Superfund Research Program
The Long-term Impacts of Early Life Exposure to Superfund Chemicals in Humans and Wildlife
Center Director: David H. Sherr
Grant Number: P42ES007381
Funding Period: 1995-2021
- 313 - New Model to Examine PFAS Sheds Light on Lipid Disruption Mechanisms -- Schlezinger, Webster
Release Date: 01/13/2021
Researchers from the Boston University (BU) Superfund Research Program (SRP) Center developed a novel study design that generated new insight on the effects of perfluorooctanoic acid (PFOA) on cholesterol regulation in the liver. Led by Jennifer Schlezinger, Ph.D., the team also investigated the molecular mechanisms of action, focusing on effects of PFOA on the human peroxisome proliferator activated receptor α (hPPARα), a transcription factor that regulates lipid homeostasis.
- 299 - Modeling Approaches Estimate Exposure and Simulate Impacts on Health -- Levy
Release Date: 11/06/2019
Researchers from the Boston University (BU) Superfund Research Program (SRP) Center developed and applied novel statistical models to cost-effectively predict chemical exposures and their associated harm to human health in large populations. These statistically powerful approaches can address the challenges of measuring exposures for large populations and quantifying the health benefits of exposure reduction.
- 294 - New Method Quickly Screens Chemicals for Cancer Risk -- Monti
Release Date: 06/05/2019
Boston University (BU) researchers, in collaboration with researchers at the National Toxicology Program (NTP) and the Broad Institute, have developed and evaluated a new approach to assess whether exposure to a chemical increases a person’s long-term cancer risk. The fast, cost-effective method uses gene expression profiling, which measures the activity of a thousand or more genes to capture what is happening in a cell. Based on gene expression profiling data, the researchers were able to infer specific biological changes at the cellular level and predict potential carcinogenicity of chemicals, or the ability of chemicals to cause cancer.
- 272 - TBT Alters Bone Marrow Microenvironment and Suppresses Important Immune Cells -- Schlezinger
Release Date: 08/02/2017
Researchers at the Boston University Superfund Research Program (BU SRP) Center reported that tributyltin (TBT) may promote aging-related problems in immune health. The team, led by Jennifer Schlezinger, Ph.D., found that TBT impacts bone marrow B cells directly by triggering cell death and indirectly by changing the microenvironment of bone marrow vital for supporting immune health.
- 270 - Prenatal PCE Exposure and Maternal Alcohol Use Linked to Increased Risks of Teenage Drug Use -- Aschengrau
Release Date: 06/07/2017
Prenatal exposure to both alcohol and tetrachloroethylene, also known as perchloroethylene or PCE, may increase the risk of using multiple illicit drugs as a teenager, according to a study by Boston University Superfund Research Program (BU SRP) Center researchers. PCE is a solvent frequently used in dry cleaning solutions, adhesives, metal degreasers, and other commercial products.
- 265 - The Genetics Behind the Killifish's Adaptation to Pollution -- Hahn
Release Date: 01/04/2017
Killifish living in four polluted East Coast estuaries have adapted quickly to survive high levels of toxic industrial pollutants. In a new study, researchers explored the complex genetics involved in the Atlantic killifish’s resilience, bringing us one step closer to understanding how they rapidly evolved to tolerate normally lethal levels of environmental contaminants. Exploring the evolutionary basis for these genetic changes may provide new information about the mechanisms of environmental chemical toxicity in both animals and humans.
- 262 - Environmental Exposures and AhR in Oral Cancer Development and Progression -- Sherr
Release Date: 10/05/2016
The aryl hydrocarbon receptor (AhR) plays an important role in oral cancer, and environmental chemicals and bacteria that activate the AhR may worsen oral cancer development and progression, according to a recent study from the Boston University Superfund Research Program (SRP) Center.
- 257 - Using Field Data and Numerical Modeling to Assess Vapor Intrusion Risk -- Pennell
Release Date: 05/04/2016
A recent Superfund Research Program (SRP) study reveals that measurements of chemical concentrations in groundwater may not be a good indicator of whether the chemicals are seeping into buildings and contaminating indoor air. The findings provide insight into how an approach incorporating multiple lines of evidence, including soil gas measurements and a 3-D model, can be used to better evaluate exposure risks from vapor intrusion into homes and buildings.
- 247 - PCE in Drinking Water Linked to Cancer and Epilepsy -- Aschengrau
Release Date: 07/01/2015
Early-life exposure to tetrachloroethylene (PCE; perchloroethylene) in drinking water may increase the risk of epilepsy and certain types of cancer into adulthood, according to Boston University Superfund Research Program (BU SRP) Center researchers. PCE is a solvent frequently used in dry cleaning solutions, adhesives, metal degreasers, and other commercial products.
- 237 - The Flame Retardant Firemaster 550, Fat Cells, and Bone Health -- Schlezinger
Release Date: 09/03/2014
Researchers from the Boston University (BU) and Duke University Superfund Research Program (SRP) Centers found that components of the flame-retardant mixture Firemaster® 550 (FM550) may stimulate growth of fat cells and reduce bone health. The results of the collaborative study suggest that triphenyl phosphate (TPP), a component of FM550 that is widespread in household products and house dust, interacts with a protein that regulates fat cell differentiation and lipid storage.
- 212 - Early-life PCE Exposure Linked to Visual Impairment in Adults -- Aschengrau
Release Date: 08/01/2012
New evidence shows exposure to the chemical PCE during development can lead to visual impairment later in life. Scientists have previously linked the chemical with neurological effects like memory and attention problems.
- 195 - Mechanism of Resistance to PCB Toxicity in Fish -- Wirgin, Hahn
Release Date: 03/02/2011
A team unravels the mystery of how Atlantic tomcod living in waters contaminated with polychlorinated biphenyls (PCBs) not only survive in their polluted environment, but thrive.
- 189 - Use of Spatial and Temporal Analyses to Provide Insights into the Environmental Etiology of Cancer -- Aschengrau, Webster
Release Date: 09/01/2010
Scientists are investigating what individuals in geographic "hot spots" for cancer have in common to reveal possible routes of exposure to environmental carcinogens.
- 125 - Epidemiologic Research on Environmental Pollution and the Risk of Disease -- Aschengrau
Release Date: 05/04/2005
- 124 - DNA Damage Index: A New Tool for Assessing Toxic Effects of Contaminants -- Malins, Stegeman
Release Date: 04/06/2005
- 112 - Using Computational Approaches to Investigate Ligand-Receptor Interactions -- Vajda
Release Date: 04/07/2004
- 81 - Developmental Neurotoxicity of Xenoestrogens in Zebrafish -- Callard
Release Date: 09/05/2001
- 63 - Stage-specific Actions of Cadmium During Spermatogenesis -- Callard
Release Date: 02/02/2000
- 59 - New Mapping Method is Developed for Analysis of Environmental Epidemiological Data -- Ozonoff
Release Date: 11/17/1999
- 39 - Tracking Down the Mechanisms of Trichloroethylene-Induced Toxicity -- Waxman
Release Date: 02/10/1999
- 35 - Organochlorine Exposure and Breast Cancer Risk -- Grandjean
Release Date: 12/09/1998
- 21 - Mechanisms of Dioxin Sensitivity and Acquired Resistance -- Hahn
Release Date: 05/27/1998
- 7 - New Methods of Spatial Analysis Are Developed for Environmental Epidemiological Data Using a Geographic Information System -- Ozonoff
Release Date: 10/29/1997