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Your Environment. Your Health.

Project Publications: Michigan State University: Development of Novel Bioassay/Biomarker Systems for Detection of Estrogen Agonists in Complex Mixtures

Superfund Research Program

Development of Novel Bioassay/Biomarker Systems for Detection of Estrogen Agonists in Complex Mixtures

Project Leader: John P. Giesy
Grant Number: P42ES004911
Funding Period: 1995 - 2000

Learn More About the Grantee

Visit the grantee's eNewsletter page Visit the grantee's eNewsletter page

Publications

1999

  • Miles-Richardson S, Kramer VJ, Fitzgerald SD, Render J, Barbee S, Giesy JP. 1999. Effects of waterborne exposure of 17 beta-estradiol on secondary sex characteristics and gonads of fathead minnows (Pimephales promelas). Aquat Toxicol 47(2):129-145. doi:10.1016/S0166-445X(99)00009-0
  • Miles-Richardson S, Pierens SL, Nichols KM, Kramer VJ, Giesy JP. 1999. Effects of waterborne exposure to 4-nonylphenol and nonylphenol ethoxylate on secondary sex characteristics and gonads of fathead minnows (Pimephales promelas). Environ Res 80(2):S122-S137. doi:10.1006/enrs.1998.3945 PMID:10092426

1998

  • Ankley GT, Giesy JP, Kendall RJ. 1998. Weight of evidence. Chapter 16. In: Principles and Processes for Evaluating Endocrine Disruptors in Wildlife. SETAC Press, Pensacola, FL.
  • Ankley GT, Mahaich E, Stahl R, Tillitt DE, Colborn T, McMaster S, Miller R, Bantle J, Campbell P, Denslow ND, Dickerson RL, Folmar LC, Fry M, Giesy JP, Gray LE, Guiney PD, Hutchinson T, Kennedy SP, Kramer VJ, LeBlank G, Mayes M, Nimrod A, Patino R, Peterson R, Purdy R, Ringer R, Thomas P, Touart L, Van Der Kraak G, Zacharewski TR. 1998. Overview of a workshop on screening methods for detecting potential (anti-) estrogenic/androgenic chemicals in wildlife. Environ Toxicol Chem 17(1):68-87.
  • Feyk LL, Giesy JP. 1998. Wildlife sentinels-xenoestrogen modulation of endocrine function in birds. Chapter 6. In: Principles and Processes for Evaluating Endocrine Disruptors in Wildlife. SETAC Press, Pensacola, FL.
  • Giesy JP, Snyder EM. 1998. Environmental endocrine disruption in fish: Weight of the evidence. Chapter 7. In: Principles and Processes for Evaluating Endocrine Disruptors in Wildlife. SETAC Press, Pensacola, FL.
  • Kannan K, Guruge KS, Thomas NJ, Tanabe S, Giesy JP. 1998. Butyltin residues in southern sea otters found dead along California coastal waters. Environ Sci Technol 32(9):1169-1175.
  • Kannan K, Nakata H, Stafford R, Masson GR, Tanabe S, Giesy JP. 1998. Bioaccumulation and toxic potential of polychlorinated biphenyl congeners in biota collected at a superfund site contaminated with Aroclor 1268. Environ Sci Technol 32(9):1214-1221.
  • Kannan K, Villenueve DA, Blankenship AL, Giesy JP. 1998. Interaction of tributyltin with 3,3',4,4',5-pentachlorobiphenyl-induced ethoxyresorufin O-deethylase activity in rat hepatoma cells. J Toxicol Environ Health A 55(5):373-384. PMID:9829560
  • Kendall JJ, Brouwer A, Giesy JP. 1998. Wildlife conservation concerns and endocrine disruption in wildlife: A risk-based field and laboratory approach to assess effects. Chapter 1. In: Principles and Processes for Evaluating Endocrine Disruptors in Wildlife. SETAC Press, Pensacola, FL.
  • Klasson-Wehler E, Bergman A, Auman H, Summer C, Murk T, van den Berg M, Kannan K, Giesy JP. 1998. Hydroxylated and methylsolfonyl PCBs in albatross from Midway Atoll, North Pacific Ocean. Environ Toxicol Chem 17(8):1620-1625.
  • Koistinen J, Soimasuo R, Tukia K, Blankenship AL, Giesy JP. 1998. Induction of EROD activity in hepa-1 mouse hepatoma cells and estrogenicity in MCF-7 human breast cancer cells by extracts of pulp mill effluents, biosludge, and sediment exposed effluents. Toxicol Sci 17(8):1499-1507.
  • Kramer VJ, Miles-Richardson S, Pierens SL, Giesy JP. 1998. Reproductive impairment and induction of alkaline-labile phosphate, a biomarker of estrogen exposure, in fathead minnows (Pimephales promelas) exposed to waterborne 17 beta-estradiol. Aquat Toxicol 40(4):335-360.
  • Mousa MA, Ganey PE, Quensen JF, Madhukar BV, Chou K, Giesy JP, Fischer L, Boyd SA. 1998. Altered biological activity of commercial PCB mixtures due to microbial reductive dechlorination. In: Proceedings of the 17th International Symposium on Chlorinated Dioxins and Related Compounds. pp.1-5.
  • Quensen JF, Mousa MA, Boyd SA, Sanderson J, Fruese KL, Giesy JP. 1998. Reduction in aryl hydrocarbon receptor-mediated activity of polychlorinated biphenyl mixtures due to anaerobic microbial dechlorination. Environ Toxicol Chem 17(5):806-813.
  • Sanderson J, Giesy JP. 1998. Functional response assays in wildlife toxicology. In: Encyclopedia of environmental analysis and remediation. Wiley-Interscience,
  • Sanderson J, Kennedy SW, Giesy JP. 1998. In vitro induction of ethoxyres orufin-O-deethylase and porphyrins by halogenated aromatic hydrocarbons in avian primary hepatocytes. Environ Toxicol Chem 17(10):2006-2018.
  • Snyder SS, Villenueve DA, Pierens SL, Nichols KM, Snyder EM, Miles-Richardson S, Blankenship AL, Giesy JP. 1998. Monitoring for Complex Mixtures of Estrogen Agonists in the Aquatic Environment. In: Proceedings of the Superfund Basic Research Program: A Decade of Improving Health through Multi-Disciplinary Research. Chapel Hill, NC.
  • Villenueve DA, Blankenship AL, Giesy JP. 1998. Estrogen receptors-environmental xenobiotics. Chapter 5. In: Toxicant-Receptor Interactions and Modulation of Gene Expression. Lippincott-Raven Publishers, Philadelphia, PA.

1997

  • Giesy JP. 1997. Trends and implications of chlorinated hydrocarbons in the Great Lakes. In: Great Lakes Fisheries Policy and Management: A Binational Perspective. Michigan State University Press, East Lansing, MI.
  • Giesy JP, Jude DJ, Tillitt DE, Gale RW, Meadows JC, Zajieck JL, Peterman PH, Verbrugge DA, Sanderson J, Schwartz TR, Tuchman ML. 1997. Polychlorinated dibenzo-p-dioxins, dibenzofurans, biphenyls and 2,3,7,8-tetrachlorodibenzo-p-dioxin equivalents in fishes from Saginaw Bay, Michigan. Environ Toxicol Chem 16(4):713-724. doi:10.1002/etc.5620160416
  • Giesy JP, Kramer VJ, Bergman A, Klasson-Wehler E. 1997. Hydroxylated polychlorinated biphenyl metabolites are anti-estrogenic in a stably transfected human breast adenocarcinoma (MCF-7) cell line. In: Biotransformation in Environmental Risk Assessment. SETAC-Europe Press, Brussels, Belgium. pp.115-121.
  • Gray LE, Klece WR, Wiese T, Tyl R, Gaido KW, Cook J, Klinefelter G, Desaulniers D, Wilson E, Zacharewski TR, Waller C, Foster P, Laskey J, Reel J, Giesy JP, Laws S, McLachlan JA, Breslin W, Cooper R, Di Giulio RT, Johnson R, Purdy R, Mihaich E, Safe SH, Sonnenschein C, Welshons W, Miller R, McMaster S, Colborn T. 1997. Endocrine screening methods workshop report: detection of estrogenic and androgenic hormonal and antihormonal activity for chemicals that act via receptor or steroidogenic enzyme mechanisms. Reprod Toxicol 11(5):719-750. PMID:9311581
  • Kannan K, Tanabe S, Giesy JP. 1997. Organochlorine pesticides and polychlorinated biphenyls in foodstuffs from Asian and oceanic countries: contamination levels and dietary exposures. Rev Environ Contam Toxicol 152:1-55. PMID:9297984
  • Koistinen J, Koivusaari J, Nuuja I, Paasivarta J, Giesy JP. 1997. 2,3,7,8-tetrachlorodibenzo-p-dioxin equivalents in extracts of Baltic White-Tailed Sea Eagles. Environ Toxicol Chem 16:1533-1544.
  • Kramer VJ, Helferich WG, Bergman A, Klasson-Wehler E, Giesy JP. 1997. Hydroxylated polychlorinated biphenyl metabolites are anti-estrogenic in a stably transfected human breast adenocarcinoma (MCF7) cell line. Toxicol Appl Pharmacol 144(2):363-376. doi:10.1006/taap.1997.8163 PMID:9194421
  • Richter CA, Giesy JP, Tieber VL, Denison MS. 1997. An in vitro rainbow trout cell bioassay for AhR-mediated toxins. Environ Toxicol Chem 16:543-550.
  • Sanderson J, Janz DM, Bellward GD, Giesy JP. 1997. Effects of embryonic and adult exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin on hepatic microsomal testosterone hydroxylase activities in Great Blue Herons (Ardea herodias). Environ Toxicol Chem 16:1304-1310.
  • Vethaak D, Jobling S, Waldock M, Bjerregaard P, Dickerson R, Giesy JP, Grothe D, Karbe L, Munkittrick KR, Schlumpf M, Sumpter J. 1997. Approaches for the conduct of field surveys and toxicity identification and evaluation in identifying the hazards of endocrine modulating chemicals in wildlife. In: Proceedings of the SETAC (Society of Environmental Toxicology and Chemistry)-Europe/OECD (Organisation for Economic Co-Operation and Development) Expert Workshop on (Endocrine Modulators and Wildlife: Assessment and Testing) EMWAT. SETAC-Europe, Brussels, Belgium. pp.13-23.

1996

  • Garrison PA, Tullis K, Aarts JM, Brouwer A, Giesy JP, Denison MS. 1996. Species-specific recombinant cell lines as bioassay systems for the detection of 2,3,7,8-tetrachlorodibenzo-p-dioxin-like chemicals. Fundam Appl Toxicol 30(2):194-203. PMID:8812265
  • Giesy JP. 1996. Are Endocrine Disruptors Impacting Wildlife? A Review of the Evidence. In: Proceedings of the ILSI (International Life Sciences Institute ), Risk Science Institute, Brookings Institution and Society for Risk Analysis. Washington, DC.
  • Giesy JP. 1996. Endocrine Modulation: Perspectives on Aquatic Exposure and Effects Testing. In: Proceedings of the Endocrine Modulators Forum at the 83rd Annual meeting of the Chemical Specialties Manufacturers Association. Fort Lauderdale, FL.
  • Giesy JP. 1996. Hydroxylated Polychlorinated Biphenyl Metabolites are Anti-estrogenic in a stably Transfected Human Breast Adenocarcinoma (MCF-7) Cell Line. In: Proceedings of the (Society of Environmental Toxicology and Chemistry) SETAC-Europe workshop: Biotransformation in Ecological Risk Assessment. Noordwijerhout, Netherlands.
  • Giesy JP. 1996. Monitoring for Complex Mixtures of Estrogen Agonists and Antagonists in Aquatic Environments. In: Proceedings of the University of Guelph Toxicology Students' Association 11th Annual Toxicology Symposium-- Endocrine Modulators: Are They Stealing Our Future?. Guelph, Canada.
  • Giesy JP. 1996. Monitoring for Complex Mixtures of Estrogen Agonists in the Aquatic Environment: Development of Biomarkers and in vitro Assays and Determination of Effects in Fishes.
  • Giesy JP. 1996. Principles for Assessing Effects on the Endocrine System: Field and Laboratory Research. In: Proceedings of a Scientific Panel Discussion on Endocrine Disruptors in the Environment. Kiawah Island, SC.
  • Koistinen J, Sanderson J, Nevalainen T, Paasivarta J, Giesy JP. 1996. Ethoxyresorufin-o-deethylase (EROD) induction potency of polychlorinated diphenyl ethers (PCDE) in H4IIE rat hepatoma cells. Environ Toxicol Chem 15:2028-2034.
  • Kramer VJ, Helferisch WT, Bergman C, Giesy JP. 1996. In vitro Estrogenicity and Anti-estrogenicity of Hydroxylated, Chlorinated Biphenyls in Human Brest Cancer Tumor (MCF-7) Cells. In: Proceedings of the Environmental Remediation and Toxicology Forum. Lansing, MI.
  • Sanderson J, Aarts JM, Brouwer A, Froese KL, Denison MS, Giesy JP. 1996. Comparison of Ah receptor-mediated luciferase and ethoxyresorufin-O-deethylase induction in H4IIE cells: implications for their use as bioanalytical tools for the detection of polyhalogenated aromatic hydrocarbons. Toxicol Appl Pharmacol 137(2):316-325. PMID:8661358
  • Starodub ME, Miller PA, Ferguson GM, Giesy JP, Willes RF. 1996. The use of risk assessment techniques to develop a protocol for determining acceptable concentrations of bioaccumulative chlorinated organic chemicals in sediments for the protection of piscivorous wildlife. Toxicol Sci 54:243-259. doi:10.1080/02772249609358316

1995

  • Kramer VJ, Giesy JP. 1995. Environmental estrogens: a significant risk?. Human and Ecological Risk Assessment: An International Journal 1:37-42.
  • Newsted JL, Giesy JP, Ankley GT, Tillitt DE, Crawford RA, Gooch JL, Jones PD, Denison MS. 1995. Development of toxic equivalency factors for PCB congeners and the assessment of TCDD and PCB mixtures in rainbow trout. Environ Toxicol Chem 14(5):861-871.
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