Superfund Research Program

PCBs and Cytosolic Phenol and Steroid Sulfotransferases

Project Leader: Michael W. Duffel
Grant Number: P42ES013661
Funding Period: 2006-2020

Project-Specific Links

Publications

2019

• Li X, Wu X, Kelly KM, Veng-Pedersen P, Lehmler H. 2019. Toxicokinetics of chiral PCB 136 and its hydroxylated metabolites in mice with a liver-specific deletion of cytochrome P450 reductase. Chem Res Toxicol 32:727-736. doi:10.1021/acs.chemrestox.8b00389 PMID:30729780 PMCID:PMC6465157
• Sethi S, Morgan RK, Feng W, Lin Y, Li X, Luna C, Koch M, Bansal R, Duffel MW, Puschner B, Zoeller RT, Lehmler H, Pessah IN, Lein PJ. 2019. Comparative analyses of the 12 most abundant PCB congeners detected in human maternal serum for activity at the thyroid hormone receptor and ryanodine receptor. Environ Sci Technol 53:3948-3958. doi:10.1021/acs.est.9b00535 PMID:30821444 PMCID:PMC6457253
• Uwimana E, Cagle B, Yeung C, Li X, Patterson EV, Doorn JA, Lehmler H. 2019. Atropselective oxidation of 2,2 ,3,3 ,4,6 -hexachlorobiphenyl (PCB 132) to hydroxylated metabolites by human liver microsomes and its implications for pcb 132 neurotoxicity. Toxicology 171:406-420. doi:10.1093/toxsci/kfz150 PMID:31268529 PMCID:PMC6760323
• Uwimana E, Ruiz P, Li X, Lehmler H. 2019. Human CYP2A6, CYP2B6, and CYP2E1 atropselectively metabolize polychlorinated biphenyls to hydroxylated metabolites. Environ Sci Technol 53(4):2114-2123. doi:10.1021/acs.est.8b05250 PMID:30576102 PMCID:PMC6380921

2018

• Alam S, Carter GS, Krager KJ, Li X, Lehmler H, Aykin-Burns N. 2018. PCB11 metabolite, 3,3-dichlorobiphenyl-4-ol, exposure alters the expression of genes governing fatty acid metabolism in the absence of functional sirtuin 3: examining the contribution of MnSOD. Antioxidants (Basel) 7(9):121. doi:10.3390/antiox7090121 PMID:30223548
• Cheng SL, Li X, Lehmler H, Phillips B, Shen D, Cui JY. 2018. Gut microbiota modulates interactions between polychlorinated biphenyls and bile acid homeostasis. Toxicol Sci 166:269-287. doi:10.1093/toxsci/kfy208 PMID:30496569 PMCID:PMC6260149
• Dhakal K, Gadupudi GS, Lehmler H, Ludewig G, Duffel MW, Robertson LW. 2018. Sources and toxicities of phenolic polychlorinated biphenyls (OH-PCBs). Environ Sci Pollut Res Int 25:16277-16290. doi:10.1007/s11356-017-9694-x PMID:28744683 PMCID:PMC5785587
• Li X, Holland EB, Feng W, Zheng J, Dong Y, Pessah IN, Duffel MW, Robertson LW, Lehmler H. 2018. Authentication of synthetic environmental contaminants and their (bio)transformation products in toxicology: polychlorinated biphenyls as an example. Environ Sci Pollut Res Int 25(17):1-14. doi:10.1007/s11356-017-1162-0 PMID:29322390 PMCID:PMC6015536
• Li X, Parkin S, Lehmler H. 2018. Absolute configuration of 2,2',3,3',6-pentachlorinatedbiphenyl (PCB 84) atropisomers. Environ Sci Pollut Res Int 25:16402-16410. doi:10.1007/s11356-017-9259-z PMID:28537024 PMCID:PMC5823790
• Parker VS, Squirewell EJ, Lehmler H, Robertson LW, Duffel MW. 2018. Hydroxylated and sulfated metabolites of commonly occurring airborne polychlorinated biphenyls inhibit human steroid sulfotransferases SULT1E1 and SULT2A1. Environ Toxicol Pharmacol 58:196-201. doi:10.1016/j.etap.2018.01.010 PMID:29408762 PMCID:PMC6078096
• Pencikova K, Svrzkova L, Strapacova S, Neca J, Bartonkova I, Dvorak Z, Hyzdalova M, Pivnicka J, Palkova L, Lehmler H, Li X, Vondracek J, Machala M. 2018. In vitro profiling of toxic effects of prominent environmental lower-chlorinated PCB congeners linked with endocrine disruption and tumor promotion. Environ Pollut 237:473-486. doi:10.1016/j.envpol.2018.02.067 PMID:29518658 PMCID:PMC5908724
• Rodriguez EA, Vanle BC, Doorn JA, Lehmler H, Robertson LW, Duffel MW. 2018. Hydroxylated and sulfated metabolites of commonly observed airborne polychlorinated biphenyls display selective uptake and toxicity in N27, SH-SY5Y, and HepG2 cells. Environ Toxicol Pharmacol 62:69-78. doi:10.1016/j.etap.2018.06.010 PMID:29986280 PMCID:PMC609219
• Uwimana E, Li X, Lehmler H. 2018. Human liver microsomes atropselectively metabolize 2,2 ',3,4 ',6-pentachlorobiphenyl (PCB 91) to a 1,2-shift product as the major metabolite. Environ Sci Technol 52:6000-6008. doi:10.1021/acs.est.8b00612 PMID:29659268 PMCID:PMC5966832

2017

• Grimm FA, Lehmler H, Koh W, DeWall J, Teesch LM, Hornbuckle KC, Thorne PS, Robertson LW, Duffel MW. 2017. Identification of a sulfate metabolite of PCB 11 in human serum. Environ Int 98:120-128. doi:10.1016/j.envint.2016.10.023 PMID:27816204 PMCID:PMC5127762
• Klinefelter K, Hoover MK, Bates C, Colter BT, Dailey A, Infante SK, Kania-Korwel I, Lehmler H, Lopez-Juarez A, Ludwig CP, Curran CP. 2017. Genetic differences in the aryl hydrocarbon receptor and CYP1A2 affect sensitivity to developmental polychlorinated biphenyl exposure in mice: relevance to studies of human neurological disorders. Mamm Genome 1-16. doi:10.1007/s00335-017-9728-1 PMID:29197979
• . 2017. Atropisomers of 2,2',3,3',6,6'-hexachlorobiphenyl (PCB 136) exhibit stereoselective effects on activation of nuclear receptors in vitro. Environ Sci Pollut Res Int 25(17):1-9. doi:10.1007/s11356-017-0683-x PMID:29124635 PMCID:PMC5943194

2016

• Ekuase EJ, van't Erve TJ, Rahaman A, Robertson LW, Duffel MW, Luthe G. 2016. Mechanistic insights into the specificity of human cytosolic sulfotransferase 2A1 (hSULT2A1) for hydroxylated polychlorinated biphenyls through the use of fluoro-tagged probes. Environ Sci Pollut Res Int 23(3):2119-2127. doi:10.1007/s11356-015-4886-8 PMID:26165989 PMCID:PMC4713379
• Kania-Korwel I, Lehmler H. 2016. Chiral polychlorinated biphenyls: absorption, metabolism and excretion--a review. Environ Sci Pollut Res Int 23(3):2042-2057. doi:10.1007/s11356-015-4150-2 PMID:25651810 PMCID:PMC4527964
• Rodriguez EA, Li X, Lehmler H, Robertson LW, Duffel MW. 2016. Sulfation of lower chlorinated polychlorinated biphenyls increases their affinity for the major drug-binding sites of human serum albumin. Environ Sci Technol 50(10):5320-5327. doi:10.1021/acs.est.6b00484 PMID:27116425 PMCID:PMC4883002

2015

• Grimm FA, He X, Teesch LM, Lehmler H, Robertson LW, Duffel MW. 2015. Tissue distribution, metabolism, and excretion of 3,3'-dichloro-4'-sulfooxy-biphenyl in the rat. Environ Sci Technol 49(13):8087-8095. doi:10.1021/acs.est.5b01499 PMID:26046945 PMCID:PMC4496304
• Grimm FA, Hu D, Kania-Korwel I, Lehmler H, Ludewig G, Hornbuckle KC, Duffel MW, Bergman A, Robertson LW. 2015. Metabolism and metabolites of polychlorinated biphenyls. Crit Rev Toxicol 45(3):245-272. doi:10.3109/10408444.2014.999365 PMID:25629923 PMCID:PMC4383295
• Grimm FA, Lehmler H, He X, Robertson LW, Duffel MW. 2015. Modulating inhibitors of transthyretin fibrillogenesis via sulfation: polychlorinated biphenyl sulfates as models. Chem Biol Interact 228:1-8. doi:10.1016/j.cbi.2015.01.002 PMID:25595224 PMCID:PMC4327905
• Kania-Korwel I, Barnhart CD, Lein PJ, Lehmler H. 2015. Effect of pregnancy on the disposition of 2,2',3,5',6-pentachlorobiphenyl (PCB 95) atropisomers and their hydroxylated metabolites in female mice. Chem Res Toxicol 28(9):1774-1783. doi:10.1021/acs.chemrestox.5b00241 PMID:26271003 PMCID:PMC4579038
• Wu X, Barnhart CD, Lein PJ, Lehmler H. 2015. Hepatic metabolism affects the atropselective disposition of 2,2',3,3',6,6'-hexachlorobiphenyl (PCB 136) in mice. Environ Sci Technol 49(1):616-625. doi:10.1021/es504766p PMID:25420130 PMCID:PMC4291784

2014

• Ekuase EJ, Lehmler H, Robertson LW, Duffel MW. 2014. Binding interactions of hydroxylated polychlorinated biphenyls (OHPCBs) with human hydroxysteroid sulfotransferase hSULT2A1. Chem Biol Interact 212:56-64. doi:10.1016/j.cbi.2014.01.018 PMID:24508592 PMCID:PMC3994546
• Sueyoshi T, Li L, Wang H, Moore R, Kodavanti PS, Lehmler H, Negishi M, Birnbaum LS. 2014. Flame retardant BDE-47 effectively activates nuclear receptor CAR in human primary hepatocytes. Toxicol Sci 137(2):292-302. doi:10.1093/toxsci/kft243 PMID:24218150 PMCID:PMC3908718
• Wu X, Kammerer A, Lehmler H. 2014. Microsomal oxidation of 2,2',3,3',6,6'-hexachlorobiphenyl (PCB 136) results in species-dependent chiral signatures of the hydroxylated metabolites. Environ Sci Technol 48(4):2436-2444. doi:10.1021/es405433t PMID:24467194 PMCID:PMC3983324
• Yang DR, Kania-Korwel I, Ghogha A, Chen H, Stamou M, Bose DD, Pessah IN, Lehmler H, Lein PJ. 2014. PCB 136 atropselectively alters morphometric and functional parameters of neuronal connectivity in cultured rat hippocampal neurons via ryanodine receptor-dependent mechanisms. Toxicol Sci 138(2):379-392. doi:10.1093/toxsci/kft334 PMID:24385416 PMCID:PMC4007107

2013

• Dhakal K, Adamcakova-Dodd A, Lehmler H, Thorne PS, Robertson LW. 2013. Sulfate conjugates are urinary markers of inhalation exposure to 4-chlorobiphenyl (PCB3). Chem Res Toxicol 26(6):853-855. doi:10.1021/tx4001539 PMID:23713983 PMCID:PMC3703249
• Grimm FA, Lehmler H, He X, Robertson LW, Duffel MW. 2013. Sulfated metabolites of polychlorinated biphenyls are high-affinity ligands for the thyroid hormone transport protein transthyretin. Environ Health Perspect 121(6):657-662. doi:10.1289/ehp.1206198 PMID:23584369 PMCID:PMC3672920
• Hu X, Lehmler H, Adamcakova-Dodd A, Thorne PS. 2013. Elimination of inhaled 3,3'-dichlorobiphenyl and the formation of the 4-hydroxylated metabolite. Environ Sci Technol 47(9):4743-4751. doi:10.1021/es3049114 PMID:23582014 PMCID:PMC3962796
• Kania-Korwel I, Lehmler H. 2013. Assigning atropisomer elution orders using atopisomerically enriched polychlorinated biphenyl fractions generated by microsomal metabolism. J Chromatogr A 1278:133-144. doi:10.1016/j.chroma.2012.12.041 PMID:23347976 PMCID:PMC3581436
• Kania-Korwel I, Lehmler H. 2013. Chlordane and heptachlor are metabolized enantioselectively by rat liver microsomes. Environ Sci Technol 47(15):8913–8922. doi:10.1021/es401916a PMID:23799267 PMCID:PMC3748599
• Lehmler H, He X, Duffel MW, Parkin S. 2013. 3,4',5-Trichloro-biphenyl-4-yl 2,2,2-trichloro-ethyl sulfate. Acta Crystallogr B 69(Pt4):o620. doi:10.1107/S1600536813007976 PMID:23634142 PMCID:PMC3629655
• Lehmler H, He X, Li X, Duffel MW, Parkin S. 2013. Effective synthesis of sulfate metabolites of chlorinated phenols. Chemosphere 93(9):1965-1971. doi:10.1016/j.chemosphere.2013.06.087 PMID:23906814 PMCID:PMC3815985
• Lehmler H, Wu H, Parkin S. 2013. 2,2',5',6-Tetra-chloro-4-[(1S)-1-methyl-prop-oxy]biphen-yl. Acta Crystallogr B 69:o983. doi:10.1107/S1600536813014098 PMID:23795135 PMCID:PMC3685116
• Lehmler H, Wu H, Parkin S. 2013. 5,5'-Dichloro-2,2'-dimeth-oxy-biphen-yl. Acta Crystallogr B 69:o650. doi:10.1107/S160053681300826X PMID:23723814 PMCID:PMC3647848
• Lu Z, Kania-Korwel I, Lehmler H, Wong CS. 2013. Stereoselective formation of mono- and dihydroxylated polychlorinated biphenyls by rat cytochrome P450 2B1. Environ Sci Technol doi:10.1021/es402838f PMID:24060104 PMCID:PMC3870094
• Niknam Y, Feng W, Cherednichenko G, Dong Y, Joshi SN, Vyas SM, Lehmler H, Pessah IN. 2013. Structure-activity relationship of selected meta- and para-hydroxylated non-dioxin like polychlorinated biphenyls: from single RyR1 channels to muscle dysfunction. Toxicol Sci 136(2):500-513. doi:10.1093/toxsci/kft202 PMID:24014653 PMCID:PMC3858193
• Qin X, Lehmler H, Teesch LM, Robertson LW, Duffel MW. 2013. Chlorinated biphenyl quinones and phenyl- 2,5-benzoquinone differentially modify the catalytic activity of human hydroxysteroid sulfotransferase hSULT2A1. Chem Res Toxicol 26(10):1474-1485. doi:10.1021/tx400207q PMID:24059442 PMCID:PMC3846294
• Qin X, Teesch LM, Duffel MW. 2013. Modification of the catalytic function of human hydroxysteroid sulfotransferase hSULT2A1 by formation of disulfide bonds. Drug Metab Dispos 41(5):1094-1103. doi:10.1124/dmd.112.050534 PMID:23444386 PMCID:PMC3629806
• Rignall B, Grote K, Gavrilov A, Weimer M, Kopp-Schneider A, Krause E, Appel KE, Buchmann A, Robertson LW, Lehmler H, Kania-Korwel I, Chahoud I, Schwarz M. 2013. Biological and tumor-promoting effects of dioxin-like and non-dioxin-like polychlorinated biphenyls in mouse liver after single or combined treatment. Toxicol Sci 133(1):29-41. doi:10.1093/toxsci/kft034 PMID:23457121 PMCID:PMC3627557
• Wu X, Duffel MW, Lehmler H. 2013. Oxidation of polychlorinated biphenyls by liver tissue slices from phenobarbital-pretreated mice is congener-specific and atropselective. Chem Res Toxicol 26(11):16421651. doi:10.1021/tx400229e PMID:24107130 PMCID:PMC3857157
• Wu X, Kania-Korwel I, Chen H, Stamou M, Dammanahalli KJ, Duffel MW, Lein PJ, Lehmler H. 2013. Metabolism of 2,2',3,3',6,6'-hexachlorobiphenyl (PCB 136) atropisomers in tissue slices from phenobarbital or dexamethasone-induced rats is sex-dependent. Xenobiotica 43(11):933-947. doi:10.3109/00498254.2013.785626 PMID:23581876 PMCID:PMC3878182
• Yucuis RA, Stanier CO, Hornbuckle KC. 2013. Cyclic siloxanes in air, including identification of high levels in Chicago and distinct diurnal variation. Chemosphere 92(8):905-910. doi:10.1016/j.chemosphere.2013.02.051 PMID:23541357 PMCID:PMC3975597

2012

• Ambati J, Song Y, Rankin S, Lehmler H. 2012. Density functional theory study of semiquinone radical anions of polychlorinated biphenyls in the syn- and anti-like conformation. J Phys Chem A 116:1586-1595. doi:10.1021/jp2077193 PMID:22257259 PMCID:PMC3417754
• Dhakal K, He X, Lehmler H, Teesch LM, Duffel MW, Robertson LW. 2012. Identification of sulfated metabolites of 4-chlorobiphenyl (PCB3) in the serum and urine of male rats. Chem Res Toxicol 25(12):2796-2804. doi:10.1021/tx300416v PMID:23137097 PMCID:PMC3524396
• Kania-Korwel I, Barnhart CD, Stamou M, Truong KM, El-Komy MH, Lein PJ, Veng-Pedersen P, Lehmler H. 2012. 2,2',3,5',6-Pentachlorobiphenyl (PCB 95) and its hydroxylated metabolites are enantiomerically enriched in female mice. Environ Sci Technol 46(20):11393-11401. doi:10.1021/es302810t PMID:22974126 PMCID:PMC3475189
• Oldham E, Xie W, Farnoud AM, Fiegel J, Lehmler H. 2012. Disruption of phosphatidylcholine mono layers and bilayers by perfluorobutane sulfonate. Journal of Physical Chemistry B 116:9999-10007. doi:10.1021/jp304412p PMID:22834732 PMCID:PMC3464004

2011

• Bunaciu RP, Tharappel JC, Lehmler H, Lee EY, Robertson LW, Bruckner GG, Spear BT, Glauert HP. 2011. Role of oil vehicle on hepatic cell proliferation in PCB-treated rats. J Environ Pathol Toxicol Oncol 30(4):273-282. PMID:22181977 PMCID:PMC3522147
• Ekuase EJ, Liu Y, Lehmler H, Robertson LW, Duffel MW. 2011. Structure-activity relationships for hydroxylated polychlorinated biphenyls as inhibitors of the sulfation of dehydroepiandrosterone catalyzed by human hydroxysteroid sulfotransferase SULT2A1. Chem Res Toxicol 24:1720-1728. doi:10.1021/tx200260h PMID:21913674 PMCID:PMC3196794
• Gulcan HO, Duffel MW. 2011. Substrate inhibition in human hydroxysteroid sulfotransferase SULT2A1: studies on the formation of catalytically non-productive enzyme complexes. Arch Biochem Biophys 507:232-240. doi:10.1016/j.abb.2010.12.027 PMID:21187059 PMCID:PMC3058861
• Joshi SN, Vyas SM, Duffel MW, Parkin S, Lehmler H. 2011. Synthesis of sterically hindered polychlorinated biphenyl derivatives. Synthesis 7:1045-1054. doi:10.1055/s-0030-1258454 PMID:21516177 PMCID:PMC3080045
• Joshi SN, Vyas SM, Wu H, Duffel MW, Parkin S, Lehmler H. 2011. Regioselective iodination of chlorinated aromatic compounds using silver salts. Tetrahedron 67(39):7461-7469. doi:10.1016/j.tet.2011.07.064 PMID:21918585 PMCID:PMC3170769
• Kania-Korwel I, Duffel MW, Lehmler H. 2011. Gas chromatographic analysis with chiral cyclodextrin phases reveals the enantioselective formation of hydroxylated polychlorinated biphenyls by rat liver microsomes. Environ Sci Technol 45:9590-9596. doi:10.1021/es2014727 PMID:21966948 PMCID:PMC3216237
• Liu Y, Lehmler H, Robertson LW, Duffel MW. 2011. Physicochemical properties of hydroxylated polychlorinated biphenyls aid in predicting their interactions with rat sulfotransferase 1A1 (rSULT1A1). Chem Biol Interact 189:153-160. doi:10.1016/j.cbi.2010.11.009 PMID:21130751 PMCID:PMC3032042
• Senthilkumar PK, Klingelhutz AJ, Jacobus JA, Lehmler H, Robertson LW, Ludewig G. 2011. Airborne polychlorinated biphenyls (PCBs) reduce telomerase activity and shorten telomere length in immortal human skin keratinocytes (HaCat). Toxicol Lett 204:64-70. doi:10.1016/j.toxlet.2011.04.012 PMID:21530622 PMCID:PMC3109099
• Song Y, Ambati J, Parkin S, Rankin S, Robertson LW, Lehmler H. 2011. Crystal structure and density functional theory studies of toxic quinone metabolites of polychlorinated biphenyls. Chemosphere 85:386-392. doi:10.1016/j.chemosphere.2011.07.004 PMID:21824639 PMCID:PMC3206982
• Wu X, Pramanik A, Duffel MW, Hrycay EG, Bandiera SM, Lehmler H, Kania-Korwel I. 2011. 2,2',3,3',6,6'-Hexachlorobiphenyl (PCB 136) is enantioselectively oxidized to hydroxylated metabolites by rat liver microsomes. Chem Res Toxicol 24(12):2249-2257. doi:10.1021/tx200360m PMID:22026639 PMCID:PMC3243785

2010

• Hu X, Adamcakova-Dodd A, Lehmler H, Hu D, Kania-Korwel I, Hornbuckle KC, Thorne PS. 2010. Time course of congener uptake and elimination in rats after short-term inhalation exposure to an airborne polychlorinated biphenyl (PCB) mixture. Environ Sci Technol 44(17):6893-6900. doi:10.1021/es101274b PMID:20698547 PMCID:PMC3408216
• Li X, Parkin S, Duffel MW, Robertson LW, Lehmler H. 2010. 3',4'-Dichlorobiphenyl-4-yl 2,2,2- trichloroethyl sulfate. Acta Crystallogr B E66:o1615-o1616. doi:10.1107/S1600536810020362 PMID:21587847 PMCID:PMC3006693
• Li X, Parkin S, Duffel MW, Robertson LW, Lehmler H. 2010. 4 '-Chlorobiphenyl-3-yl 2,2,2-trichloroethyl sulfate. Acta Crystallogr B 66:O2306-U305. doi:10.1107/s1600536810031338 PMID:25681997 PMCID:PMC3008081
• Li X, Parkin S, Duffel MW, Robertson LW, Lehmler H. 2010. An efficient approach to sulfate metabolites of polychlorinated biphenyls. Environ Int 36:843-848. doi:10.1016/j.envint.2009.02.005 PMID:19345419 PMCID:PMC2939219
• Li X, Parkin S, Duffel MW, Robertson LW, Lehmler H. 2010. Biphenyl-4-yl 2,2,2-trichloroethyl sulfate. Acta Crystallogr B E66:o1073. doi:10.1107/S1600536810012845 PMID:21579128 PMCID:PMC2979148
• Wangpradit O, Moman E, Nolan K, Buettner GR, Robertson LW, Luthe G. 2010. Observation of an unusual electronically distorted semiquinone radical of PCB metabolites in the active site of prostaglandin H synthase-2. Chemosphere 81:1501-1508. doi:10.1016/j.chemosphere.2010.08.041 PMID:20843536 PMCID:PMC3622869
• Zhai G, Lehmler H, Schnoor JL. 2010. Identification of hydroxylated metabolites of 3,3 ',4,4 '-tetrachlorobiphenyl and metabolic pathway in whole poplar plants. Chemosphere 81:523-528. doi:10.1016/j.chemosphere.2010.07.036 PMID:20708213 PMCID:PMC2943055

2008

• Glauert HP, Tharappel JC, Banerjee S, Chan NL, Kania-Korwel I, Lehmler H, Lee EY, Robertson LW, Spear BT. 2008. Inhibition of the promotion of hepatocarcinogenesis by 2,2',4,4',5,5'-hexachlorobiphenyl (PCB-153) by the deletion of the p50 subunit of NF-kappa B in mice. Toxicol Appl Pharmacol 232(2):302-308. doi:10.1016/j.taap.2008.06.013 PMID:18644402 PMCID:PMC2583134
• Glauert HP, Tharappel JC, Lu Z, Stemm DN, Banerjee S, Chan L, Lee EY, Lehmler H, Robertson LW, Spear BT. 2008. Role of oxidative stress in the promoting activities of pcbs. Environ Toxicol Pharmacol 25(2):247-250. doi:10.1016/j.etap.2007.10.025 PMID:19122744 PMCID:PMC2836878
• Gulcan HO, Duffel MW. 2008. Pentachlorophenol and other chlorinated phenols are substrates for human hydroxysteroid sulfotransferase hSULT2A1. Chem Res Toxicol 21(8):1503-1508. doi:10.1021/tx800133d PMID:18656962 PMCID:PMC2548291
• Jacobus JA, Flor S, Klingelhutz AJ, Robertson LW, Ludewig G. 2008. 2-(4'-Chlorophenyl)-1,4-benxoquinone increases the frequency of micronuclei and shortens telomeres. Environ Toxicol Pharmacol 25(2):267-272. doi:10.1016/j.etap.2007.10.022 PMID:18438462 PMCID:PMC2346440
• Kania-Korwel I, Hornbuckle KC, Robertson LW, Lehmler H. 2008. Dose-dependent enantiomeric enrichment of 2,2',3,3',6,6'-hexachlorobiphenyl in female mice. Environ Toxicol Chem 27(2):299-305. doi:10.1897/07-359R.1 PMID:18348647
• Kania-Korwel I, Hornbuckle KC, Robertson LW, Lehmler H. 2008. Influence of dietary fat on the enantioselective disposition of 2,2',3,3',6,6'-hexachlorobiphenyl (PCB 136) in female mice. Food Chem Toxicol 46(2):637-644. doi:10.1016/j.fct.2007.09.072 PMID:17950514 PMCID:PMC2289907
• Klosener J, Swenson DC, Robertson LW, Luthe G. 2008. Effects of fluoro substitution on 4-bromodiphenyl ether (PBDE 3). Acta Crystallogr B 64(Pt1):108-119. doi:10.1107/S0108768107067079 PMID:18204217 PMCID:PMC3120100
• Ludewig G, Lehmann L, Esch HL, Robertson LW. 2008. Metabolic activation of PCBs to carcinogens in vivo - a review. Environ Toxicol Pharmacol 25(2):241-246. doi:10.1016/j.etap.2007.10.029 PMID:18452002 PMCID:PMC2364599
• Luthe G, Jacobus JA, Robertson LW. 2008. Receptor interactions by polybrominated diphenyl ethers versus polychlorinated biphenyls: a theoretical Structure-activity assessment. Environ Toxicol Pharmacol 25(2):202-210. doi:10.1016/j.etap.2007.10.017 PMID:19768137 PMCID:PMC2746664
• Sacco JC, Lehmler H, Robertson LW, Li W, James MO. 2008. Glucuronidation of polychlorinated biphenylols and UDP-glucuronic acid concentrations in channel catfish liver and intestine. Drug Metab Dispos 36(4):623-630. doi:10.1124/dmd.107.019596 PMID:18180271

2007

• Luthe G, Swenson DC, Robertson LW. 2007. Influence of fluoro-substitution on the planarity of 4-chlorobiphenyl (PCB 3). Acta Crystallogr B 63:319-327. PMID:17374943
• Sadeghi-aliabadi H, Chan K, Lehmler H, Robertson LW, O-Brian PJ. 2007. Molecular cytotoxic mechanisms of catecholic polychlorinated biphenyl metabolites in isolated rat hepatocytes. Chem Biol Interact 167:184-192. PMID:17408604
• Zettner M, Flor S, Ludewig G, Wagner J, Robertson LW, Lehmann L. 2007. Quinoid metabolites of 4-monochlorobiphenyl (PCB3) induce gene mutations in cultured Chinese hamster V79 Cells. Toxicol Sci 100:88-98. PMID:17686921

1997

• Duffel MW. 1997. Sulfotransferases. Chapter 18 in: Comprehensive Toxicology, 3rd Edition. Vol. 10. Elsevier, NY. pp.407-428.