Superfund Research Program
Combustion-Generated EPFRs: Assessing Cardiovascular Risks of Exposure
Project Leader: Tammy R. Dugas
Co-Investigators: Kurt J. Varner, Huijing Xia (LSU Health Sciences Center - New Orleans)
Grant Number: P42ES013648
Funding Period: 2011-2025
Project-Specific Links
Publications
2024
- Aryal A, Harmon AC, Varner K, Noël A, Cormier SA, Nde D, Mottram P, Maxie J, Dugas TR. 2024. Inhalation of particulate matter containing environmentally persistent free radicals induces endothelial dysfunction mediated via AhR activation at the air-blood interface. Toxicol Sci doi:10.1093/toxsci/kfae007 PMID:38310335
2023
- Aryal A, Noel A, Khachatryan L, Cormier SA, Chowdhury PH, Penn A, Dugas TR, Harmon AC. 2023. Environmentally persistent free radicals: Methods for combustion generation, whole-body inhalation and assessing cardiopulmonary consequences. Environ Pollut 334:122183. doi:10.1016/j.envpol.2023.122183 PMID:37442324
- Noël A, Harmon AC, Subramanian B, Perveen Z, Aryal A, Legendre K, Zaman H, Paulsen DB, Varner KJ, Dugas TR, Penn A. 2023. Adjuvant effect of inhaled particulate matter containing free radicals following house-dust mite induction of asthma in mice. Inhal Toxicol 35:333-349. doi:10.1080/08958378.2023.2289024 PMID:38060410 PMCID:10903547
2021
- Aryal A, Harmon AC, Dugas TR. 2021. Particulate matter air pollutants and cardiovascular disease: Strategies for intervention. Pharmacol Ther 223:107890. doi:10.1016/j.pharmthera.2021.107890 PMID:33992684 PMCID:PMC8216045
- Harmon AC, Noel A, Subramanian B, Perveen Z, Jennings MH, Chen Y, Penn A, Legendre K, Paulsen DB, Varner KJ, Dugas TR. 2021. Inhalation of particulate matter containing free radicals leads to decreased vascular responsiveness associated with an altered pulmonary function. Am J Physiol Heart Circ Physiol 321(4):H667-H683. doi:10.1152/ajpheart.00725.2020 PMID:34415187
2020
- Dugas TR, Varner KJ. 2020. Cardiovascular Toxicology. Chapter 15 in: An Introduction to Interdisciplinary Toxicology: From Molecules to Man. Elsevier,
2017
- Chuang GC, Xia H, Mahne S, Varner KJ. 2017. Environmentally persistent free radicals cause apoptosis in HL-1 cardiomyocytes. Cardiovasc Toxicol 17(2):140-149. doi:10.1007/s12012-016-9367-x PMID:27052339 PMCID:PMC5053829
2015
- Burn B, Varner KJ. 2015. Environmentally persistent free radicals compromise left ventricular function during ischemia/reperfusion injury. Am J Physiol Heart Circ Physiol 308(9):H998-H1006. doi:10.1152/ajpheart.00891.2014 PMID:25681431 PMCID:PMC4551132
2014
- Burn B, Varner KJ. 2014. Radical-containing ultrafine particulate matter exacerbates cardiac functional decline induced by ischemia-reperfusion injury. Society of Toxicology
- Chuang GC, Varner KJ. 2014. Radical-containing ultrafine particulate matter suppresses cardiomyocyte NRF-2 signaling. Society of Toxicology
2013
- Kelley MA, Hebert VY, Thibeaux TM, Orchard MA, Hasan F, Cormier SA, Thevenot PT, Lomnicki S, Varner KJ, Dellinger B, Latimer BM, Dugas TR. 2013. Model combustion-generated particulate matter containing persistent free radicals redox cycle to produce reactive oxygen species. Chem Res Toxicol 26(12):1862-1871. doi:10.1021/tx400227s PMID:24224526 PMCID:PMC4112599
2012
- Mahne S, Chuang GC, Pankey E, Kiruri LW, Kadowitz PJ, Dellinger B, Varner KJ. 2012. Environmentally persistent free radicals decrease cardiac function and increase pulmonary artery pressure. Am J Physiol Heart Circ Physiol 303:H1135-H1142. doi:10.1152/ajpheart.00545.2012 PMID:22942180 PMCID:PMC3517644