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Your Environment. Your Health.

Project Publications: University of Florida: Bioavailability of Chlorinated Compounds

Superfund Research Program

Bioavailability of Chlorinated Compounds

Project Leader: Margaret O. James
Grant Number: P42ES007375
Funding Period: 1995-2006

Learn More About the Grantee

Visit the grantee's eNewsletter page

Publications

2018

  • Mangal N, James MO, Stacpoole PW, Schmidt S. 2018. Model informed dose optimization of dichloroacetate for the treatment of congenital lactic acidosis in children. J Clin Pharmacol 58:212-220. doi:10.1002/jcph.1009 PMID:28914978

2014

2009

  • Nyagode BA, James MO, Kleinow KM. 2009. Influence of dietary Coexposure to benzo(a)pyrene on the biotransformation and distribution of 14C-methoxychlor in the channel catfish (Ictalurus punctatus). Toxicol Sci 108(2):320-329. doi:10.1093/toxsci/kfp018 PMID:19181613 PMCID:PMC2664691

2008

  • Guo X, James MO, Stacpoole PW. 2008. Age-dependent kinetics and metabolism of dichloroacetate: possible relevance to toxicity. J Pharmacol Exp Ther 324(3):1163-71. PMID:18096758

2007

2005

  • Wang L, Lehmler H, Robertson LW, James MO. 2005. In vitro inhibition of human hepatic and cDNA-expressed sulfotransferase activity with 3-hydroxybenzo[a]pyrene by polychlorobiphenylols. Environ Health Perspect 113(6):680-687. PMID:15929889 PMCID:PMC1257591

2004

  • James MO, Kleinow KM, Zhang Y, Zheng R, Wang L, Faux LR. 2004. Increased toxicity of benzo(a)pyrene-7,8-dihydrodiol in the presence of polychlorobiphenylols. Mar Environ Res 58(2-5):343-346. doi:10.1016/j.marenvres.2004.03.079 PMID:15178052
  • Kleinow KM, Hummelke GC, Zhang Y, Uppu P, Baillif C. 2004. Inhibition of P-glycoprotein transport: a mechanism for endocrine disruption in the channel catfish?. Mar Environ Res 58(2-5):205-208. doi:10.1016/j.marenvres.2004.03.015 PMID:15178033
  • Sacco JC, James MO. 2004. Glucuronidation in the polar bear (Ursus maritimus). Mar Environ Res 58(2-5):475-479. PMID:15178068

2003

  • James MO, Faux LR. 2003. Hydroxylated polychlorinated biphenyls as poor substrates but good inhibitors of the glucuronidation and sulfonation of hydroxylated benzo(a)pyrene metabolites. Fresenius Environmental Bulletin 12(2):227-231.
  • James MO, Kleinow KM, Zhang Y, Zheng R, Wang L, Faux LR. 2003. Inhibition of (-)-benzo(a)pyrene-7,8-dihydrodiol (BaP-7,8D) glucuronidation by a mixture of polychlorobiphenylols (OH-PCBs) results in increased DNA binding in a perfused channel catfish liver. In: Proceedings of the 12th International Symposium on Pollutant Responses in Marine Organisms. Safety Harbor, FL.
  • James MO, Zheng R. 2003. Glucuronidation of polychlorobiphenylols in catfish liver and intestine. In: Proceedings of the 12th International Symposium on Pollutant Responses in Marine Organisms. Safety Harbor, FL.
  • Kleinow KM, Hummelke GC, Zhang Y, Uppu P, Baillif C. 2003. Inhibition of p-glycoprotein transport: a mechanism for endocrine disruption in the channel catfish?. In: Proceedings of the 12th International Symposium on Pollutant Responses in Marine Organisms. Safety Harbor, FL.
  • Stuchal L, James MO. 2003. Biotransformation of metoxychlor in largemouth bass and channel catfish. In: Proceedings of the 12th International Symposium on Pollutant Responses in Marine Organisms. Safety Harbor, FL.
  • Sugihara N, James MO. 2003. Binding of 3-hydroxybenzo[a]pyrene to bovine hemoglobin and albumin. J Biochem Mol Toxicol 17(4):239-247. doi:10.1002/jbt.10084 PMID:12898648
  • Tan X, Zhang Y, Uppu P, Kleinow KM. 2003. The role of p-glycoprotein in the biliary excretion of tetracycline in catfish, Ictalurus punctatus. In: Proceedings of the 12th International Symposium on Pollutant Responses in Marine Organisms. Safety Harbor, FL.
  • Wang L, James MO. 2003. Triclosan as inhibitor of the sulfonation and glucuronidation of 3-hydroxy-benzo(a)pyrene in human liver. In: Proceedings of the 42nd Annual Meeting of the Society of Toxicology (SOT), March 9-13, 2003. Salt Lake City, UT.
  • Wang L, James MO. 2003. Triclosan as inhibitor of the sulfonation and glucuronidation of 3-hydroxy-benzo(a)pyrene in human liver. Environ Health Perspect 72:189. PMID:15269185

2002

  • James MO. 2002. Inhibition of UDP-glucuronosyltransferase and PAPS-sulfotransferase activities by hydroxylated PCBs. In: Proceedings of the 11th North American ISSX (International Study of Xenobiotics) Meeting, October 27-31. Orlando, FL.
  • James MO. 2002. Inhibition of UDP-glucuronosyltransferase and PAPS-sulfotransferase activities by hydroxylated PCBs. J Mol Biol Suppl34:36.
  • James MO, van den Hurk P, Kubiczak GA, Robertson LW, Lehmler H. 2002. Hydroxylated PCBs that are poor substrates but good inhibitors of UDP-glucuronosyltransferase in the channel catfish. FASEB J 16:A573.
  • James MO, Wang L, Faux LR, Lehmler H, Robertson LW. 2002. Hydroxylated PCB as inhibitors of the glucuronidation and sulfonation of hydroxylated benzo(a)pyrene metabolites. In: Proceedings of the 2nd International PCB (Polychlorinated Biphenyls) workshop. Brno, Czech Republic.
  • Lou Z, Johnson JV, James MO. 2002. Intestinal and hepatic microsomal metabolism of testosterone and progesterone by a 3 alpha-hydroxysteroid dehydrogenase to the 3 alpha-hydroxy derivatives in the channel catfish, Ictalurus punctatus. Psychiatr Pol 82(4-5):413-424. PMID:12589949
  • Wang L, Lehmler H, Robertson LW, James MO. 2002. In vitro inhibition of sulfotransferase activity of 3-hydroxy-benzo(a)pyrene by hydroxylated PCBs. In: Proceedings of the 11th North American ISSX (International Study of Xenobiotics) Meeting, October 27-31. Orlando, FL.
  • Wang L, Lehmler H, Robertson LW, James MO. 2002. In vitro inhibition of sulfotransferase activity of 3-hydroxy-benzo(a)pyrene by hydroxylated PCBs. J Mol Biol Suppl34:195.

2001

  • Doi AM, Holmes E, Kleinow KM. 2001. P-glycoprotein in the catfish intestine: inducibility by xenobiotics and functional properties. Aquat Toxicol 55(3-4):157-170. PMID:11595306
  • Fowler BA, Haasch ML, Kleinow KM, Squibb KS, Hayes AW. 2001. Organelles as Tools in Toxicology. In: Principles and Methods of Toxicology. 4th edition. Taylor and Francis, Philadelphia, PA. pp.1585-1624.
  • James MO. 2001. Polychlorinated biphenyls: metabolism and metabolites. In: Recent Advances in the Environmental Toxicology and Health Effects of PCBs. University of Kentucky Press, Lexington, KY. pp.35-46.
  • James MO, Tong Z, Faux LR, Venugopal CS, Kleinow KM. 2001. Intestinal bioavailability and biotransformation of 3-hydroxybenzo(a)pyrene in an isolated perfused preparation from channel catfish, Ictalurus punctatus. Drug Metab Dispos 29(5):721-728. PMID:11302939
  • Kleinow KM, James MO. 2001. Response of the teleost gastrointestinal system to xenobiotics. In: Target Organ Toxicity in Marine and Freshwater Teleosts. Taylor and Francis, New York, NY. pp.269-362.

2000

  • Doi AM, Lou Z, Holmes E, Li CL, Venugopal CS, James MO, Kleinow KM. 2000. Effect of micelle fatty acid composition and 3,4,3',4'-tetrachlorobiphenyl (TCB) exposure on intestinal [14C]-TCB bioavailability and biotransformation in channel catfish in situ preparations. Toxicol Sci 55(1):85-96. PMID:10788563
  • Gadagbui BK, James MO. 2000. Activities of affinity-isolated glutathione S-transferase (GST) from channel catfish whole intestine. Aquat Toxicol 49(1-2):27-37. PMID:10814804
  • Gadagbui BK, James MO. 2000. Differential expression of -like glutathione S-transferase (GST) isoforms in catfish intestine. Mar Environ Res 50(1-5):353-356. PMID:11460717
  • Gadagbui BK, James MO. 2000. The influence of diet on the regional distribution of glutathione S-transferase activity in channel catfish intestine. J Biochem Mol Toxicol 14(3):148-154. PMID:10711630
  • Kleinow KM. 2000. Autoradiography of fishes. In: Handbook of Experimental Animals -The Laboratory Fish. Academic Press, London, England. pp.579-588.
  • Kleinow KM, Doi AM, Smith AA. 2000. Distribution and inducibility of P-glycoprotein in the catfish: immunohistochemical detection using the mammalian C-219 monoclonal. Mar Environ Res 50(1-5):313-317. PMID:11460710
  • Lou Z, Celander MC, James MO. 2000. Expression and steroid hydroxylation activity of a CYP3A-like protein in channel catfish proximal and distal intestine. Toxicol Sci 54:97-98.

1999

  • Doi AM, Kleinow KM, Lou Z, James MO, Venugopalan CS, Holmes E. 1999. Bioavailability and biotransformation of 3,4,3',4'-tetrachlorobiphenyl (TCB) in in situ intestinal preparations of uninduced and TCB induced channel catfish. In: Proceedings of the PRIMO Meeting.
  • Doi AM, Kleinow KM, Venugopalan CS, Holmes E. 1999. Multixenobiotic resistance mechanism in the catfish intestine. In: Proceedings of the PRIMO Meeting.
  • Doi AM, Lou Z, Kleinow KM, James MO, Venugopalan CS, Holmes E. 1999. Effect of beta-naphthoflavone induction upon 3,4,3',4'-tetrachlorobiphenyl bioavailability in in situ preparations of channel catfish. Environ Health Perspect 48:262.
  • Gadagbui BK, James MO. 1999. Glutathione transferases: potential biomarkers of polycyclic aromatic compounds in channel catfish intestine. In: Proceedings of the PRIMO Meeting.
  • Gadagbui BK, James MO. 1999. Purification, characterization and regional distribution of glutathione S-transferase from channel catfish intestine. Environ Health Perspect 48:394.

1998

  • Doi AM, Kleinow KM, James MO, Venugopalan CS, Holmes E. 1998. Bioavailability and biotransformation of 3,4,3',4'-tetrachlorobiphenyl (TCB) in in situ intestinal preparations of uninduced and TCB-induced channel catfish. Toxicol Sci 42:337.
  • Gadagbui BK, James MO, Faux LR, Sikazwe DN. 1998. Distribution of glutathione S-transferase (GST) activity and anti GST-p cross-reactive protein in intestine of the channel catfish. Toxicol Sci 42:274.
  • James MO, Gadagbui BK, Hackett JC. 1998. Glutathione S-transferases in fish and crustacea. In: Proceedings of the American Chemical Society Symposium.
  • James MO, Kleinow KM, Li CL, Lou Z, Doi AM, Venugopalan CS, Holmes E. 1998. Intestinal bioavailability and biotransformation of 3,3',4,4'-tetrachlorobiphenyl. ISSX Proceedings 13:131.
  • James MO, Sikazwe DN, Gadagbui BK. 1998. Isolation of a pi class glutathione S-transferase from the intestinal mucosa of channel catfish, Ictalurus punctatus. Mar Environ Res 46:57-60.
  • Kleinow KM, James MO, Tong Z, Venugopalan CS. 1998. Bioavailability and biotransformation of benzo(a)pyrene in an isolated perfused in situ catfish intestinal preparation. Environ Health Perspect 106:155-166. PMID:9449680

1997

  • James MO, Cornett R, Yan Z, Henderson GN, Stacpoole PW. 1997. Glutathione-dependent conversion to glyoxylate, a major pathway of dichloroacetate biotransformation in hepatic cytosol from humans and rats, is reduced in dichloroacetate-treated rats. Drug Metab Dispos 25(11):1223-1227. PMID:9351896

1996

  • Kleinow KM, Venugopalan CS, Smith AA, Wiles JE, Holmes E. 1996. P-Glycoprotein distribution and inducibility in the catfish intestine: Role in benzo(a)pyrene (BaP) transport. Fundam Appl Toxicol 30:35.
  • Sikazwe DN, James MO. 1996. Glutathione S-transferases (GST) in intestinal and hepatic cytosol from channel catfish. Fundam Appl Toxicol 30:285.
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