Superfund Research Program

Epigenomic Actions of Environmental Arsenicals

Project Leader: Bernard W. Futscher
Grant Number: P42ES004940
Funding Period: 2010-2015

Project-Specific Links

Publications

2015

• Vrba L, Garbe JC, Stampfer MR, Futscher BW. 2015. A lincRNA connected to cell mortality and epigenetically-silenced in most common human cancers. Epigenetics 10(11):1074-1083. doi:10.1080/15592294.2015.1106673 PMID:26646903 PMCID:PMC4844203

2014

• Severson PL, Vrba L, Stampfer MR, Futscher BW. 2014. Exome-wide mutation profile in benzo[a]pyrene-derived post-stasis and immortal human mammary epithelial cells. Mutat Res 775-776:48-54. doi:10.1016/j.mrgentox.2014.10.011 PMID:25435355 PMCID:PMC4250937
• Vorrink SU, Severson PL, Kulak MV, Futscher BW, Domann FE. 2014. Hypoxia perturbs aryl hydrocarbon receptor signaling and CYP1A1 expression induced by PCB 126 in human skin and liver-derived cell lines. Toxicol Appl Pharmacol 274(3):408-416. doi:10.1016/j.taap.2013.12.002 PMID:24355420 PMCID:PMC3919493

2013

• Severson PL, Tokar EJ, Vrba L, Waalkes MP, Futscher BW. 2013. Coordinate H3K9 and DNA methylation silencing of ZNFs in toxicant-induced malignant transformation. Epigenetics 8(10):1080–1088. doi:10.4161/epi.25926 PMID:23974009 PMCID:PMC3891689
• Zhao F, Severson PL, Pacheco S, Futscher BW, Klimecki WT. 2013. Arsenic exposure induces the Warburg effect in cultured human cells. Toxicol Appl Pharmacol 271(1):72-77. doi:10.1016/j.taap.2013.04.020 PMID:23648393 PMCID:PMC3714307

2012

• Severson PL, Tokar EJ, Vrba L, Waalkes MP, Futscher BW. 2012. Agglomerates of aberrant DNA methylation are associated with toxicant-induced malignant transformation. Epigenetics 7(11):1238-1248. doi:10.4161/epi.22163 PMID:22976526 PMCID:PMC3499325

2011

• States JC, Barchowsky A, Cartwright IL, Reichard JF, Futscher BW, Lantz RC. 2011. Arsenic toxicology: translating between experimental models and human pathology. Environ Health Perspect 119:1356-1363. doi:10.1289/ehp.1103441 PMID:21684831 PMCID:PMC3230447

2010

• Wnek SM, Jensen TJ, Severson PL, Futscher BW, Gandolfi A. 2010. Monomethylarsonous acid produces irreversible events resulting in malignant transformation of a human bladder cell line following 12 weeks of low-level exposure. Toxicol Sci 116(1):44-57. doi:10.1093/toxsci/kfq106 PMID:20375083 PMCID:PMC2886861