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Project Publications: University of Washington: Mechanisms and Biomarkers of Metal Olfactory Injury in Salmon

Superfund Research Program

Mechanisms and Biomarkers of Metal Olfactory Injury in Salmon

Project Leader: Evan P. Gallagher
Co-Investigators: Zhengui Xia, Daniel Storm, Rebecca B. Neumann
Grant Number: P42ES004696
Funding Period: 2009-2023
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  • Putman NF, Williams CR, Gallagher EP, Dittman AH. 2020. A sense of place: Pink salmon use a magnetic map for orientation. J Exp Bio doi:10.1242/jeb.218735
  • Steele WB, Kristofco LA, Corrales J, Saari GN, Corcoran EJ, Hill BN, Mills MG, Gallagher EP, Kavanagh TJ, Melnikov F, Zimmerman JB, Voutchkova-Kostal A, Anastas P, Kostal J, Brooks BW. 2020. Toward less hazardous industrial compounds: Coupling quantum mechanical computations, biomarker responses, and behavioral profiles to identify bioactivity of S(N)2 electrophiles in alternative vertebrate models. Chem Res Toxicol 33(2):367-380. doi:10.1021/acs.chemrestox.9b00290 PMID:31789507


  • Melnikov F, Botta D, White CC, Schmuck S, Winfough M, Schaupp C, Gallagher EP, Brooks BW, Williams E, Coish P, Anastas P, Voutchkova-Kostal A, Kostal J, Kavanagh TJ. 2019. Kinetics of Glutathione Depletion and Antioxidant Gene Expression as Indicators of Chemical Modes of Action Assessed in vitro in Mouse Hepatocytes with Enhanced Glutathione Synthesis. Chem Res Toxicol 32(3):421-436. doi:10.1021/acs.chemrestox.8b00259
  • Mills MG, Ramsden R, Ma EY, Corrales J, Kristofco LA, Steele WB, Saari GN, Melnikov F, Kostal J, Kavanagh TJ, Zimmerman JB, Voutchkova-Kostal A, Brooks BW, Coish P, Anastas P, Gallagher EP. 2019. CRISPR-generated Nrf2a loss- and gain-of-function mutants facilitate mechanistic analysis of chemical oxidative stress-mediated toxicity in zebrafish. Chem Res Toxicol doi:10.1021/acs.chemrestox.9b00346


  • Heffern K, Tierney KB, Gallagher EP. 2018. Comparative effects of cadmium, zinc, arsenic and chromium on olfactory-mediated neurobehavior and gene expression in larval zebrafish (Danio rerio). Aquat Toxicol 201:83-90. doi:10.1016/j.aquatox.2018.05.016 PMID:29890505 PMCID:PMC6062444
  • Ma EY, Heffern K, Cheresh J, Gallagher EP. 2018. Differential copper-induced death and regeneration of olfactory sensory neuron populations and neurobehavioral function in larval zebrafish. Neurotoxicology 69:141-151. doi:10.1016/j.neuro.2018.10.002 PMID:30292653
  • Meador J, Yeh A, Gallagher EP. 2018. Adverse metabolic effects in fish exposed to contaminants of emerging concern in the field and laboratory. Environ Pollut 236:850-861. doi:10.1016/j.envpol.2018.02.007 PMID:29471284 PMCID:PMC5858870
  • Steele WB, Kristofco LA, Corrales J, Saari GN, Haddad SP, Gallagher EP, Kavanagh TJ, Kostal J, Zimmerman JB, Voutchkova-Kostal A, Anastas P, Brooks BW. 2018. Comparative behavioral toxicology with two common larval fish models: exploring relationships among modes of action and locomotor responses. Sci Total Environ 640-641:1587-1600. doi:10.1016/j.scitotenv.2018.05.402 PMID:30021323
  • Williams CR, Dittman AH, McElhany P, Busch DS, Maher MT, Bammler TK, MacDonald JW, Gallagher EP. 2018. Elevated CO2 impairs olfactory mediated neural and behavioral responses and gene expression in ocean-phase coho salmon (Oncorhynchus kisutch). Glob Chang Biol 25(3):963-977. doi:10.1111/gcb.14532 PMID:30561876 PMCID:PMC7065673




  • Maryoung LA, Blunt B, Tierney KB, Schlenk D. 2015. Sublethal toxicity of chlorpyrifos to salmonid olfaction after hypersaline acclimation. Aquat Toxicol 161:94-101. doi:10.1016/j.aquatox.2015.01.026 PMID:25697678
  • Maryoung LA, Lavado R, Bammler TK, Gallagher EP, Stapleton PL, Beyer RP, Farin FM, Hardiman G, Schlenk D. 2015. Differential gene expression in liver, gill, and olfactory rosettes of Coho salmon (Oncorhynchus kisutch) after acclimation to salinity. Mar Biotechnol (NY) 17(6):703-717. doi:10.1007/s10126-015-9649-5 PMID:26260986 PMCID:PMC4636457





  • Lavado R, Maryoung LA, Schlenk D. 2011. Hypersalinity acclimation increases the toxicity of the insecticide phorate in Coho salmon (Oncorhynchus kisutch). Environ Sci Technol 45:4623-4629. doi:10.1021/es200451j PMID:21488666 PMCID:PMC3627486
  • Lavado R, Schlenk D. 2011. Microsomal biotransformation of chlorpyrifos, parathion and fenthion in rainbow trout (Oncorhynchus mykiss) and coho salmon (Oncorhynchus kisutch): mechanistic insights into interspecific differences in toxicity. Aquat Toxicol 101(1):57-63. doi:10.1016/j.aquatox.2010.09.002 PMID:20947181 PMCID:PMC3005852
  • Tilton F, Tilton SC, Bammler TK, Beyer RP, Stapleton PL, Scholz N, Gallagher EP. 2011. Transcriptional impact of organophosphate and metal mixtures on olfaction: Copper dominates the chlorpyrifos-induced response in adult zebrafish. Aquat Toxicol 102(3-4):205-215. doi:10.1016/j.aquatox.2011.01.012 PMID:21356183 PMCID:PMC3991301


  • Browne E, Kelley MA, Zhou GD, He L, McDonald TJ, Wang S, Duncan B, Meador J, Donnelly KC, Gallagher EP. 2010. In situ biomonitoring of juvenile Chinook salmon (Onchorhynchus tshawytscha) using biomarkers of chemical exposures and effects in a partially remediated urbanized waterway of the Puget Sound, WA. Environ Res 110(7):675-683. doi:10.1016/j.envres.2010.06.007 PMID:20619832 PMCID:PMC3321373
  • Shao J, Dabrowski MJ, White CC, Kavanagh TJ, Gallagher EP. 2010. Flow cytometric analysis of BDE 47 mediated injury to rainbow trout gill epithelial cells. Aquat Toxicol 97(1):42-50. doi:10.1016/j.aquatox.2009.11.013 PMID:20053465 PMCID:PMC3321377


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