Superfund Research Program
Environmental PPARγ Pathway Activators: Multifaceted Metabolic Disruptors Impacting Adipose and Bone Homeostatsis
- 272 - TBT Alters Bone Marrow Microenvironment and Suppresses Important Immune Cells -- Schlezinger
Release Date: 08/02/2017
Researchers at the Boston University Superfund Research Program (BU SRP) Center reported that tributyltin (TBT) may promote aging-related problems in immune health. The team, led by Jennifer Schlezinger, Ph.D., found that TBT impacts bone marrow B cells directly by triggering cell death and indirectly by changing the microenvironment of bone marrow vital for supporting immune health.
- 237 - The Flame Retardant Firemaster 550, Fat Cells, and Bone Health -- Schlezinger
Release Date: 09/03/2014
Researchers from the Boston University (BU) and Duke University Superfund Research Program (SRP) Centers found that components of the flame-retardant mixture Firemaster® 550 (FM550) may stimulate growth of fat cells and reduce bone health. The results of the collaborative study suggest that triphenyl phosphate (TPP), a component of FM550 that is widespread in household products and house dust, interacts with a protein that regulates fat cell differentiation and lipid storage.