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Research Briefs: Boston University

Superfund Research Program

Environmental PPARγ Pathway Activators: Multifaceted Metabolic Disruptors Impacting Adipose and Bone Homeostasis

Project Leader: Jennifer J. Schlezinger
Co-Investigator: James Hamilton
Grant Number: P42ES007381
Funding Period: 2005-2021

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Research Briefs

  • 313 - New Model to Examine PFAS Sheds Light on Lipid Disruption Mechanisms -- Schlezinger, Webster
    Release Date: 01/13/2021

    Researchers from the Boston University (BU) Superfund Research Program (SRP) Center developed a novel study design that generated new insight on the effects of perfluorooctanoic acid (PFOA) on cholesterol regulation in the liver. Led by Jennifer Schlezinger, Ph.D., the team also investigated the molecular mechanisms of action, focusing on effects of PFOA on the human peroxisome proliferator activated receptor α (hPPARα), a transcription factor that regulates lipid homeostasis.

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Last Reviewed: December 05, 2024