Superfund Research Program

The Aryl Hydrocarbon Receptor/Transcription Factor as a Regulator of Hydrocarbon Bioactivity

Project Leader: David H. Sherr
Grant Number: P42ES007381
Funding Period: 1995 - 2005

Project-Specific Links

Publications

2013

• Quintana FJ, Sherr DH. 2013. Aryl hydrocarbon receptor control of adaptive immunity. Pharmacol Rev 65(4):1148-1161. doi:10.1124/pr.113.007823 PMID:23908379 PMCID:PMC3799235

2010

• Allan LL, Sherr DH. 2010. Disruption of human plasma cell differentiation by an environmental polycyclic aromatic hydrocarbon: a mechanistic immunotoxicological study. Environ Health 9:15. doi:10.1186/1476-069X-9-15 PMID:20334656 PMCID:PMC2851679

2009

• Hahn ME, Allan LL, Sherr DH. 2009. Regulation of constitutive and inducible AHR signaling: complex interactions involving the AHR repressor. Biochem Pharmacol 77(4):485-497. doi:10.1016/j.bcp.2008.09.016 PMID:18848529 PMCID:PMC2701375

2006

• Allan LL, Schlezinger JJ, Shansab M, Sherr DH. 2006. CYP1A1 in polycyclic aromatic hydrocarbon-induced B lymphocyte growth suppression. Biochem Biophys Res Commun 342(1):227-235. PMID:16472762

2003

• Allan LL, Mann KK, Matulka RA, Ryu H, Schlezinger JJ, Sherr DH. 2003. Bone marrow stromal-B cell interactions in polycyclic aromatic hydrocarbon-induced pro/pre-B cell apoptosis. Toxicol Sci 76(2):357-365. PMID:14514961
• Ryu H, Mann KK, Schlezinger JJ, Jensen B, Sherr DH. 2003. Environmental chemical-induced pro/pre-B cell apoptosis: analysis of c-Myc, p27(Kipl), and p21(WAF1) reveals a death pathway distinct from clonal deletion. J Immunol 170(10):4897-4907. PMID:12734332
• Takai Y, Canning J, Perez GI, Pru JK, Schlezinger JJ, Sherr DH, Kolesnick RN, Yuan J, Flavell RA, Korsmeyer SJ, Tilly JL. 2003. Bax, caspase-2, and caspase-3 are required for ovarian follicle loss caused by 4-vinylcyclohexene diepoxide exposure of female mice in vivo. Endocrinology 144(1):69-74. PMID:12488331

2002

• Schlezinger JJ, Jensen B, Mann KK, Ryu H, Sherr DH. 2002. Peroxisome proliferator-activated receptor gamma-mediated NF-kappa B activation and apoptosis in pre-B cells. J Immunol 169(12):6831-6841. PMID:12471115

2001

• Mann KK, Doerre S, Schlezinger JJ, Sherr DH, Quadri SA. 2001. The role of NF-kB as a survival factor in environmental chemical-induced preB cell apoptosis. Mol Pharmacol 59(2):302-309. PMID:11160867
• Matikainen T, Perez GI, Jurisicova A, Pru JK, Schlezinger JJ, Ryu H, Laine J, Sakai T, Korsmeyer SJ, Casper RF, Sherr DH, Tilly JL. 2001. Aromatic hydrocarbon receptor-driven Bax gene expression is required for premature ovarian failure caused by biohazardous environmental chemicals. Nat Genet 28(4):355-360. PMID:11455387

2000

• Kim DW, Gazourian L, Quadri SA, Romieu-Mourez R, Sherr DH, Sonenshein GE. 2000. The RelA NF-kappaB subunit and the aryl hydrocarbon receptor (AhR) cooperate to transactivate the c-myc promoter in mammary cells. Oncogene 19(48):5498. PMID:11114727
• Quadri SA, Qadri AN, Hahn ME, Mann KK, Sherr DH. 2000. The bioflavonoid galangin blocks aryl hydrocarbon receptor (AhR) activation and polycyclic aromatic hydrocarbon-induced Pre-B cell apoptosis. Mol Pharmacol 58:515-525. PMID:10953044
• Robles R, Morita Y, Mann KK, Perez GI, Yang S, Matikainen T, Sherr DH, Tilly JL. 2000. The aryl hydrocarbon receptor, a basic helix-loop-helix transcription factor of the PAS gene family, is required for normal ovarian germ cell dynamics in the mouse. Endocrinology 141(1):450-453. PMID:10614669
• Schlezinger JJ, Blickarz CE, Mann KK, Doerre S, Stegeman JJ. 2000. Identification of NF-kB in the marine fish Stenotomus chrysops and examination of its activation by aryl hydrocarbon receptor agonists. Chem Biol Interact 126(2):137-157. PMID:10862814
• Schlezinger JJ, Stegeman JJ. 2000. Dose and inducer-dependent induction of cytochrome P450 1A in endothelia of the eel, including in the swimbladder rete mirabile, a model microvascular structure. Drug Metab Dispos 28(6):701-708. PMID:10820144
• Trombino AF, Near RI, Matulka RA, Yang S, Hafer LF, Toselli P, Kim DW, Rogers AE, Sonenshein GE, Sherr DH. 2000. Expression of the aryl hydrocarbon receptor/transcription factor (AhR) and AhR-regulated CYP1 gene transcription in a rat model of mammary tumorigenesis. Breast Cancer Res Treat 63(2):117-131. PMID:11097088

1999

• Mann KK, Matulka RA, Hahn ME, Trombino AF, Lawrence BP, Kerkvliet NI, Sherr DH. 1999. The role of polycyclic aromatic hydrocarbon metabolism in dimethylbenzanthracene-induced pre-B cell apoptosis. Toxicol Appl Pharmacol 161:10-22.
• Mann KK, Matulka RA, Lawrence BP, Kerkvliet NI, Sherr DH. 1999. The role of cytochrome P-450 enzymes in 7,12-dimethylbenz[a]anthracene-induced apoptosis. Toxicol Appl Pharmacol 161:10. PMID:10558919

1998

• Mann KK, Quadri SA, Qadri AN, Shneider AM, Sherr DH. 1998. Involvement of NF-CB and c-myc in DMBA-induced preB lymphocyte apoptosis. Environ Health Perspect 42:89.
• Matulka RA, Mann KK, Sherr DH. 1998. DMBA (7,12-dimethlbenzanthracene) induces preB cell death via a soluble stromal cell factor. Environ Health Perspect 42:190.
• Quadri SA, Qadri AN, Sherr DH. 1998. Inhibition of polyaromatic hydrocarbon-induced apoptosis in murine pre-B cells by a dietary flavonoid, galangin. Environ Health Perspect 42:189.
• Trombino AF, Matulka RA, Yang S, Hafer LF, Rogers AE, Sherr DH. 1998. Nuclear expression of the aryl hydrocarbon receptor (AhR) in 7,12-dimethylbenz[a]anthracene (DMBA)- induced rat mammary tumors and human breast cancer cell lines. Environ Health Perspect 42:316.

1997

• Mann KK, Kerkvliet NI, Lawrence BP, Sherr DH, Trombino AF. 1997. DMBA-induced pre-B cell apoptosis is both stromal and AhR-dependent, but not P-4501A mediated. Environ Health Perspect
• Shneider AM, Sherr DH. 1997. Benzo(a)pyrene induces NF-XB in mouse hepatoma cells. Environ Health Perspect
• Trombino AF, Yang S, Hafer LF, Qadri AN, Rogers AE, Sherr DH. 1997. Modulation of aromatic hydrocarbon receptor expression in 7,12-dimethylbenz[a]anthracene-induced rat mammary tumors. Environ Health Perspect
• White RD, Shea D, Stegeman JJ. 1997. Metabolism of the aromatic hydrocarbon receptor agonist 3,3',4,4'-tetrachlorobiphenyl by the marine fish scup (Stenotomus chrysops) in vivo and in vitro. Drug Metab Dispos 25(5):564-572. PMID:9152595
• Yamaguchi K, Matulka RA, Shneider AM, Toselli P, Trombino AF, Yang S, Hafer LJ, Mann KK, Tao X, Tilly JL, Near RI, Sherr DH. 1997. Induction of preB cell apoptosis by 7,12 dimethylbenz[a]anthracene in long term primary bone marrow cultures. Toxicol Appl Pharmacol 147(2):190-203. PMID:9439715
• Yamaguchi K, Near RI, Matulka RA, Shneider AM, Toselli P, Trombino AF, Sherr DH. 1997. Activation of the aryl hydrocarbon receptor/transcription factor and bone marrow stromal cell-dependent preB cell apoptosis. J Immunol 158(5):2165-2173. PMID:9036962

1996

• Cui H, Ju S, Sherr DH. 1996. Functional expression of Fas (CD95) protein in autoimmune lpr mice. Cell Immunol 174:35-41. PMID:8929452
• Wu M, Arsura M, Bellas RE, Fitzgerald MJ, Lee H, Schauer SL, Sherr DH, Sonenshein GE. 1996. Inhibition of c-myc expression induces apoptosis of WEHI 231 murine B cells. Mol Cell Biol 16(9):5015-5025. PMID:8756660
• Yamaguchi K, Near RI, Shneider AM, Cui H, Ju S, Sherr DH. 1996. Fluoranthene-induced apoptosis in murine T cell hybridomas is independent of the aromatic hydrocarbon receptor. Toxicol Appl Pharmacol 139(1):144-152. PMID:8685897