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Project Publications: Duke University: Cholinergic and Monoaminergic Mechanisms of Persistent Neurobehavioral Toxicity

Superfund Research Program

Cholinergic and Monoaminergic Mechanisms of Persistent Neurobehavioral Toxicity

Project Leader: Edward D. Levin
Co-Investigators: Theodore A. Slotkin (Duke University Medical Center), Frederic J. Seidler
Grant Number: P42ES010356
Funding Period: 2017-2022
View this project in the NIH Research Portfolio Online Reporting Tools (RePORT)

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Publications

2020

  • Brenner RG, Oliveri A, Sinnott-Armstrong W, Levin ED. 2020. Effects of sub-chronic methylphenidate on risk-taking and sociability in zebrafish (Danio rerio). Naunyn Schmiedebergs Arch Pharmacol
  • Brenner RG, Oliveri A, Sinnott-Armstrong W, Levin ED. 2020. Effects of sub-chronic methylphenidate on risk-taking and sociability in zebrafish (Danio rerio). Naunyn Schmiedebergs Arch Pharmacol doi:10.1007/s00210-020-01835-z PMID:32025747
  • Hawkey AB, Pippen E, White H, Kim J, Greengrove E, Kenou B, Holloway Z, Levin ED. 2020. Gestational and perinatal exposure to diazinon causes long-lasting neurobehavioral consequences in the Rat. Toxicology 429:doi:10.1016/j.tox.2019.152327 PMID:31704166 PMCID:PMC6925319

2019

  • Hawkey AB, Junaid S, Yao L, Spiera Z, White H, Cauley M, Levin ED. 2019. Gestational exposure to nicotine and/or benzo[a]pyrene causes long-lasting neurobehavioral consequences. Birth Defects Res 111(17):1248-1258. doi:10.1002/bdr2.1568 PMID:31368242 PMCID:PMC6983916
  • Levin ED. 2019. What can fish tell us about developmental neurotoxic risks of the sea?. Neurotoxicol Teratol 73:76-94.
  • Levin ED, Pippen E, White H, Kim J, Kenou B, Hawkey AB, Holloway Z. 2019. Chronic steady low-dose prenatal diazinon exposure of rats causes locomotor hyperactivity, increased risk-taking behavior and cognitive impairment. Neurotoxicol Teratol 73:83.
  • Oliveri A, Levin ED. 2019. Dopamine D1 and D2 receptor antagonism during development alters later behavior in zebrafish. Behav Brain Res 356:250-256. doi:10.1016/j.bbr.2018.08.028 PMID:30172631 PMCID:PMC6192051
  • Slotkin TA, Skavicus S, Ko A, Levin ED, Seidler FJ. 2019. Perinatal diazinon exposure compromises the development of acetylcholine and serotonin systems. Toxicology 424:10. doi:10.1016/j.tox.2019.152240 PMID:31251962 PMCID:PMC6689134
  • Slotkin TA, Skavicus S, Ko A, Levin ED, Seidler FJ. 2019. The developmental neurotoxicity of tobacco smoke can be mimicked by a combination of nicotine and benzo[a]pyrene: effects on cholinergic and serotonergic systems. Toxicol Sci 168:280. doi:10.1093/toxsci/kfy304 PMID:30247698 PMCID:PMC6681680

2018

  • Glazer L, Hawkey AB, Wells C, Drastal M, Odamah K, Behl M, Levin ED. 2018. Developmental exposure to low concentrations of organophosphate flame retardants causes life-long behavioral alterations in zebrafish. Toxicol Sci 165(2):487-498. doi:10.1093/toxsci/kfy173 PMID:29982741 PMCID:PMC6154272
  • Massarsky A, Abdel A, Glazer L, Levin ED, Di Giulio RT. 2018. Neurobehavioral effects of 1,2-propanediol in zebrafish (Danio rerio). Neurotoxicology 65:111-124. doi:10.1016/j.neuro.2018.02.007 PMID:29432853
  • Oliveri A, Ortiz E, Levin ED. 2018. Developmental exposure to an organophosphate flame retardant alters later behavioral responses to dopamine antagonism in zebrafish larvae. Neurotoxicol Teratol 67:25-30. doi:10.1016/j.ntt.2018.03.002 PMID:29559250 PMCID:PMC5970957
  • Pitt JA, Trevisan R, Massarsky A, Kozal JS, Levin ED, Di Giulio RT. 2018. Maternal transfer of nanoplastics to offspring in zebrafish (Danio rerio): A case study with nanopolystyrene. Sci Total Environ 643:324-334. doi:10.1016/j.scitotenv.2018.06.186 PMID:29940444
  • Slotkin TA, Skavicus S, Seidler FJ. 2018. Developmental neurotoxicity resulting from pharmacotherapy of preterm labor, modeled In Vitro: Terbutaline and dexamethasone, separately and together. Toxicology 30033-30037. doi:10.1016/j.tox.2018.03.001 PMID:29524569 PMCID:PMC5903951

2017

  • Glazer L, Wells C, Drastal M, Odamah K, Galat RE, Behl M, Levin ED. 2017. Developmental exposure to low concentrations of two brominated flame retardants, BDE-47 and BDE-99, causes life-long behavioral alterations in zebrafish. Neurotoxicology doi:10.1016/j.neuro.2017.09.007 PMID:28935585 PMCID:PMC5858967 (in press)
  • Slotkin TA, Skavicus S, Card JA, Di Giulio RT, Seidler FJ. 2017. In vitro models reveal differences in the developmental neurotoxicity of an environmental polycylic aromatic hydrocarbon mixture compared to benzo[a]pyrene: Neuronotypic PC12 Cells and embryonic neural stem cells. Toxicology 377:49-56. doi:10.1016/j.tox.2016.12.008 PMID:28049045 PMCID:PMC5250555
  • Slotkin TA, Skavicus S, Seidler FJ. 2017. Diazinon and parathion diverge in their effects on development of noradrenergic systems. Brain Res Bull 130:268-273. doi:10.1016/j.brainresbull.2017.02.004 PMID:28235599
  • Slotkin TA, Skavicus S, Stapleton HM, Seidler FJ. 2017. Brominated and organophosphate flame retardants target different neurodevelopmental stages, characterized with embryonic neural stem cells and neuronotypic PC12 cells. Toxicology 390:32-42. doi:10.1016/j.tox.2017.08.009 PMID:28851516 PMCID:PMC5633518

2016

  • Abreu-Villaca Y, Levin ED. 2016. Developmental neurobehavioral neurotoxicity of insecticides. In: Handbook of Development Neurotoxicology. Academic Press, San Diego, CA. pp.453-466.
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