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Project Publications: Northeastern University: Toxicant-Stimulated Disruption of Gestational Tissues with Implications for Adverse Pregnancy Outcomes

Superfund Research Program

Toxicant-Stimulated Disruption of Gestational Tissues with Implications for Adverse Pregnancy Outcomes

Project Leader: Sean Harris (University of Michigan)
Co-Investigators: Kelly M. Bakulski (University of Michigan), April Z. Gu (Cornell University), Chuanwu Xi (University of Michigan)
Grant Number: P42ES017198
Funding Period: 2010-2025
View this project in the NIH Research Portfolio Online Reporting Tools (RePORT)

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Publications

2024

  • Harris SM, Su AL, Dou JF, Loch-Caruso R, Elkin ER, Jaber S, Bakulski KM. 2024. Placental cell conditioned media modifies hematopoietic stem cell transcriptome in vitro. Placenta 145:117-125. doi:10.1016/j.placenta.2023.12.016 PMID:38128222
  • Park H, Harris SM, Boldenow E, Aronoff DM, Rea M, Xi C, Loch-Caruso R. 2024. The antioxidant N-acetyl cysteine inhibits cytokine and prostaglandin release in human fetal membranes stimulated ex vivo with lipoteichoic acid or live group B streptococcus. Am J Reprod Immunol 91(1):e13807. doi:10.1111/aji.13807 PMID:38282602 PMCID:10832889

2023

  • Campbell KA, Colacino JA, Puttabyatappa M, Dou JF, Elkin ER, Hammoud SS, Domino SE, Dolinoy DC, Goodrich JM, Loch-Caruso R, Padmanabhan V, Bakulski KM. 2023. Placental cell type deconvolution reveals that cell proportions drive preeclampsia gene expression differences. Commun Biol 6(1):264. doi:10.1038/s42003-023-04623-6 PMID:36914823 PMCID:PMC1001142
  • Elkin ER, Campbell KA, Lapehn S, Harris SM, Padmanabhan V, Bakulski KM, Paquette AG. 2023. Placental single cell transcriptomics: Opportunities for endocrine disrupting chemical toxicology. Mol Cell Endocrinol 578:112066. doi:10.1016/j.mce.2023.112066 PMID:37690473 PMCID:PMC10591899
  • Elkin ER, Su AL, Dou JF, Colacino JA, Bridges D, Padmanabhan V, Harris SM, Boldenow E, Loch-Caruso R, Bakulski KM. 2023. Sexually concordant and dimorphic transcriptional responses to maternal trichloroethylene and/or N-acetyl cysteine exposure in Wistar rat placental tissue. Toxicology 483:153371. doi:10.1016/j.tox.2022.153371 PMID:36396003 PMCID:PMC10078828
  • Park H, Hogan KA, Harris SM, Chames MC, Loch-Caruso R. 2023. Group B streptococcus induces cellular senescence in human amnion epithelial cells through a partial interleukin-1-mediated mechanism. Biol Reprod doi:10.1093/biolre/ioad149 PMID:37903065
  • Su AL, Harris S, Elkin ER, Karnovsky A, Colacino JA, Loch-Caruso R. 2023. Trichloroethylene metabolite S-(1,2-dichlorovinyl)-1-cysteine stimulates changes in energy metabolites and amino acids in the BeWo Human Placental Trophoblast Model during syncytialization. Chem Res Toxicol 36(6):882-899. doi:10.1021/acs.chemrestox.3c00007 PMID:37162359
  • Su AL, Lash LH, Loch-Caruso R. 2023. N-Acetyl-L-cysteine and aminooxyacetic acid differentially modulate toxicity of the trichloroethylene metabolite S-(1,2-dichlorovinyl)-L-cysteine in human placental villous trophoblast BeWo cells. Toxicology 495:153611. doi:10.1016/j.tox.2023.153611 PMID:37544576
  • Su AL, Loch-Caruso R. 2023. Apoptotic responses stimulated by the trichloroethylene metabolite S-(1,2-dichlorovinyl)-L-cysteine depend on cell differentiation state in BeWo human trophoblast cells. Toxicol Vitro doi:10.1016/j.tiv.2022.105514 PMID:36336211 PMCID:PMC9949904

2022

  • Abdulhasan M, Ruden X, Marben T, Harris S, Ruden D, Awonuga AO, Puscheck EE, Rappolee DA. 2022. Using live imaging and fluorescence ubiquitinated cell cycle indicator embryonic stem cells to distinguish G1 cell cycle delays for general stressors like perfluoro-octanoic acid and hyperosmotic sorbitol or G2 cell cycle delay for mutagenic stressors like benzo(a)pyrene. Stem Cells Dev 31(11-12):296-310. doi:10.1089/scd.2021.0330 PMID:35678645 PMCID:PMC9232235
  • Bailey RE, Loch-Caruso R. 2022. Atmosphere of wet basements as a novel route for potential residential exposure to 1,4-dioxane vapor. Current Opinion in Environmental Science & Health 30:100406. doi:10.1016/j.coesh.2022.100406 PMID:36643950 PMCID:PMC9838188
  • Elkin ER, Su AL, Kilburn BA, Bakulski KM, Armant DR, Loch-Caruso R. 2022. Toxicity assessments of selected trichloroethylene and perchloroethylene metabolites in three in vitro human placental models. Reprod Toxicol 109:109-120. doi:10.1016/j.reprotox.2022.03.003 PMID:35304307 PMCID:PMC9107309
  • Harris S, Bakulski KM, Dou JF, Houskamp E, Scheeres EC, Schellenboom E, Harlow O, Loch-Caruso R, Boldenow E. 2022. The trichloroethylene metabolite S-(1,2-dichlorovinyl)-l-cysteine inhibits lipopolysaccharide-induced inflammation transcriptomic pathways and cytokine secretion in a macrophage cell model. Toxicol Vitro 84:105429. doi:10.1016/j.tiv.2022.105429 PMID:35811015
  • Harris SM, Colacino JA, Buxton MA, Croxton L, Nguyen VK, Loch-Caruso R, Bakulski KM. 2022. A data mining approach reveals chemicals detected at higher levels in non-Hispanic Black women target preterm birth genes and pathways. Reprod Sci doi:10.1007/s43032-022-00870-w PMID:35107823
  • Loch-Caruso R, Rayle R, Caruso VP, Bailey RE, Collins E, Knol KP. 2022. Michigan's Gelman site 1,4-dioxane groundwater contamination: still spreading decades after detection. Current Opinion in Environmental Science & Health 30:100405. doi:10.1016/j.coesh.2022.100405 PMID:36643949 PMCID:PMC9835328
  • Su AL, Harris SM, Elkin ER, Karnovsky A, Colacino JA, Loch-Caruso R. 2022. Trichloroethylene modifies energy metabolites in the amniotic fluid of Wistar rats. Reprod Toxicol 109:80-92. doi:10.1016/j.reprotox.2022.03.004 PMID:35301063 PMCID:PMC9000924

2021

  • Ashrap P, Watkins DJ, Milne GL, Ferguson KK, Loch-Caruso R, Fernandez J, Rosario Z, Velez Vega CM, Alshawabkeh AN, Cordero JF, Meeker JD. 2021. Maternal Urinary Metal and Metalloid Concentrations in Association with Oxidative Stress Biomarkers. Antioxidants (Basel) 10:114. doi:10.3390/antiox10010114 PMID:33467519
  • Aung MT, Ashrap P, Watkins DJ, Mukherjee B, Rosario Z, Velez Vega CM, Alshawabkeh AN, Cordero JF, Meeker JD. 2021. Maternal lipidomic signatures in relation to spontaneous preterm birth and large-for-gestational age neonates. Sci Rep 11:8115. doi:10.1038/s41598-021-87472-9 PMID:33854141 PMCID:PMC8046995
  • Aung MT, Bakulski KM, Feinberg JI, Dou JF, Meeker JD, Mukherjee B, Loch-Caruso R, Ladd-Acosta C, Volk HE, Croen LA, Hertz-Picciotto I, Newschaffer CJ, Fallin MD. 2021. Maternal blood metal concentrations and whole blood DNA methylation during pregnancy in the Early Autism Risk Longitudinal Investigation (EARLI). Epigenetics 1-16. doi:10.1080/15592294.2021.1897059 PMID:33794742
  • Cathey A, Watkins DJ, Rosario Z, Velez Vega CM, Mukherjee B, O'Neill MS, Loch-Caruso R, Alshawabkeh AN, Cordero JF, Meeker JD. 2021. Gestational hormone concentrations are associated with timing of delivery in a fetal sex-dependent manner. Front. Endocrinol 12(10):doi:10.3389/fendo.2021.742145 PMID:34603214 PMCID:PMC8479114
  • Elkin ER, Bakulski KM, Colacino JA, Bridges D, Kilburn BA, Armant DR, Loch-Caruso R. 2021. Transcriptional profiling of the response to the trichloroethylene metabolite S-(1,2-dichlorovinyl)-L-cysteine revealed activation of the eIF2a/ATF4 integrated stress response in two in vitro placental models. Arch Toxicol 95(5):1-25. doi:10.1007/s00204-021-03011-5 PMID:33725128 PMCID:PMC7961173 (ahead of print)
  • Jiang T, Amadei CA, Lin Y, Gao N, Rahman SM, Lan J, Vecitis CD, Gu AZ. 2021. Dependence of graphene oxide (GO) toxicity on oxidation level, elemental composition, and size. Int J Mol Sci 22(19):doi:10.3390/ijms221910578 PMID:34638921 PMCID:PMC8508828
  • Su AL, Lash LH, Bergin IL, Bjork F, Loch-Caruso R. 2021. N-Acetyl-L-cysteine and aminooxyacetic acid differentially modulate trichloroethylene reproductive toxicity via metabolism in Wistar rats. Arch Toxicol 95(4):doi:10.1007/s00204-021-02991-8 PMID:33599830 (ahead of print)

2020

2019

  • Aung MT, Ferguson KK, Cantonwine DE, Bakulski KM, Mukherjee B, Loch-Caruso R, McElrath TF, Meeker JD. 2019. Associations between maternal plasma measurements of inflammatory markers and urinary levels of phenols and parabens during pregnancy: a repeated measures study. Sci Total Environ 650(Pt1):1131-1140. doi:10.1016/j.scitotenv.2018.08.356 PMID:30308801 PMCID:PMC6236678
  • Elkin ER, Bridges D, Loch-Caruso R. 2019. The trichloroethylene metabolite S-(1,2-dichlorovinyl)-L-cysteine induces progressive mitochondrial dysfunction in HTR-8/SVneo trophoblasts. Toxicology 427:152283. doi:10.1016/j.tox.2019.152283 PMID:31476333 PMCID:PMC6943978
  • Loch-Caruso R, Hassan I, Harris SM, Kumar AM, Bjork F, Lash LH. 2019. Trichloroethylene exposure in mid-pregnancy decreased fetal weight and increased placental markers of oxidative stress in rats. Reprod Toxicol 83:38-45. doi:10.1016/j.reprotox.2018.11.002 PMID:30468822 PMCID:PMC6404769

2018

  • Elkin ER, Harris SM, Loch-Caruso R. 2018. Trichloroethylene metabolite S-(1,2-dichlorovinyl)-l-cysteine induces lipid peroxidation-associated apoptosis via the intrinsic and extrinsic apoptosis pathways in a first-trimester placental cell line. Toxicol Appl Pharmacol 338:30-42. doi:10.1016/j.taap.2017.11.006 PMID:29129777 PMCID:PMC5741094

2017

  • Cordero JF, Meeker JD, Loch-Caruso R, Giese RW, Padilla IY, Vesper D, Kaeli D, Sheahan TC, Brown P, Velez Vega CM, Alshawabkeh AN. 2017. Team science applied to environmental health research: karst hydrogeology and preterm birth in Puerto Rico. In: Karst Groundwater Contamination and Public Health: Beyond Case Studies. Springer, New York, NY. pp.17-25.
  • Park H, Harris SM, Boldenow E, McEachin RC, Sartor MA, Chames MC, Loch-Caruso R. 2017. Group B streptococcus activates transcriptomic pathways related to premature birth in human extraplacental membranes in vitro. Biol Reprod 98(3):396-407. doi:10.1093/biolre/iox147 PMID:29155939 PMCID:PMC6248496

2016

  • Hassan I, Kumar AM, Park H, Lash LH, Loch-Caruso R. 2016. Reactive oxygen stimulation of interleukin-6 release in the human trophoblast cell line HTR-8/SVneo by the trichlorethylene metabolite S-(1,2-Dichloro)-l-Cysteine. Biol Reprod 95(3):66. doi:10.1095/biolreprod.116.139261 PMID:27488030

2015

2014

  • Ferguson KK, Cantonwine DE, Rivera-Gonzalez LO, Loch-Caruso R, Mukherjee B, Anzalota del Toro LV, Jimenez B, Calafat AM, Ye X, Alshawabkeh AN, Cordero JF, Meeker JD. 2014. Urinary phthalate metabolite associations with biomarkers of inflammation and oxidative stress across pregnancy in Puerto Rico. Environ Sci Technol 48(12):7018-7025. doi:10.1021/es502076j PMID:24845688 PMCID:PMC4066910
  • Korir ML, Knupp D, LeMerise K, Boldenow E, Loch-Caruso R, Aronoff DM, Manning SD. 2014. Association and virulence gene expression vary among serotype III group B streptococcus isolates following exposure to decidual and lung epithelial cells. Infect Immun 82(11):4587-4595. doi:10.1128/IAI.02181-14 PMID:25135682 PMCID:PMC4249324
  • Park H, Kamau PW, Loch-Caruso R. 2014. Involvement of reactive oxygen species in brominated diphenyl ether-47-induced inflammatory cytokine release from human extravillous trophoblasts in vitro. Toxicol Appl Pharmacol 274(2):283-292. doi:10.1016/j.taap.2013.11.015 PMID:24296301 PMCID:PMC3931445
  • Park H, Loch-Caruso R. 2014. Protective effect of nuclear factor E2-related factor 2 on inflammatory cytokine response to brominated diphenyl ether-47 in the HTR-8/SVneo human first trimester extravillous trophoblast cell line. Toxicol Appl Pharmacol 281(1):67-77. doi:10.1016/j.taap.2014.09.015 PMID:25305463 PMCID:PMC4393751
  • Park HR, Kamau PW, Korte CS, Loch-Caruso R. 2014. Tetrabromobisphenol A activates inflammatory pathways in human first trimester extravillous trophoblasts in vitro. Reprod Toxicol 50:154-162. doi:10.1016/j.reprotox.2014.10.005 PMID:25461914 PMCID:PMC4260776

2013

2012

  • Ferguson KK, Loch-Caruso R, Meeker JD. 2012. Exploration of oxidative stress and inflammatory markers in relation to urinary phthalate metabolites: NHANES 1999-2006. Environ Sci Technol 46(1):477-485. doi:10.1021/es202340b PMID:22085025 PMCID:PMC3258337
  • Mao X, Ciblak A, Baek K, Amiri M, Loch-Caruso R, Alshawabkeh AN. 2012. Optimization of electrochemical dechlorination of trichloroethylene in reducing electrolytes. Water Res 46(6):1847–1857. doi:10.1016/j.watres.2012.01.002 PMID:22264798 PMCID:PMC3288245
  • Mao X, Yuan S, Fallahpour N, Ciblak A, Howard J, Padilla IY, Loch-Caruso R, Alshawabkeh AN. 2012. Electrochemically induced dual reactive barriers for transformation of TCE and mixture of contaminants in groundwater. Environ Sci Technol 46(21):12003-12011. doi:10.1021/es301711a PMID:23067023 PMCID:PMC3493133

2011

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