Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Internet Explorer is no longer a supported browser.

This website may not display properly with Internet Explorer. For the best experience, please use a more recent browser such as the latest versions of Google Chrome, Microsoft Edge, and/or Mozilla Firefox. Thank you.

Your Environment. Your Health.

Boston University

Superfund Research Program

Superfund Research Program at Boston University

Center Director: David M. Ozonoff
Grant Number: P42ES007381
Funding Period: 1995-2020

Learn More About the Grantee

Visit the grantee's eNewsletter page Visit the grantee's eNewsletter page Visit the grantee's Twitter page View the grantee's Factsheet(377KB)

Summary (2005-2012)

The scientific theme for this competitive renewal continues the theme from the previous grant submission: effects of exposures to environmentally hazardous substances on reproduction and development in humans and wildlife. Special emphasis is placed on substances commonly encountered as a result of improperly managed waste disposal. The chemicals under study are all organics, both halogenated and nonhalogenated compounds. This program will focus on the underlying mechanics of xenobiotic/endocrine interactions and their effects to allow a better understanding of the implications of perturbations of reproductive and developmental processes by hazardous substances in the environment. Nine projects, 5 biomedical and 4 non-biomedical will study:

  1. Epidemiological studies of effects on neurodevelopment of a population exposed to perchloroethylene (PCE, a peroxisome proliferator) in drinking water, and epidemiological techniques to study similar environmental problems (two biomedical projects);
  2. Receptor based mechanistic studies of the role of intracellular receptors and signaling pathways in the development of organisms and tissues (receptors/pathway: Ah receptor, AhR; peroxisome proliferator activated receptor, PPAR; estrogen receptor, ER; androgen receptor, AR; MAP kinase pathway) for important xenobiotics (planar halogenated aromatic hydrocarbons, PHAHs; polycyclic aromatic hydrocarbons, PAHs; and peroxisome proliferators, especially phthalates) (three biomedical projects);
  3. Mechanisms of toxicity and resistance of fish populations to PHAHs and xenoestrogens involving receptors (AhRs, PPARs, and ERs) and cytochrome P450s (one non-biomedical and two biomedical projects);
  4. Studies of the mechanistic basis for reproductive and developmental effects observed in wildlife (including those mediated by receptors such as AhR and ER) exposed to a complex mixture in surface water from a Superfund site via groundwater and sediment (one non-biomedical project);
  5. Mechanisms of oxidative dechlorination by an abiotic non-Heme iron catalyst for remediation of a wide variety of xenobiotics, including all those under study in other projects. The use of chlorinated ethylenes as a probe to study the oxidative mechanism of this biomimetic catalyst will also shed light on metabolism of these compounds by P450s (one non-biomedical project).
Back
to Top