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Project Publications: Brown University: Adverse Human Health Impacts of Nanomaterials

Superfund Research Program

Adverse Human Health Impacts of Nanomaterials

Project Leader: Agnes B. Kane
Grant Number: P42ES013660
Funding Period: 2009-2021

Project-Specific Links



  • Shukla V, Stone A, McGrath M, Kane AB, Hurt RH. 2022. Chemical degradation kinetics for two-dimensional materials in natural and biological environments - a data-driven review. Environ Sci Nano 23:doi:10.1039/d1en01171e




  • Kabadi PK, Rodd AL, Simmons AE, Messier N, Hurt RH, Kane AB. 2019. A novel human 3D lung microtissue model for nanoparticle-induced cell-matrix alterations. Part Fibre Toxicol 16(1):15. doi:10.1186/s12989-019-0298-0 PMID:30943996 PMCID:PMC6448215
  • Kane AB. 2019. Inflammation. Chapter 17 in: Tumour Site Concordance and Mechanisms of Carcinogenesis. IARC Publications, pp.165-174.


  • Gray EP, Browning CL, Wang M, Gion K, Chao EY, Koski K, Kane AB, Hurt RH. 2018. Biodissolution and cellular response to MoO3 nanoribbons and a new framework for early hazard screening for 2D materials. Environ Sci Nano 5(11):2545-2559. doi:10.1039/C8EN00362A
  • Kane AB, Hurt RH, Gao H. 2018. The asbestos-carbon nanotube analogy: An update. Toxicol Appl Pharmacol 361:68-80. doi:10.1016/j.taap.2018.06.027 PMID:29960000 PMCID:PMC6298811
  • Rodd AL, Castilho CJ, Chaparro CE, Rangel-Mendez JR, Hurt RH, Kane AB. 2018. Impact of emerging, high-production-volume graphene-based materials on the bioavailability of benzo(a)pyrene to brine shrimp and fish liver cells. Environ Sci Nano 5(9):2144-2161. doi:10.1039/C8EN00352A
  • Rodd AL, Kane AB. 2018. Fish liver microtissues for aquatic toxicology: integrating morphological and molecular responses for in vitro assessment of environmental pollutants. Abstr Pap Am Chem Soc 255:1.
  • Sears C, Braun JM, Ryan P, Xu Y, Werner E, Lanphear BP, Wellenius GA. 2018. The association of traffic-related air and noise pollution with maternal blood pressure and hypertensive disorders of pregnancy in the HOME study cohort. Environ Int 121:574-581. doi:10.1016/j.envint.2018.09.049 PMID:30300815


  • Kuempel E, Jaurand MC, Moller P, Morimoto Y, Kobayashi N, Pinkerton KE, Sargent LM, Vermeulen R, Fubini B, Kane AB. 2017. Evaluating the mechanistic evidence and key data gaps in assessing the potential carcinogenicity of carbon nanotubes and nanofibers in humans. Crit Rev Toxicol 47(1):1-58. doi:10.1080/10408444.2016.1206061 PMID:27537422
  • Rodd AL, Messier N, Vaslet CA, Kane AB. 2017. A 3D fish liver model for aquatic toxicology: Morphological changes and Cyp1a induction in PLHC-1 microtissues after repeated benzo(a)pyrene exposures. Aquat Toxicol 186:134-144. doi:10.1016/j.aquatox.2017.02.018 PMID:28282620 PMCID:PMC5436724


  • Holden PA, Gardea-Torresdey JL, Klaessig F, Turco RF, Mortimer M, Hund-Rinke K, Cohen Hubal EA, Avery D, Barcelo D, Behra R, Cohen Y, Deydier-Stephan L, Ferguson PL, Fernandes TF, Herr Harthorn B, Henderson WM, Hoke RA, Hristozov D, Johnston JM, Kane AB, Kapustka L, Keller AA, Lenihan HS, Lovell W, Murphy CJ, Nisbet RM, Petersen EJ, Salinas ER, Scheringer M, Sharma M, Speed DE, Sultan Y, Westerhoff P, White JC, Wiesner MR, Wong E, Xing B, Steele Horan M, Godwin H, Nel AE. 2016. Considerations of environmentally relevant test conditions for improved evaluation of ecological hazards of engineered nanomaterials. Environ Sci Technol 50(12):6124-6145. doi:10.1021/acs.est.6b00608 PMID:27177237 PMCID:PMC4967154
  • Wang Z, von dem Bussche A, Qiu Y, Valentine TM, Gion K, Kane AB, Hurt RH. 2016. Chemical dissolution pathways of MoS2 nanosheets in biological and environmental media. Environ Sci Technol 50(13):7208-7217. doi:10.1021/acs.est.6b01881 PMID:27267956 PMCID:PMC5217159
  • Wang Z, Zhu W, Qiu Y, Yi X, von dem Bussche A, Kane AB, Gao H, Koski K, Hurt RH. 2016. Biological and environmental interactions of emerging two-dimensional nanomaterials. Chem Soc Rev 45(6):1750-1780. doi:10.1039/c5cs00914f PMID:26923057 PMCID:PMC4820079
  • Zhu WP, von dem Bussche A, Yi X, Qiu Y, Wang Z, Weston P, Hurt RH, Kane AB, Gao H. 2016. Nanomechanical mechanism for lipid bilayer damage induced by carbon nanotubes confined in intracellular vesicles. Proc Natl Acad Sci U S A 113(44):12374-12379. doi:10.1073/pnas.1605030113 PMID:27791073 PMCID:PMC5098676


  • Godwin H, Brown SS, Holden PA, Kane AB, Bergeson L, Bernard D, Beryt E, Boyes W, Clippinger A, Cohen Y, Doa M, Hendren C, Houck K, Klaessig F, Kodas T, Landsiedel R, Lynch I, Malloy T, Miller MB, Muller J, Petersen EJ, Pleus RC, Sayre P, Stone V, Sullivan KM, Tentschert J, Wallis P, Nel AE, Oberdorster G, Nameth C, Avery D. 2015. Nanomaterial categorization for assessing risk potential to facilitate regulatory decision-making. ACS Nano 9(4):3409-3417. doi:10.1021/acsnano.5b00941 PMID:25791861
  • Kabadi PK, Vantangoli MM, Rodd AL, Kane AB, Boekelheide K, Leary E, Madnick SJ, Morgan J. 2015. Into the depths: Techniques for in vitro three-dimensional microtissue visualization. Biotechniques 59(5):279-286. doi:10.2144/000114353 PMID:26554505 PMCID:PMC4804457


  • Qiu Y, Wang Z, Owens AC, Kulaots I, Chen Y, Kane AB, Hurt RH. 2014. Antioxidant chemistry of graphene-based materials and its role in oxidation protection technology. Nanoscale 6(20):11744-11755. doi:10.1039/c4nr03275f PMID:25157875 PMCID:PMC4312421
  • Rodd AL, Creighton M, Vaslet CA, Rangel-Mendez JR, Hurt RH, Kane AB. 2014. Effects of surface-engineered nanoparticle-based dispersants for marine oil spills on the model organism Artemia franciscana. Environ Sci Technol 48(11):6419-6427. doi:10.1021/es500892m PMID:24823274 PMCID:PMC4046867




  • Lau BW, Kane AB. 2010. SDF1/CXCL12 is involved in recruitment of stem-like progenitor cells to orthotopic murine malignant mesothelioma spheroids. Anticancer Res 30(6):2153-2160. PMID:20651364 PMCID:PMC3641861


  • Sanchez V, Pietruska JR, Miselis NR, Hurt RH, Kane AB. 2009. Biopersistence and potential adverse health impacts of fibrous nanomaterials: what have we learned from asbestos?. Wiley Interdiscip Rev Nanomed Nanobiotechnol 1(5):511-529. doi:10.1002/wnan.41 PMID:20049814 PMCID:PMC2864601


  • Oberdorster G, Kane AB, Klaper RD, Hurt RH. 2007. Nanotoxicology. Chapter 28 in: Casarett & Doull's Toxicology: The Basic Science of Poisons. AK.
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