Superfund Research Program

Assessment of Genotoxic Health Risks at Superfund Sites through Mutational Signatures

Project Leader: John M. Essigmann
Co-Investigator: Robert G. Croy
Grant Number: P42ES027707
Funding Period: 2017-2022

Project-Specific Links

Publications

2022

• Basu AK, Essigmann JM. 2022. Establishing linkages among DNA damage, mutagenesis, and genetic diseases. Chem Res Toxicol doi:10.1021/acs.chemrestox.2c00155 PMID:35881568

2021

• Fedeles BI, Essigmann JM. 2021. Mutational spectra provide insight into the mechanisms bridging DNA damage to genetic disease. DNA Damage, DNA Repair and Disease 15:214-253.
• Lu R, Yuan W, Croy RG, Essigmann JM, Swager TM. 2021. Metallocalix[4]arene polymers for gravimetric detection of N-nitrosodialkylamines. J Am Chem Soc 143:doi:10.1021/jacs.1c08739 PMID:34793165 PMCID:PMC8811785
• Tajai P, Suriyo T, Rangkadilok N, Fedeles BI, Essigmann JM, Satayavivad J. 2021. Andrographolide, an antioxidant, counteracts paraquat-induced mutagenesis in mammalian cells. Asian Pac. J. Cancer Prev 22:PMID:33576206

2020

• Thongararm P, Fedeles BI, Khumsubdee S, Armijo AL, Kim L, Thiantanawat A, Promvijit J, Navasumrit P, Ruchirawat K, Croy RG, Essigmann JM. 2020. Modulation of N-Methyl-N-nitrosourea mutagenesis in mouse embryo fibroblasts derived from the gpt delta mouse by an inhibitor of the O6-Methylguanine Methyltransferase, MGMT. Chem Res Toxicol 33:625-633. doi:10.1021/acs.chemrestox.9b00444 PMID:31841318 PMCID:PMC7033946

2019

• He M, Croy RG, Essigmann JM, Swager TM. 2019. Chemiresistive carbon nanotube sensors for n-nitrosodialkylamines. ACS Sens 4(10):2819-2824. doi:10.1021/acssensors.9b01532 PMID:31573183 PMCID:PMC6939299

2018

• Fedeles BI, Essigmann JM. 2018. Impact of DNA lesion repair, replication and formation on the mutational spectra of environmental carcinogens: Aflatoxin B1 as a case study. DNA Repair (Amst) 71:12-22. doi:10.1016/j.dnarep.2018.08.008 PMID:30309820 PMCID:PMC6340726