Skip Navigation

Project Publications: Oregon Health and Science University: Biomarkers of Neurotoxicant Exposure and Neurodegeneration

Superfund Research Program

Biomarkers of Neurotoxicant Exposure and Neurodegeneration

Project Leaders: Mohammad I. Sabri, Peter S. Spencer
Grant Number: P42ES010338
Funding Period: 2000-2006

Project-Specific Links

Connect with the Grant Recipients

Visit the grantee's eNewsletter page

Publications

2013

2008

  • Dziennis S, Yang, D, Cheng J, Anderson KA, Alkayed NJ, Hurn PD, Lein PJ. 2008. Developmental exposure to polychlorinated biphenyls influences stroke outcome in adult rats. Environ Health Perspect 116(4):474-80. PMID:18414629

2005

  • Tshala-Katumbay DD, Palmer VS, Kayton RJ, Sabri MI, Spencer PS. 2005. A new murine model of giant proximal axonopathy. Acta Neuropathol 109(4):405-410. PMID:15759132

2004

  • Palmer VS, Tshala-Katumbay DD, Hashemi SB, Sabri MI, Spencer PS. 2004. Tetralin and metabolites: protein reactivity, chromogenicity and neurotoxicity. In: Proceedings of the 43rd Annual Meeting of the Society of Toxicology (SOT), March 21-25, 2004. Baltimore, MD.
  • Tshala-Katumbay DD, Palmer VS, Dixon DA, Deinzer ML, Sabri MI, Spencer PS. 2004. Structural requirements for hydrocarbon axonopathy. J Neurochem 90:19-19Suppl.1.
  • Zhan C, Spencer PS, Dixon DA. 2004. Chromogenic and neurotoxic effects of an aliphatic gamma-diketone: Computational insights into the molecular structures and mechanism. Journal of Physical Chemistry B 108(19):6098-6104.

2003

  • Dixon DA, Zhan C. 2003. High performance computing, computational chemistry, and toxicology. In: Proceedings of the 226th ACS (American Chemical Society) National Meeting - Fall 2003. New York, NY. pp.028-TOXIPart1.
  • Dixon DA, Zhan C, Spencer PS, Sabri MI, Kim M. 2003. Theoretical determination of chromophores to determine the chromogenic effects of neurotoxicants. In: Proceedings of the 226th ACS (American Chemical Society) National Meeting - Fall 2003. New York, NY.
  • Kim M, Lasarev MR, Hashemi SB, Nagalla SR, Sabri MI, Spencer PS. 2003. Gene modulation patterns associated with aromatic y-diketones neurotoxicity. Environ Health Perspect 67:740.
  • McCauley L, Rohlman DS, Rothlein J, Weston S, Tamulinas A, Muniz J, Lasarev MR, Scherer J. 2003. Orgnophosphate pesticide exposure: neurobehavioral assessment of Latino adults and children residing in agricultural communities. In: Proceedings of the Annual NIEHS SBRP (National Institute of Environmental Health Sciences and Superfund Basic Research Program) Conference: Integration Perspectives: Interdisciplinary Research and Outreach within the NIEHS SBRP, November 9-12. Dartmouth College, Hanover, NH.
  • Rohlman DS, Arcury TA, Quadri SA, Rothlein J, Traver RD, Early J, Phillips J, Marin A, Zavala A, Weston S, Tamulinas A, Scherer J, McCauley L. 2003. Neurobehavioral performance in preschool children from agricultural and non-agricultural communities in Oregon and North Carolina. In: Proceedings of the 21st International Neurotoxicology Conference: Infant and Child Neurotoxicity Studies: Subltle and Long-term Effects. Honolulu, HI.
  • Sabri MI, Hashemi SB, Spencer PS. 2003. Neurotoxicity and reactivity of 1,2-diacetylbenzene (1,2-DAB) with motor and cytoskeletal proteins in rat spinal cord and sciatic nerves. Toxicol Lett 144(Suppl.1):s130.
  • Tshala-Katumbay DD, Palmer VS, Kayton RJ, Sabri MI, Spencer PS. 2003. Demonstration of murine neurotoxic responses to 1,2-diacetylbenzene preparatory to toxicogenomic characterization. Environ Health Perspect 67:357.
  • Zhan C, Spencer PS, Dixon DA. 2003. Computational insights into the chemical structures and mechanisms of the chromogenic and neurotoxic effects of aromatic gamma-diketones. Journal of Physical Chemistry B 107(12):2853-2861.

2002

  • Kim M, Spencer PS, Sabri MI. 2002. Amino acid and protein targets of 1,2-diacetylbenzene, a potent aromatic gamma-diketone that induces proximal neurofilamentous axonopathy. Toxicol Appl Pharmacol 183(1):55-65. PMID:12217642
  • Kim M, Taylor MJ, Sabri MI, Spencer PS. 2002. In vivo reactivity of the axonal toxin 1,2-diacetylbenzene with neurofilament and microtubule proteins. Environ Health Perspect 66:15.
  • Sabri MI, Hashemi SB, Kim M, Spencer PS. 2002. Aromatic hydrocarbon 1,2-diacetylbenzene cross-links neurofilaments and other proteins. J Neurochem 81:103.
  • Sabri MI, Spencer PS. 2002. How does acrylamide perturb axon transport and induce nerve fiber degeneration? Commentary on forum position paper. Neurotoxicology 23(2):259-63;discussion265-70. PMID:12224766
  • Spencer PS, Kim M, Sabri MI. 2002. Aromatic as well as aliphatic hydrocarbon solvent axonopathy. Int J Hyg Environ Health 205(1-2):131-136. PMID:12018006
  • Zhan C, Dixon DA. 2002. Electronic excitations in pyrrole: A test case for determination of chromophores in the chromogenic effects of neurotoxic hydrocarbons by time-dependent density functional theory and single-excitation configuration interaction methods. Journal of Molecular Spectroscopy 216(1):81-89.
  • Zhan C, Dixon DA, Spencer PS, Kim M, Sabri MI. 2002. Theoretical determination of chromophores in the chromogenic effects of aromatic neurotoxicants. J Am Chem Soc 124(11):2744-2752. PMID:11890826

2001

  • Kim M, Sabri MI, Miller VH, Kayton RJ, Dixon DA, Spencer PS. 2001. 1,2-diacetylbenzene, the neurotoxic metabolite of a chromogenic aromatic solvent, induces proximal axonopathy. Toxicol Appl Pharmacol 177(2):121-131. PMID:11740911
  • Kim M, Spencer PS. 2001. Protein reactivity of the neurotoxic metabolite (1,2-DAB) of the aromatic hydrocarbon solvent 1,2-diethylbenzene. Environ Health Perspect 60(1):366.

2000

  • Sabri MI, Kim M, Spencer PS. 2000. The aromatic hydrocarbon 1,2-diacetylbenzene induces pathological changes in the rodent nervous system. Toxicol Lett 116(1):72.
Back
to Top