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Project Publications: University of California-Davis: Bioanalytical and Statistics Core

Superfund Research Program

Bioanalytical and Statistics Core

Project Leader: Daniel J. Tancredi
Grant Number: P42ES004699
Funding Period: 2017-2023
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  • Aleman M, Zhang R, Feng W, Qi L, Lopez JR, Crowe C, Dong Y, Cherednichenko G, Pessah IN. 2020. Dietary Caffeine Synergizes Adverse Peripheral and Central Responses to Anesthesia in Malignant Hyperthermia Susceptible Mice. Mol Pharmacol 98:351-363. doi:10.1124/mol.120.119412 PMID:32764093 PMCID:PMC7491310
  • Brighty GJ, Botham RC, Li S, Nelson L, Mortenson DE, Li G, Morisseau C, Wang H, Hammock BD, Sharpless KB, Kelly JW. 2020. Using sulfuramidimidoyl fluorides that undergo sulfur(vi) fluoride exchange for inverse drug discovery. Nat Chem 12:doi:10.1038/s41557-020-0530-4 PMID:32868886 PMCID:PMC7541551
  • Burmistrov V, Morisseau C, DYachenko V, Karlov D, Butov GM, Hammock BD. 2020. Imidazolidine-2,4,5-and pirimidine-2,4,6-triones - New primary pharmacophore for soluble epoxide hydrolase inhibitors with enhanced water solubility. Bioorg Med Chem Lett 30(3):126908. doi:10.1016/j.bmcl.2019.126908 PMID:31870649 PMCID:PMC6957307
  • Codony S, Pujol E, Pizarro J, Feixas F, Valverde E, Loza I, Brea J, Saez E, Oyarzabal J, Pineda-Lucena A, Perez B, Perez C, Rodriguez-Franco M, Leiva R, Osuna S, Morisseau C, Hammock BD, Vasquez-Carrera M, Vazquez S. 2020. 2-Oxaadamant-1-yl Ureas as Soluble Epoxide Hydrolase Inhibitors: In Vivo Evaluation in a Murine Model of Acute Pancreatitis. J Med Chem 63:9237-9257. doi:10.1021/acs.jmedchem.0c00310 PMID:32787085 PMCID:PMC7755424
  • Faber SC, Tagliabue SG, Bonati L, Denison MS. 2020. The cellular and molecular determinants of naphthoquinone-dependent activation of the aryl hydrocarbon receptor. Int J Mol Sci 21:doi:10.3390/ijms21114111 PMID:32526934 PMCID:PMC7312509
  • Haedrich J, Stumpf C, Denison MS. 2020. Rapid extraction of total lipids and lipophilic POPs from all EU-regulated foods of animal origin: Smedes' method revisited and enhanced. Environ Sci Eur 32:doi:10.1186/s12302-020-00396-5 PMID:33614386 PMCID:PMC7891496
  • Hayashi A, Denison MS. 2020. Development of a novel recombinant cell line for detection and characterization of Ah receptor nuclear translocation in intact cells. Toxicol In Vitro 66:9. doi:10.1016/j.tiv.2020.104873 PMID:32333947 PMCID:PMC7260106
  • Shihadih DS, Harris TR, Kodani SD, Hwang SH, Lee KS, Mavangira V, Hamamoto B, Guedes AP, Hammock BD, Morisseau C. 2020. Selection of Potent Inhibitors of Soluble Epoxide Hydrolase for Usage in Veterinary Medicine. Front Vet Sci 7:doi:10.3389/fvets.2020.00580 PMID:33005645 PMCID:PMC7479175
  • Truong KM, Feng W, Pessah IN. 2020. Ryanodine Receptor Type 2: A Molecular Target for Dichlorodiphenyltrichloroethane- and Dichlorodiphenyldichloroethylene-Mediated Cardiotoxicity. Toxicol Sci 178:159-172. doi:10.1093/toxsci/kfaa139 PMID:32894766
  • Wilt S, Kodani SD, Le TN, Nguyen L, Vo N, Ly T, Rodriguez M, Hudson PK, Morrisseau C, Hammock BD, Pecic S. 2020. Development of multitarget inhibitors for the treatment of pain: Design, synthesis, biological evaluation and molecular modeling studies. Bioorg Chem 103:17. doi:10.1016/j.bioorg.2020.104165 PMID:32891856 PMCID:PMC7723751
  • Wu N, Hammock BD, Lee KS, An G. 2020. Simultaneous target-mediated drug disposition model for two small-molecule compounds competing for their pharmacological target: Soluble epoxide hydrolase. J Pharmacol Exp Ther 374:223-232. doi:10.1124/jpet.120.265330 PMID:32238455 PMCID:PMC7318792


  • Burmistrov V, Morisseau C, DYachenko V, Rybakov V, Butov GM, Hammock BD. 2019. Fluoroaromatic fragments on 1,3-disubstituted ureas enhance soluble epoxide hydrolase inhibition. J Fluor Chem 220:48-53. doi:10.1016/j.jfluchem.2019.02.005 PMID:32132741 PMCID:PMC7055688
  • Codony S, Valverde E, Leiva R, Brea J, Loza I, Morisseau C, Hammock BD, Vazquez S. 2019. Exploring the size of the lipophilic unit of the soluble epoxide hydrolase inhibitors. Bioorg Med Chem 27(20):115078. doi:10.1016/j.bmc.2019.115078 PMID:31488357 PMCID:PMC6892585
  • de Oliveira GS, Adriani PP, Ribeiro JA, Morisseau C, Hammock BD, Dias MV, Chambergo FS. 2019. The molecular structure of an epoxide hydrolase from trichoderma reesei in complex with urea or amide-based inhibitors. Int J Biol Macromol 129:653-658. doi:10.1016/j.ijbiomac.2019.02.070 PMID:30771398 PMCID:PMC6447457
  • Duflot T, Moreau-Grange L, Roche C, Lacob M, Wils J, Remy-Jouet I, Cailleux A, Leuillier M, Renet S, Li D, Morisseau C, Lamoureux F, Richard V, Prevost G, Joannides R, Bellien J. 2019. Altered bioavailability of epoxyeicosatrienoic acids is associated with conduit artery endothelial dysfunction in type 2 diabetic patients. Cardiovasc Diabetol 18:35. doi:10.1186/s12933-019-0843-z PMID:30885203 PMCID:PMC6423843
  • Hiesinger K, Kramer JS, Achenbach J, Moser D, Weber J, Wittmann SK, Morisseau C, Angioni C, Geisslinger G, Kahnt AS, Kaiser A, Proschak A, Steinhilber D, Pogoryelov D, Wagner KM, Hammock BD, Proschak E. 2019. Computer-aided selective optimization of side activities of talinolol. ACS Med Chem Lett 10(6):899-903. doi:10.1021/acsmedchemlett.9b00075 PMID:31223445 PMCID:PMC6580380
  • Kramer JS, Woltersdorf S, Duflot T, Hiesinger K, Lillich FF, Knoll F, Wittmann SK, Klingler FM, Brunst S, Chaikuad A, Morisseau C, Hammock BD, Buccellati C, Sala A, Rovati E, Leuillier M, Fraineau S, Rondeaux J, Hernandez-Olmos V, Heering J, Merk D, Pogoryelov D, Steinhilber D, Knapp S, Bellien J, Proschak E. 2019. Discovery of the first in vivo active inhibitors of the soluble epoxide hydrolase phosphatase domain. J Med Chem 62:8443-8460. doi:10.1021/acs.jmedchem.9b00445
  • Lee KS, Yang J, Niu J, Ng CJ, Wagner KM, Dong H, Kodani SD, Wan D, Morisseau C, Hammock BD. 2019. Drug-target residence time affects in vivo target occupancy through multiple pathways. ACS Cent Sci 5:1614-1624. doi:10.1021/acscentsci.9b00770 PMID:31572788 PMCID:PMC6764161
  • McReynolds C, Hee-Hwang S, Yang J, Wan D, Wagner KM, Morisseau C, Li D, Schmidt WK, Hammock BD. 2019. Pharmaceutical effects of inhibiting the soluble epoxide hydrolase in canine osteoarthritis. Front Pharmacol 10:12. doi:10.3389/fphar.2019.00533 PMID:31214021 PMCID:PMC6554663
  • Pessah IN, Lein PJ, Seegal R, Sagiv SK. 2019. Neurotoxicity of polychlorinated biphenyls and related organohalogens. Acta Neuropathol 138(3):363-387. doi:10.1007/s00401-019-01978-1 PMID:30976975 PMCID:PMC6708608
  • Pessah IN, Truong KM. 2019. Additional safety assessments needed for diamide insecticides. Toxicol Sci 171(2):282. doi:10.1093/toxsci/kfz062 PMID:30830166 PMCID:PMC6760268
  • Truong KM, Cherednichenko G, Pessah IN. 2019. Interactions of Dichlorodiphenyltrichloroethane (DDT) and dichlorodiphenyldichloroethylene (DDE) with skeletal muscle ryanodine receptor type 1. Toxicol Sci 170(2):50-524. doi:10.1093/toxsci/kfz120 PMID:31127943 PMCID:PMC6657572
  • Vasylieva N, Kitamura S, Dong J, Barnych B, Hvorecny KL, Madden DR, Gee SJ, Wolan DW, Morisseau C, Hammock BD. 2019. Nanobody-based binding assay for the discovery of potent inhibitors of CFTR inhibitory factor (Cif). Anal Chim Acta 1057:106-113. doi:10.1016/j.aca.2018.12.060 PMID:30832908 PMCID:PMC6426448
  • Zheng J, Yu Y, Feng W, Li J, Liu J, Zhang C, Dong Y, Pessah IN, Cao Z. 2019. Influence of nanomolar deltamethrin on the hallmarks of primary cultured cortical neuronal network and the role of ryanodine receptors. Environ Health Perspect 127(6):67003. doi:10.1289/EHP4583 PMID:31166131 PMCID:PMC6792378
  • Zhu M, Wang L, Wu X, Na R, Wang Y, Li QX, Hammock BD. 2019. A novel and simple imidazo[1,2-a]pyridin fluorescent probe for the sensitive and selective imaging of cysteine in living cells and zebrafish. Anal Chim Acta 1058:155-165. doi:10.1016/j.aca.2019.01.023


  • de Oliveira GS, Adriani PP, Wu H, Morisseau C, Hammock BD, Chambergo FS. 2018. Substrate and inhibitor selectivity, and biological activity of an epoxide hydrolase from Trichoderma reesei. Molecular Biology Reports 46(1):371-9. doi:10.1007/s11033-018-4481-4 PMID:30426381 PMCID:PMC6426676
  • Faber SC, Soshilov AA, Tagliabue SG, Bonati L, Denison MS. 2018. Comparative in vitro and in silico analysis of the selectivity of indirubin as a human Ah receptor agonist. Int J Mol Sci 19(9):2692. doi:10.3390/ijms19092692 PMID:30201897 PMCID:PMC6165432
  • Vandermarken T, Gaoa Y, Baeyens W, Denison MS, Croes K. 2018. Dioxins, furans and dioxin-like PCBs in sediment samples and suspended particulate matter from the Scheldt estuary and the North Sea Coast: comparison of CALUX concentration levels in historical and recent samples. Sci Total Environ 626:109-116. doi:10.1016/j.scitotenv.2018.01.084 PMID:29335165


  • Anderson CG, Joshi G, Bair DA, Oriol C, He G, Parikh SJ, Denison MS, Scow KM. 2017. Use of nuclear receptor luciferase-based bioassays to detect endocrine active chemicals in a biosolids-biochar amended soil. Chemosphere 181:160-167. doi:10.1016/j.chemosphere.2017.04.035 PMID:28437741
  • Denison MS, Faber SC. 2017. And now for something completely different: Diversity in ligand-dependent activation of Ah receptor response. Curr Opin Toxicol 2:124-131. doi:10.1016/j.cotox.2017.01.006 PMID:28845473 PMCID:PMC5570615
  • Guo W, Van Langenhove K, Denison MS, Baeyens W, Elskens M, Gao Y. 2017. Estrogenic activity measurements in water using diffusive gradients in thin-film coupled with an estrogen bioassay. Anal Chem 89:13357-13364. doi:10.1021/acs.analchem.7b03537 PMID:29151339
  • Holland EB, Feng W, Zheng J, Dong Y, Li X, Lehmler H, Pessah IN. 2017. An extended structure-activity relationship of nondioxin-like PCBs evaluates and supports modeling predictions and identifies picomolar potency of PCB 202 towards ryanodine receptors. Toxicol Sci 155(1):170-181. doi:10.1093/toxsci/kfw189 PMID:27655348 PMCID:PMC5216651
  • Khedidji S, Croes K, Yassaa N, Ladji R, Denison MS, Baeyens W, Elskens M. 2017. Assessment of dioxin-like activity in PM10 air samples from an industrial location in Algeria, using the DRE-CALUX bioassay. Environ Sci Pollut Res Int 24(13):11868–11877. doi:10.1007/s11356-015-5841-4 PMID:26611627
  • Kitamura S, Morisseau C, Harris TR, Inceoglu B, Hammock BD. 2017. Occurrence of urea-based soluble epoxide hydrolase inhibitors from the plants in the order Brassicales. PLoS One 12(5):e0176571. doi:10.1371/journal.pone.0176571 PMID:28472063 PMCID:PMC5417501
  • Kodani SD, Barthelemy M, Kamita SG, Hammock BD, Morisseau C. 2017. Development of amide-based fluorescent probes for selective measurement of carboxylesterase 1 activity in tissue extracts. Anal Biochem 539:81-89. doi:10.1016/j.ab.2017.10.014 PMID:29054529 PMCID:PMC5696082
  • Li D, Cui Y, Morisseau C, Gee SJ, Bever C, Liu X, Wu J, Hammock BD, Ying Y. 2017. Nanobody based immunoassay for human soluble epoxide hydrolase detection using Polymeric Horseradish Peroxidase (PolyHRP) for signal enhancement: The rediscovery of PolyHRP?. Anal Chem 89(11):6248-6256. doi:10.1021/acs.analchem.7b01247 PMID:28460522 PMCID:PMC5611449
  • Mehinto AC, VanDervort DR, Lao W, He G, Denison MS, Vliet SM, Volz DC, Mazor RD, Maruya KA. 2017. High throughput in vitro and in vivo screening of inland waters of Southern California. Environ Sci Process Impacts 19:1142-1149. doi:10.1039/c7em00170c PMID:28612856
  • Orcholski ME, Khurshudyan A, Shamskhou EA, Yuan K, Chen IY, Kodani SD, Morisseau C, Hammock BD, Hong EM, Alexandrova L, Alastalo T, Berry G, Zamanian RT, de Jesus Perez VA. 2017. Reduced carboxylesterase 1 is associated with endothelial injury in methamphetamine-induced pulmonary arterial hypertension. Am J Physiol Lung Cell Mol Physiol 313:L252-L266. doi:10.1152/ajplung.00453.2016 PMID:28473326


  • Brennan JC, Bassal A, He G, Denison MS. 2016. Development of a recombinant human ovarian (BG1) cell line containing estrogen receptor alpha and beta for improved detection of estrogenic/antiestrogenic chemicals. Environ Toxicol Chem 35(1):91-100. doi:10.1002/etc.3146 PMID:26139245 PMCID:PMC4772679
  • Cole BJ, Brander SM, Jeffries KM, Hasenbein S, He G, Denison MS, Fangue NA, Connon RE. 2016. Changes in Menidia beryllina gene expression and in vitro hormone-receptor activation after exposure to estuarine waters near treated wastewater outfalls. Arch Environ Contam Toxicol 71(2):210-223. doi:10.1007/s00244-016-0282-8 PMID:27155869 PMCID:PMC4772679
  • Croes K, Debaillie P, Van den Bril B, Staelens J, Vandermarken T, Van Langenhove K, Denison MS, Leermakers M, Elskens M. 2016. Assessment of estrogenic activity in PM₁₀ air samples with the ERE-CALUX bioassay: Method optimization and implementation at an urban location in Flanders (Belgium). Chemosphere 144:392-398. doi:10.1016/j.chemosphere.2015.09.020 PMID:26383266
  • Denison MS, Croes K, Van den Heuvel R, Van den Bril B, Van Langenhove K, Staelens J, Vandermarken T, Elskens M. 2016. Assessment of estrogenic and androgenic activity in PM10 air samples from an urban, industrial and rural area in Flanders (Belgium) using the CALUX bioassay. Environ Res 150:66-72. doi:10.1016/j.envres.2016.05.044 PMID:27257826
  • Joshi G, Schmidt R, Denison MS, Hristova KR. 2016. Effect of benzene and ethylbenzene on the transcription of methyl-tert-butyl ether degradation genes of Methylibium petroleiphilum PM1. Microbiology 162(9):1563-1571. doi:10.1099/mic.0.000338 PMID:27450417 PMCID:PMC4459789
  • Liu J, Morisseau C, Huang H, Hammock BD. 2016. Screening of soluble epoxide hydrolase inhibitory ingredients from traditional Chinese medicines for anti-inflammatory use. J Ethnopharmacol 194:475-482. doi:10.1016/j.jep.2016.09.044 PMID:27702689
  • Ronjat M, Feng W, Dardevet L, Dong Y, Khoury SA, Chatelain F, Vialla V, Chahboun S, Lesage F, Darbon H, Pessah IN, De Waard M. 2016. In cellulo phosphorylation induces pharmacological reprogramming of maurocalcin, a cell-penetrating venom peptide. Proc Natl Acad Sci U S A 113(17):E2460-E2468. doi:10.1073/pnas.1517342113 PMID:27071086 PMCID:PMC4855579
  • Vandermarken T, de Galan S, Croes K, Van Langenhove K, Vercammen J, Sanctorum H, Denison MS, Goeyens L, Elskens M, Baeyens W. 2016. Characterisation and implementation of the ERE-CALUX bioassay on indoor dust samples of kindergartens to assess estrogenic potencies. Psychiatr Pol 155(PtB):182-189. doi:10.1016/j.jsbmb.2015.01.005 PMID:25595043
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