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Project Publications: University of California-San Diego: Training Core: Environmental Science Training and Career Development Core

Superfund Research Program

Training Core: Environmental Science Training and Career Development Core

Project Leader: Pamela L. Mellon
Grant Number: P42ES010337
Funding Period: 2000-2023

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  • Ho EV, Shi C, Cassin J, He MY, Nguyen RD, Ryan GE, Tonsfeldt KJ, Mellon PL. 2021. Reproductive deficits induced by prenatal Antimullerian hormone exposure require androgen receptor in kisspeptin cells. Endocrinology 162:doi:10.1210/endocr/bqab197 PMID:34529765 PMCID:PMC8507963
  • Weber AA, Mennillo E, Yang X, van der Schoor LW, Jonker JW, Chen S, Tukey RH. 2021. Regulation of Intestinal UDP-Glucuronosyltransferase 1A1 by the Farnesoid X Receptor Agonist Obeticholic Acid Is Controlled by Constitutive Androstane Receptor through Intestinal Maturation. Drug Metab Dispos 49:12-19. doi:10.1124/dmd.120.000240 PMID:33154041 PMCID:PMC7745083


  • Dhar D, Baglieri J, Kisseleva T, Brenner DA. 2020. Mechanisms of liver fibrosis and its role in liver cancer. Exp Biol Med (Maywood) 13:doi:10.1177/1535370219898141 PMID:31924111 PMCID:PMC7016420
  • Hansmann E, Mennillo E, Yoda E, Verreault M, Barbier O, Chen S, Tukey RH. 2020. Differential role of LXRa and LXRy in the regulation of UDP-glucuronosyltransferase 1A1 in humanized UGT1 mice. Drug Metab Dispos 48:255-263. doi:10.1124/dmd.119.090068 PMID:31980500 PMCID:PMC7065491
  • Mennillo E, Yang X, Paszek M, Auwerx J, Benner CW, Chen S. 2020. NCoR1 protects mice from dextran sodium sulfate-induced colitis by guarding colonic crypt cells from luminal insult. Cell Mol Gastroenterol Hepatol 10:133-147. doi:10.1016/j.jcmgh.2020.01.014 PMID:32044398 PMCID:PMC7229481
  • Nicholas DA, Knight VS, Tonsfeldt KJ, Terasaka T, Molinar-Inglis O, Stephens SB, Trejo J, Kauffman AS, Mellon PL, Lawson MA. 2020. GLUT1-mediated glycolysis supports GnRH-induced secretion of luteinizing hormone from female gonadotropes. Sci Rep 10:13063. doi:10.1038/s41598-020-69913-z PMID:32747664 PMCID:PMC7400764
  • Todoric J, Di Caro G, Reibe S, Henstridge DC, Green CR, Vrbanac AF, Ceteci F, Conche C, McNulty R, Shalapour S, Taniguchi K, Meikle PJ, Watrous JD, Moranchel R, Najhawan M, Jain M, Liu X, Kisseleva T, Diaz-Meco MT, Moscat J, Knight R, Greten FR, Lau LF, Metallo CM, Febbraio MA, Karin M. 2020. Fructose stimulated de novo lipogenesis is promoted by inflammation. Nat Metab 2:1034-1045. doi:10.1038/s42255-020-0261-2 PMID:32839596 PMCID:PMC8018782
  • Xu J, Ma H, Liu X, Rosenthal SB, Baglieri J, Mccubbin R, Sun M, Koyama Y, Geoffroy C, Saijo K, Shang L, Nishio T, Maricic I, Kriefeldt M, Kusumanchi P, Roberts a, Zheng B, Kumar V, Zengler K, Pizzo D, Hosseini M, Contet C, Glass CK, Liangpunsakul S, Tsukamoto H, Gao B, Karin M, Brenner DA, Koob G, Kisseleva T. 2020. Blockade of IL-17 signaling reverses alcohol-induced liver injury and excessive alcohol drinking in mice. JCI Insight doi:10.1172/jci.insight.131277 PMID:32051339 PMCID:PMC7098802






  • Kauffman AS, Thackray VG, Ryan GE, Tolson KP, Glidewell-Kenney CA, Semaan SJ, Poling MC, Iwata N, Breen KM, Duleba AJ, Stener-Victorin E, Shimasaki S, Webster NJ, Mellon PL. 2015. A novel letrozole model recapitulates both the reproductive and metabolic phenotypes of polycystic ovary syndrome in female mice. Biol Reprod 93(3):69. doi:10.1095/biolreprod.115.131631 PMID:26203175 PMCID:PMC4710190


  • Mendoza-Cozatl DG, Xie Q, Akmakjian GZ, Jobe TO, Patel AU, Stacey MG, Song L, Demoin DW, Jurisson SS, Stacey G, Schroeder JI. 2014. OPT3 is a component of the iron-signaling network between leaves and roots and misregulation of OPT3 leads to an over-accumulation of cadmium in seeds. Mol Plant 7(9):1455-1469. doi:10.1093/mp/ssu067 PMID:24880337 PMCID:PMC4153440


  • Konopnicki CM, Dickmann LJ, Tracy JM, Tukey RH, Wienkers LC, Foti RS. 2013. Evaluation of UGT protein interactions in human hepatocytes: Effect of siRNA down regulation of UGT1A9 and UGT2B7 on propofol glucuronidation in human hepatocytes. Arch Biochem Biophys 535(2):143-149. doi:10.1016/ PMID:23562620 PMCID:PMC4059507
  • Witham EA, Meadows JD, Hoffmann HM, Shojaei S, Cross D, Kauffman AS, Mellon PL. 2013. Kisspeptin regulates gonadotropin genes via immediate early gene induction in pituitary gonadotropes. Mol Endocrinol 27(8):1283-1294. doi:10.1210/me.2012-1405 PMID:23770611 PMCID:PMC3725344
  • Xie H, Cherrington BD, Meadows JD, Whitham E, Mellon PL. 2013. Msx1 homeodomain protein represses the αGSU and GnRH receptor genes during Gonadotrope development. Mol Endocrinol 27(3):422-436. doi:10.1210/me.2012-1289 PMID:23371388 PMCID:PMC3589667



  • Anderson CR, Davis RE, Bandolin NS, Baptista AM, Tebo BM. 2011. Analysis of in situ manganese(II) oxidation in the Columbia River and offshore plume: linking Aurantimonas and the associated microbial community to an active biogeochemical cycle. Environ Microbiol 13(6):1561-1576. doi:10.1111/j.1462-2920.2011.02462.x PMID:21418498
  • Hatziapostolou M, Polytarchou C, Aggelidou E, Drakaki A, Poultsides GA, Jaeger SA, Ogata H, Karin M, Struhl K, Hadzopoulou-Cladaras M, Iliopoulos D. 2011. An HNF4alpha-miRNA inflammatory feedback circuit regulates hepatocellular oncogenesis. Cell 147(6):1233-1247. doi:10.1016/j.cell.2011.10.043 PMID:22153071 PMCID:PMC3251960
  • Holzer RG, Park E, Li N, Tran H, Chen M, Choi C, Solinas G, Karin M. 2011. Saturated fatty acids induce c-Src clustering within membrane subdomains, leading to JNK activation. Cell 147(1):173-184. doi:10.1016/j.cell.2011.08.034 PMID:21962514 PMCID:PMC3295636
  • Mendoza-Cozatl DG, Jobe TO, Hauser F, Schroeder JI. 2011. Long-distance transport, vacuolar sequestration, tolerance, and transcriptional responses induced by cadmium and arsenic. Curr Opin Plant Biol 14:554-562. doi:10.1016/j.pbi.2011.07.004 PMID:21820943 PMCID:PMC3191310
  • Miller MT, Mileni M, Comoletti D, Stevens RC, Harel M, Taylor PW. 2011. The crystal structure of the alpha-neurexin-1 extracellular region reveals a hinge point for mediating synaptic adhesion and function. Structure 19(6):767-778. doi:10.1016/j.str.2011.03.011 PMID:21620717 PMCID:PMC3279696



  • Akamine P, Madhusudan, Brunton LL, Ou HD, Canaves JM, Xuong N, Taylor SS. 2004. Balanol analogues probe specificity determinants and the conformational malleability of the cyclic 3',5'-adenosine monophosphate-dependent protein kinase catalytic subunit. Biochemistry 43(1):85-96. doi:10.1021/bi035042p PMID:14705934
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