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Project Publications: University of California-Davis: Administrative Core

Superfund Research Program

Administrative Core

Project Leader: Bruce D. Hammock
Co-Investigator: Thomas Michael Young
Grant Number: P42ES004699
Funding Period: 1995-2023
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  • McReynolds C, Morisseau C, Wagner KM, Hammock BD. Epoxy Fatty Acids Are Promising Targets for Treatment of Pain, Cardiovascular Disease and Other Indications Characterized by Mitochondrial Dysfunction, Endoplasmic Stress and Inflammation. In: Druggable Lipid Signaling Pathways. Springer, pp.71-99.


  • Brooks H, de Castro Bras L, Brunt K, Sylvester M, Parvatiyar M, Sirish P, Bansal S, Sule RO, Eadie A, Knepper M, Fenton R, Lindsey M, DeLeon-Pennell K, Gomes AV. 2024. Guidelines on antibody use for physiology research. Am J Physiol Renal Physiol doi:10.1152/ajprenal.00347.2023 PMID:38234298
  • Chen Y, Jianwen S, Tong H, Wang J, Ruolin C, Xu H, Chen L, Morisseau C, Zhang M, Shi Y, Han C, Zhuang J, Jing Y, Liu Z, Hammock BG, Chen G. 2024. Design and synthesis of dual-targeting inhibitors of sEH and HDAC6 for the treatment of neuropathic pain and lipopolysaccharide-induced mortality. J Med Chem 67(3):2095-2117. doi:10.1021/acs.jmedchem.3c02006 PMID:38236416
  • Deng W, Wang D, Dai P, Hong Y, Xiong J, Duan L, Lu R, Wan J, Du H, Hammock BG, Yang W. 2024. Development of a sensitive direct competitive chemiluminescent enzyme immunoassay for gentamicin based on the construction of a specific single-chain variable fragment-alkaline phosphatase fusion protein. Microchemical Journal 197:doi:10.1016/j.microc.2023.109706 PMID:38283367 PMCID:10810264
  • Fang X, Liu T, Xue C, Xue G, Wu M, Liu P, Hammock BD, Lai W, Peng J, Zhang C. 2024. Competitive ratiometric fluorescent lateral flow immunoassay based on dual emission signal for sensitive detection of chlorothalonil. Food Chem 433:137200. doi:10.1016/j.foodchem.2023.137200 PMID:37678117
  • Gao Q, Chen L, An Z, Wang Y, Yang D, Wang Z, Kang J, Barnych B, Hammock BD, Huo J, Zhang J. 2024. Development of an immunoassay based on a specific antibody for the detection of diphenyl ether herbicide fomesafen. Sci Total Environ 914:169858. doi:10.1016/j.scitotenv.2023.169858 PMID:38190900
  • Gao S, Abd El-Aty AM, Xu L, Zhao J, Li J, Lei X, Zhao Y, She Y, Jin F, Wang J, Yuan S, Jin M, Zheng L, Hammock BD. 2024. Rapid detection of prometryn residues in agricultural samples: Method comparison of the ic-ELISA and colloidal gold immunochromatographic test strips. ACS Agric Sci Technol doi:10.1021/acsagscitech.3c00490
  • Kelly A, Wang W, Rothenberger E, Yang J, Gilligan MM, Kipper FC, Attaya A, Gartung A, Hwang SH, Gillespie M, Bayer R, Quinlivan K, Torres K, Huang S, Mitsiades N, Yang H, Hammock BD, Panigrahy D. 2024. Enhancing cancer immunotherapy via inhibition of soluble epoxide hydrolase. Proc Natl Acad Sci U S A 121(7):doi:10.1073/pnas.2314085121 PMID:38330013
  • Li P, Abd El-Aty AM, Jiang H, Shen J, Wang Z, Wen K, Li J, Wang S, Wang J, Hammock BD, Jin M. 2024. Immunoassays and emerging analytical techniques of fipronil and its metabolites for food safety: A review. J Agric Food Chem 72(4):2059-2076. doi:10.1021/acs.jafc.3c07428 PMID:38252458
  • Naeem Z, Zukunft S, Huard A, Hu J, Hammock BD, Weigert A, Frömel T, Fleming I. 2024. Role of the soluble epoxide hydrolase in keratinocyte proliferation and sensitivity of skin to inflammatory stimuli. Biomed Pharmacother 171:116127. doi:10.1016/j.biopha.2024.116127 PMID:38198951 PMCID:10857809
  • Trindade-da-Silva C, Yang J, Fonseca F, Pham H, Napimoga M, Abdalla HB, Aver G, De Oliveira M, Hammock BD, Clemente-Napimoga J. 2024. Eicosanoid profiles in an arthritis model: Effects of a soluble epoxide hydrolase inhibitor. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1869(2):159432. doi:10.1016/j.bbalip.2023.159432 PMID:37984607 PMCID:10842726
  • Wang Y, Zhou H, Fu Y, Wang Z, Gao Q, Yang D, Kang J, Chen L, An Z, Hammock BD, Zhang J, Huo J. 2024. Establishment of an indirect competitive immunoassay for the detection of dicamba based on a highly specific nanobody. Sci Total Environ 917:170567. doi:10.1016/j.scitotenv.2024.170567 PMID:38296098
  • Warner J, Hardesty JE, Song Y, Floyd A, Deng Z, Jebet A, He L, Zhang XH, McClain CJ, Hammock BD, Warner D, Kirpich IA. 2024. Hepatic transcriptome and its regulation following soluble epoxide hydrolase inhibition in alcohol-associated liver disease. Am J Pathol 194(1):71-84. doi:10.1016/j.ajpath.2023.09.016 PMID:37925018 PMCID:10768534


  • Angelia J, Weng X, Solomatov A, Chin C, Fernandez A, Hudson PK, Morisseau C, Hammock BD, Kandasamy R, Pecic S. 2023. Structure-activity relationship studies of benzothiazole-phenyl analogs as multi-target ligands to alleviate pain without affecting normal behavior. Prostaglandins Other Lipid Mediat 164:106702. doi:10.1016/j.prostaglandins.2022.106702 PMID:36529320 PMCID:PMC9879382
  • Basting RT, Napimoga M, Trindade da Silva CA, Abdalla HB, Durso BC, Martins LH, Cavalcanti Hd, Hammock BD, Clemente-Napimoga JT. 2023. Soluble epoxide hydrolase inhibitor blockage microglial cell activation in subnucleus caudalis in a persistent model of arthritis. Int Immunopharmacol 120:110320. doi:10.1016/j.intimp.2023.110320 PMID:37230034
  • Chen Y, Chen L, Xu H, Cao R, Morisseau C, Zhang M, Shi Y, Hammock BD, Wang J, Zhuang J, Liu Z, Chen G. 2023. Structure-directed discovery of potent soluble epoxide hydrolase inhibitors for the treatment of inflammatory disease. J Med Chem 66(4):2979-3009. doi:10.1021/acs.jmedchem.2c01996 PMID:36689364 PMCID:PMC9974930
  • Deans J, Deol P, Titova N, Radi S, Vuong L, Evans J, Pan S, Fahrmann J, Yang J, Hammock BD, Fiehn O, Fekry B, Eckel-Mahan K, Sladek FM. 2023. HNF4α isoforms regulate the circadian balance between carbohydrate and lipid metabolism in the liver. Front. Endocrinol 14:1266527. doi:10.3389/fendo.2023.1266527 PMID:38111711 PMCID:10726135
  • Dover M, Moseley T, Biskaduros A, Paulchakrabarti M, Hwang SH, Hammock BD, Choudhury B, Kaczor-Urbanowicz KE, Urbanowicz A, Morselli M, Dang J, Pellegrini M, Paul K, Bentolila LA, Fiala M. 2023. Polyunsaturated fatty acids mend macrophage transcriptome, glycome, and phenotype in the patients with neurodegenerative diseases, including Alzheimer's disease. Journal of Alzheimers Disease 91(1):245-261. doi:10.3233/JAD-220764 PMID:36373322 PMCID:PMC9881025
  • El-Sheikh EA, Li D, Hamed I, Ashour M, Hammock BD. 2023. Residue analysis and risk exposure assessment of multiple pesticides in tomato and strawberry ad their products from markets. Foods 12(10):1936. doi:10.3390/foods12101936 PMID:37238754 PMCID:PMC1021775
  • He Q, McCoy MR, Yang H, Lin M, Cui X, Zhao S, Morisseau C, Li D, Hammock BD. 2023. Mix-and-read nanobody-based sandwich homogeneous split-luciferase assay for the rapid detection of human soluble epoxide hydrolase. Anal Chem 95(14):6038-6045. doi:10.1021/acs.analchem.3c00079 PMID:36972550 PMCID:PMC10335774
  • Kulkarni R, Mehta R, Goswami SK, Hammock BD, Morisseau C, Hwang SH, Mallappa O, Azeemuddin MM, Rafiq M, N MS. 2023. Neuroprotective effect of herbal extracts inhibiting soluble epoxide hydrolase (sEH) and cyclooxygenase (COX) against chemotherapy-induced cognitive impairment in mice. Biochem Biophys Res Commun 667:64-72. doi:10.1016/j.bbrc.2023.05.008 PMID:37209564
  • Leuillier M, Platel V, Tu L, Feugray G, Thuillet R, Groussard D, Messaoudi H, Ottaviani M, Chelgham M, Nicol L, Mulder P, Humbert M, Richard V, Morisseau C, Brunel V, Duflot T, Guignabert C, Bellien J. 2023. Inhibition of soluble epoxide hydrolase does not promote or aggravate pulmonary hypertension in rats. Cells 12(4):665. doi:10.3390/cells12040665 PMID:36831332 PMCID:PMC9954493
  • Luo A, Wu Z, Li S, McReynolds C, Wang D, Liu H, Huang C, He T, Zhang X, Wang Y, Liu C, Hammock BD, Hashimoto K, Yang CZ. 2023. The soluble epoxide hydrolase inhibitor TPPU improves comorbidity of chronic pain and depression via the AHR and TSPO signaling. J Transl Med 21(1):71. doi:10.1186/s12967-023-03917-x PMID:36732752 PMCID:PMC9896784
  • McReynolds C, Hammock BD, Morisseau C. 2023. Regulatory lipid vicinal diols counteract the biological activity of epoxy fatty acids and can act as biomarkers and mechanisms for disease progression. Pharmacol Ther 248:108454. doi:10.1016/j.pharmthera.2023.108454 PMID:37268114
  • Oh YT, Yang J, Stefanovski D, Hammock BD, Youn JH. 2023. Determinants of meal-induce changes in circulating FFA epoxides, diols, and diol-to-epoxide ratios as indices of soluble epoxide hydrolase activity. Int J Mol Sci 24(24):17351. doi:10.3390/ijms242417351 PMID:38139180 PMCID:PMC10743433
  • Pan S, Karey E, Nieves-Cintron M, Chen Y, Hwang SH, Hammock BD, Pinkerton KE, Chen C. 2023. Effects of chronic secondhand smoke exposure on cardiovascular regulation and the role of soluble epoxide hydrolase in mice. Front Physiol 14:1185744. doi:10.3389/fphys.2023.1185744 PMID:37362438 PMCID:PMC10285070
  • Peyman M, Barroso E, Turcu AL, Estrany F, Smith D, Jurado-Aguilar J, Rada P, Morisseau C, Hammock BD, Valverde AM, Palomer X, Galdeano C, Vazquez S, Vazquez-Carrera M. 2023. Soluble epoxide hydrolase-targeting PROTAC activates AMPK and inhibits endoplasmic reticulum stress. Biomed Pharmacother 168:115667. doi:10.1016/j.biopha.2023.115667 PMID:37826940
  • Pu Y, Cheng R, Zhang Q, Huang T, Lu C, Tang Z, Zhong Y, Wu L, Hammock BD, Hashimoto K, Luo Y, Liu Y. 2023. Role of soluble epoxide hydrolase in the abnormal activation of fibroblast-like synoviocytes from patients with rheumatoid arthritis. Clin Immunol 257:doi:10.1016/j.clim.2023.109850 PMID:38013165 PMCID:10872286
  • Shen Q, Yang J, Zamora D, Horowitz M, Faurot KR, MacIntosh BA, Mann JD, Hammock BD, Ramsden CE, Taha AY. 2023. Associations between plasma lipid mediators and chronic daily headache outcomes in patients randomized to a low linoleic acid diet with or without added omega-3 fatty acids. Metabolites 13(6):690. doi:10.3390/metabo13060690 PMID:37367848 PMCID:PMC10304617
  • Sule RO, Phinney BS, Salemi MR, Gomes AV. 2023. Mitochondrial and proteasome dysfunction occurs in the hearts of mice treated with triazine herbicide prometryn. Int J Mol Sci 24(20):15266. doi:10.3390/ijms242015266 PMID:37894945 PMCID:PMC10607192
  • Sule RO, Rivera G, Gomes AV. 2023. Western blotting (immunoblotting): history, theory, uses, protocol and problems. Biotechniques doi:10.2144/btn-2022-0034 PMID:36971113
  • Thai PN, Ren L, Xu W, Overton J, Timofeyev V, Nader CE, Haddad MJ, Yang J, Gomes AV, Hammock BD, Chiamvimonvat N, Sirish P. 2023. Chronic diclofenac exposure increases mitochondrial oxidative stress, inflammatory mediators, and cardiac dysfunction. Cardiovasc Drugs Ther 37(1):25-37. doi:10.1007/s10557-021-07253-4 PMID:34499283 PMCID:PMC8904649
  • Wang Y, Abd El-Aty AM, Wang S, Cui X, Zhao J, Lei X, Xu L, She Y, Jin F, Eun J, Shim J, Wang J, Jin M, Hammock BD. 2023. Competitive fluorescent immunosensor based on catalytic hairpin self-assembly for multiresidue detection of organophosphate pesticides in agricultural products. Food Chem 413:135607. doi:10.1016/j.foodchem.2023.135607 PMID:36773354 PMCID:PMC10013200
  • Wang Y, Liu P, Ye Y, Hammock BD, Zhang C. 2023. An integrated approach to improve the assay performance of quantum dot-based lateral flow immunoassays by using silver deposition. Microchemical Journal 192:108932. doi:10.1016/j.microc.2023.108932
  • Wang Y, Morisseau C, Takamura A, Wan D, Li D, Sidoli S, Yang J, Wolan DW, Hammock BD, Kitamura S. 2023. PROTAC-mediated selective degradation of cytosolic soluble epoxide hydrolase enhances ER stress reduction. ACS Chem Biol doi:10.1021/acschembio.3c00017 PMID:36947831
  • Yang H, Qi M, He Q, Hwang SH, Yang J, McCoy MR, Morisseau C, Zhao S, Hammock BD. 2023. Quantification of soluble epoxide hydrolase inhibitors in experimental and clinical samples using the nanobody-based ELISA. J Pharm Anal 13(9):1013-1023. doi:10.1016/j.jpha.2023.05.006 PMID:37842656 PMCID:10568103
  • Yang H, Vasylieva N, Wang J, Li Z, Duan W, Chen S, Wen K, Meng H, Yu X, Shen J, Hammock BD, Wang Z. 2023. Precise isolation and structural origin of an ultra-specific nanobody against chemical compound. J Hazard Mater 458:131958. doi:10.1016/j.jhazmat.2023.131958 PMID:37429192
  • Yin Z, He Q, Yang H, Morisseau C, El-Sheikh EA, Li D, Hammock BD. 2023. Development of a sandwich ELISA for the specific quantitation of hemagglutinin (HA)-tagged proteins during their inducible expression in Escherichia coli. Anal Bioanal Chem doi:10.1007/s00216-023-04846-w PMID:37505234


  • Abdalla HB, Napimoga M, Teixeira JM, Trindade da Silva CA, Pieroni VL, Araujo FS, Hammock BD, Clemente-Napimoga JT. 2022. Soluble epoxide hydrolase inhibition avoid formalin-induced inflammatory hyperalgesia in the temporomandibular joint. Inflammopharmacology doi:10.1007/s10787-022-00965-5 PMID:35303234
  • Bergmann CB, McReynolds C, Wan D, Singh N, Goetzman H, Caldwell CC, Supp DM, Hammock BD. 2022. sEH-derived metabolites of linoleic acid drive pathologic inflammation while impairing key innate immune cell function in burn injury. Proc Natl Acad Sci U S A 119:doi:10.1073/pnas.2120691119 PMID:35312372 PMCID:PMC9060469
  • Chen H, Carty RK, Bautista AC, Hayakawa K, Lein PJ. 2022. Triiodothyronine or antioxidants block the inhibitory effects of BDE-47 and BDE-49 on axonal growth in rat hippocampal neuron-glia co-cultures. Toxics 10(2):doi:10.3390/toxics10020092 PMID:35202279 PMCID:PMC8879960
  • Chen Z, Wu H, Shen Y, Wang H, Zhang Y, Hammock BD, Li Z, Luo L, Lei H, Xu Z. 2022. Phosphate-triggered ratiometric fluoroimmunoassay based on nanobody-alkaline phosphatase fusion for sensitive detection of 1-naphthol for the exposure assessment of pesticide carbaryl. J Hazard Mater 424:doi:10.1016/j.jhazmat.2021.127411 PMID:34629198
  • Codony S, Entrena JM, Calvo-Tusell C, Jora B, Gonzalez-Cano R, Osuna S, Corpas R, Morisseau C, Perez B, Barniol-Xicota M, Grinan-Ferre C, Perez C, Rodriguez-Franco M, Martinez AL, Loza MI, Pallas M, Verhelst SH, Sanfeliu C, Feixas F, Hammock BD, Brea J, Cobos EJ, Vasquez S. 2022. Synthesis, in vitro profiling, and in vivo evaluation of benzohomoadamantane-based ureas for visceral pain: a new indication for soluble epoxide hydrolase inhibitors. J Med Chem 65(20):13660-13680. doi:10.1021/acs.jmedchem.2c00515 PMID:36222708 PMCID:PMC9620236
  • Codony S, Pont C, Grinan-Ferre C, Pede-Mattatelli AD, Calvo-Tusell C, Feixas F, Osuna S, Jarne-Ferrer J, Naldi M, Bartolini M, Loza MI, Brea J, Perez B, Bartra C, Sanfeliu C, Juarez-Jimenez J, Morisseau C, Hammock BD, Pallas M, Vasquez S, Munoz-Torrero D. 2022. Discovery and in vivo proof of concept of a highly potent dual inhibitor of soluble epoxide hydrolase and acetylcholinesterase for the treatment of Alzheimers disease. J Med Chem 65(6):4909-4925. doi:10.1021/acs.jmedchem.1c02150 PMID:35271276 PMCID:PMC8958510
  • Ding Y, Cui P, Chen H, Li J, Huang L, Gonzalez-Sapienza GG, Hammock BD, Wang M, Hua X. 2022. Ready-to-use immunosensor for the detection of small molecules with fast readout. Biosens Bioelectron 209:doi:10.1016/j.bios.2022.113968 PMID:35007993
  • Du F, Cao R, Chen L, Sun J, Shi Y, Fu Y, Hammock BD, Zheng Z, Liu Z, Chen G. 2022. Structure-guided discovery of potent and oral soluble epoxide hydrolase inhibitors for the treatment of neuropathic pain. Acta Pharm Sin B 12:1377-1389. doi:10.1016/j.apsb.2021.09.018 PMID:35530144 PMCID:PMC9072249
  • Escolano C, Bagan A, Turcu AL, Morisseau C, Loza MI, Brea J, Bartra C, Sanfeliu C, Hammock BD, Vazquez S. 2022. A new family of subnanomolar inhibitors of soluble epoxide hydrolase. FASEB J 36(S1):doi:10.1096/fasebj.2022.36.S1.R2281
  • Gowler PR, Turnbull J, Shahtaheri M, Gohir S, Kelly T, McReynolds C, Yang J, Jha RR, Fernandes GS, Zhang W, Doherty M, Walsh DA, Hammock BD, Valdes AM, Barrett DA, Chapman V. 2022. Clinical and preclinical evidence for roles of soluble epoxide hydrolase in osteoarthritis knee pain. Arthritis Rheumatol 74(4):doi:10.1002/art.42000 PMID:34672113 PMCID:PMC8957539
  • He Q, Yang L, Lin M, Yang H, Cui X, McCoy MR, Hammock BD, Fang Y, Zhao S. 2022. Generation of bioluminescent enzyme immunoassay for ferritin by single-chain variable fragment and its NanoLuc luciferase fusion. Anal Bioanal Chem doi:10.1007/s00216-022-04261-7 PMID:35945290
  • Matsumoto N, Singh N, Lee KS, Barnych B, Morisseau C, Hammock BD. 2022. The epoxy fatty acid pathway enhances cAMP in mammalian cells through multiple mechanisms. Prostaglandins Other Lipid Mediat 162:doi:10.1016/j.prostaglandins.2022.106662 PMID:35779854
  • Mengeling BJ, Vetter LF, Furlow JD. 2022. Retinoid-X receptor agonists increase thyroid hormone competence in lower jaw remodeling of pre-metamorphic Xenopus laevis tadpoles. PLoS One 17(4):20. doi:10.1371/journal.pone.0266946 PMID:35417489 PMCID:PMC9007347
  • Morisseau C. 2022. The role of hydrolases in biology and xenobiotics metabolism. Int J Mol Sci 23:4870. doi:10.3390/ijms23094870 PMID:35563260 PMCID:PMC9105290
  • Naeem Z, Zukunft S, Gunther S, Liebner S, Weigert A, Hammock BD, Fromel T, Fleming I. 2022. Role of the soluble epoxide hydrolase in the hair follicle stem cell homeostasis and hair growth. Pflugers Arch doi:10.1007/s00424-022-02709-4 PMID:35648219
  • Nguyen N, Morisseau C, Li D, Yang J, Lam E, Woodside DB, Hammock BD, Shih P. 2022. Soluble epoxide hydrolase is associated with postprandial anxiety decrease in healthy adult women. Int J Mol Sci 23(19):11798. doi:10.3390/ijms231911798 PMID:36233100 PMCID:PMC9569757
  • Pang Q, Chen Y, Mukhtar H, Xiong J, Wang X, Xu T, Hammock BD, Wang J. 2022. Camelization of a murine single-domain antibody against aflatoxin B1 and its antigen-binding analysis. Mycotoxin Res 38:51-60. doi:10.1007/s12550-021-00433-z PMID:35023020 PMCID:PMC8754551
  • Salvador J, Vasylieva N, Gonzalez-Garcia I, Jin M, Caster RW, Siegel JB, Hammock BD. 2022. Nanobody-based lateral flow immunoassay for the rapid detection of aflatoxin B1 in almond milk. ACS Food Sci Technol 2(8):1276-1282. doi:10.1021/acsfoodscitech.2c00118
  • Singh N, Li D, McReynolds C, Morisseau C, Hammock BD. 2022. Improved ELISA for linoleate-derived diols in human plasma utilizing a polyHRP-based secondary tracer. Analytical Methods doi:10.1039/d2ay00272h PMID:35481804 PMCID:PMC9116231
  • Song J, He K, Xing B, Pei Y, Wang D, Wang Y, Li S, Li J, Huan W, Zhang Y, Hammock BD. 2022. Rapid measurement of residual kanamycin using highly specific biomimetic recognition paper-based chip. Anal Chem 94(50):17567-17576. doi:10.1021/acs.analchem.2c03932 PMID:36458677
  • Song M, Wu Q, Liu B, Li P, Jiang L, Wang Y, Dong S, Xiong Y, Hammock BD, Zhang C. 2022. Using a quantum dot bead-based lateral flow immunoassay to broadly detect the adulteration of PDE-5 inhibitors in functional foods. Analytical Methods 10:doi:10.1039/d2ay00580h PMID:35723455
  • Sule RO, Condon L, Gomes AV. 2022. A common feature of pesticides: Oxidative stress- the role of oxidative stress in pesticide-induced toxicity. Oxid Med Cell Longev doi:10.1155/2022/5563759 PMID:35096268 PMCID:PMC8791758
  • Sun C, Zhou J, Yu Z, Huo X, Zhang J, Morisseau C, Hammock BD, Ma X. 2022. Kurarinone alleviated Parkinsons disease via stabilization of epoxyeicosatrienoic acids in animal model. Proc Natl Acad Sci U S A 119:doi:10.1073/pnas.2118818119 PMID:35217618 PMCID:PMC8892522
  • Wan D, Morisseau C, Hammock BD, Yang J. 2022. A fast and selective approach for profiling vicinal diols using liquid chromatography-post column derivatization-double precursor ion scanning mass spectrometry. Molecules 27(1):283. doi:10.3390/molecules27010283 PMID:35011515 PMCID:PMC8747065
  • Wang Y, Abd El-Aty AM, Chen G, Jia H, Cui X, Xu L, Cao Z, She Y, Jin F, Zhang Y, Hacimuftuoglu A, Lamu S, Wang J, Zheng L, Jin M, Hammock BD. 2022. A competitive immunoassay for detecting triazophos based on fluorescent catalytic hairpin self-assembly. Microchimica Acta 189:doi:10.1007/s00604-022-05217-5 PMID:35190860
  • Xu J, Qiu X, Yu G, Ly M, Yang J, Silva RM, Zhang X, Yu M, Wang Y, Hammock BD, Pinkerton KE, Zhao D. 2022. Soluble epoxide hydrolase inhibitor can protect the femoral head against tobacco smoke exposure-induced osteonecrosis in spontaneously hypertensive rats. Toxicology 465(15):doi:10.1016/j.tox.2021.153045 PMID:34801612
  • Xu L, Abd El-Aty AM, Eun J, Shim J, Zhao J, Lei X, Gao S, She Y, Jin F, Wang J, Jin M, Hammock BD. 2022. Recent advances in rapid detection techniques for pesticide residue: a review. J Agric Food Chem 70(41):13093-13117. doi:10.1021/acs.jafc.2c05284 PMID:36210513
  • Xu L, Abd El-Aty AM, Shim J, Eun J, Lei X, Zhao J, Zhang X, Cui X, She Y, Jin F, Zheng L, Wang J, Jin M, Hammock BD. 2022. Design and characterization of a novel hapten and preparation of monoclonal antibody for detecting atrazine. Foods 11(12):doi:10.3390/foods11121726 PMID:35741925 PMCID:PMC9223028
  • Xu L, Abd El-Aty AM, Zhao J, Lei X, Zhang X, Zhao Y, Cui X, She Y, Jin F, Wang J, Jin M, Hammock BD. 2022. Obtaining a monoclonal antibody against a novel prometryn-like hapten and characterization of its selectivity for triazine herbicides. Biosensors 13(1):22. doi:10.3390/bios13010022 PMID:36671858 PMCID:PMC9855386
  • Xu L, Zhang X, Abd El-Aty AM, Wang Y, Cao Z, Jia H, Salvador J, Hacimuftuoglu A, Cui X, Zhang Y, Wang K, She Y, Jin F, Zheng L, Pujia B, Wang J, Jin M, Hammock BD. 2022. A highly sensitive bio-barcode immunoassay for multi-residue detection of organophosphate pesticides based on fluorescence anti-quenching. J Pharm Anal 12(4):637-644. doi:10.1016/j.jpha.2022.05.004 PMID:36105157 PMCID:PMC9463527
  • Youn J, Rai N, Tagkopoulos I. 2022. Knowledge integration and decision support for accelerated discovery of antibiotic resistance genes. Nat Commun doi:10.1038/s41467-022-29993-z PMID:35487919 PMCID:PMC9055065
  • Zhang C, Li W, Li X, Wan D, Mack S, Zhang J, Wagner KM, Wang C, Tan B, Chen J, Wu C, Tsuji K, Takeuchi M, Chen Z, Hammock BD, Pinkerton KE, Yang J. 2022. Novel aerosol treatment of airway hyper-reactivity and inflammation in a murine model of asthma with a soluble epoxide hydrolase inhibitor. PLoS One 17(4):doi:10.1371/journal.pone.0266608 PMID:35443010 PMCID:PMC9020733
  • Zhou H, He C, Li Z, Huo J, Xue Y, Xu X, Qi M, Chen L, Hammock BD, Zhang J. 2022. Development of a rapid gold nanoparticle immunochromatographic strip based on the nanobody for detecting 2,4-dichlorophenoxyacetic acid. Biosensors 12(2):doi:10.3390/bios12020084 PMID:35200344 PMCID:PMC8869386


  • Bergmann CB, Hammock BD, Wan D, Gogolla F, Goetzman H, Caldwell CC, Supp DM. 2021. TPPU treatment of burned mice dampens inflammation and generation of bioactive DHET which impairs neutrophil function. Sci Rep 11(1):16555. doi:10.1038/s41598-021-96014-2 PMID:34400718 PMCID:PMC8368302
  • Boonen I, De Nys S, Vervliet P, Covaci A, Van Landuyt KL, Duca RC, Godderis L, Denison MS, Elskens M. 2021. Assessing the estrogenic activity of chemicals present in resin based dental composites and in leachates of commercially available composites using the ERa-CALUX bioassay. Dent Mater 37(12):PMID:34579959
  • Codony S, Calvo-Tusell C, Valverde E, Osuna S, Morisseau C, Loza MI, Brea J, Perez C, Rodriguez-Franco M, Pizarro-Delgado J, Corpas R, Grinan-Ferre C, Pallas M, Sanfeliu C, Vazquez-Carrera M, Hammock BD, Feixas F, Vazquez S. 2021. From the design to the in vivo evaluation of benzohomoadamantane-derived soluble epoxide hydrolase inhibitors for the treatment of acute pancreatitis. J Med Chem 64:doi:10.1021/acs.jmedchem.0c01601 PMID:33945278
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  • Huerta-Yepez S, Tirado-Rodriguez A, Montecillo-Aguado M, Yang J, Hammock BD, Hankinson O. 2020. Aryl Hydrocarbon Receptor-Dependent inductions of omega-3 and omega-6 polyunsaturated fatty acid metabolism act inversely on tumor progression. Sci Rep 10:17. doi:10.1038/s41598-020-64146-6 PMID:32398692 PMCID:PMC7217871
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  • Knuth M, Mahapatra D, Jima DD, Wan D, Hammock BD, Law M, Kullman SW. 2020. Vitamin D deficiency serves as a precursor to stunted growth and central adiposity in zebrafish. Sci Rep 10:doi:10.1038/s41598-020-72622-2 PMID:32994480 PMCID:PMC7524799
  • Lee KS, Ng JC, Yang J, Hwang SH, Morisseau C, Wagner KM, Hammock BD. 2020. Preparation and evaluation of soluble epoxide hydrolase inhibitors with improved physical properties and potencies for treating diabetic neuropathic pain. Bioorg Med Chem 28:doi:10.1016/j.bmc.2020.115735 PMID:33007552
  • Li D, Morisseau C, McReynolds C, Duflot T, Bellien J, Nagra RM, Taha AY, Hammock BD. 2020. Development of improved double-nanobody sandwich ELISAs for human soluble epoxide hydrolase detection in peripheral blood mononuclear cells of diabetic patients and the prefrontal cortex of multiple sclerosis patients. Anal Chem 92:7334-7342. doi:10.1021/acs.analchem.0c01115 PMID:32253910 PMCID:PMC7744119
  • Li P, Yang C, Liu B, Wu Q, Wang Y, Dong S, Zhang H, Vasylieva N, Hammock BD, Zhang C. 2020. Sensitive immunochromatographic assay using highly luminescent quantum dot nanobeads as tracer for the detection of cyproheptadine hydrochloride in animal-derived food. Front Chem 8:575. doi:10.3389/fchem.2020.00575 PMID:32760698 PMCID:PMC7372008
  • Li Z, Dong J, Vasylieva N, Cui Y, Wan D, Hua X, Huo J, Yang D, Gee SJ, Hammock BD. 2020. Highly specific nanobody against herbicide 2,4-dichlorophenoxyacetic acid for monitoring of its contamination in environmental water. Sci Total Environ 753:doi:10.1016/j.scitotenv.2020.141950 PMID:32906044 PMCID:PMC7674261
  • Li Z, Wang Y, Vasylieva N, Wan D, Yin Z, Dong J, Hammock BD. 2020. An ultrasensitive bioluminescent enzyme immunoassay based on nanobody/nanoluciferase heptamer fusion for the detection of Tetrabromobisphenol A in sediment. Anal Chem 92:10083-10090. doi:10.1021/acs.analchem.0c01908 PMID:32559059
  • Matin N, Fisher C, Lansdell TA, Hammock BD, Yang J, Jackson WF, Dorrance AM. 2020. Soluble epoxide hydrolase inhibition improves cognitive function and parenchymal artery dilation in a hypertensive model of chronic cerebral hypoperfusion. Microcirculation 11:doi:10.1111/micc.12653 PMID:32767848 PMCID:PMC7990111
  • Montecillo-Aguado M, Tirado-Rodriguez B, Tong Z, Vega OM, Morales-Martinez M, Abkenari S, Pedraza-Chaverri J, Huerta-Yepez S. 2020. Importance of the role of omega-3 and omega-6 polyunsaturated fatty acids in the progression of brain cancer. Brain Sci 10:18. doi:10.3390/brainsci10060381 PMID:32560280 PMCID:PMC7349634
  • Overby HB, Yang Y, Xu X, Graham K, Hildreth K, Choi S, Wan D, Morisseau C, Zeldin DC, Hammock BD, Wang S, Bettaieb A, Zhao L. 2020. Soluble Epoxide Hydrolase Inhibition by t-TUCB Promotes Brown Adipogenesis and Reduces Serum Triglycerides in Diet-Induced Obesity. Int J Mol Sci 21:doi:10.3390/ijms21197039 PMID:32987880 PMCID:PMC7582898
  • Panigrahy D, Gilligan MM, Gartung A, Cortes-Puch I, Sime PJ, Phipps RP, Serhan CN, Hammock BD. 2020. Inflammation resolution: a dual-pronged approach to averting cytokine storms in COVID-19?. Cancer Metastasis Rev 4:doi:10.1007/s10555-020-09889-4 PMID:32385712 PMCID:PMC7207990
  • Pu Y, Yang J, Chang L, Qu Y, Wang S, Zhang K, Xiong Z, Zhang J, Tan Y, Wang X, Fujita Y, Ishima T, Wan D, Hee-Hwang S, Hammock BD, Hashimoto K. 2020. Maternal glyphosate exposure causes autism-like behaviors in offspring through increased expression of soluble epoxide hydrolase. Proc Natl Acad Sci U S A 117:11753-11759. doi:10.1073/pnas.1922287117 PMID:32398374 PMCID:PMC7260984
  • Ren W, Xu Y, Huang Z, Li YP, Tu Z, Zou L, He Q, Fu J, Liu S, Hammock BD. 2020. Single chain variable fragment antibody based immunochromatographic strip for rapid detection of fumonisin B-1 in maize samples. Food Chem 319:doi:10.1016/j.foodchem.2020.126546 PMID:32179370
  • Risner D, Li F, Fell JS, Pace SA, Siegel JB, Tagkopoulos I, Spang ES. 2020. Preliminary Techno-Economic Assessment of Animal Cell-Based Meat. Foods 10:doi:10.3390/foods10010003 PMID:33374916
  • Shihadih DS, Harris TR, Kodani SD, Hwang SH, Lee KS, Mavangira V, Hamamoto B, Guedes AP, Hammock BD, Morisseau C. 2020. Selection of Potent Inhibitors of Soluble Epoxide Hydrolase for Usage in Veterinary Medicine. Front Vet Sci 7:doi:10.3389/fvets.2020.00580 PMID:33005645 PMCID:PMC7479175
  • Singh N, Barnych B, Morisseau C, Wagner KM, Wan D, Takeshita A, Pham H, Xu T, Dandekar A, Liu J, Hammock BD. 2020. N-Benzyl-linoleamide, a constituent of Lepidium meyenii (Maca), is an orally bioavailable soluble epoxide hydrolase inhibitor that alleviates inflammatory pain. J Nat Prod 83:3689-3697. doi:10.1021/acs.jnatprod.0c00938 PMID:33320645
  • Sirish P, Thai PN, Lee JH, Yang J, Zhang X, Ren L, Li N, Timofeyev V, Lee KS, Nader CE, Rowland DJ, Yechikov S, Ganaga S, Young JN, Lieu DK, Yamoah EN, Hammock BD, Chiamvimonvat N. 2020. Suppression of inflammation and fibrosis using soluble epoxide hydrolase inhibitors enhances cardiac stem cell-based therapy. Stem Cells Transl Med doi:10.1002/sctm.20-0143 PMID:32790136
  • Stefanovski D, Shih P, Hammock BD, Watanabe RM, Youn JH. 2020. Assessment of soluble epoxide hydrolase activity in vivo: A metabolomic approach. Prostaglandins Other Lipid Mediat 148:11. doi:10.1016/j.prostaglandins.2020.106410 PMID:31931080
  • Sun C, Zhang J, Zhao W, Yi J, Yan J, Wang Y, Morisseau C, Liu Z, Hammock BD, Ma X. 2020. Protostane type triterpenoids as natural soluble epoxide hydrolase inhibitors: Inhibition potentials and molecular dynamics. Biochemistry 96:doi:10.1016/j.bioorg.2020.103637 PMID:32032849
  • Sun Y, Wang G, Jing Z, Liang J, Sui J, Fan J, Li J. 2020. Microfluidic pneumatic printed sandwiched microdroplet array for high-throughput enzymatic reaction and screening. SLAS Technol 9:doi:10.1177/2472630320908248 PMID:32406795
  • Tang Z, Liu X, Su B, Chen Q, Cao H, Yun Y, Xu Y, Hammock BD. 2020. Ultrasensitive and rapid detection of ochratoxin A in agro-products by a nanobody-mediated FRET-based immunosensor. J Hazard Mater 387:121678. doi:10.1016/j.jhazmat.2019.121678 PMID:31753666
  • Teixeira JM, Abdalla HB, Basting RT, Hammock BD, Napimoga MH, Clemente-Napimoga JT. 2020. Peripheral soluble epoxide hydrolase inhibition reduces hypernociception and inflammation in albumin-induced arthritis in temporomandibular joint of rats. Int Immunopharmacol 87:106841. doi:10.1016/j.intimp.2020.106841 PMID:32736189 PMCID:PMC8015648
  • Trindade da Silva CA, Clemente-Napimoga JT, Abdalla HB, Rosa S, Ueira-Vieira C, Morisseau C, Verri WA, Montalli V, Hammock BD, Napimoga MH. 2020. Soluble epoxide hydrolase inhibitor, TPPU, increases regulatory T cells pathway in an arthritis model. Faseb J doi:10.1096/fj.202000415R PMID:32400048
  • Truong KM, Feng W, Pessah IN. 2020. Ryanodine Receptor Type 2: A Molecular Target for Dichlorodiphenyltrichloroethane- and Dichlorodiphenyldichloroethylene-Mediated Cardiotoxicity. Toxicol Sci 178:159-172. doi:10.1093/toxsci/kfaa139 PMID:32894766
  • Tu M, Wang W, Zhang G, Hammock BD. 2020. omega-3 polyunsaturated fatty acids on colonic inflammation and colon cancer: roles of lipid-metabolizing enzymes involved. Nutrients 12(11):3301. doi:10.3390/nu12113301 PMID:33126566 PMCID:PMC7693568
  • Wagner KM, Gomes AV, McReynolds C, Hammock BD. 2020. Soluble Epoxide Hydrolase Regulation of Lipid Mediators Limits Pain. Neurotherapeutics doi:10.1007/s13311-020-00916-4 PMID:32875445
  • Wang F, Li Z, Yang Y, Wan D, Vasylieva N, Zhang Y, Cai J, Wang H, Shen Y, Xu Z, Hammock BD. 2020. Chemiluminescent enzyme immunoassay and bioluminescent enzyme immunoassay for tenuazonic acid mycotoxin by exploitation of nanobody and nanobody-nanoluciferase fusion. Anal Chem 92:11935-11942. doi:10.1021/acs.analchem.0c02338 PMID:32702970
  • Wang L, Zhao D, Tang L, Li H, Liu Z, Gao J, Edin ML, Zhang H, Chen J, Zhu X, Wang D, Zeldin DC, Hammock BD, Wang J, Huang H. 2020. Soluble epoxide hydrolase deficiency attenuates lipotoxic cardiomyopathy via upregulation of AMPK-mTORC mediated autophagy. J Mol Cell Cardiol 154:80-91. doi:10.1016/j.yjmcc.2020.12.013 PMID:33378686 PMCID:PMC8068623
  • Wang Y, Yang J, Wang W, Sanidad KZ, Cinelli MA, Wan D, Hee-Hwang S, Kim D, Lee KS, Xiao H, Hammock BD, Zhang G. 2020. Soluble epoxide hydrolase is an endogenous regulator of obesity-induced intestinal barrier dysfunction and bacterial translocation. Proc Natl Acad Sci U S A 117:8431-8436. doi:10.1073/pnas.1916189117 PMID:32220957 PMCID:PMC7165420
  • Wilt S, Kodani SD, Le TN, Nguyen L, Vo N, Ly T, Rodriguez M, Hudson PK, Morrisseau C, Hammock BD, Pecic S. 2020. Development of multitarget inhibitors for the treatment of pain: Design, synthesis, biological evaluation and molecular modeling studies. Bioorg Chem 103:17. doi:10.1016/j.bioorg.2020.104165 PMID:32891856 PMCID:PMC7723751
  • Wu N, Hammock BD, Lee KS, An G. 2020. Simultaneous target-mediated drug disposition model for two small-molecule compounds competing for their pharmacological target: Soluble epoxide hydrolase. J Pharmacol Exp Ther 374:223-232. doi:10.1124/jpet.120.265330 PMID:32238455 PMCID:PMC7318792
  • Xie M, Yang J, Zhang J, Sherman HL, Zhang Z, Minter LM, Hammock BD, Park Y, Zhang G. 2020. Effects of linoleic acid-rich diet on plasma profiles of eicosanoids and development of colitis in Il-10(-/-) mice. J Agric Food Chem 68:7641-7647. doi:10.1021/acs.jafc.0c03024 PMID:32594738
  • Yang H, Duan J, Liu S, Xiong J, Guan X, Zhong W, Sun C, Zhang C, Luo X, Zhang Y, Chen P, Hammock BD, Hwang SH, Jiang J, Zhou Y, Guan C. 2020. A COX-2/sEH dual inhibitor PTUPB alleviates lipopolysaccharide induced acute lung injury in mice by inhibiting NLRP3 inflammasome activation. Thno 10:4749-4761. doi:10.7150/thno.43108
  • Zhang J, Tan Y, Chang L, Hammock BD, Hashimoto K. 2020. Increased expression of soluble epoxide hydrolase in the brain and liver from patients with major psychiatric disorders: A role of brain - liver axis. J Affect Disord 270:131-134. doi:10.1016/j.jad.2020.03.070 PMID:32339103
  • Zhang X, Du P, Cui X, Chen G, Wang Y, Zhang Y, El-Aty AA, Hacimuftuoglu A, Wang J, He H, Jin M, Hammock BD. 2020. A sensitive fluorometric bio barcodes immunoassay for detection of triazophos residue in agricultural products and water samples by iterative cycles of DNA RNA hybridization and dissociation of fluorophores by Ribonuclease H. Sci Total Environ 717:doi:10.1016/j.scitotenv.2020.137268 PMID:32084695


  • Joshi U, Pearson A, Evans JE, Langlois H, Saltiel N, Ojo J, Klimas N, Sullivan K, Keegan AP, Oberlin S, Darcey T, Cseresznye A, Raya B, Paris D, Hammock BD, Vasylieva N, Hongsibsong S, Stern LJ, Crawford F, Mullan M, Abdullah L. 2019. A permethrin metabolite is associated with adaptive immune responses in Gulf War Illness. Brain Behav Immun 81:545-559. doi:10.1016/j.bbi.2019.07.015
  • Kramer JS, Woltersdorf S, Duflot T, Hiesinger K, Lillich FF, Knoll F, Wittmann SK, Klingler FM, Brunst S, Chaikuad A, Morisseau C, Hammock BD, Buccellati C, Sala A, Rovati E, Leuillier M, Fraineau S, Rondeaux J, Hernandez-Olmos V, Heering J, Merk D, Pogoryelov D, Steinhilber D, Knapp S, Bellien J, Proschak E. 2019. Discovery of the first in vivo active inhibitors of the soluble epoxide hydrolase phosphatase domain. J Med Chem 62:8443-8460. doi:10.1021/acs.jmedchem.9b00445
  • Luo L, Wei X, Jia B, Yang J, Shen Y, Hammock BD, Dong J, Wang H, Lei H, Xu Z. 2019. Modulating linker composition of haptens resulted in improved immunoassay for histamine. Biomolecules 9:10. doi:10.3390/biom9100597 PMID:31614550 PMCID:PMC6843301
  • Rand AA, Rajamani A, Kodani SD, Harris TR, Schlatt L, Barnych B, Passerini AG, Hammock BD. 2019. Epoxyeicosatrienoic acid (EET)-stimulated angiogenesis is mediated by epoxy hydroxyeicosatrienoic acids (EHETs) formed from COX-2. J Lipid Res 60:1996-2005. doi:10.1194/jlr.M094219 PMID:31641036 PMCID:PMC6889709
  • Shen Y, Peng W, Chen Q, Hammock BD, Liu J, Li D, Yang J, Ding J, Wang X. 2019. Anti-inflammatory treatment with a soluble epoxide hydrolase inhibitor attenuates seizures and epilepsy-associated depression in the LiCl-pilocarpine post-status epilepticus rat model. Brain Behav Immun 81:535-544. doi:10.1016/j.bbi.2019.07.014 PMID:31306773 PMCID:PMC6873816
  • Tang Z, Mo F, Liu A, Siliang D, Xiaomei Y, Liang L, Hou X, Yin S, Jiang X, Vasylieva N, Dong J, Barnych B, Hammock BD, Lu X. 2019. A nanobody against cytotoxic t-lymphocyte associated antigen-4 increases the anti-tumor effects of specific CD8(+) T cells. J Biomed Nanotechnol 15:2229-2239. doi:10.1166/jbn.2019.2859 PMID:31847937
  • Yang J, Bruun DA, Wang C, Wan D, McReynolds C, Phu K, Inceoglu B, Lein PJ, Hammock BD. 2019. Lipidomes of brain from rats acutely intoxicated with diisopropylfluorophosphate identifies potential therapeutic targets. Toxicol Appl Pharmacol 382:114749. doi:10.1016/j.taap.2019.114749 PMID:31521729 PMCID:PMC6957308


  • Haedrich J, Stumpf C, Denison MS. 2018. Bioanalytical screening for Dioxins and PCBs in EU-regulated foods: new analytical criteria adopted by the European Union in Commission Regulation (EU) 2017/644. Part 2: sample analysis criteria and the nature of bioanalytical results. Dtsch Lebensmitt Rundsch 114:167-175.




  • Chabova VC, Walkowska A, Kompanowska-Jezierska E, Sadowski J, Kujal P, Vernerova Z, Vanourkova Z, Kopkan L, Kramer HJ, Imig JD, Hammock BD, Vaneckova I, Cervenka L, Falck JR. 2010. Combined inhibition of 20-hydroxyeicosatetraenoic acid formation and of epoxyeicosatrienoic acids degradation attenuates hypertension and hypertension-induced end-organ damage in Ren-2 transgenic rats. Clin Sci (Lond) 118(10):617-632. doi:10.1042/CS20090459 PMID:20050826 PMCID:PMC2854172
  • Kim H, Rossotti MA, Ahn K, Gonzalez-Sapienza GG, Gee SJ, Musker R, Hammock BD. 2010. Development of a noncompetitive phage anti-immunocomplex assay for brominated diphenyl ether 47. Anal Biochem 401(1):38-46. doi:10.1016/j.ab.2010.01.040 PMID:20152791 PMCID:PMC2861364
  • Tsai H, Hwang SH, Morisseau C, Yang J, Jones PD, Kasagami T, Kim I, Hammock BD. 2010. Pharmacokinetic screening of soluble epoxide hydrolase inhibitors in dogs. European Journal of Pharmaceutical Sciences 40(3):222-238. doi:10.1016/j.ejps.2010.03.018 PMID:20359531 PMCID:PMC3285443
  • Wang Y, Ulu A, Zhang L, Hammock BD. 2010. Soluble epoxide hydrolase in atherosclerosis. Curr Atheroscler Rep 12(3):174-183. doi:10.1007/s11883-010-0108-5 PMID:20425256 PMCID:PMC2857794


  • Nishi K, Inoue H, Schnier JB, Rice RH. 2009. Cyclin D1 downregulation is important for permanent cell cycle exit and initiation of differentiation induced by anchorage-deprivation in human keratinocytes. J Cell Biochem 106(1):63-72. doi:10.1002/jcb.21978 PMID:19021145 PMCID:PMC2987797


  • Chawengsub Y, Aggarwal N, Nithipatikom K, Gauthier KM, Anjaiah S, Hammock BD, Falck JR, Campbell WB. 2008. Identification of 15-hydroxy-11,12-epoxyeicosatrienoic acid as a vasoactive 15-lipoxygenase metabolite in rabbit aorta. Am J Physiol Heart Circ Physiol 294(3):H1348-H1356. doi:10.1152/ajpheart.01326.2007 PMID:18192225
  • Morisseau C, Hammock BD. 2008. Gerry Brooks and epoxide hydrolases: four decades to a pharmaceutical. Pest Manag Sci 64(6):594-609. doi:10.1002/ps.1583 PMID:18383502
  • Wheelock CE, Forshed J, Goto S, Hammock BD, Newman JW. 2008. Effects of pyridine exposure upon structural lipid metabolism in Swiss Webster mice. Chem Res Toxicol 21(3):583-590. doi:10.1021/tx7002454 PMID:18251509


  • Ahn K, Lohstroh PN, Gee SJ, Gee NA, Lasley BL, Hammock BD. 2007. High-throughput automated luminescent magnetic particle-based immunoassay to monitor human exposure to pyrethroid insecticides. Anal Chem 79(23):8883-8890. doi:10.1021/ac070675l PMID:17983205
  • Akatsuka T, Ishikawa T, Kobayashi N, Saito T, Shindo M, Yamauchi M, Kurokohchi K, Miyazawa H, Duan H, Matsunaga T, Komoda T, Morisseau C, Hammock BD. 2007. Autoantibody response to microsomal epoxide hydrolase in hepatitis C and A. J Autoimmun 28(1):7-18. doi:10.1016/j.jaut.2006.12.005 PMID:17296285 PMCID:PMC1892246
  • Chen J, Ahn K, Gee SJ, Gee NA, Hammock BD, Lasley BL. 2007. Antiandrogenic properties of parabens and other phenolic containing small molecules in personal care products. Toxicol Appl Pharmacol 221(3):278-284. doi:10.1016/j.taap.2007.03.015 PMID:17481686 PMCID:PMC1978490
  • Chiappe C, Leandri E, Hammock BD, Morisseau C. 2007. Effect of ionic liquids on epoxide hydrolase-catalyzed synthesis of chiral 1,2-diols. Green Chem 2007(9):162-168. doi:10.1039/b612106c PMID:18160974 PMCID:PMC2153531
  • Endsley MP, Aggarwal N, Isbell MA, Wheelock CE, Hammock BD, Flack JR, Nithipatikom K, Campbell WB. 2007. Diverse roles of 2-arachidonoylglycerol in invasion of prostate carcinoma cells: Location, hydrolysis and 12-lipoxygenase metabolism. Int J Cancer 121(5):984-991. doi:10.1002/ijc.22761 PMID:17443494 PMCID:PMC2565646
  • Hwang SH, Tsai H, Liu J, Morisseau C, Hammock BD. 2007. Orally bioavailable potent soluble epoxide hydrolase inhibitors. J Med Chem 50(16):3825-3840. doi:10.1021/jm070270t PMID:17616115 PMCID:PMC2596069
  • Kim I, Tsai H, Nishi K, Kasagami T, Morisseau C, Hammock BD. 2007. 1,3-disubstituted ureas functionalized with ether groups are potent inhibitors of the soluble epoxide hydrolase with improved pharmacokinetic properties. J Med Chem 50(21):5217-5226. doi:10.1021/jm070705c PMID:17894481 PMCID:PMC2543935
  • Loch D, Hoey A, Morisseau C, Hammock BD, Brown L. 2007. Prevention of hypertension in DOCA-salt rats by an inhibitor of soluble epoxide hydrolase. Cell Biochem Biophys 47:87-97. PMID:17406062
  • Newman JW, Kaysen GA, Hammock BD, Shearer GC. 2007. Proteinuria increases oxylipid concentrations in VLDL and HDL, but not LDL particles in the rat. J Lipid Res 48:1792-1800. PMID:17496268
  • Thompson DA, Hammock BD. 2007. Dihydroxyoctadecamonoenoate esters inhibit the neutrophil respiratory burst. J Biosci 32(2):279-291. PMID:17435320 PMCID:PMC1904342
  • Wheelock CE, Goto S, Hammock BD, Newman JW. 2007. Clofibrate-induced changes in the liver, heart, brain and white adipose lipid metabolome of Swiss-Webster mice. Metabolomics 3(2):137-145. doi:10.1007/s11306-007-0052-8 PMID:19079556 PMCID:PMC2597807


  • Ahn K, Gee SJ, Kim HJ, Nichkova MJ, Hammock BD. 2005. Progress in the development of biosensors for environmental and human monitoring of agrochemicals. Proceedings of the American Chemical Society Pacifichem 966:138-154.


  • Nichkova MJ, Feng J, Sanchez-Baeza F, Marco M, Hammock BD, Kennedy IM. 2003. Competitive quenching fluorescence immunoassy for chlorophenols based on laser-induced fluorescence detection in microdroplets. Anal Chem 75(1):83-90. PMID:12530822


  • Denison MS, Nagy SR, Ziccardi MH, Clark GC, Chu MD, Brown DJ, Shan G, Sugawara Y, Gee SJ, Sanborn JR, Hammock BD. 2002. Bioanalytical approaches for the detection of dioxin and related halogenated aromatic hydrocarbons. In: Biomarkers of Environmentally Associated Disease: Technologies, Concepts, and Perspectives. CRC Press Company, Boca Raton, FL. pp.483-494.
  • Feng J, Shan G, Hammock BD, Kennedy IM. 2002. Fluorescence quenching competitive fluoroimmunoassay in micro droplets. In: Methods for Ultrasensitive Detection II, Proceedings of the International Society for Optical Engineering. SPIE, Bellingham, WA. pp.118-127.
  • Hennig B, Hammock BD, Slim RM, Toborek M, Viswanathan S, Robertson LW. 2002. PCB-induced oxidative stress in endothelial cells: modulation by nutrients. Int J Hyg Environ Health 205(1-2):95-102. PMID:12018021
  • Krig SR, Chandraratna RA, Chang MM, Wu R, Rice RH. 2002. Gene-specific TCDD suppression of RAR- and RXR-mediated induction of tissue transglutaminase. Toxicol Sci 68(1):102-108. PMID:12075115
  • Leppert VJ, Harvey AS, McCool GD, Quinlan FT, Feng J, Shan G, Stroeve P, Risbud SH, Hammock BD, Kennedy IM. 2002. Long-wavelength emitting nanocrystals for bioassay applications. In: Nanoscale Optics and Applications. Proceedings of SPIE, pp.110-121.
  • Morisseau C, Goodrow MH, Newman JW, Wheelock CE, Dowdy DL, Hammock BD. 2002. Structural refinement of inhibitors of urea based soluble epoxide hydrolases. Biochem Pharmacol 63(9):1599-1608. PMID:12007563
  • Natarajan K, Overstreet JW, Rogers JM, Denison MS, Chen J, Lohstroh PN, McConnell DS, Lasley BL. 2002. Detection of xenoestrogens in serum after immunoprecipitation of endogenous steroidal estrogens. Environ Health Perspect 110(8):791-795. PMID:12153760
  • Newman JW, Watanabe T, Hammock BD. 2002. The simultaneous quantification of cytochrome P450 dependent linoleate and arachidonate metabolites in urine by HPLC-MS/MS. J Lipid Res 43(9):1563-1578. PMID:12235189
  • Pakehham G, Lango J, Buonarati M, Morin D, Buckpitt AR. 2002. Urinary naphthalene mercapturates as biomarkers of exposure and stereoselectivity of naphthalene epoxidation. Drug Metab Dispos 30(3):247-253. PMID:11854141
  • West JA, Williams KJ, Toskala E, Nishio SJ, Fleschner CA, Forman HJ, Buckpitt AR, Plopper CG. 2002. Induction of tolerance to naphthalene in Clara cells is dependent on a stable phenotypic adaptation favoring maintenance of the glutathione pool. Am J Pathol 160(3):1115-1127. PMID:11891208
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