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Your Environment. Your Health.

Project Publications: Boston University: Environmental PPARγ Pathway Activators: Multifaceted Metabolic Disruptors Impacting Adipose and Bone Homeostasis

Superfund Research Program

Environmental PPARγ Pathway Activators: Multifaceted Metabolic Disruptors Impacting Adipose and Bone Homeostasis

Project Leader: Jennifer J. Schlezinger
Co-Investigator: James Hamilton
Grant Number: P42ES007381
Funding Period: 2005-2021
View this project in the NIH Research Portfolio Online Reporting Tools (RePORT)

Learn More About the Grantee

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  • Andrews FV, Kim S, Edwards L, Schlezinger JJ. 2020. Identifying adipogenic chemicals: Disparate effects in 3T3-L1, OP9 and primary mesenchymal multipotent cell models. Toxicol In Vitro 67:12. doi:10.1016/j.tiv.2020.104904 PMID:32473317
  • Crawford KA, Clark BW, Heiger-Bernays WJ, Karchner SI, Hahn ME, Nacci DE, Schlezinger JJ. 2020. Tributyltin disrupts fin development in Fundulus heteroclitus from both PCB-sensitive and resistant populations: Investigations of potential interactions between AHR and PPARy. Aquat Toxicol 218:105334. doi:10.1016/j.aquatox.2019.105334 PMID:31743820 PMCID:PMC6935467
  • Kim S, Rabhi N, Blum BC, Hekman R, Wynne K, Emili A, Farmer S, Schlezinger JJ. 2020. Triphenyl phosphate is a selective PPARy modulator that does not induce brite adipogenesis in vitro and in vivo. Arch Toxicol 17:3087-3103. doi:10.1007/s00204-020-02815-1 PMID:32683515
  • Schlezinger JJ, Puckett H, Nielsen OG, Heiger-Bernays WJ, Webster TF. 2020. Perfluorooctanoic acid activates multiple nuclear receptor pathways and skews expression of genes regulating cholesterol homeostasis in liver of humanized PPAR alpha mice fed an American diet. Toxicol Appl Pharmacol 405:115204. doi:10.1016/j.taap.2020.115204 PMID:32822737 PMCID:PMC7503133


  • Crawford KA, Clark BW, Heiger-Bernays WJ, Karchner SI, Claus Henn B, Griffith KN, Howes BL, Schlezinger DR, Hahn ME, Nacci DE, Schlezinger JJ. 2019. Altered lipid homeostasis in a PCB-resistant Atlantic killifish (Fundulus heteroclitus) population from New Bedford Harbor, MA, U.S.A. Aquat Toxicol 210:30-43. doi:10.1016/j.aquatox.2019.02.011 PMID:30822701 PMCID:PMC6544361
  • Edwards L, Watt J, Webster TF, Schlezinger JJ. 2019. Assessment of total, ligand-induced peroxisome proliferator activated receptor gamma ligand activity in serum. Environ Health 18(45):doi:10.1186/s12940-019-0486-2 PMID:31072366 PMCID:PMC6506953


  • Kim S, Li A, Monti S, Schlezinger JJ. 2018. Tributyltin induces a transcriptional response without a brite adipocyte signature in adipocyte models. Arch Toxicol 1-16. doi:10.1007/s00204-018-2268-y PMID:30027469
  • Narasimhan S, Zulick ES, Novikov O, Parks A, Schlezinger JJ, Wang Z, Laroche F, Feng H, Mulas F, Monti S, Sherr DH. 2018. Towards resolving the pro- and anti-tumor effects of the aryl hydrocarbon receptor. Int J Mol Sci 19:24. doi:10.3390/ijms19051388 PMID:29735912 PMCID:PMC5983651
  • Watt J, Baker AH, Meeks B, Pajevic PD, Morgan EF, Gerstenfeld LC, Schlezinger JJ. 2018. Tributyltin induces distinct effects on cortical and trabecular bone in female C57Bl/6J mice. Journal of Cellular Physiology 233:7007-7021. doi:10.1002/jcp.26495 PMID:29380368


  • Kassotis CD, Masse L, Kim S, Schlezinger JJ, Webster TF, Stapleton HM. 2017. Characterization of adipogenic chemicals in three different cell culture systems: Implications for reproducibility based on cell source and handling. Sci Rep 7(42104):doi:10.1038/srep42104 PMID:28176856 PMCID:PMC5296734


  • Auerbach SS, Filer D, Reif DM, Walker V, Blumberg B, Clegg D, Holloway A, Schlezinger JJ, Srinivasan S, White M, Svoboda D, Judson RR, Bucher JR, Thayer KA. 2016. Identifying environmental chemicals to test for obesity and diabetes outcomes: clues from ToxCast high throughput screening data. Environ Health Perspect 128:1141-1154.
  • Bolt AM, Grant MP, Flores Molina M, Plourde D, Kelly AD, Negro Silva LF, Lemaire M, Schlezinger JJ, Mwale F, Mann KK. 2016. Tungsten promotes sex-specific adipogenesis in the bone by altering differentiation of bone marrow-resident mesenchymal stromal cells. Toxicol Sci 150(2):333-346. doi:10.1093/toxsci/kfw008 PMID:26865663 PMCID:PMC4900133
  • Watt J, Webster TF, Schlezinger JJ. 2016. Generalized concentration addition modeling predicts mixture effects of environmental PPARγ agonists. Toxicol Sci 153(1):18-27. doi:10.1093/toxsci/kfw100 PMID:27255385 PMCID:PMC5013877


  • Baker AH, Watt J, Huang CK, Gerstenfeld LC, Schlezinger JJ. 2015. Tributyltin engages multiple nuclear receptor pathways and suppresses osteogenesis in bone marrow multipotent stromal cells. Chem Res Toxicol 28(6):1156-1166. doi:10.1021/tx500433r PMID:25932594 PMCID:PMC4737589
  • Bragdon B, Burns R, Baker AH, Belkina AC, Morgan EF, Denis GV, Gerstenfeld LC, Schlezinger JJ. 2015. Intrinsic sex-linked variations in osteogenic and adipogenic differentiation potential of bone marrow multipotent stromal cells. Journal of Cellular Physiology 230(2):296-307. doi:10.1002/jcp.24705 PMID:24962433 PMCID:PMC4317374
  • Watt J, Schlezinger JJ. 2015. Structurally-diverse, PPARγ-activating environmental toxicants induce adipogenesis and suppress osteogenesis in bone marrow mesenchymal stromal cells. Toxicology 331:66-77. doi:10.1016/j.tox.2015.03.006 PMID:25777084 PMCID:PMC4406869


  • Lowe MM, Mold JE, Kanwar B, Huang Y, Louie A, Pollastri MP, Wang C, Patel G, Franks DG, Schlezinger JJ, Sherr DH, Silverstone AE, Hahn ME, McCune JM. 2014. Identification of cinnabarinic acid as a novel endogenous aryl hydrocarbon receptor ligand that drives IL-22 production. PLoS One 9(2):15. doi:10.1371/journal.pone.0087877 PMID:24498387 PMCID:PMC3912126
  • Parks A, Pollastri MP, Hahn ME, Stanford EA, Novikov O, Franks DG, Haigh SE, Narasimhan S, Ashton TD, Hopper TG, Kozakov D, Beglov D, Vajda S, Schlezinger JJ, Sherr DH. 2014. In silico identification of an aryl hydrocarbon receptor antagonist with biological activity in vitro and in vivo. Mol Pharmacol 86(5):593-608. doi:10.1124/mol.114.093369 PMID:25159092 PMCID:PMC4201140
  • Pillai HK, Fang M, Beglov D, Kozakov D, Vajda S, Stapleton HM, Webster TF, Schlezinger JJ. 2014. Ligand binding and activation of PPARγ by Firemaster® 550: effects on adipogenesis and osteogenesis in vitro. Environ Health Perspect 122(11):1225-1232. doi:10.1289/ehp.1408111 PMID:25062436 PMCID:PMC4216168
  • Simmons AL, Schlezinger JJ, Corkey BE. 2014. What are we putting in our food that is making us fat? Food additives, contaminants, and other putative contributors to obesity. Curr Obes Rep 3(2):273-285. doi:10.1007/s13679-014-0094-y PMID:25045594 PMCID:PMC4101898


  • Bissonnette SL, Haas A, Mann KK, Schlezinger JJ. 2010. The role of CaMKII in calcium-activated death pathways in bone marrow B cells. Toxicol Sci 118(1):108-118. doi:10.1093/toxsci/kfq256 PMID:20810541 PMCID:PMC2955217
  • Howard G, Schlezinger JJ, Hahn ME, Webster TF. 2010. Generalized concentration addition predicts joint effects of aryl hydrocarbon receptor agonists with partial agonists and competitive antagonists. Environ Health Perspect 118(5):666-672. doi:10.1289/ehp.0901312 PMID:20435555 PMCID:PMC2866683
  • Teague J, Ryu H, Kirber M, Sherr DH, Schlezinger JJ. 2010. Proximal events in 7,12-dimethylbenz a anthracene-induced, stromal cell-dependent bone marrow B cell apoptosis: stromal cell-B cell communication and apoptosis signaling. J Immunol 185:3369-3378. doi:10.4049/jimmunol.0902541 PMID:20720205 PMCID:PMC2933279


  • Bissonnette SL, Emberley JK, Sherr DH. 2008. An endogenous prostaglandin enhances environmental phthalate-induced apoptosis in bone marrow B cells: activation of distinct but overlapping pathways. J Immunol 181:1728-1736. PMID:18641309


  • Schlezinger JJ, Emberley JK, Sherr DH, Bissonnette SL. 2007. An L-tyrosine derivative and PPARγ agonist, GW7845, activates a multi-faceted capase cascade in bone marrow B cells. Toxicol Sci 98(1):125-36. PMID:17400580


  • Allan LL, Schlezinger JJ, Shansab M, Sherr DH. 2006. CYP1A1 in polycyclic aromatic hydrocarbon-induced B lymphocyte growth suppression. Biochem Biophys Res Commun 342(1):227-235. PMID:16472762
  • Schlezinger JJ, Emberley JK, Sherr DH. 2006. Activation of multiple mitogen-activated protein kinases in pro/pre-B cells by GW7845, a peroxisome proliferator-activated receptor gamma agonist, and their contribution to GW7845-induced apoptosis. Toxicol Sci 92(2):433-44. PMID:16672323
  • Schlezinger JJ, Struntz WD, Goldstone JV, Stegeman JJ. 2006. Uncoupling of cytochrome P450 1A and stimulation of reactive oxygen species production by co-planar polychlorinated biphenyl congeners. Aquat Toxicol 77(4):422-432. PMID:16500718
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