Superfund Research Program
Diabetogenic Mine Tailings: Mechanistic Link Between Arsenic, NRF2, Autophagy, and Diabetes
Project Leader: Donna D. Zhang
Grant Number: P42ES004940
Funding Period: 2020-2025
Project-Specific Links
- Project Summary
Publications
2023
- Anandhan A, Dodson M, Shakya A, Chen J, Liu P, Wei Y, Tan H, Wang Q, Jiang Z, Yang K, Garcia JG, Chambers SK, Chapman E, Ooi A, Yang-Hartwich Y, Stockwell BR, Zhang DD. 2023. NRF2 controls iron homeostasis and ferroptosis through HERC2 and VAMP8. Sci Adv 9(5):doi:10.1126/sciadv.ade9585 PMID:36724221 PMCID:PMC9891695
- Shakya A, Mckee NW, Dodson M, Chapman E, Zhang DD. 2023. Anti-ferroptotic effects of Nrf2: beyond the antioxidant response. Mol Cells 46(3):165-175. doi:10.14348/molcells.2023.0005 PMID:36994475 PMCID:PMC10070163
2022
- Anandhan A, Chen W, Nguyen N, Madhavan L, Dodson M, Zhang DD. 2022. Alpha-Syn overexpression, NRF2 suppression, and enhanced ferroptosis create a vicious cycle of neuronal loss in Parkinson's disease. Free Radic Biol Med 192:130-140. doi:10.1016/j.freeradbiomed.2022.09.015 PMID:36150560
- Dodson M, Dai W, Anandhan A, Schmidlin CJ, Liu P, Wilson NC, Wei Y, Kitamura N, Galligan JJ, Ooi A, Chapman E, Zhang DD. 2022. CHML is an NRF2 target gene that regulates mTOR function. Mol Oncol 16:1714-1727. doi:10.1002/1878-0261.13194 PMID:35184380 PMCID:PMC9019883
- Dodson M, Shakya A, Anandhan A, Chen J, Garcia JG, Zhang DD. 2022. NRF2 and diabetes: the good, the bad, and the complex. Diabetes 71(12):2463-2476. doi:10.2337/db22-0623 PMID:36409792
- Li H, Fan X, Wu X, Han W, Amistadi M, Liu P, Zhang DD, Chorover J, Ding X, Zhang Q. 2022. Differential effects of arsenic in drinking water on mouse hepatic and intestinal heme oxygenase-1 expression. Antioxidants (Basel) 11(9):1835. doi:10.3390/antiox11091835 PMID:36139908 PMCID:PMC9495312
- Liu P, Anandhan A, Chen J, Shakya A, Dodson M, Ooi A, Chapman E, White E, Garcia JG, Zhang DD. 2022. Decreased autophagosome biogenesis, reduced NRF2, and enhanced ferroptotic cell death are underlying molecular mechanisms of non-alcoholic fatty liver disease. Redox Biol 59:102570. doi:10.1016/j.redox.2022.102570 PMID:36495698 PMCID:PMC9731892
- Schiro G, Liu P, Dodson M, Zhang DD, Ghishan FK, Barberan A, Kiela PR. 2022. Interactions between arsenic exposure, high-fat diet and NRF2 shape the complex responses in the murine gut microbiome and hepatic metabolism. Front Microbiomes 1:doi:10.3389/frmbi.2022.1041188
2021
- Annadurai A, Nhat N, Arjun S, Luke A D, Matthew D, Donna D Z, Lalitha M. 2021. NRF2 Loss Accentuates Parkinsonian Pathology and Behavioral Dysfunction in Human a-Synuclein Overexpressing Mice. Aging Dis 12:964-982. doi:10.14336/ad.2021.0511 PMID:34221542 PMCID:PMC8219498
- Dodson M, Anandhan A, Zhang DD, Madhavan L. 2021. An NRF2 perspective on stem cells and aging. Front Aging 2:690686. doi:10.3389/fragi.2021.690686 PMID:36213179 PMCID:PMC9536878
- Liu P, Dodson M, Li H, Schmidlin C, Shakya A, Wei Y, Garcia JG, Chapman E, Kiela PR, Zhang Q, White E, Ding X, Ooi A, Zhang DD. 2021. Non-canonical NRF2 activation promotes a pro-diabetic shift in hepatic glucose metabolism. Mol Metab 51:101243. doi:10.1016/j.molmet.2021.101243 PMID:33933676 PMCID:PMC8164084
- Schmidlin C, Shakya A, Dodson M, Chapman E, Zhang DD. 2021. The intricacies of NRF2 regulation in cancer. Semin Cancer Biol 76:110-119. doi:10.1016/j.semcancer.2021.05.016 PMID:34020028 PMCID:PMC8599504
- Schmidlin C, Tian W, Dodson M, Chapman E, Zhang DD. 2021. FAM129B-dependent activation of NRF2 promotes an invasive phenotype in BRAF mutant melanoma cells. Mol Carcinog doi:10.1002/mc.23295 PMID:33684228 PMCID:PMC8189631
2020
- Anandhan A, Dodson M, Schmidlin C, Liu P, Zhang DD. 2020. Breakdown of an ironclad defense system: The critical role of NRF2 in mediating ferroptosis. Cell Chem Biol 27:436-447. doi:10.1016/j.chembiol.2020.03.011 PMID:32275864
- Liu P, Dodson M, Fang D, Chapman E, Zhang DD. 2020. NRF2 negatively regulates primary ciliogenesis and hedgehog signaling. PLoS Biol 18(2):doi:10.1371/journal.pbio.3000620 PMID:32053600 PMCID:PMC7043785
- Schmidlin CJ, Zeng T, Liu P, Wei Y, Dodson M, Chapman E, Zhang DD. 2020. Chronic arsenic exposure enhances metastatic potential via NRF2-mediated upregulation of SOX9. Toxicol Appl Pharmacol 402:12. doi:10.1016/j.taap.2020.115138 PMID:32682831
2019
- Dodson M, de la Vega MR, Cholanians AB, Schmidlin CJ, Chapman E, Zhang DD. 2019. Modulating NRF2 in disease: timing is everything. Annu Rev Pharmacol Toxicol 59:555-575. doi:10.1146/annurev-pharmtox-010818-021856 PMID:30256716 PMCID:PMC6538038
- Kerins M, Liu P, Tian W, Mannheim W, Zhang DD, Ooi A. 2019. Genome-wide CRISPR screen reveals autophagy disruption as the convergence mechanism that regulates the NRF2 transcription factor. Mol Cell Biol 39(13):e00037-19. doi:10.1128/MCB.00037-19 PMID:31010806 PMCID:PMC6580702