Superfund Research Program
Mechanisms of Exposure
Project Leader: Angela L. Slitt
Co-Investigators: Fatemeh Akhlaghi, Geoffrey D. Bothun
Grant Number: P42ES027706
Funding Period: 2022-2027
Project-Specific Links
- Project Summary
Publications
2024
- Alesio J, Bothun GD. 2024. Differential scanning fluorimetry to assess PFAS binding to bovine serum albumin protein. Sci Rep 14(1):6501. doi:10.1038/s41598-024-57140-9 PMID:38499613
- Hmila I, Hill J, Shalaby K, Ouararhni K, Abedsselem H, Modaresi SM, Bihaqi SW, Marques E, Sondhi A, Slitt AL, Zawia N. 2024. Perinatal exposure to PFOS and sustained high-fat diet promote neurodevelopmental disorders via genomic reprogramming of pathways associated with neuromotor development. Ecotoxicol Environ Saf 272:doi:10.1016/j.ecoenv.2024.116070
- Kaye EM, Marques E, Agudelo Areiza J, Modaresi SM, Slitt AL. 2024. Exposure to a PFOA, PFOS and PFHxS mixture during gestation and lactation alters the liver proteome in offspring of CD-1 mice. Toxics 12(5):doi:10.3390/toxics12050348 PMID:38787127 PMCID:11126053
- Ryu S, Burchett W, Zhang S, Jia X, Modaresi SM, Agudelo Areiza J, Rodrigues D, Zhu H, Sunderland EM, Fischer F, Slitt AL. 2024. Unbound fractions of PFAS in human and rodent tissues: rat liver a suitable proxy for evaluating emerging PFAS?. Environ Sci Technol 58(33):14641-14650. doi:10.1021/acs.est.4c04050 PMID:39161261
- Ryu S, Burchett W, Zhang S, Modaresi SM, Agudelo Areiza J, Kaye EM, Fischer F, Slitt AL. 2024. Species-specific unbound fraction differences in highly bound PFAS: A comparative study across human, rat, and mouse plasma and albumin. Toxics 12(4):doi:10.3390/toxics12040253 PMID:38668476 PMCID:11054487
2023
- Zhang Y, Mustieles V, Wang Y, Sun Q, Coull BA, Sun Y, Slitt AL, Messerlian C. 2023. Red blood cell folate modifies the association between serum per- and polyfluoroalkyl substances and antibody concentrations in U.S. adolescents. Environ Sci Technol 57(6):2445-2456. doi:10.1021/acs.est.2c07152 PMID:36715557
- Zhang Y, Mustieles V, Wang Y, Sun Y, Agudelo J, Bibi Z, Torres N, Oulhote Y, Slitt AL, Messerlian C. 2023. Folate concentrations and serum perfluoroalkyl and polyfluoroalkyl substance concentrations in adolescents and adults in the USA (National Health and Nutrition Examination Study 2003-16): an observational study. Lancet Planet Health 7(6):e449-e458. doi:10.1016/s2542-5196(23)00088-8 PMID:37286242 PMCID:10901144