Superfund Research Program

Environmentally Persistent Free Radicals Alter Pulmonary Immunologic Homeostasis

Project Leader: Stephania A. Cormier
Co-Investigators: Wayne L. Backes (LSU Health Sciences Center - New Orleans), James R. Reed (LSU Health Sciences Center - New Orleans), Peter D. Sly (University of Queensland)
Grant Number: P42ES013648
Funding Period: 2020-2025

Project-Specific Links

Publications

2023

• Aryal A, Noel A, Khachatryan L, Cormier SA, Chowdhury PH, Penn A, Dugas TR, Harmon AC. 2023. Environmentally persistent free radicals: Methods for combustion generation, whole-body inhalation and assessing cardiopulmonary consequences. Environ Pollut 334:122183. doi:10.1016/j.envpol.2023.122183 PMID:37442324
• Connick J, Reed JR, Cawley GF, Saha A, Backes WL. 2023. Functional characterization of CYP1 enzymes: Complex formation, membrane localization and function. J Inorg Biochem 247:112325. doi:10.1016/j.jinorgbio.2023.112325 PMID:37479567
• Reed JR, Guidry JJ, Eyer M, Backes WL. 2023. The influence of lipid microdomain heterogeneity on protein-protein interactions: Proteomic analysis of co-immunoprecipitated binding partners of P450 1A2 and P450 3A in rate liver microsomes. Drug Metab Dispos 51(9):1196-1206. doi:10.1124/dmd.123.001287 PMID:37349115 PMCID:PMC10449098
• Yamamoto A, Sly PD, Chew KY, Khachatryan L, Begum N, Yeo AJ, Vu LD, Short KR, Cormier SA, Fantino E. 2023. Environmentally persistent free radicals enhance SARS-CoV-2 replication in respiratory epithelium. Exp Biol Med (Maywood) doi:10.1177/15353702221142616 PMID:36628928 PMCID:PMC9836833
• Yu Q, Cao W, Hamer D, Urbanek N, Straif-Bourgeois S, Cormier SA, Ferguson T, Richmond-Bryant J. 2023. Associations of COVID-19 hospitalizations, ICU admissions, and mortality with Black and White race by air pollution and other risk factors in the Louisiana Industrial Corridor, March, 2020 - August, 2021. J Racial Ethn Health Disparities 20(5):4611. doi:10.3390/ijerph20054611 PMID:36901619 PMCID:PMC10001987

2022

• Cormier SA, Yamamoto A, Short KR, Vu LD, Suk WA. 2022. Environmental impacts of COVID-19: mechanisms of increased susceptibility. Ann Glob Health 88(1):94. doi:10.5334/aogh.3907 PMID:36348703 PMCID:PMC9585976
• Khachatryan L, Barekati-Goudarzi M, Asatryan R, Ozarowski A, Boldor D, Lomnicki S, Cormier SA. 2022. Metal-free Biomass-Derived Environmentally Persistent Free Radicals (Bio-EPFRs) from lignin pyrolysis. ACS Omega 7(34):30241-30249. doi:10.1021/acsomega.2c03381 PMID:36061701 PMCID:PMC9434622
• Noel A, Ashbrook DG, Xu F, Cormier SA, Lu L, O'Callaghan JP, Menon SK, Zhao W, Penn A, Jones BC. 2022. Genomic basis for individual differences in susceptibility to the neurotoxic effects of diesel exhaust. Int J Mol Sci 23(20):12461. doi:10.3390/ijms232012461 PMID:36293318 PMCID:PMC9603950
• Yamamoto A, Sly PD, Begum N, Yeo AJ, Fantino E. 2022. Resveratrol and astaxanthin protect primary human nasal epithelial cells cultured at an air-liquid interface from an acute oxidant exposure. J Cell Signal 3(4):207-217. doi:10.33696/signaling.3.084 PMID:36777035 PMCID:PMC9910318
• Yamamoto A, Sly PD, Henningham A, Begum N, Yeo AJ, Fantino E. 2022. Redox homeostasis in well-differentiated primary human nasal epithelial cells. J Cell Signal 3(4):193-206. doi:10.33696/signaling.3.083 PMID:36777036 PMCID:PMC9912202

2021

• Guan X, Truong L, Lomnicki S, Tanguay RL, Cormier SA. 2021. Developmental hazard of environmentally persistent free radicals and protective effect of TEMPOL in zebrafish model. Toxics 9:doi:10.3390/toxics9010012 PMID:33467068 PMCID:PMC7829864
• Harding JN, Gross M, Potter S, Patel V, Cormier SA. 2021. Association between particulate matter containing EPFRs and neutrophilic asthma through AhR and Th17. Respir Res 22(275):doi:10.1186/s12931-021-01867-w PMID:34702270 PMCID:PMC8549224
• Kumar A, Patel VS, Harding JN, You D, Cormier SA. 2021. Exposure to combustion derived particulate matter exacerbates influenza infection in neonatal mice by inhibiting IL22 production. Part Fibre Toxicol 18(1):43. doi:10.1186/s12989-021-00438-7 PMID:34906172 PMCID:PMC8670221
• Liu J, Li S, Fei X, Nan X, Shen Y, Xiu H, Cormier SA, Lu C, Guo C, Wang S, Cai Z, Wang P. 2021. Increased alveolar epithelial TRAF6 via autophagy-dependent TRIM37 degradation mediates particulate matter-induced lung metastasis. Autophagy doi:10.1080/15548627.2021.1965421 PMID:34524943
• Oyana T, Minso J, Jones TL, McCullers JA, Arnold SR, Cormier SA. 2021. Particulate matter exposure predicts residence in high-risk areas for community acquired pneumonia among hospitalized children. Exp Biol Med (Maywood) 246(17):1907-1916. doi:10.1177/15353702211014456 PMID:34053235 PMCID:PMC8424632
• Saha A, Connick J, Reed JR, Lott CS, Backes WL. 2021. Identification of the contact region responsible for the formation of the homomeric CYP1A2-CYP1A2 complex. Biochem J 478(11):2163-2178. doi:10.1042/BCJ20210269 PMID:34032264 PMCID:PMC8522333
• Sly PD, Trottier BA, Bulka C, Cormier SA, Fobil J, Fry RC, Kim K, Kleeberger SR, Kumar P, Landrigan PJ, Lodrop Carlsen KC, Pascale A, Polack FP, Ruchirawat K, Zar H, Suk WA. 2021. The interplay between environmental exposures and COVID-19 risks in the health of children. Environ Health 20(1):34. doi:10.1186/s12940-021-00716-z PMID:33771185 PMCID:PMC7996114
• Violi A, Cormier SA, Gullett BK, Jansson S, Lomnicki S, Luyet C, Mayer A, Zimmermann R. 2021. Combustion by-products and their health effects: Summary of the 16th international congress. Fuel 283:118562. doi:10.1016/j.fuel.2020.118562 PMID:33446939 PMCID:PMC7802799
• Yamamoto A, Yeo AJ, Sly PD, Cormier SA, Lomnicki S, Khachatryan L, Fantino E. 2021. The effect of combustion generated environmentally persistent free radicals on well-differentiated human airway epithelial cells. Am J Respir Crit Care Med 203:doi:10.1164/ajrccm-conference.2021.203.1

2020

• Flanagan TW, Billac GB, Landry AN, Sebastian MN, Cormier SA, Nichols CD. 2020. Structure-activity relationship analysis of psychedelics in a rat model of asthma reveals the anti-inflammatory pharmacophore. ACS Pharmacol Transl Sci 4(2):488-502. doi:10.1021/acsptsci.0c00063 PMID:33860179 PMCID:PMC8033619
• Harding JN, Siefker DT, Vu LD, You D, DeVincenzo JP, Pierre JF, Cormier SA. 2020. Altered gut microbiota in infants is associated with respiratory syncytial virus disease severity. BMC Microbiol 20(1):140. doi:10.1186/s12866-020-01816-5 PMID:32487019 PMCID:PMC7268675
• Siefker DT, Vu LD, You D, McBride A, Taylor R, Jones TL, DeVincenzo JP, Cormier SA. 2020. Respiratory syncytial virus disease severity is associated with distinct CD8 + T-Cell profiles. Am J Respir Crit Care Med 201(3):325-334. doi:10.1164/rccm.201903-0588OC PMID:31644878 PMCID:PMC6999109
• Willis KA, Pierre JF, Cormier SA, Talati AJ. 2020. Mice without a microbiome are partially protected from lung injury by hyperoxia. Am J Physiol Lung Cell Mol Physiol 318:L419-L420. doi:10.1152/ajplung.00433.2019 PMID:31664852 PMCID:PMC7052673
• Willis KA, Siefker DT, Aziz MM, White CT, Mussarat N, Gomes CK, Bajwa A, Pierre JF, Cormier SA, Talati AJ. 2020. Perinatal maternal antibiotic exposure augments lung injury in offspring in experimental bronchopulmonary dysplasia. Am J Physiol Lung Cell Mol Physiol 318:L407-L418. doi:10.1152/ajplung.00561.2018 PMID:31644311 PMCID:PMC7132329

2019

• Sly PD, Trottier BA, Carpenter DO, Cha'on U, Cormier SA, Galluzzo B, Ghosh S, Goldizen FC, Heacock M, Jagals P, Joshi H, Kathuria P, Ha L, Magsumbol MS, Navasumrit P, Prabhakaran P, Sen B, Skelly C, Suraweera I, Vong S, Wangdi C, Suk WA. 2019. Children's environmental health in South and Southeast Asia: Networking for better child health outcomes. Ann Glob Health 85:doi:10.5334/aogh.2403 PMID:30873796 PMCID:PMC6571144
• Vu LD, Siefker D, Jones TL, You D, Taylor R, DeVincenzo JP, Cormier SA. 2019. Elevated Levels of Type 2 Respiratory Innate Lymphoid Cells in Human Infants with Severe Respiratory Syncytial Virus Bronchiolitis. Am J Respir Crit Care Med 1414-1423. doi:10.1164/rccm.201812-2366OC PMID:31237777 PMCID:PMC6884055