Superfund Research Program

Development of Rapid, Miniaturized Biosensors

Project Leader: Ian M. Kennedy
Grant Number: P42ES004699
Funding Period: 2000-2015

Project-Specific Links

Publications

2017

• Zamuruyev KO, Zrodnikov Y, Davis CE. 2017. Photolithography-free laser-patterned HF acid-resistant chromium-polyimide mask for rapid fabrication of microfluidic systems in glass. J Micromech Microeng 27(1):doi:10.1088/0960-1317/27/1/015010 PMID:28533633 PMCID:PMC5438096

2016

• Gee SJ, Kennedy IR, Lee NA, Ohkawa H, Prapamontol T, Xu T. 2016. Immunoanalysis for environmental monitoring and human health. Anal Bioanal Chem 408(22):5959-5961. doi:10.1007/s00216-016-9666-x PMID:27277933

2015

• Ding Y, Li J, Xiao W, Xiao K, Lee JK, Bhardwaj U, Zhu Z, Digiglio P, Yang G, Lam KS, Pan T. 2015. Microfluidic-enabled print-to-screen platform for high-throughput screening of combinatorial chemotherapy. Anal Chem 87(20):10166-10171. doi:10.1021/acs.analchem.5b00826 PMID:26334956
• Fan J, Li B, Xing S, Pan T. 2015. Reconfigurable microfluidic dilution for high-throughput quantitative assays. Lab Chip 15(12):2670-2679. doi:10.1039/c5lc00432b PMID:25994379
• Han J, Sudheendra L, Kennedy IM. 2015. FRET-based homogeneous immunoassay on a nanoparticle-based photonic crystal. Anal Bioanal Chem 407(18):5243-5247. doi:10.1007/s00216-015-8708-0 PMID:25956600 PMCID:PMC4481177
• Li B, Fan J, Li J, Chu J, Pan T. 2015. Piezoelectric-driven droplet impact printing with an interchangeable microfluidic cartridge. Biomicrofluidics 9(5):054101. doi:10.1063/1.4928298 PMID:26392833 PMCID:PMC4560724

2014

• Chen A, Pan T. 2014. Manually operatable on-chip bistable pneumatic microstructures for microfluidic manipulations. Lab Chip 14(17):3401-3408. doi:10.1039/c4lc00540f PMID:25007840 PMCID:PMC4140693
• Han J, Tan M, Sudheendra L, Weiss RH, Kennedy IM. 2014. On-chip detection of a single nucleotide polymorphism without polymerase amplification. Nano Res 7(9):1302-1310. doi:10.1007/s12274-014-0494-z PMID:25580203 PMCID:PMC4286159
• Han J, Wang M, Das J, Sudheendra L, Vonasek E, Nitin N, Kennedy IM. 2014. Capture and detection of T7 bacteriophages on a nanostructured interface. ACS Appl Mater Interfaces 6(7):4758-4765. doi:10.1021/am500655r PMID:24650205 PMCID:PMC3985741
• Sudheendra L, Das GK, Li C, Stark D, Cena J, Cherry S, Kennedy IM. 2014. NaGdF4:Eu3+ nanoparticles for enhanced x-ray excited optical imaging. Chemistry of Materials 26:1881-1888. doi:10.1021/cm404044n PMID:24803724 PMCID:PMC3985768

2013

• Abid AD, Kanematsu M, Young TM, Kennedy IM. 2013. Arsenic removal from water using flame-synthesized iron oxide nanoparticles with variable oxidation states. Aerosol Science and Technology 47(2):169-176. doi:10.1080/02786826.2012.735380 PMID:23645964 PMCID:PMC3640798
• Han J, Kim H, Sudheendra L, Gee SJ, Hammock BD, Kennedy IM. 2013. Photonic crystal lab-on-a-chip for detecting staphylococcal entertoxin B at low attomolar concentration. Anal Chem 85(6):3104-3109. doi:10.1021/ac303016h PMID:23418954 PMCID:PMC3608201
• Han J, Kim H, Sudheendra L, Hass EA, Gee SJ, Hammock BD, Kennedy IM. 2013. Electrophoretic build-up of multi nanoparticle array for a highly sensitive immunoassay. Biosens Bioelectron 41:302-308. doi:10.1016/j.bios.2012.08.042 PMID:23021853 PMCID:PMC3525773

2012

• Han J, Sudheendra L, Kim H, Gee SJ, Hammock BD, Kennedy IM. 2012. Ultrasensitive on-chip immunoassays with a nanoparticle-assembled photonic crystal. ACS Nano 6(10):8570-8582. doi:10.1021/nn301656c PMID:22957818 PMCID:PMC3479307
• Lee J, Abid AD, Cheung K, Sudheendra L, Kennedy IM. 2012. Superparamagnetic particle dynamics and mixing in a rotating capillary tube with a stationary magnetic field. Microfluid Nanofluidics 13(3):461-468. doi:10.1007/s10404-012-0981-z PMID:23066382 PMCID:PMC3467020
• Lee J, Sudheendra L, Kennedy IM. 2012. Accelerated immunoassays based on magnetic particle dynamics in a rotating capillary tube with stationary magnetic field. Anal Chem 84(19):8317-8322. doi:10.1021/ac301848q PMID:22931580 PMCID:PMC3463766

2011

• Chan M, Jaramillo G, Hristova KR, Horsley D. 2011. Magnetic scanometric DNA microarray detection of methyl tertiary butyl ether degrading bacteria for environmental monitoring. Biosens Bioelectron 26(5):2060-2066. doi:10.1016/j.bios.2010.09.002 PMID:20889328 PMCID:PMC3014382
• Deng W, Sudheendra L, Zhao J, Fu J, Jin D, Kennedy IM, Goldys EM. 2011. Upconversion in NaYF(4):Yb, Er nanoparticles amplified by metal nanostructures. Nanotechnology 22(32):doi:10.1088/0957-4484/22/32/325604 PMID:21772069 PMCID:PMC3962131
• Shi J, Abid AD, Kennedy IM, Hristova KR, Silk WK. 2011. To duckweeds (Landoltia punctata), nanoparticulate copper oxide is more inhibitory than the soluble copper in the bulk solution. Environ Pollut 159(5):1277-1282. doi:10.1016/j.envpol.2011.01.028 PMID:21333422 PMCID:PMC3277788
• Sudheendra L, Ortalan V, Dey S, Kennedy IM. 2011. Plasmonic enhanced emissions from cubic NaYF4:Yb:Er/Tm nanophosphors. Chemistry of Materials 23:2987-2993. doi:10.1021/cm2006814 PMID:21709812 PMCID:PMC3119558
• Yang J, Rasa E, Tantayotai P, Scow KM, Yuan H, Hristova KR. 2011. Mathematical model of Chlorella minutissima UTEX2341 growth and lipid production under photoheterotrophic fermentation conditions. Bioresour Technol 102(3):3077-3082. doi:10.1016/j.biortech.2010.10.049 PMID:21115343 PMCID:PMC3267903

2010

• Kong AY, Hristova KR, Scow KM, Six J. 2010. Impacts of different N management regimes on nitrifier and denitrifier communities and N cycling in soil microenvironments. Soil Biol Biochem 42(9):1523-1533. doi:10.1016/j.soilbio.2010.05.021 PMID:21339865 PMCID:PMC3040239
• Son A, Kennedy IM, Scow KM, Hristova KR. 2010. Quantitative gene monitoring of microbial tetracycline resistance using magnetic luminescent nanoparticles. J Environ Monit 12:1362-1367. doi:10.1039/c001974g PMID:20424797 PMCID:PMC3267904

2009

• Ma Z, Dosev D, Kennedy IM. 2009. A microemulsion preparation of nanoparticles of europium in silica with luminescence enhancement using silver. Nanotechnology 20(8):085608. doi:10.1088/0957-4484/20/8/085608 PMID:19417456 PMCID:PMC2858688
• Ma Z, Dosev D, Nichkova MJ, Dumas RK, Gee SJ, Hammock BD, Kennedy IM. 2009. Synthesis and characterization of multifunctional silica core-shell nanocomposites with magnetic and fluorescent functionalities. J Magn Magn Mater 321(10):1368-1371. doi:10.1016/j.jmmm.2009.02.040 PMID:20336173 PMCID:PMC2844650
• Ma Z, Dosev D, Nichkova MJ, Gee SJ, Hammock BD, Kennedy IM. 2009. Synthesis and bio-functionalization of multifunctional magnetic Fe3O4@Y2O3:Eu nanocomposites. J Mater Chem 19:4695-4700. doi:10.1039/B901427F PMID:20357905 PMCID:PMC2847302

2008

• Dosev D, Nichkova MJ, Kennedy IM. 2008. Inorganic lanthanide nanophosphors in biotechnology. J Nanosci Nanotechnol 8(3):1052-1067. PMID:18468107
• Son A, Dhirapong A, Dosev D, Kennedy IM, Weiss RH, Hristova KR. 2008. Rapid and quantitative DNA analysis of genetic mutations for polycystic kidney disease (PKD) using magnetic/luminescent nanoparticles. Anal Bioanal Chem 390(7):1829-1835. doi:10.1007/s00216-008-1892-4 PMID:18256809
• Son A, Nichkova MJ, Dosev D, Kennedy IM, Hristova KR. 2008. Luminescent lanthanide nanoparticle labels in DNA-based microarray approach for quantification of MTBE degrading bacteria. J Nanosci Nanotechnol 8(5):2463-7. doi:10.1166/jnn.2008.347 PMID:18572664

2007

• Chang M, Dosev D, Kennedy IM. 2007. Zeta-potential analyses using micro electrical field flow fractionation with fluorescent nanoparticles. Sens Actuators B Chem 124(1):172-178. doi:10.1016/j.snb.2006.12.019 PMID:18542710 PMCID:PMC2000823
• Dettmer K, Hanna D, Whetstone P, Hansen R, Hammock BD. 2007. Autism and urinary exogenous neuropeptides: development of an on-line SPE-HPLC-tandem mass spectrometry method to test the opioid excess theory. Anal Bioanal Chem 388(8):1643-1651. doi:10.1007/s00216-007-1301-4 PMID:17520243 PMCID:PMC4871698
• Dosev D, Nichkova MJ, Dumas RK, Gee SJ, Hammock BD, Liu K, Kennedy IM. 2007. Magnetic/luminescent core/shell particles synthesized by spray pyrolysis and their application in immunoassays with internal standard. Nanotechnology 18(5):055102(6pp). PMID:18974844
• Gojova A, Guo B, Kota RS, Rutledge JC, Kennedy IM, Barakat AI. 2007. Induction of inflammation in vascular endothelial cells by metal oxide nanoparticles: effect of particle composition. Environ Health Perspect 115(3):403-409. PMID:17431490
• Guo B, Harvey AS, Neill J, Kennedy IM, Navrotsky A, Risbud SH. 2007. Synthesis of monoclinic and cubic heavy rare earth sesquioxide nanoparticles in a gas-phase flame process. Journal of the American Ceramic Society 90(11):3683-3686. doi:10.1111/j.1551-2916.2007.01961.x
• Guo B, Kennedy IM. 2007. Gas-phase flame synthesis and characterization of iron oxide nanoparticles for use in a health effects study. Aerosol Science and Technology 41:944-951.
• Kennedy IM. 2007. The health effects of combustion-generated aerosols. Proc Combust Inst 31:2757-2770.
• Nichkova MJ, Dosev D, Davies AE, Gee SJ, Kennedy IM, Hammock BD. 2007. Quantum dots as reporters in multiplexed immunoassays for biomarkers of exposure to agrochemicals. Anal Lett 40(7):1423-1433. doi:10.1080/00032710701327088 PMID:19079795 PMCID:PMC2600528
• Nichkova MJ, Dosev D, Gee SJ, Hammock BD, Kennedy IM. 2007. Multiplexed immunoassays for proteins using magnetic luminescent nanoparticles for internal calibration. Anal Biochem 369(a):34-40. PMID:17681270
• Tanyeri M, Perron R, Kennedy IM. 2007. Lasing droplets in a microfabricated channel. Opt Lett 32(17):2529-2531. PMID:17767294
• Tanyeri M, Perron R, Kennedy IM. 2007. Lasing droplets in a microfluidic T-junction device with integrated optics. Proc SPIE Int Soc Opt Eng 6465:

2006

• Dosev D, Guo B, Kennedy IM. 2006. Photoluminescence of Eu3+:Y2O3 as an indication of crystal structure and particle size in nanoparticles synthesized by flame spray pyrolysis. J Aerosol Sci 37(3):402-412.
• Dosev D, Nichkova MJ, Dumas RK, Liu K, Kennedy IM. 2006. Spray pyrolysis synthesis of particles possessing magnetic and luminescent properties: application of magnetic/luminescent particles in immunoassays. Chapter 6036 in: BioMEMs and Nanotechnology II. Proceedings of SPIE, pp.209-218.
• Guo B, Harvey AS, Risbud SH, Kennedy IM. 2006. The formation of cubic and monoclinic Y 2 O 3 nanoparticles in a gas-phase flame process. Philosophical Magazine Letters 86(7):457-467.
• Jung HS, Guo B, Anastasio C, Kennedy IM. 2006. Quantitative measurements of the generation of hydroxyl radicals by soot particles in a surrogate lung fluid. Atmos Environ (1994) 40:1043-1052.
• Kennedy IM. 2006. Optical Biosensors. Chapter Vol. 7 in: Encyclopedia of Sensors. American Scientific Publishers, pp.93-105.
• Nichkova MJ, Dosev D, Perron R, Gee SJ, Hammock BD, Kennedy IM. 2006. Eu3+-doped Gd2O3 nanoparticles as reporters for optical detection and visualization of antibodies patterned by microcontact printing. Anal Bioanal Chem 384(3):631-637. PMID:16416096
• Werner M, Nico P, Guo B, Kennedy IM, Anastasio C. 2006. Laboratory study of simulated atmospheric transformations of chromium in ultrafine combustion aerosol particles. Aerosol Science and Technology 40(7):545-556.

2003

• Chen S, Yuen P, Collins SD, Smith R, Koivunen ME, Hammock BD. 2003. Time gated detection of europium nanoparticles in a microchannel-based environmental immunoassay. In: Proceedings of SPIE (The International Society for Optical Engineering).
• Feng J, Mack JS, Shan G, Hammock BD. 2003. C60 nanoparticle quenching used as a biological label. In: Proceedings of SPIE (The International Society for Optical Engineering). pp.156-163.
• Feng J, Shan G, Hammock BD, Kennedy IM. 2003. Fluorescence quenching competitive immunoassay in micro droplets. Biosens Bioelectron 18(8):1055-1063. PMID:12782469
• Feng J, Shan G, Maquieira A, Koivunen ME, Guo B, Hammock BD. 2003. Functionalized europium oxide nanoparticles used as a fluorescent label in an immunoassay for atrazine. Anal Chem 75(19):5282-5286.
• Nichkova MJ, Feng J, Sanchez-Baeza F, Marco M, Hammock BD, Kennedy IM. 2003. Competitive quenching fluorescence immunoassy for chlorophenols based on laser-induced fluorescence detection in microdroplets. Anal Chem 75(1):83-90. PMID:12530822
• Tanyeri M, Perron R, Collins SD, Smith R. 2003. Microdroplets applied in microchannels for integrated high sensitivity biosensors. In: Proceedings of SPIE (The International Society for Optical Engineering).

2002

• Feng J, Shan G, Hammock BD, Kennedy IM. 2002. Fluorescence quenching competitive fluoroimmunoassay in micro droplets. In: Methods for Ultrasensitive Detection II, Proceedings of the International Society for Optical Engineering. SPIE, Bellingham, WA. pp.118-127.
• Leppert VJ, Harvey AS, McCool GD, Quinlan FT, Feng J, Shan G, Stroeve P, Risbud SH, Hammock BD, Kennedy IM. 2002. Long-wavelength emitting nanocrystals for bioassay applications. In: Nanoscale Optics and Applications. Proceedings of SPIE, pp.110-121.

2001

• Matveeva EG, Shan G, Kennedy IM, Gee SJ, Hammock BD. 2001. Homogeneous fluoroimmunoassay of a pyrethroid metabolite in urine. Anal Chim Acta 444:103-117.