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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Project Publications: Louisiana State University: Combustion-Generated EPFRs: Assessing Cardiovascular Risks of Exposure

Superfund Research Program

Combustion-Generated EPFRs: Assessing Cardiovascular Risks of Exposure

Project Leader: Tammy R. Dugas
Co-Investigators: Kurt J. Varner, Huijing Xia (LSU Health Sciences Center - New Orleans)
Grant Number: P42ES013648
Funding Period: 2011-2025
View this project in the NIH Research Portfolio Online Reporting Tools (RePORT)

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Publications

2024

  • Aryal A, Harmon AC, Varner K, Noël A, Cormier SA, Nde D, Mottram P, Maxie J, Dugas TR. 2024. Inhalation of particulate matter containing environmentally persistent free radicals induces endothelial dysfunction mediated via AhR activation at the air-blood interface. Toxicol Sci doi:10.1093/toxsci/kfae007 PMID:38310335

2023

  • Aryal A, Noel A, Khachatryan L, Cormier SA, Chowdhury PH, Penn A, Dugas TR, Harmon AC. 2023. Environmentally persistent free radicals: Methods for combustion generation, whole-body inhalation and assessing cardiopulmonary consequences. Environ Pollut 334:122183. doi:10.1016/j.envpol.2023.122183 PMID:37442324
  • Noël A, Harmon AC, Subramanian B, Perveen Z, Aryal A, Legendre K, Zaman H, Paulsen DB, Varner KJ, Dugas TR, Penn A. 2023. Adjuvant effect of inhaled particulate matter containing free radicals following house-dust mite induction of asthma in mice. Inhal Toxicol 35:333-349. doi:10.1080/08958378.2023.2289024 PMID:38060410 PMCID:10903547

2021

  • Aryal A, Harmon AC, Dugas TR. 2021. Particulate matter air pollutants and cardiovascular disease: Strategies for intervention. Pharmacol Ther 223:107890. doi:10.1016/j.pharmthera.2021.107890 PMID:33992684 PMCID:PMC8216045
  • Harmon AC, Noel A, Subramanian B, Perveen Z, Jennings MH, Chen Y, Penn A, Legendre K, Paulsen DB, Varner KJ, Dugas TR. 2021. Inhalation of particulate matter containing free radicals leads to decreased vascular responsiveness associated with an altered pulmonary function. Am J Physiol Heart Circ Physiol 321(4):H667-H683. doi:10.1152/ajpheart.00725.2020 PMID:34415187

2020

2017

2015

2014

  • Burn B, Varner KJ. 2014. Radical-containing ultrafine particulate matter exacerbates cardiac functional decline induced by ischemia-reperfusion injury. Society of Toxicology
  • Chuang GC, Varner KJ. 2014. Radical-containing ultrafine particulate matter suppresses cardiomyocyte NRF-2 signaling. Society of Toxicology

2013

  • Kelley MA, Hebert VY, Thibeaux TM, Orchard MA, Hasan F, Cormier SA, Thevenot PT, Lomnicki S, Varner KJ, Dellinger B, Latimer BM, Dugas TR. 2013. Model combustion-generated particulate matter containing persistent free radicals redox cycle to produce reactive oxygen species. Chem Res Toxicol 26(12):1862-1871. doi:10.1021/tx400227s PMID:24224526 PMCID:PMC4112599

2012

  • Mahne S, Chuang GC, Pankey E, Kiruri LW, Kadowitz PJ, Dellinger B, Varner KJ. 2012. Environmentally persistent free radicals decrease cardiac function and increase pulmonary artery pressure. Am J Physiol Heart Circ Physiol 303:H1135-H1142. doi:10.1152/ajpheart.00545.2012 PMID:22942180 PMCID:PMC3517644
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