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Your Environment. Your Health.

Research Briefs: Boston University

Superfund Research Program

Environmental PPARγ Pathway Activators: Multifaceted Metabolic Disruptors Impacting Adipose and Bone Homeostasis

Project Leader: Jennifer J. Schlezinger
Co-Investigator: James Hamilton
Grant Number: P42ES007381
Funding Period: 2005-2021
View this project in the NIH Research Portfolio Online Reporting Tools (RePORT)

Learn More About the Grantee

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Research Briefs

  • 313 - New Model to Examine PFAS Sheds Light on Lipid Disruption Mechanisms -- Schlezinger, Webster
    Release Date: 01/13/2021

    Researchers from the Boston University (BU) Superfund Research Program (SRP) Center developed a novel study design that generated new insight on the effects of perfluorooctanoic acid (PFOA) on cholesterol regulation in the liver. Led by Jennifer Schlezinger, Ph.D., the team also investigated the molecular mechanisms of action, focusing on effects of PFOA on the human peroxisome proliferator activated receptor α (hPPARα), a transcription factor that regulates lipid homeostasis.

  • 272 - TBT Alters Bone Marrow Microenvironment and Suppresses Important Immune Cells -- Schlezinger
    Release Date: 08/02/2017

    Researchers at the Boston University Superfund Research Program (BU SRP) Center reported that tributyltin (TBT) may promote aging-related problems in immune health. The team, led by Jennifer Schlezinger, Ph.D., found that TBT impacts bone marrow B cells directly by triggering cell death and indirectly by changing the microenvironment of bone marrow vital for supporting immune health.

  • 237 - The Flame Retardant Firemaster 550, Fat Cells, and Bone Health -- Schlezinger
    Release Date: 09/03/2014

    Researchers from the Boston University (BU) and Duke University Superfund Research Program (SRP) Centers found that components of the flame-retardant mixture Firemaster® 550 (FM550) may stimulate growth of fat cells and reduce bone health. The results of the collaborative study suggest that triphenyl phosphate (TPP), a component of FM550 that is widespread in household products and house dust, interacts with a protein that regulates fat cell differentiation and lipid storage.

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