Superfund Research Program

Mechanisms and Biomarkers of Metal Olfactory Injury in Salmon

Project Leader: Evan P. Gallagher
Co-Investigators: Zhengui Xia, Daniel Storm, Rebecca B. Neumann
Grant Number: P42ES004696
Funding Period: 2009-2023

Project-Specific Links

Publications

2020

• Putman NF, Williams CR, Gallagher EP, Dittman AH. 2020. A sense of place: Pink salmon use a magnetic map for orientation. J Exp Bio doi:10.1242/jeb.218735
• Steele WB, Kristofco LA, Corrales J, Saari GN, Corcoran EJ, Hill BN, Mills MG, Gallagher EP, Kavanagh TJ, Melnikov F, Zimmerman JB, Voutchkova-Kostal A, Anastas P, Kostal J, Brooks BW. 2020. Toward less hazardous industrial compounds: Coupling quantum mechanical computations, biomarker responses, and behavioral profiles to identify bioactivity of S(N)2 electrophiles in alternative vertebrate models. Chem Res Toxicol 33(2):367-380. doi:10.1021/acs.chemrestox.9b00290 PMID:31789507

2019

• Melnikov F, Botta D, White CC, Schmuck S, Winfough M, Schaupp C, Gallagher EP, Brooks BW, Williams E, Coish P, Anastas P, Voutchkova-Kostal A, Kostal J, Kavanagh TJ. 2019. Kinetics of Glutathione Depletion and Antioxidant Gene Expression as Indicators of Chemical Modes of Action Assessed in vitro in Mouse Hepatocytes with Enhanced Glutathione Synthesis. Chem Res Toxicol 32(3):421-436. doi:10.1021/acs.chemrestox.8b00259
• Mills MG, Ramsden R, Ma EY, Corrales J, Kristofco LA, Steele WB, Saari GN, Melnikov F, Kostal J, Kavanagh TJ, Zimmerman JB, Voutchkova-Kostal A, Brooks BW, Coish P, Anastas P, Gallagher EP. 2019. CRISPR-generated Nrf2a loss- and gain-of-function mutants facilitate mechanistic analysis of chemical oxidative stress-mediated toxicity in zebrafish. Chem Res Toxicol doi:10.1021/acs.chemrestox.9b00346

2018

• Heffern K, Tierney KB, Gallagher EP. 2018. Comparative effects of cadmium, zinc, arsenic and chromium on olfactory-mediated neurobehavior and gene expression in larval zebrafish (Danio rerio). Aquat Toxicol 201:83-90. doi:10.1016/j.aquatox.2018.05.016 PMID:29890505 PMCID:PMC6062444
• Ma EY, Heffern K, Cheresh J, Gallagher EP. 2018. Differential copper-induced death and regeneration of olfactory sensory neuron populations and neurobehavioral function in larval zebrafish. Neurotoxicology 69:141-151. doi:10.1016/j.neuro.2018.10.002 PMID:30292653
• Meador J, Yeh A, Gallagher EP. 2018. Adverse metabolic effects in fish exposed to contaminants of emerging concern in the field and laboratory. Environ Pollut 236:850-861. doi:10.1016/j.envpol.2018.02.007 PMID:29471284 PMCID:PMC5858870
• Steele WB, Kristofco LA, Corrales J, Saari GN, Haddad SP, Gallagher EP, Kavanagh TJ, Kostal J, Zimmerman JB, Voutchkova-Kostal A, Anastas P, Brooks BW. 2018. Comparative behavioral toxicology with two common larval fish models: exploring relationships among modes of action and locomotor responses. Sci Total Environ 640-641:1587-1600. doi:10.1016/j.scitotenv.2018.05.402 PMID:30021323
• Williams CR, Dittman AH, McElhany P, Busch DS, Maher MT, Bammler TK, MacDonald JW, Gallagher EP. 2018. Elevated CO2 impairs olfactory mediated neural and behavioral responses and gene expression in ocean-phase coho salmon (Oncorhynchus kisutch). Glob Chang Biol 25(3):963-977. doi:10.1111/gcb.14532 PMID:30561876 PMCID:PMC7065673

2017

• Meador J, Yeh A, Gallagher EP. 2017. Determining potential adverse effects in marine fish exposed to pharmaceuticals and personal care products with the fish plasma model and whole-body tissue concentrations. Environ Pollut 230:1018-1029. doi:10.1016/j.envpol.2017.07.047 PMID:28764109 PMCID:PMC5595653
• Mills MG, Gallagher EP. 2017. A targeted gene expression platform allows for rapid analysis of chemical-induced antioxidant mRNA expression in zebrafish larvae. PLoS One 12(2):e0171025. doi:10.1371/journal.pone.0171025 PMID:28212397 PMCID:PMC5315391
• Yeh A, Marcinek DJ, Meador J, Gallagher EP. 2017. Effect of contaminants of emerging concern on liver mitochondrial function in Chinook salmon. Aquat Toxicol 190:21-31. doi:10.1016/j.aquatox.2017.06.011 PMID:28668760 PMCID:PMC5590637

2016

• Meador J, Yeh A, Young G, Gallagher EP. 2016. Contaminants of emerging concern in a large temperate estuary. Environ Pollut 213:254-267. doi:10.1016/j.envpol.2016.01.088 PMID:26907702
• Ramsden R, Gallagher EP. 2016. Dual NRF2 paralogs in Coho salmon and their antioxidant response element targets. Redox Biol 9:114-123. doi:10.1016/j.redox.2016.07.001 PMID:27470083 PMCID:PMC5068245
• Wang L, Espinoza HM, MacDonald JW, Bammler TK, Williams CR, Yeh A, Louie KW, Marcinek DJ, Gallagher EP. 2016. Olfactory transcriptional analysis of salmon exposed to mixtures of chlorpyrifos and malathion reveal novel molecular pathways of neurobehavioral injury. Toxicol Sci 149(1):145-157. doi:10.1093/toxsci/kfv223 PMID:26494550 PMCID:PMC4731405
• Williams CR, MacDonald JW, Bammler TK, Simpson C, Paulsen M, Gallagher EP. 2016. From the cover: cadmium exposure differentially alters odorant-driven behaviors and expression of olfactory receptors in juvenile Coho salmon (Oncorhynchus kisutch). Toxicol Sci 154(2):267-277. doi:10.1093/toxsci/kfw172 PMID:27621283 PMCID:PMC5139070

2015

• Maryoung LA, Blunt B, Tierney KB, Schlenk D. 2015. Sublethal toxicity of chlorpyrifos to salmonid olfaction after hypersaline acclimation. Aquat Toxicol 161:94-101. doi:10.1016/j.aquatox.2015.01.026 PMID:25697678
• Maryoung LA, Lavado R, Bammler TK, Gallagher EP, Stapleton PL, Beyer RP, Farin FM, Hardiman G, Schlenk D. 2015. Differential gene expression in liver, gill, and olfactory rosettes of Coho salmon (Oncorhynchus kisutch) after acclimation to salinity. Mar Biotechnol (NY) 17(6):703-717. doi:10.1007/s10126-015-9649-5 PMID:26260986 PMCID:PMC4636457

2014

• Hook SE, Gallagher EP, Batley GE. 2014. The role of biomarkers in the assessment of aquatic ecosystem health. Integr Environ Assess Manag 10(3):327-341. doi:10.1002/ieam.1530 PMID:24574147 PMCID:PMC4750648
• Kupsco A, Schlenk D. 2014. Mechanisms of selenomethionine developmental toxicity and the impacts of combined hypersaline conditions on Japanese Medaka (Oryzias latipes). Environ Sci Technol 48(12):7062-7068. doi:10.1021/es5019948 PMID:24856650 PMCID:PMC4066905
• Lavado R, Aparicio-Fabre R, Schlenk D. 2014. Effects of salinity acclimation on the expression and activity of Phase I enzymes (CYP450 and FMOs) in Coho salmon (Oncorhynchus kisutch). Fish Physiol Biochem 40(1):267-278. doi:10.1007/s10695-013-9842-2 PMID:23925894 PMCID:PMC3946875
• Maryoung LA, Lavado R, Schlenk D. 2014. Impacts of hypersaline acclimation on the acute toxicity of the organophosphate chlorpyrifos to salmonids. Aquat Toxicol 152:284-290. doi:10.1016/j.aquatox.2014.04.017 PMID:24799192

2013

• Lavado R, Aparicio-Fabre R, Schlenk D. 2013. Effects of salinity acclimation on the pesticide-metabolizing enzyme flavin-containing monooxygenase (FMO) in rainbow trout (Oncorhynchus mykiss). Comp Biochem Physiol C Toxicol Pharmacol 157:9-15. doi:10.1016/j.cbpc.2012.08.004 PMID:22981832 PMCID:PMC3508337
• Wang L, Bammler TK, Beyer RP, Gallagher EP. 2013. Copper-induced deregulation of microRNA expression in the zebrafish olfactory system. Environ Sci Technol 47(13):7466-7474. doi:10.1021/es400615q PMID:23745839 PMCID:PMC4750873
• Wang L, Espinoza HM, Gallagher EP. 2013. Brief exposure to copper induces apoptosis and alters mediators of olfactory signal transduction in coho salmon. Chemosphere 93(10):2639-2643. doi:10.1016/j.chemosphere.2013.08.044 PMID:24050714 PMCID:PMC3840796
• Wang L, Gallagher EP. 2013. Role of Nrf2 antioxidant defense in mitigating cadmium-induced oxidative stress in the olfactory system of zebrafish. Toxicol Appl Pharmacol 266(2):177-186. doi:10.1016/j.taap.2012.11.010 PMID:23174481
• Williams CR, Gallagher EP. 2013. Effects of cadmium on olfactory mediated behaviors and molecular biomarkers in coho salmon (Oncorhynchus kisutch). Aquat Toxicol 140-141:295-302. doi:10.1016/j.aquatox.2013.06.010 PMID:23851056 PMCID:PMC3770528

2012

• Harris SM, Espinoza HM, McClain V, Gallagher EP, Wang L. 2012. Characterization of phospholipid hydroperoxide glutathione metabolizing peroxidase (gpx4) isoforms in Coho Salmon olfactory and liver tissues and their modulation by cadmium. Aquat Toxicol 114-115:134-141. doi:10.1016/j.aquatox.2012.02.025 PMID:22446825 PMCID:PMC3660139
• McClain V, Stapleton HM, Tilton F, Gallagher EP. 2012. BDE 49 and developmental toxicity in zebrafish. Comp Biochem Physiol C Toxicol Pharmacol 155:253-258. doi:10.1016/j.cbpc.2011.09.004 PMID:21951712 PMCID:PMC3246048

2011

• Lavado R, Maryoung LA, Schlenk D. 2011. Hypersalinity acclimation increases the toxicity of the insecticide phorate in Coho salmon (Oncorhynchus kisutch). Environ Sci Technol 45:4623-4629. doi:10.1021/es200451j PMID:21488666 PMCID:PMC3627486
• Lavado R, Schlenk D. 2011. Microsomal biotransformation of chlorpyrifos, parathion and fenthion in rainbow trout (Oncorhynchus mykiss) and coho salmon (Oncorhynchus kisutch): mechanistic insights into interspecific differences in toxicity. Aquat Toxicol 101(1):57-63. doi:10.1016/j.aquatox.2010.09.002 PMID:20947181 PMCID:PMC3005852
• Tilton F, Tilton SC, Bammler TK, Beyer RP, Stapleton PL, Scholz N, Gallagher EP. 2011. Transcriptional impact of organophosphate and metal mixtures on olfaction: Copper dominates the chlorpyrifos-induced response in adult zebrafish. Aquat Toxicol 102(3-4):205-215. doi:10.1016/j.aquatox.2011.01.012 PMID:21356183 PMCID:PMC3991301

2010

• Browne E, Kelley MA, Zhou GD, He L, McDonald TJ, Wang S, Duncan B, Meador J, Donnelly KC, Gallagher EP. 2010. In situ biomonitoring of juvenile Chinook salmon (Onchorhynchus tshawytscha) using biomarkers of chemical exposures and effects in a partially remediated urbanized waterway of the Puget Sound, WA. Environ Res 110(7):675-683. doi:10.1016/j.envres.2010.06.007 PMID:20619832 PMCID:PMC3321373
• Shao J, Dabrowski MJ, White CC, Kavanagh TJ, Gallagher EP. 2010. Flow cytometric analysis of BDE 47 mediated injury to rainbow trout gill epithelial cells. Aquat Toxicol 97(1):42-50. doi:10.1016/j.aquatox.2009.11.013 PMID:20053465 PMCID:PMC3321377

2009

• Lavado R, Rimoldi JM, Schlenk D. 2009. Mechanisms of fenthion activation in rainbow trout (Oncorhynchus mykiss) acclimated to hypersaline environments. Toxicol Appl Pharmacol 235(2):143-152. doi:10.1016/j.taap.2008.11.017 PMID:19111563 PMCID:PMC2858921
• Rodriguez-Fuentes G, Coburn C, Currás-Collazo M, Schlenk D, Guillén G. 2009. Effect of hyperosmotic conditions on flavin-containing monooxygenase activity, protein and mRNA expression in rat kidney. Toxicol Lett 187(2):115-118. doi:10.1016/j.toxlet.2009.02.006 PMID:19429252 PMCID:PMC2858923