Superfund Research Program

A Proteomic Analysis of the AHR signaling Network

Project Leader: John J. LaPres
Grant Number: P42ES004911
Funding Period: 2006-2013

Project-Specific Links

Publications

2010

• Saini Y, Greenwood K, Merrill C, Kim KY, Patial S, Parameswaran N, Harkema JR, LaPres JJ. 2010. Acute cobalt-induced lung injury and the role of hypoxia-inducible factor 1 alpha in modulating inflammation. Toxicol Sci 116:673-681. doi:10.1093/toxsci/kfq155 PMID:20511350 PMCID:PMC2905409
• Saini Y, Lewandowski R, Bramble L, Harkema JR, LaPres JJ, Kim KY. 2010. Role of hypoxia-inducible factor 1{alpha} in modulating cobalt-induced lung inflammation. Am J Physiol 298(2):L139-L147. doi:10.1152/ajplung.00252.2009 PMID:19915160 PMCID:PMC2822559

2009

• Wang B, Bobe G, Bourquin LD, LaPres JJ. 2009. High sucrose diets promote intestinal epithelial cell proliferation and tumorigenesis in APC(Min) mice by increasing insulin and IGF-I levels. Nutr Cancer 61(1):81-93. doi:10.1080/01635580802372609 PMID:19116878
• Wang B, Bobe G, LaPres JJ, Bourquin LD. 2009. Dietary carbohydrate source alters gene expression profile of intestinal epithelium in mice. Nutr Cancer 61(1):146-155. doi:10.1080/01635580802372617 PMID:19116885

2008

• Lee K, Lynd JD, O'Reilly S, Kiupel M, McCormick JJ, LaPres JJ. 2008. The biphasic role of the hypoxia-inducible factor prolyl-4-hydroxylase, PHD2, in modulating tumor-forming potential. Mol Cancer Res 6(5):829-842. doi:10.1158/1541-7786.MCR-07-2113 PMID:18505927
• Saini Y, Harkema JR, LaPres JJ. 2008. HIF1alpha is essential for normal intrauterine differentiation of alveolar epithelium and surfactant production in the newborn lung of mice. J Biol Chem 283(48):33650-33657. doi:10.1074/jbc.M805927200 PMID:18801745 PMCID:PMC2586263

2007

• Lee K, Roth RA, LaPres JJ. 2007. Hypoxia, therapeutics, and toxicity. J Pharmacol Exp Ther 113(2):229-46. PMID:17046066

2006

• Lee K, Burgoon LD, Lamb L, Dere E, Zacharewski TR, Hogenesch JB, LaPres JJ. 2006. Identification and characterization of genes susceptible to transcriptional cross-talk between the hypoxia and dioxin signaling cascades. Chem Res Toxicol 19(10):1284-1293. doi:10.1021/tx060068d PMID:17040097 PMCID:PMC3152583