, Furlong CE, Gee D, Loraine T, Terry AV, Midavaine J, Petersen H, Bron D, Soskolne CL, Michaelis S. 2023. Health consequences of exposure to aircraft contaminated air and fume events: a narrative review and medical protocol for the investigation of exposed aircrew and passengers. Environmental Health 22(1):43. doi:10.1186/s12940-023-00987-8 PMID:37194087 PMCID:PMC10186727
- Doung RA, Garrick JM, Marsillach J. 2023. Advances in the use of residual newborn dried blood spots within environmental epidemiology. Curr Epidemiol Rep 10:264-274. doi:10.1007/s40471-023-00338-8
- Garrick JM, Cole TB, Dao K, Phillips A, Costa LG. 2023. Perinatal diesel exhaust exposure causes persistent changes in the brains of aged mice: an assessment of behavioral and biochemical endpoints related to neurodegenerative disease. Environ Toxicol doi:10.1002/tox.23733 PMID:36629036
2022
- Garrick JM, Dao K, Costa LG, Marsillach J, Furlong CE. 2022. Examining the role of paraoxonase 2 in the dopaminergic system of the mouse brain. BMC Neurosci 23(1):52. doi:10.1186/s12868-022-00738-4 PMID:36056313 PMCID:PMC9438175
2021
- Costa LG, Aschner M, eds. 2021. Neurotoxicity of metals: Old issues and new developments
- Garrick JM, Cole TB, Bammler TK, MacDonald JW, Marsillach J, Furlong CE, Costa LG. 2021. Paraoxonase 2 deficiency in mice alters motor behavior and causes region-specific transcript changes in the brain. Neurotoxicol Teratol 87(14):doi:10.1016/j.ntt.2021.107010 PMID:34216730 PMCID:PMC8440460
- Garrick JM, Costa LG, Cole TB, Marsillach J. 2021. Evaluating gait and locomotion in rodents with the CatWalk system. Curr Protoc 1(8):e220. doi:10.1002/cpz1.220 PMID:34370398 PMCID:PMC8363132
- Marsillach J, Richter RJ, Costa LG, Furlong CE. 2021. Paraoxonase-1 (PON1) status analysis using non organophosphate substrates. Curr Protoc 1:e25. doi:10.1002/cpz1.25 PMID:33484495 PMCID:PMC7924808
- Salazar JG, Marsillach J, Reverte I, Mackness B, Joven J, Camps J, Colomina MT. 2021. Paraoxonase-1 and -3 protein expression in brain of the Tg2576 mouse model of Alzheimer's disease. Antioxidants (Basel) 10(3):339. doi:10.3390/antiox10030339 PMID:33668379 PMCID:PMC7996151
- Stingone JA, Triantafillou S, Larsen A, Kitt JP, Shaw GM, Marsillach J. 2021. Interdisciplinary data science to advance environmental health research and improve birth outcomes. Environ Res 197:doi:10.1016/j.envres.2021.111019 PMID:33737076 PMCID:PMC8187296
- Zimetti F, Adorni MP, Marsillach J, Marchi C, Trentini A, Valacchi G, Cervellati C. 2021. Connection between the altered HDL antioxidant and anti-inflammatory properties and the risk to develop Alzheimer's disease: A narrative review. Oxid Med Cell Longev doi:10.1155/2021/6695796 PMID:33505588 PMCID:PMC7811424
2020
- Cole TB, Chang Y, Dao K, Daza R, Hevner R, Costa LG. 2020. Developmental exposure to diesel exhaust upregulates transcription factor expression, decreases hippocampal neurogenesis, and alters cortical lamina organization: relevance to neurodevelopmental disorders. J Neurodev Disord 12:41. doi:10.1186/s11689-020-09340-3 PMID:33327933 PMCID:PMC7745370
- Costa LG, Cole TB, Dao K, Chang Y, Coburn J, Garrick JM. 2020. Effects of air pollution on the nervous system and its possible role in neurodevelopmental and neurodegenerative disorders. Pharmacol Ther 210:107523. doi:10.1016/j.pharmthera.2020.107523 PMID:32165138 PMCID:PMC7245732
- Kahng S, Soelberg SD, Fondjo F, Kim J, Furlong CE, Chung J. 2020. Carbon nanotube-based thin-film resistive sensor for point-of-care screening of tuberculosis. Biomed Microdevices 22(3):50. doi:10.1007/s10544-020-00506-3 PMID:32725281
- Marsillach J, Adorni MP, Zimetti F, Papotti B, Zuliani G, Cervellati C. 2020. HDL proteome and Alzheimer's disease: Evidence of a link. Antioxidants (Basel) doi:10.3390/antiox9121224 PMID:33287338 PMCID:PMC7761753
2019
- Cervellati C, Valacchi G, Tisato V, Zuliani G, Marsillach J. 2019. Evaluating the link between Paraoxonase-1 levels and Alzheimer's disease development. Minerva Med 110(3):238-250. doi:10.23736/S0026-4806.18.05875-5 PMID:30334443
- Chang Y, Daza R, Hevner R, Costa LG, Cole TB. 2019. Prenatal and early life diesel exhaust exposure disrupts cortical lamina organization: Evidence for a reelin-related pathogenic pathway induced by interleukin-6. Brain Behav Immun 78:105-115. doi:10.1016/j.bbi.2019.01.013 PMID:30668980 PMCID:PMC6557404
2018
- Chang Y, Cole TB, Costa LG. 2018. Prenatal and early-life diesel exhaust exposure causes autism-like behavioral changes in mice. Part Fibre Toxicol 15:18. doi:10.1186/s12989-018-0254-4 PMID:29678176 PMCID:PMC5910592
- Coburn J, Cole TB, Dao K, Costa LG. 2018. Acute exposure to diesel exhaust impairs adult neurogenesis in mice: prominence in males and protective effect of pioglitazone. Arch Toxicol 92(5):1815-1829. doi:10.1007/s00204-018-2180-5 PMID:29523932
- Costa LG. 2018. Organophosphorus compounds at 80: some old and new issues. Toxicol Sci 162:24-35. doi:10.1093/toxsci/kfx266 PMID:29228398
2017
- Chang Y, Cole TB, Costa LG. 2017. Behavioral phenotyping for autism spectrum disorders in mice. Curr Protoc Toxicol 72:11.22.1-11.22.21. doi:10.1002/cptx.19 PMID:28463420 PMCID:PMC5494990
- Costa LG, Cole TB, Coburn J, Chang Y, Dao K, Roque PJ. 2017. Neurotoxicity of traffic-related air pollution. Neurotoxicology 59:133-139. doi:10.1016/j.neuro.2015.11.008 PMID:26610921 PMCID:PMC4875879
- Costa LG, Cole TB, Garrick JM, Marsillach J, Furlong CE. 2017. Metals and paraoxonases. Adv Neurobiol 18:85-111. doi:10.1007/978-3-319-60189-2_5 PMID:28889264
- Roque PJ, Costa LG. 2017. Co-Culture of neurons and microglia. Curr Protoc Toxicol 74:11.24.1-11.24.17. doi:10.1002/cptx.32 PMID:29117434 PMCID:PMC5774987
2016
- Cole TB, Coburn J, Dao K, Roque PJ, Chang Y, Kalia V, Guilarte TR, Dziedzic J, Costa LG. 2016. Sex and genetic differences in the effects of acute diesel exhaust exposure on inflammation and oxidative stress in mouse brain. Toxicology 374:1-9. doi:10.1016/j.tox.2016.11.010 PMID:27865893 PMCID:PMC5154914
- Costa LG, Garrick JM, Roque PJ, Pellacani C. 2016. Mechanisms of neuroprotection by quercetin: counteracting oxidative stress and more. Oxid Med Cell Longev 2016:2986796. doi:10.1155/2016/2986796 PMID:26904161 PMCID:PMC4745323
- Furlong CE, Marsillach J, Jarvik GP, Costa LG. 2016. Paraoxonases-1, -2 and -3: what are their functions?. Chem Biol Interact 259(PtB):51-62. doi:10.1016/j.cbi.2016.05.036 PMID:27238723
- Garrick JM, Dao K, de Laat R, Elsworth J, Cole TB, Marsillach J, Furlong CE, Costa LG. 2016. Developmental expression of paraoxonase 2. Chem Biol Interact 259(PtB):168-174. doi:10.1016/j.cbi.2016.04.001 PMID:27062895 PMCID:PMC5055469
- Marsillach J, Costa LG, Furlong CE. 2016. Paraoxonase-1 and early life environmental exposures. Ann Glob Health 82(1):100-110. doi:10.1016/j.aogh.2016.01.009 PMID:27325068 PMCID:PMC4916371
- Roque PJ, Dao K, Costa LG. 2016. Microglia mediate diesel exhaust particle-induced cerebellar neuronal toxicity through neuroinflammatory mechanisms. Neurotoxicology 56:204-214. doi:10.1016/j.neuro.2016.08.006 PMID:27543421 PMCID:PMC5048600
2015
- Burton C, Marsillach J, Zhang YS, Zhao W, Zheng X. 2015. Announcing our finalists. Bioanalysis 7(13):1667-1673. doi:10.4155/bio.15.90 PMID:26150248
- Costa LG, Cole TB, Furlong CE. 2015. Paraoxonase (PON1) and Detoxication of Nerve Agents. Chapter 73 in: Handbook of Toxicology of Chemical Warfare Agents, 2nd edition. Academic Press,
- Kim D, Burt AA, Ranchalis J, Vuletic S, Vaisar T, Li WF, Rosenthal EA, Dong W, Eintracht JF, Motulsky AG, Brunzell J, Albers JJ, Furlong CE, Jarvik GP. 2015. PLTP activity inversely correlates with CAAD: effects of PON1 enzyme activity and genetic variants on PLTP activity. J Lipid Res 56(7):1351-1362. doi:10.1194/jlr.P058032 PMID:26009633 PMCID:PMC4479339
- Krenz JE, Hofmann JN, Smith TR, Cunningham RN, Fenske RA, Simpson C, Keifer M. 2015. Determinants of butyrylcholinesterase inhibition among agricultural pesticide handlers in Washington State: an update. Ann Occup Hyg 59(1):25-40. doi:10.1093/annhyg/meu072 PMID:25261454 PMCID:PMC4290628
- Marsillach J, Becker J, Vaisar T, Hahn B, Brunzell J, Furlong CE, de Boer I, McMahon M, Hoofnagle A. 2015. Paraoxonase-3 is depleted from the high-density lipoproteins of autoimmune disease patients with subclinical atherosclerosis. J Proteome Res 14(5):2046-2054. doi:10.1021/pr5011586 PMID:25723336 PMCID:PMC4434596
2014
- Cole TB, Li WF, Co AL, Hay AM, MacDonald JW, Bammler TK, Farin FM, Costa LG, Furlong CE. 2014. Repeated gestational exposure of mice to chlorpyrifos oxon is associated with paraoxonase 1 (PON1) modulated effects in maternal and fetal tissues. Toxicol Sci 141(2):409-422. doi:10.1093/toxsci/kfu144 PMID:25070982 PMCID:PMC4271046
- Costa LG, de Laat R, Dao K, Pellacani C, Cole TB, Furlong CE. 2014. Paraoxonase-2 (PON2) in brain and its potential role in neuroprotection. Neurotoxicology 43:3-9. doi:10.1016/j.neuro.2013.08.011 PMID:24012887 PMCID:PMC3942372
- Costa LG, de Laat R, Tagliaferri S, Pellacani C. 2014. A mechanistic view of polybrominated diphenyl ether (PBDE) developmental neurotoxicity. Toxicol Lett 230(2):282-294. doi:10.1016/j.toxlet.2013.11.011 PMID:24270005 PMCID:PMC4028440
- Inoue S, Becker AL, Kim J, Shu Z, Soelberg SD, Weigel KM, Hiraiwa M, Cairns A, Lee H, Furlong CE, Oh K, Lee K, Gao D, Chung J, Cangelosi GA. 2014. Semi-automated, occupationally safe immunofluorescence microtip sensor for rapid detection of Mycobacterium cells in sputum. PLoS One 9(1):e86018. doi:10.1371/journal.pone.0086018 PMID:24465845 PMCID:PMC3899086
- Kim D, Burt AA, Rosenthal EA, Ranchalis J, Eintracht JF, Hatsukami TS, Furlong CE, Marcovina S, Albers JJ, Jarvik GP. 2014. HDL-3 is a superior predictor of carotid artery disease in a case-control cohort of 1725 participants. J Am Heart Assoc 3(3):e000902. doi:10.1161/JAHA.114.000902 PMID:24965026 PMCID:PMC4309059
- Kim D, Crosslin DR, Auer PL, Suzuki SM, Marsillach J, Burt AA, Gordon AS, Meschia JF, Nalls MA, Worrall BB, Longstreth WT, Gottesman RF, Furlong CE, Peters U, Rich SS, Nickerson DA, Jarvik GP. 2014. Rare coding variation in paraoxonase-1 is associated with ischemic stroke in the NHLBI Exome Sequencing Project. J Lipid Res 55(6):1173-1178. doi:10.1194/jlr.P049247 PMID:24711634 PMCID:PMC4031948
- Marsillach J, Suzuki SM, Richter RJ, McDonald MG, Rademacher PM, MacCoss MJ, Hsieh EJ, Rettie AE, Furlong CE. 2014. Human valacyclovir hydrolase/biphenyl hydrolase-like protein is a highly efficient homocysteine thiolactonase. PLoS One 9(10):e110054. doi:10.1371/journal.pone.0110054 PMID:25333274 PMCID:PMC4198189
- Strelitz J, Engel LS, Keifer M. 2014. Blood acetylcholinesterase and butyrylcholinesterase as biomarkers of cholinesterase depression among pesticide handlers. Occup Environ Med 71(12):842-847. doi:10.1136/oemed-2014-102315 PMID:25189163 PMCID:PMC4224972
2013
- Baker PE, Cole TB, Cartwright M, Suzuki SM, Thummel KE, Lin YS, Co AL, Rettie AE, Kim JH, Furlong CE. 2013. Identifying safer anti-wear triaryl phosphate additives for jet engine lubricants. Chem Biol Interact 203(1):257-264. doi:10.1016/j.cbi.2012.10.005 PMID:23085349 PMCID:PMC3618534
- Costa LG, Giordano G, Cole TB, Marsillach J, Furlong CE. 2013. Paraoxonase 1 (PON1) as a genetic determinant of susceptibility to organophosphate toxicity. Toxicology 307:115-122. doi:10.1016/j.tox.2012.07.011 PMID:22884923 PMCID:PMC3516631
- Costa LG, Tait L, de Laat R, Dao K, Giordano G, Pellacani C, Cole TB, Furlong CE. 2013. Modulation of paraoxonase 2 (PON2) in mouse brain by the polyphenol quercetin: a mechanism of neuroprotection?. Neurochem Res 38(9):1809-1818. doi:10.1007/s11064-013-1085-1 PMID:23743621 PMCID:PMC3735620
- Giordano G, Tait L, Furlong CE, Cole TB, Kavanagh TJ, Costa LG. 2013. Gender differences in brain susceptibility to oxidative stress are mediated by levels of paraoxonase-2 expression. Free Radic Biol Med 58:98-108. doi:10.1016/j.freeradbiomed.2013.01.019 PMID:23376469 PMCID:PMC3622778
- Kim D, Marsillach J, Furlong CE, Jarvik GP. 2013. Pharmacogenetics of paraoxonase activity: elucidating the role of high-density lipoprotein in disease. Pharmacogenomics 14:1495-1515. doi:10.2217/pgs.13.147 PMID:24024900 PMCID:PMC3888096
- Marsillach J, Costa LG, Furlong CE. 2013. Protein adducts as biomarkers of exposure to organophosphorus compounds. Toxicology 307:46-54. doi:10.1016/j.tox.2012.12.007 PMID:23261756 PMCID:PMC3747771
- Marsillach J, Hsieh EJ, Richter RJ, MacCoss MJ, Furlong CE. 2013. Proteomic analysis of adducted butyrylcholinesterase for biomonitoring organophosphorus exposures. Chem Biol Interact 203(1):85-90. doi:10.1016/j.cbi.2012.10.019 PMID:23123252 PMCID:PMC4108156
2012
- Cole TB, Fisher JC, Burbacher T, Costa LG, Furlong CE. 2012. Neurobehavioral assessment of mice following repeated postnatal exposure to chlorpyrifos-oxon. Neurotoxicol Teratol 34(3):311-322. doi:10.1016/j.ntt.2012.02.003 PMID:22425525 PMCID:PMC3367041
- Furlong CE, Richter RJ, Costa LG, Jarvik GP. 2012. Paraoxonase 1 (PON1) Status in Risk Assessment for Organophosphate Exposure and Pharmacokinetics. Chapter 9 in: Parameters for pesticide QSAR and PBPK/PD models for human risk assessment. American Chemical Society, Washington, DC. pp.133-147.
2011
- Cole TB, Beyer RP, Bammler TK, Park SS, Farin FM, Costa LG, Furlong CE. 2011. Repeated developmental exposure of mice to chlorpyrifos oxon is associated with paraoxonase 1 (PON1)-modulated effects on cerebellar gene expression. Toxicol Sci 123:155-169. doi:10.1093/toxsci/kfr157 PMID:21673326 PMCID:PMC3164442
- Costa LG, Furlong CE. 2011. Paraoxonase 1: Structure, Function and Polymorphisms. Chapter 7 in: Anticholinesterase Pesticides: Metabolism, Neurotoxicity, and Epidemiology. Wiley, Hoboken, NJ. pp.85-96.
- Costa LG, Giordano G, Furlong CE. 2011. Pharmacological and dietary modulators of paraoxonase 1 (PON1) activity and expression: the hunt goes on. Biochem Pharmacol 81(3):337-344. doi:10.1016/j.bcp.2010.11.008 PMID:21093416 PMCID:PMC3077125
- Giordano G, Cole TB, Furlong CE, Costa LG. 2011. Paraoxonase 2 (PON2) in the mouse central nervous system: a neuroprotective role?. Toxicol Appl Pharmacol 256:369-378. doi:10.1016/j.taap.2011.02.014 PMID:21354197 PMCID:PMC3155737
- Kim JH, Stevens RC, MacCoss MJ, Goodlett DR, Scherl A, Richter RJ, Suzuki SM, Furlong CE, Marsillach J, Tomazela D, Schopfer LM, Lockridge O. 2011. Biomarkers of organophosphorus (OP) exposures in humans. Neurotoxicology 32:656-660. doi:10.1016/j.neuro.2011.06.005 PMID:21767566 PMCID:PMC3279568
- Liyasova M, Li B, Schopfer LM, Nachon F, Masson P, Furlong CE, Lockridge O. 2011. Exposure to tri-o-cresyl phosphate detected in jet airplant passengers. Toxicol Appl Pharmacol 256:337-347. doi:10.1016/j.taap.2011.06.016 PMID:21723309 PMCID:PMC3205265
2010
- Cole TB, Park SS, Li WF, Furlong CE, Costa LG, Jansen KL. 2010. The toxicity of mixtures of specific organophosphorus (OP) compounds is modulated by paraoxonase 1 status. Advances in Experimental Medicine and Biology 660:47-60. doi:10.1007/978-1-60761-350-3_6 PMID:20221870 PMCID:PMC3035621
- Furlong CE, Suzuki SM, Stevens RC, Marsillach J, Richter RJ, Jarvik GP, Checkoway H, Samii A, Costa LG, Griffith A, Roberts JW, Yearout D, Zabetian CP. 2010. Human PON1, a biomarker of risk of disease and exposure. Chem Biol Interact 187(1-3):355-361. doi:10.1016/j.cbi.2010.03.033 PMID:20338154 PMCID:PMC3035622
- Hofmann JN, Keifer M, Checkoway H, De Roos AJ, Farin FM, Fenske RA, Richter RJ, van Belle G, Furlong CE. 2010. Biomarkers of sensitivity and exposure in Washington state pesticide handlers. Advances in Experimental Medicine and Biology 660:19-27. doi:10.1007/978-1-60761-350-3_3 PMID:20221867 PMCID:PMC3041670
- Hofmann JN, Keifer M, De Roos AJ, Fenske RA, Furlong CE, van Belle G, Checkoway H. 2010. Occupational determinants of serum cholinesterase inhibition among organophosphate-exposed agricultural pesticide handlers in Washington State. Occup Environ Med 67(6):375-386. doi:10.1136/oem.2009.046391 PMID:19819864 PMCID:PMC2908529
- Kim JH, Stevens RC, MacCoss MJ, Goodlett DR, Scherl A, Richter RJ, Suzuki SM, Furlong CE. 2010. Identification and characterization of biomarkers of organophosphorus (OP) exposures in humans. Advances in Experimental Medicine and Biology 660:61-71. doi:10.1007/978-1-60761-350-3_7 PMID:20221871 PMCID:PMC2878371
- Richter RJ, Cole TB, Park SS, Otto TC, Cerasoli DM, Lenz DE, Furlong CE, Suzuki SM, Stevens RC. 2010. Engineering Human P0N1 in an E. coli Expression System. In: Paraoxonases in Inflammation, Infection and Toxicology. Humana Press, pp.37-46.
- Richter RJ, Jarvik GP, Furlong CE. 2010. Paraoxonase 1 status as a risk factor for disease or exposure. Advances in Experimental Medicine and Biology 660:29-35. doi:10.1007/978-1-60761-350-3_4 PMID:20221868 PMCID:PMC2868909
- Ross S, Brewin C, Curran H, Furlong CE, Abraham-Smith K, Harrison V. 2010. Neuropsychological and psychiatric functioning in sheep farmers exposed to low levels of organophosphate pesticides. Neurotoxicol Teratol 32(4):452-459. doi:10.1016/j.ntt.2010.03.004 PMID:20227490 PMCID:PMC3042861
- Schopfer L, Furlong CE, Lockridge O. 2010. Development of diagnostics in the search for an explanation of aerotoxic syndrome. Anal Biochem 404(1):64-74. doi:10.1016/j.ab.2010.04.032 PMID:20447373 PMCID:PMC2900449
- Suzuki SM, Stevens RC, Richter RJ, Cole TB, Park SS, Otto TC, Cerasoli DM, Lenz DE, Furlong CE. 2010. Engineering human PON1 in an E. coli expression system. Advances in Experimental Medicine and Biology 660:37-45. doi:10.1007/978-1-60761-350-3_5 PMID:20221869 PMCID:PMC3056878
- Ticozzi N, LeClerc AL, Keagle PJ, Glass JD, Wills AM, van Blitterswijk M, Bosco DA, Rodriguez-Leyva I, Gellera C, Ratti A, Taroni F, McKenna-Yasek D, Sapp PC, Silvani V, Furlong CE, Brown RH, Landers JE. 2010. Paraoxonase gene mutations in amyotrophic lateral sclerosis. Ann Neurol 68(1):102-107. doi:10.1002/ana.21993 PMID:20582942 PMCID:PMC2945725
2009
- Hofmann JN, Keifer M, Furlong CE, De Roos AJ, Farin FM, Fenske RA, van Belle G, Checkoway H. 2009. Serum cholinesterase inhibition in relation to paraoxonase-1 (PON1) status among organophosphate-exposed agricultural pesticide handlers. Environ Health Perspect 117:1402-1408. PMID:19750105
- Huen K, Richter RJ, Furlong CE, Eskenazi B, Holland NT. 2009. Validation of PON1 enzyme activity assays for longitudinal studies. Clin Chim Acta 402(1-2):67-74. doi:10.1016/j.cca.2008.12.019 PMID:19146843 PMCID:PMC2683673
- Jansen KL, Cole TB, Park SS, Furlong CE, Costa LG. 2009. Paraoxonase 1 (PON1) modulates the toxicity of mixed organophosphorus compounds. Toxicol Appl Pharmacol 236(2):142-153. doi:10.1016/j.taap.2009.02.001 PMID:19371602 PMCID:PMC2717945
- Richter RJ, Jarvik GP, Furlong CE. 2009. Paraoxonase 1 (PON1) status and substrate hydrolysis. Toxicol Appl Pharmacol 235(1):1-9. doi:10.1016/j.taap.2008.11.001 PMID:19071155 PMCID:PMC3045428
2008
- Richter RJ, Jarvik GP, Furlong CE. 2008. Determination of paraoxonase 1 status without the use of toxic organophosphate substrates. Circ Cardiovasc Genet 1(2):147-152. doi:10.1161/CIRCGENETICS.108.811638 PMID:20031556 PMCID:PMC3035628
- Stevens RC, Suzuki SM, Cole TB, Park SS, Richter RJ, Furlong CE. 2008. Engineered recombinant human paraoxonase 1 (rHuPON1) purified from Escherichia coli protects against organophosphate poisoning. Proc Natl Acad Sci U S A 105(35):12780-12784. doi:10.1073/pnas.0805865105 PMID:18711144 PMCID:PMC2529096