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Project Publications: Boston University: A Novel Mechanism of Ortho-PCB-induced Toxicity: Targeting Nuclear Receptors in Brain of Fish

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Superfund Research Program

A Novel Mechanism of Ortho-PCB-induced Toxicity: Targeting Nuclear Receptors in Brain of Fish

Project Leader: John J. Stegeman (Woods Hole Oceanographic Institution)
Co-Investigators: Jared V. Goldstone (Woods Hole Oceanographic Institution), Neelakanteswar Aluru (Woods Hole Oceanographic Institution), Makoto Saito (Woods Hole Oceanographic Institution)
Grant Number: P42ES007381
Funding Period: 2017-2021

Project-Specific Links



  • Brun NR, Panlilio JM, Zhang K, Zhao Y, Ivashkin E, Stegeman JJ, Goldstone JV. 2021. Developmental exposure to non-dioxin-like polychlorinated biphenyls promotes sensory deficits and disrupts dopaminergic and GABAergic signaling in zebrafish. Commun Biol 4:doi:10.1038/s42003-021-02626-9 PMID:34561524 PMCID:PMC8463681
  • Brun NR, Salanga MC, Mora-Zamorano FX, Lamb DC, Goldstone JV, Stegeman JJ. 2021. Orphan cytochrome P450 20a1 CRISPR/Cas9 mutants and neurobehavioral phenotypes in zebrafish. Sci Rep 11:doi:10.1038/s41598-021-03068-3 PMID:34903767 PMCID:PMC8669017
  • Celander MC, Goldstone JV, Brun NR, Clark BW, Jayaraman S, Nacci DE, Stegeman JJ. 2021. Resistance to Cyp3a induction by polychlorinated biphenyls, including non-dioxin-like PCB153, in gills of killifish (Fundulus heteroclitus) from New Bedford Harbor. Environ Toxicol Pharmacol 83:103580. doi:10.1016/j.etap.2020.103580 PMID:33429071
  • Crespi E, Burnap R, Chen J, Das M, Gassman N, Rosa E, Simmons R, Wada H, Wang ZQ, Xiao J, Yang B, Yin J, Goldstone JV. 2021. Resolving the rules of robustness and resilience in biology across scales. Integr Comp Biol 61(6):doi:10.1093/icb/icab183 PMID:34427654 PMCID:PMC8825770
  • Eide M, Zhang X, Karlsen OA, Goldstone JV, Stegeman JJ, Jonassen I, Goksoyr A. 2021. The chemical defensome of five model teleost fish. Sci Rep doi:10.1038/s41598-021-89948-0 PMID:34006915 PMCID:PMC8131381



  • Eide M, Rydbeck H, Torresen OK, Lille-Langoy R, Puntervoll P, Goldstone JV, Jakobsen KS, Stegeman JJ, Goksoyr A, Karlsen OA. 2018. Independent losses of a xenobiotic receptor across teleost evolution. Sci Rep 8(1):10404. doi:10.1038/s41598-018-28498-4 PMID:29991818 PMCID:PMC6039460
  • Glazer L, Kido Soule MC, Longnecker K, Kujawinski EB, Aluru N. 2018. Hepatic metabolite profiling of polychlorinated biphenyl (PCB)-resistant and sensitive populations of Atlantic killifish (Fundulus heteroclitus). Aquat Toxicol 205:114-122. doi:10.1016/j.aquatox.2018.10.007 PMID:30368057 PMCID:PMC6246827
  • Lemaire B, Karchner SI, Goldstone JV, Lamb DC, Drazen JC, Rees F, Hahn ME, Stegeman JJ. 2018. Molecular adaptation to high pressure in cytochrome P450 1A and aryl hydrocarbon receptor systems of the deep-sea fish Coryphaenoides armatus. Biochim Biophys Acta 1866:155-165. doi:10.1016/j.bbapap.2017.06.026 PMID:28694077 PMCID:PMC5693637
  • Lille-Langoy R, Karlsen OA, Myklebust LM, Goldstone JV, Mork-Jansson A, Male R, Blumberg B, Stegeman JJ, Goksoyr A. 2018. Sequence variations in pxr (nr1i2) from zebrafish (Danio rerio) strains affect nuclear receptor function. Toxicol Sci 168:28-39. doi:10.1093/toxsci/kfy269 PMID:30371853 PMCID:PMC6390661
  • Ulin A, Henderson J, Pham MT, Meyo J, Chen Y, Karchner SI, Goldstone JV, Hahn ME, Williams LM. 2018. Developmental regulation of nuclear factor erythroid-2 related factors (nrfs) by AHR1b in zebrafish (Danio rerio). Toxicol Sci 167(2):536-545. doi:10.1093/toxsci/kfy257 PMID:30321412 PMCID:PMC6358246


  • Leung MC, Procter AC, Goldstone JV, Foox J, DeSalle R, Mattingly CJ, Siddall ME, Timme-Laragy AR. 2017. Applying evolutionary genetics to developmental toxicology and risk assessment. Reprod Toxicol 69:174-186. doi:10.1016/j.reprotox.2017.03.003 PMID:28267574
  • Sant KE, Hansen JM, Williams LM, Tran NL, Goldstone JV, Stegeman JJ, Hahn ME, Timme-Laragy AR. 2017. The role of Nrf1 and Nrf2 in the regulation of glutathione and redox dynamics in the developing zebrafish embryo. Redox Biol 13:207-218. doi:10.1016/j.redox.2017.05.023 PMID:28582729 PMCID:PMC5458767
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