Superfund Research Program

Assessment of Toxicity and Risk of Inhaled Environmental PCB Mixtures

Project Leader: Peter S. Thorne
Grant Number: P42ES013661
Funding Period: 2015-2020

Project-Specific Links

Publications

2020

• Wang H, Adamcakova-Dodd A, Flor S, Gosse L, Klenov V, Stolwijk J, Lehmler H, Hornbuckle KC, Ludewig G, Thorne PS. 2020. Comprehensive subchronic inhalation toxicity assessment of an indoor school air mixture of PCBs. Environ Sci Technol 54:15976-15985. doi:10.1021/acs.est.0c04470 PMID:33256405 PMCID:PMC7879961
• Wu X, Zhai G, Schnoor JL, Lehmler H. 2020. Atropselective disposition of 2,2 ,3,4 ,6-Pentachlorobiphenyl (PCB 91) and identification of its metabolites in mice with liver-specific deletion of Cytochrome P450 Reductase. Chem Res Toxicol 33:1328-1338. doi:10.1021/acs.chemrestox.9b00255 PMID:31403789 PMCID:PMC7042073

2017

• Grimm FA, Lehmler H, Koh W, DeWall J, Teesch LM, Hornbuckle KC, Thorne PS, Robertson LW, Duffel MW. 2017. Identification of a sulfate metabolite of PCB 11 in human serum. Environ Int 98:120-128. doi:10.1016/j.envint.2016.10.023 PMID:27816204 PMCID:PMC5127762
• Schon P, Ctistis G, Bakker W, Luthe G. 2017. Nanoparticular surface-bound PCBs, PCDDs, and PCDFs-a novel class of potentially higher toxic POPs. Environ Sci Pollut Res Int 24(14):12758-12766. doi:10.1007/s11356-016-6211-6 PMID:26939687

2015

• Ampleman MD, Martinez A, DeWall J, Rawn DF, Hornbuckle KC, Thorne PS. 2015. Inhalation and dietary exposure to PCBs in urban and rural cohorts via congener-specific measurements. Environ Sci Technol 49(2):1156-1164. doi:10.1021/es5048039 PMID:25510359 PMCID:PMC4303332
• Hu X, Adamcakova-Dodd A, Lehmler H, Gibson-Corley KN, Thorne PS. 2015. Toxicity evaluation of exposure to an atmospheric mixture of polychlorinated biphenyls by nose-only and whole-body inhalation regimens. Environ Sci Technol 49(19):11875-11883. doi:10.1021/acs.est.5b02865 PMID:26348937 PMCID:PMC4711378

2014

• Hu X, Adamcakova-Dodd A, Thorne PS. 2014. The fate of inhaled (14)C-labeled PCB11 and its metabolites in vivo. Environ Int 63:92-100. doi:10.1016/j.envint.2013.10.017 PMID:24275706 PMCID:PMC3950335
• Marek RF, Thorne PS, DeWall J, Hornbuckle KC. 2014. Variability in PCB and OH-PCB serum levels in children and their mothers in urban and rural US communities. Environ Sci Technol 48(22):13459-13467. doi:10.1021/es502490w PMID:25300024 PMCID:PMC4238695

2013

• Dhakal K, Adamcakova-Dodd A, Lehmler H, Thorne PS, Robertson LW. 2013. Sulfate conjugates are urinary markers of inhalation exposure to 4-chlorobiphenyl (PCB3). Chem Res Toxicol 26(6):853-855. doi:10.1021/tx4001539 PMID:23713983 PMCID:PMC3703249
• Hu X, Lehmler H, Adamcakova-Dodd A, Thorne PS. 2013. Elimination of inhaled 3,3'-dichlorobiphenyl and the formation of the 4-hydroxylated metabolite. Environ Sci Technol 47(9):4743-4751. doi:10.1021/es3049114 PMID:23582014 PMCID:PMC3962796

2012

• Hu X, Adamcakova-Dodd A, Lehmler H, Hu D, Hornbuckle KC, Thorne PS. 2012. Subchronic inhalation exposure study of an airborne polychlorinated biphenyl mixture resembling the Chicago ambient air congener profile. Environ Sci Technol 46(17):9653-9662. doi:10.1021/es301129h PMID:22846166 PMCID:PMC3573703

2010

• Hu X, Adamcakova-Dodd A, Lehmler H, Hu D, Kania-Korwel I, Hornbuckle KC, Thorne PS. 2010. Time course of congener uptake and elimination in rats after short-term inhalation exposure to an airborne polychlorinated biphenyl (PCB) mixture. Environ Sci Technol 44(17):6893-6900. doi:10.1021/es101274b PMID:20698547 PMCID:PMC3408216