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Your Environment. Your Health.

Project Publications: Michigan State University: An Integrated Experimental and Computational Approach to Understand the Effects of Population Variability on the Shape of the Dose-Response Curve

Superfund Research Program

An Integrated Experimental and Computational Approach to Understand the Effects of Population Variability on the Shape of the Dose-Response Curve

Project Leader: John J. LaPres
Grant Number: P42ES004911
Funding Period: 2006-2021
View this project in the NIH Research Portfolio Online Reporting Tools (RePORT)

Learn More About the Grantee

Visit the grantee's eNewsletter page Visit the grantee's eNewsletter page

Publications

2020

2019

2018

2016

  • Dornbos P, Crawford RB, Kaminski NE, Hession SL, LaPres JJ. 2016. The influence of human interindividual variability on the low-dose region of dose-response curve induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in primary B cells. Toxicol Sci 153(2):352-360. doi:10.1093/toxsci/kfw128 PMID:27473338 PMCID:PMC5036619
  • Hwang HJ, Dornbos P, LaPres JJ. 2016. Data on AHR-dependent changes in the mitochondrial proteome in response to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Data Brief 8:191-195. doi:10.1016/j.dib.2016.05.023 PMID:27331086 PMCID:PMC4898910
  • Hwang HJ, Dornbos P, Steidemann M, Dunivin TK, Rizzo M, LaPres JJ. 2016. Mitochondrial-targeted aryl hydrocarbon receptor and the impact of 2,3,7,8-tetrachlorodibenzo-p-dioxin on cellular respiration and the mitochondrial proteome. Toxicol Appl Pharmacol 304:121-132. doi:10.1016/j.taap.2016.04.005 PMID:27105554 PMCID:PMC4930739
  • Hwang HJ, Steidemann M, Dunivin TK, Rizzo M, LaPres JJ. 2016. Data of enzymatic activities of the electron transport chain and ATP synthase complexes in mouse hepatoma cells following exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Data Brief 8:93-97. doi:10.1016/j.dib.2016.05.018 PMID:27284569 PMCID:PMC4887554

2013

  • Zhang Q, Kline DE, Bhattacharya S, Crawford RB, Conolly RB, Thomas RS, Andersen ME, Kaminski NE. 2013. All-or-none suppression of B cell terminal differentiation by environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Appl Pharmacol 268(1):17-26. doi:10.1016/j.taap.2013.01.015 PMID:23357550 PMCID:PMC3594464

2011

  • De Abrew KN, Phadnis AS, Crawford RB, Kaminski NE, Thomas RS. 2011. Regulation of Bach2 by the aryl hydrocarbon receptor as a mechanism for suppression of B-cell differentiation by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Appl Pharmacol 252(2):150-158. doi:10.1016/j.taap.2011.01.020 PMID:21296099 PMCID:PMC3106294
  • McClure EA, North CM, Kaminski NE, Goodman JI. 2011. Changes in DNA methylation and gene expression during 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced suppression of the lipopolysaccharide-stimulated IgM response in splenocytes. Toxicol Sci 120(2):339-348. doi:10.1093/toxsci/kfq396 PMID:21212295 PMCID:PMC3061478

2010

  • Crawford RB, Kaminski NE, Lu H, North CM. 2010. 2,3,7,8-Tetrachlorodibenzo-p-dioxin-mediated suppression of toll-like receptor stimulated B-lymphocyte activation and initiation of plasmacytic differentiation. Toxicol Sci 116:99-112. doi:10.1093/toxsci/kfq095 PMID:20348231 PMCID:PMC2886857
  • De Abrew KN, Kaminski NE, Thomas RS. 2010. An integrated genomic analysis of aryl hydrocarbon receptor-mediated inhibition of B-cell differentiation. Toxicol Sci 118(2):454-469. doi:10.1093/toxsci/kfq265 PMID:20819909 PMCID:PMC3003543
  • Lu H, Crawford RB, Suarez-Martinez J, Kaplan BL, Kaminski NE. 2010. Induction of the aryl hydrocarbon receptor-responsive genes and modulation of the immunoglobulin M response by 2,3,7,8-tetrachlorodibenzo-p-dioxin in primary human B cells. Toxicol Sci 118(1):86-97. doi:10.1093/toxsci/kfq234 PMID:20702590 PMCID:PMC2955211
  • Zhang Q, Bhattacharya S, Kline DE, Crawford RB, Thomas RS, Kaminski NE, Andersen ME, Conolly RB. 2010. Stochastic modeling of B lymphocyte terminal differentiation and its suppression by dioxin. BMC Syst Biol 4:40. doi:10.1186/1752-0509-4-40 PMID:20359356 PMCID:PMC2859749

2007

  • Shnaider D, Byung SY, Kaminski NE. 2007. A putative role for Blimp-1 and AP-1 in TCDD-induced suppression of the IgM response in B cells. Environ Health Perspect 96(1):(Abst.828).
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