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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Project Publications: Michigan State University: Mechanisms and Consequences of Neutrophil Activation by Hazardous Chemicals

Superfund Research Program

Mechanisms and Consequences of Neutrophil Activation by Hazardous Chemicals

Project Leader: Robert A. Roth
Grant Number: P42ES004911
Funding Period: 1995 - 2000

Project-Specific Links

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Publications

2021

  • Olivero-Verbal J, Harkema JR, Roth RA, Ganey PE. 2021. Fenofibrate, a peroxisome proliferator-activated receptor-alpha agonist, blocks steatosis and alters the inflammatory response in a mouse model of inflammation-dioxin interaction. Chem Biol Interact 345:PMID:34052195

2000

  • Ganey PE, Quensen JF, Mousa MA, Boyd SA, Wagner JG, Fischer L. 2000. Biological activity associated with noncoplanar polychlorinated biphenyls after microbial dechlorination of Aroclor 1242 and Aroclor 1254. Environ Toxicol Chem 19:1311-1316.
  • Olivero-Verbal J, Ganey PE. 2000. Role of protein phosphorylation in activation of phospholipase A2 by the polychlorinated biphenyl mixture Aroclor 1242. Toxicol Appl Pharmacol 163:9-16. PMID:10662600
  • Tithof PK, Olivero J, Ruehle K, Ganey PE. 2000. Activation of neutrophil calcium-dependent and -independent phospholipases A2 by organochlorine compounds. Toxicol Sci 53(1):40-47. PMID:10653519

1998

  • Fischer L, Seegal R, Ganey PE, Pessah IN, Kodavanti PR. 1998. Symposium overview: toxicity of non-coplanar PCBs. Toxicol Sci 41(1):49-61. doi:10.1006/toxs.1997.2386 PMID:9520341
  • Mousa MA, Ganey PE, Quensen JF, Madhukar BV, Chou K, Giesy JP, Fischer L, Boyd SA. 1998. Altered biological activity of commercial PCB mixtures due to microbial reductive dechlorination. In: Proceedings of the 17th International Symposium on Chlorinated Dioxins and Related Compounds. pp.1-5.
  • Narayanan PK, Carter WO, Ganey PE, Roth RA, Voytik-Harbin SL, Robinson JP. 1998. Impairment of human neutrophil oxidative burst by polychlorinated biphenyls: inhibition of superoxide dismutase activity. J Leukoc Biol 63:216-224. PMID:9468280
  • Tithof PK, Peters-Golden M, Ganey PE. 1998. Distinct phospholipases A2 regulate the release of arachidonic acid for eicosanoid production and superoxide anion generation in neutrophils. J Immunol 160:953-960. PMID:9551934

1997

  • Tithof PK, Watts S, Ganey PE. 1997. Protein tyrosine kinase involvement in the production of superoxide anion by neutrophils exposed to Aroclor 1242, a mixture of polychlorinated biphenyls. Biochem Pharmacol 53:1833-1842. PMID:9256158

1996

  • Brown AP, Schultze AE, Holdan W, Buchweitz JP, Roth RA, Ganey PE. 1996. Lipopolysaccharide-induced hepatic injury is enhanced by polychlorinated biphenyls. Environ Health Perspect 104(6):634-640. PMID:8793352
  • Ho JS, Buchweitz JP, Roth RA, Ganey PE. 1996. Identification of factors from rat neutrophils responsible for cytotoxicity to isolated hepatocytes. J Leukoc Biol 59:716-724. PMID:8656057
  • Jaeschke H, Smith CW, Clemens MG, Ganey PE, Roth RA. 1996. Mechanisms of inflammatory liver injury: adhesion molecules and cytotoxicity of neutrophils. Toxicol Appl Pharmacol 139:213-226. PMID:8806837
  • Tithof PK, Peters-Golden M, Schiamburg L, Ganey PE. 1996. Aroclor 1242 activates neutrophils by a mechanism which involves phospholipase A2. Environ Health Perspect 104:52-58.
  • Wagner JG, Ganey PE, Roth RA. 1996. Nitric oxide is not involved in hepatocyte killing by neutrophils activated by N-formyl-methionyl-leucyl-phenylalanine or phorbol myristate acetate in vitro. Hepatology 23(4):803-810. PMID:8666335

1995

  • Brown AP, Ganey PE. 1995. Neutrophil degranulation and superoxide production induced by polychlorinated biphenyl are calcium dependent. Toxicol Appl Pharmacol 131(2):198-205. PMID:7716762
  • Tithof PK, Contreras ML, Ganey PE. 1995. Aroclor 1242 stimulates the production of inositol phosphates in polymorphonuclear neutrophils. Toxicol Appl Pharmacol 131:136-143. PMID:7878669
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